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map2k2b mitogen-activated protein kinase kinase 2b [ Danio rerio (zebrafish) ]

Gene ID: 100002225, updated on 27-Mar-2024

Summary

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Official Symbol
map2k2bprovided by ZNC
Official Full Name
mitogen-activated protein kinase kinase 2bprovided by ZNC
Primary source
ZFIN:ZDB-GENE-080219-34
See related
Ensembl:ENSDARG00000068918 AllianceGenome:ZFIN:ZDB-GENE-080219-34
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
zgc:172250
Summary
Predicted to enable MAP kinase kinase activity. Predicted to be involved in MAPK cascade. Predicted to act upstream of or within protein phosphorylation. Human ortholog(s) of this gene implicated in cardiofaciocutaneous syndrome 4 and small intestine adenocarcinoma. Orthologous to human MAP2K2 (mitogen-activated protein kinase kinase 2). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
all
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Genomic context

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Location:
chromosome: 2
Exon count:
12
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 2 NC_007113.7 (57416844..57444145, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 2 NC_007113.6 (57282690..57309976, complement)

Chromosome 2 - NC_007113.7Genomic Context describing neighboring genes Neighboring gene si:ch1073-325m22.2 Neighboring gene uncharacterized LOC108180185 Neighboring gene transcription factor 3a Neighboring gene protein inhibitor of activated STAT, 4b Neighboring gene one cut homeobox 3b

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Activation of MEK2 is sufficient to induce skin papilloma formation in transgenic zebrafish. Chou CM, et al. J Biomed Sci, 2015 Nov 17. PMID 26572230, Free PMC Article
  2. Evolution of complexity in the zebrafish synapse proteome. Bayés À, et al. Nat Commun, 2017 Mar 2. PMID 28252024, Free PMC Article
  3. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables MAP kinase kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables MAP kinase kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in MAPK cascade IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within phosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of Golgi inheritance IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of early endosome to late endosome transport IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of stress-activated MAPK cascade IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in early endosome IEA
Inferred from Electronic Annotation
more info
  
located_in focal adhesion IEA
Inferred from Electronic Annotation
more info
  
located_in late endosome IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
dual specificity mitogen-activated protein kinase kinase 2; dual specificity mitogen-activated protein kinase kinase 2b
NP_001121753.1
XP_009297220.1
XP_021333936.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001128281.1 → NP_001121753.1  dual specificity mitogen-activated protein kinase kinase 2b

    See identical proteins and their annotated locations for NP_001121753.1

    Status: PROVISIONAL

    Source sequence(s)
    BC155634
    UniProtKB/TrEMBL
    A9JRF0
    Related
    ENSDARP00000090612.2, ENSDART00000099839.3
    Conserved Domains (2) summary
    cd06615
    Location:69 → 382
    PKc_MEK; Catalytic domain of the dual-specificity Protein Kinase, Mitogen-Activated Protein (MAP)/Extracellular signal-Regulated Kinase (ERK) Kinase
    smart00220
    Location:71 → 364
    S_TKc; Serine/Threonine protein kinases, catalytic domain

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007113.7 Reference GRCz11 Primary Assembly

    Range
    57416844..57444145 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_021478261.1 → XP_021333936.1  dual specificity mitogen-activated protein kinase kinase 2 isoform X1

    UniProtKB/TrEMBL
    A0A8M9QDR9
    Related
    ENSDARP00000124788.1, ENSDART00000149838.3
    Conserved Domains (1) summary
    cd06615
    Location:69 → 382
    PKc_MEK; Catalytic domain of the dual-specificity Protein Kinase, Mitogen-Activated Protein (MAP)/Extracellular signal-Regulated Kinase (ERK) Kinase

  2. XM_009298945.3 → XP_009297220.1  dual specificity mitogen-activated protein kinase kinase 2 isoform X2

    UniProtKB/TrEMBL
    A0A8M3B0K9
    Conserved Domains (2) summary
    smart00220
    Location:71 → 265
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cl21453
    Location:69 → 323
    PKc_like; Protein Kinases, catalytic domain
Nucleotide Protein Strain
Heading Accession and Version

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