KEGG   REACTION: R04418
Entry
R04418                      Reaction                               
Name
5-carboxymethyl-2-hydroxymuconic-semialdehyde:NAD+ oxidoreductase
Definition
2-Hydroxy-5-carboxymethylmuconate semialdehyde + NAD+ + H2O <=> 5-Carboxymethyl-2-hydroxymuconate + NADH + H+
Equation
C04642 + C00003 + C00001 <=> C04186 + C00004 + C00080
Reaction class
RC00001  C00003_C00004
RC00254  C04186_C04642
Enzyme
1.1.1.312       1.2.1.60
Pathway
rn00350  Tyrosine metabolism
rn01100  Metabolic pathways
rn01120  Microbial metabolism in diverse environments
rn01220  Degradation of aromatic compounds
Module
M00533  Homoprotocatechuate degradation, homoprotocatechuate => 2-oxohept-3-enedioate
Brite
Enzymatic reactions [BR:br08201]
 1. Oxidoreductase reactions
  1.1  Acting on the CH-OH group of donors
   1.1.1  With NAD+ or NADP+ as acceptor
    1.1.1.312
     R04418  2-Hydroxy-5-carboxymethylmuconate semialdehyde + NAD+ + H2O <=> 5-Carboxymethyl-2-hydroxymuconate + NADH + H+
  1.2  Acting on the aldehyde or oxo group of donors
   1.2.1  With NAD+ or NADP+ as acceptor
    1.2.1.60
     R04418  2-Hydroxy-5-carboxymethylmuconate semialdehyde + NAD+ + H2O <=> 5-Carboxymethyl-2-hydroxymuconate + NADH + H+
Orthology
K00151  5-carboxymethyl-2-hydroxymuconic-semialdehyde dehydrogenase [EC:1.2.1.60]
K10219  2-hydroxy-4-carboxymuconate semialdehyde hemiacetal dehydrogenase [EC:1.1.1.312]
Other DBs
RHEA: 15684
LinkDB

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