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zfyve9a zinc finger, FYVE domain containing 9a [ Danio rerio (zebrafish) ]

Gene ID: 100005449, updated on 27-Mar-2024

Summary

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Official Symbol
zfyve9aprovided by ZNC
Official Full Name
zinc finger, FYVE domain containing 9aprovided by ZNC
Primary source
ZFIN:ZDB-GENE-070705-182
See related
Ensembl:ENSDARG00000101903 AllianceGenome:ZFIN:ZDB-GENE-070705-182
Gene type
protein coding
RefSeq status
MODEL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
sara; zfyve9; si:ch211-57g18.2
Summary
Predicted to enable metal ion binding activity. Acts upstream of or within generation of neurons and hepatocyte proliferation. Located in endosome. Is expressed in brain and liver. Orthologous to human ZFYVE9 (zinc finger FYVE-type containing 9). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
all
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Genomic context

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Location:
chromosome: 2
Exon count:
19
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 2 NC_007113.7 (19280813..19354619, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 2 NC_007113.6 (19631753..19705555, complement)

Chromosome 2 - NC_007113.7Genomic Context describing neighboring genes Neighboring gene cell division cycle 20 homolog Neighboring gene coiled-coil and C2 domain containing 1B Neighboring gene serine/threonine-protein kinase pim-1-like Neighboring gene Pim proto-oncogene, serine/threonine kinase, related 141

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Asymmetric neurogenic commitment of retinal progenitors involves Notch through the endocytic pathway. Nerli E, et al. Elife, 2020 Nov 3. PMID 33141024, Free PMC Article
  2. Directional Notch trafficking in Sara endosomes during asymmetric cell division in the spinal cord. Kressmann S, et al. Nat Cell Biol, 2015 Mar. PMID 25706234
  3. Zfyve9a regulates the proliferation of hepatic cells during zebrafish embryogenesis. Liu N, et al. Int J Dev Biol, 2013. PMID 24307302
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article
  5. Gene evolution and gene expression after whole genome duplication in fish: the PhyloFish database. Pasquier J, et al. BMC Genomics, 2016 May 18. PMID 27189481, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. zfyve9a is enriched in the zebrafish embryonic liver and required for hepatogenesis.
    Title: Zfyve9a regulates the proliferation of hepatic cells during zebrafish embryogenesis.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in endosomal transport IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within generation of neurons IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within hepatocyte proliferation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in liver development IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within liver development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in early endosome membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endosome IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
zinc finger FYVE domain-containing protein 9
Names
sara1b
zinc finger, FYVE domain containing 9

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007113.7 Reference GRCz11 Primary Assembly

    Range
    19280813..19354619 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_001344468.6 → XP_001344504.2  zinc finger FYVE domain-containing protein 9 isoform X2

    UniProtKB/TrEMBL
    A0A8M1PZT4
    Conserved Domains (3) summary
    cd15729
    Location:480 → 547
    FYVE_endofin; FYVE domain found in endofin and similar proteins
    pfam11409
    Location:563 → 601
    SARA; Smad anchor for receptor activation (SARA)
    pfam11979
    Location:832 → 1184
    DUF3480; Domain of unknown function (DUF3480)

  2. XM_005171197.4 → XP_005171254.1  zinc finger FYVE domain-containing protein 9 isoform X1

    UniProtKB/TrEMBL
    A0A8M2BIH3, A5PMI2, F1RDB3
    Related
    ENSDARP00000131596.1, ENSDART00000168627.2
    Conserved Domains (3) summary
    cd15729
    Location:480 → 547
    FYVE_endofin; FYVE domain found in endofin and similar proteins
    pfam11409
    Location:563 → 601
    SARA; Smad anchor for receptor activation (SARA)
    pfam11979
    Location:839 → 1191
    DUF3480; Domain of unknown function (DUF3480)

RNA

  1. XR_002455890.1 RNA Sequence

Nucleotide Protein
Heading Accession and Version

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