KEGG   REACTION: R06266
Entry
R06266                      Reaction                               
Name
magnesium-protoporphyrin-IX 13-monomethyl ester,NADPH:oxygen oxidoreductase (hydroxylating)
Definition
13(1)-Hydroxy-magnesium-protoporphyrin IX 13-monomethyl ester + NADPH + H+ + Oxygen <=> 13(1)-Oxo-magnesium-protoporphyrin IX 13-monomethyl ester + NADP+ + 2 H2O
Equation
C11829 + C00005 + C00080 + C00007 <=> C11830 + C00006 + 2 C00001
Comment
second step of three-step reaction (see R10068, R06265+R06266+R06267)
Reaction class
RC00001  C00005_C00006
RC01491  C11829_C11830
Enzyme
1.14.13.81
Pathway
rn00860  Porphyrin metabolism
rn01110  Biosynthesis of secondary metabolites
Brite
Enzymatic reactions [BR:br08201]
 1. Oxidoreductase reactions
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.13  With NADH or NADPH as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.13.81
     R06266  13(1)-Hydroxy-magnesium-protoporphyrin IX 13-monomethyl ester + NADPH + H+ + Oxygen <=> 13(1)-Oxo-magnesium-protoporphyrin IX 13-monomethyl ester + NADP+ + 2 H2O
Orthology
K04035  magnesium-protoporphyrin IX monomethyl ester (oxidative) cyclase [EC:1.14.13.81]
Other DBs
RHEA: 20544
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