KEGG   REACTION: R04440
Entry
R04440                      Reaction                               
Name
(R)-2,3-dihydroxy-3-methylbutanoate:NADP+ oxidoreductase (isomerizing)
Definition
(R)-2,3-Dihydroxy-3-methylbutanoate + NADP+ <=> 3-Hydroxy-3-methyl-2-oxobutanoic acid + NADPH + H+
Equation
C04272 + C00006 <=> C04181 + C00005 + C00080
Reaction class
RC00001  C00005_C00006
RC00726  C04181_C04272
Enzyme
1.1.1.86
Pathway
rn00290  Valine, leucine and isoleucine biosynthesis
rn01100  Metabolic pathways
rn01110  Biosynthesis of secondary metabolites
rn01210  2-Oxocarboxylic acid metabolism
rn01230  Biosynthesis of amino acids
Module
M00019  Valine/isoleucine biosynthesis, pyruvate => valine / 2-oxobutanoate => isoleucine
Brite
Enzymatic reactions [BR:br08201]
 1. Oxidoreductase reactions
  1.1  Acting on the CH-OH group of donors
   1.1.1  With NAD+ or NADP+ as acceptor
    1.1.1.86
     R04440  (R)-2,3-Dihydroxy-3-methylbutanoate + NADP+ <=> 3-Hydroxy-3-methyl-2-oxobutanoic acid + NADPH + H+
Orthology
K00053  ketol-acid reductoisomerase [EC:1.1.1.86]
Other DBs
RHEA: 31142
LinkDB

DBGET integrated database retrieval system