KEGG   REACTION: R04537
Entry
R04537                      Reaction                               
Name
(3R)-3-hydroxyoctanoyl-[acyl-carrier-protein] hydro-lyase
Definition
(3R)-3-Hydroxyoctanoyl-[acyl-carrier protein] <=> trans-Oct-2-enoyl-[acp] + H2O
Equation
Reaction class
RC01095  C04620_C05751
Enzyme
2.3.1.85        2.3.1.86        2.3.1.-         4.2.1.59        
4.2.1.-
Pathway
rn00061  Fatty acid biosynthesis
rn01100  Metabolic pathways
rn01212  Fatty acid metabolism
Module
M00083  Fatty acid biosynthesis, elongation
Brite
Enzymatic reactions [BR:br08201]
 2. Transferase reactions
  2.3  Acyltransferases
   2.3.1  Transferring groups other than aminoacyl groups
    2.3.1.85
     R04537  (3R)-3-Hydroxyoctanoyl-[acyl-carrier protein] <=> trans-Oct-2-enoyl-[acp] + H2O
    2.3.1.86
     R04537  (3R)-3-Hydroxyoctanoyl-[acyl-carrier protein] <=> trans-Oct-2-enoyl-[acp] + H2O
    2.3.1.-
     R04537  (3R)-3-Hydroxyoctanoyl-[acyl-carrier protein] <=> trans-Oct-2-enoyl-[acp] + H2O
 4. Lyase reactions
  4.2  Carbon-oxygen lyases
   4.2.1  Hydro-lyases
    4.2.1.59
     R04537  (3R)-3-Hydroxyoctanoyl-[acyl-carrier protein] <=> trans-Oct-2-enoyl-[acp] + H2O
    4.2.1.-
     R04537  (3R)-3-Hydroxyoctanoyl-[acyl-carrier protein] <=> trans-Oct-2-enoyl-[acp] + H2O
IUBMB reaction hierarchy [BR:br08202]
 4. Lyase reactions
  4.2.1.59
   R10208  (3R)-3-Hydroxyacyl-[acyl-carrier protein] <=> trans-2,3-Dehydroacyl-[acyl-carrier protein]
    R04537  (3R)-3-Hydroxyoctanoyl-[acyl-carrier protein] <=> trans-Oct-2-enoyl-[acp]
Orthology
K00665  fatty acid synthase, animal type [EC:2.3.1.85]
K00668  fatty acid synthase subunit beta, fungi type [EC:2.3.1.86]
K01716  3-hydroxyacyl-[acyl-carrier protein] dehydratase / trans-2-decenoyl-[acyl-carrier protein] isomerase [EC:4.2.1.59 5.3.3.14]
K02372  3-hydroxyacyl-[acyl-carrier-protein] dehydratase [EC:4.2.1.59]
K11533  fatty acid synthase, bacteria type [EC:2.3.1.-]
K16363  UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase / 3-hydroxyacyl-[acyl-carrier-protein] dehydratase [EC:3.5.1.108 4.2.1.59]
K22540  3-hydroxyacyl-thioester dehydratase, animal type [EC:4.2.1.-]
K22541  3-hydroxyacyl-thioester dehydratase, fungi type [EC:4.2.1.-]
Reference
1  [PMID:27553474]
  Authors
Kastaniotis AJ, Autio KJ, Keratar JM, Monteuuis G, Makela AM, Nair RR, Pietikainen LP, Shvetsova A, Chen Z, Hiltunen JK
  Title
Mitochondrial fatty acid synthesis, fatty acids and mitochondrial physiology.
  Journal
Biochim Biophys Acta Mol Cell Biol Lipids 1862:39-48 (2017)
DOI:10.1016/j.bbalip.2016.08.011
Other DBs
RHEA: 41847
LinkDB

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