REACTION: R07601
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Entry
R07601 Reaction
Definition
4-Methyl-2-oxopentanoate + Thiamin diphosphate <=> 3-Methyl-1-hydroxybutyl-ThPP + CO2
Equation
C00233
+
C00068
<=>
C15974
+
C00011
Comment
Oxo-acid dehydrogenase complexes (see
R01702
), subsequently
R07602
Reaction class
RC00027
C00068_C15974
RC02743
C00233_C15974
Enzyme
1.2.4.4
Pathway
rn00280
Valine, leucine and isoleucine degradation
rn00785
Lipoic acid metabolism
rn01100
Metabolic pathways
Module
M00036
Leucine degradation, leucine => acetoacetate + acetyl-CoA
Brite
Enzymatic reactions [BR:
br08201
]
1. Oxidoreductase reactions
1.2 Acting on the aldehyde or oxo group of donors
1.2.4 With a disulfide as acceptor
1.2.4.4
R07601 4-Methyl-2-oxopentanoate + Thiamin diphosphate <=> 3-Methyl-1-hydroxybutyl-ThPP + CO2
BRITE hierarchy
Orthology
K00166
2-oxoisovalerate dehydrogenase E1 component subunit alpha [EC:
1.2.4.4
]
K00167
2-oxoisovalerate dehydrogenase E1 component subunit beta [EC:
1.2.4.4
]
K11381
2-oxoisovalerate dehydrogenase E1 component [EC:
1.2.4.4
]
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