REACTION: R08549
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Entry
R08549 Reaction
Name
2-oxoglutarate:NAD+ 2-oxidoreductase (CoA-succinylating);
2-oxoglutarate dehydrogenase complex
Definition
2-Oxoglutarate + CoA + NAD+ <=> Succinyl-CoA + CO2 + NADH + H+
Equation
C00026
+
C00010
+
C00003
<=>
C00091
+
C00011
+
C00004
+
C00080
Comment
multienzyme system: ec
1.2.4.2
, ec
2.3.1.61
and ec
1.8.1.4
multi-step reaction (see
R01700+R02570+R07618
)
Reaction class
RC00001
C00003_C00004
RC00004
C00010_C00091
RC02833
C00026_C00091
Enzyme
1.2.1.105
Pathway
rn01100
Metabolic pathways
rn01110
Biosynthesis of secondary metabolites
rn01120
Microbial metabolism in diverse environments
rn01200
Carbon metabolism
rn01210
2-Oxocarboxylic acid metabolism
Brite
Enzymatic reactions [BR:
br08201
]
1. Oxidoreductase reactions
1.2 Acting on the aldehyde or oxo group of donors
1.2.1 With NAD+ or NADP+ as acceptor
1.2.1.105
R08549 2-Oxoglutarate + CoA + NAD+ <=> Succinyl-CoA + CO2 + NADH + H+
BRITE hierarchy
Orthology
K00164
2-oxoglutarate dehydrogenase E1 component [EC:
1.2.4.2
]
K00382
dihydrolipoyl dehydrogenase [EC:
1.8.1.4
]
K00658
2-oxoglutarate dehydrogenase E2 component (dihydrolipoamide succinyltransferase) [EC:
2.3.1.61
]
K01616
multifunctional 2-oxoglutarate metabolism enzyme [EC:
2.2.1.5
4.1.1.71
1.2.4.2
2.3.1.61
]
Other DBs
RHEA:
27789
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