KEGG   REACTION: R06613
Entry
R06613                      Reaction                               
Name
5,10-methylenetetrahydrofolate,NADPH:dUMP C-methyltransferase
Definition
5,10-Methylenetetrahydrofolate + dUMP + NADPH + H+ <=> Tetrahydrofolate + dTMP + NADP+
Equation
C00143 + C00365 + C00005 + C00080 <=> C00101 + C00364 + C00006
Reaction class
RC00001  C00005_C00006
RC00022  C00101_C00143
RC00332  C00364_C00365
Enzyme
2.1.1.148
Pathway
rn00240  Pyrimidine metabolism
rn00670  One carbon pool by folate
rn01100  Metabolic pathways
rn01232  Nucleotide metabolism
Module
M00938  Pyrimidine deoxyribonucleotide biosynthesis, UDP => dTTP
Brite
Enzymatic reactions [BR:br08201]
 2. Transferase reactions
  2.1  Transferring one-carbon groups
   2.1.1  Methyltransferases
    2.1.1.148
     R06613  5,10-Methylenetetrahydrofolate + dUMP + NADPH + H+ <=> Tetrahydrofolate + dTMP + NADP+
Orthology
K03465  thymidylate synthase (FAD) [EC:2.1.1.148]
Other DBs
RHEA: 29046
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