KEGG   REACTION: R04445
Entry
R04445                      Reaction                               
Name
L-1-pyrroline-3-hydroxy-5-carboxylate:NADP+ oxidoreductase
Definition
L-1-Pyrroline-3-hydroxy-5-carboxylate + NADP+ + 2 H2O <=> L-erythro-4-Hydroxyglutamate + NADPH + H+
Equation
C04281 + C00006 + 2 C00001 <=> C05947 + C00005 + C00080
Comment
possibly two-step reaction
NADH (see R04444)
Reaction class
RC00001  C00005_C00006
RC00255  C04281_C05947
Enzyme
1.2.1.88
Pathway
rn00330  Arginine and proline metabolism
rn01100  Metabolic pathways
Brite
Enzymatic reactions [BR:br08201]
 1. Oxidoreductase reactions
  1.2  Acting on the aldehyde or oxo group of donors
   1.2.1  With NAD+ or NADP+ as acceptor
    1.2.1.88
     R04445  L-1-Pyrroline-3-hydroxy-5-carboxylate + NADP+ + 2 H2O <=> L-erythro-4-Hydroxyglutamate + NADPH + H+
Orthology
K00294  1-pyrroline-5-carboxylate dehydrogenase [EC:1.2.1.88]
K13821  RHH-type transcriptional regulator, proline utilization regulon repressor / proline dehydrogenase / delta 1-pyrroline-5-carboxylate dehydrogenase [EC:1.5.5.2 1.2.1.88]
Other DBs
RHEA: 24946
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