U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Osbpl9 oxysterol binding protein-like 9 [ Mus musculus (house mouse) ]

Gene ID: 100273, updated on 11-Apr-2024

Summary

Go to the top of the page Help
Official Symbol
Osbpl9provided by MGI
Official Full Name
oxysterol binding protein-like 9provided by MGI
Primary source
MGI:MGI:1923784
See related
Ensembl:ENSMUSG00000028559 AllianceGenome:MGI:1923784
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Orp-9; 2600011I06Rik
Summary
Predicted to enable sterol binding activity and sterol transporter activity. Predicted to act upstream of or within lipid transport. Predicted to be located in Golgi apparatus. Predicted to be active in cytosol; intracellular membrane-bounded organelle; and membrane. Is expressed in several structures, including central nervous system; ganglia; genitourinary system; immune system; and liver. Orthologous to human OSBPL9 (oxysterol binding protein like 9). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in bladder adult (RPKM 17.6), kidney adult (RPKM 16.6) and 28 other tissues See more
Orthologs
human all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
4 C7; 4 50.77 cM
Exon count:
30
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (108918342..109059469, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (109061145..109202272, complement)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene RAB3B, member RAS oncogene family Neighboring gene RIKEN cDNA 8030443G20 gene Neighboring gene STARR-seq mESC enhancer starr_11059 Neighboring gene STARR-positive B cell enhancer ABC_E520 Neighboring gene STARR-seq mESC enhancer starr_11060 Neighboring gene nardilysin convertase Neighboring gene microRNA 761 Neighboring gene STARR-seq mESC enhancer starr_11061 Neighboring gene STARR-seq mESC enhancer starr_11062 Neighboring gene STARR-positive B cell enhancer mm9_chr4:108777798-108778099 Neighboring gene predicted gene, 32581 Neighboring gene STARR-positive B cell enhancer ABC_E521 Neighboring gene STARR-positive B cell enhancer ABC_E6198 Neighboring gene STARR-seq mESC enhancer starr_11065 Neighboring gene predicted gene, 52703 Neighboring gene STARR-positive B cell enhancer ABC_E11807 Neighboring gene predicted gene, 46867 Neighboring gene predicted gene, 40225 Neighboring gene calreticulin 4 Neighboring gene STARR-positive B cell enhancer ABC_E2703 Neighboring gene epidermal growth factor receptor pathway substrate 15 Neighboring gene predicted gene, 52753

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. An oxysterol-binding protein family identified in the mouse. Anniss AM, et al. DNA Cell Biol, 2002 Aug. PMID 12215260
  2. Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach. Gauci S, et al. Anal Chem, 2009 Jun 1. PMID 19413330
  3. Cracking the egg: molecular dynamics and evolutionary aspects of the transition from the fully grown oocyte to embryo. Evsikov AV, et al. Genes Dev, 2006 Oct 1. PMID 17015433, Free PMC Article
  4. Transcriptome analysis of mouse stem cells and early embryos. Sharov AA, et al. PLoS Biol, 2003 Dec. PMID 14691545, Free PMC Article
  5. Widespread and dynamic translational control of red blood cell development. Alvarez-Dominguez JR, et al. Blood, 2017 Feb 2. PMID 27899360, Free PMC Article

See all (27) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

Go to the top of the page Help

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Targeted (1) 
  • Endonuclease-mediated (1) 

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Clone Names

  • MGC30367, MGC38458

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables lipid binding IEA
Inferred from Electronic Annotation
more info
  
enables sterol binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within lipid transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in Golgi apparatus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in endosome IEA
Inferred from Electronic Annotation
more info
  
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
  
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

Go to the top of the page Help
Preferred Names
oxysterol-binding protein-related protein 9
Names
OSBP-related protein 9

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001134791.2 → NP_001128263.1  oxysterol-binding protein-related protein 9 isoform c

    See identical proteins and their annotated locations for NP_001128263.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (c) has multiple differences in the 5' UTR and 5' coding region, compared to variant a, resulting in a protein (isoform c) with a shorter and distinct N-terminus when compared to isoform a.
    Source sequence(s)
    AK035658, AL627406, BC089163, CJ088630
    Consensus CDS
    CCDS51257.1
    UniProtKB/TrEMBL
    F6UHR6, Q5FWX7
    Related
    ENSMUSP00000124112.2, ENSMUST00000160271.8
    Conserved Domains (1) summary
    pfam01237
    Location:267 → 613
    Oxysterol_BP; Oxysterol-binding protein

  2. NM_001346502.2 → NP_001333431.1  oxysterol-binding protein-related protein 9 isoform d

    Status: VALIDATED

    Description
    Transcript Variant: This variant (d) contains an alternate, internal exon compared to variant a. It encodes isoform d, which is longer than isoform a.
    Source sequence(s)
    AK035658, AL627103, BE861957, CA318269, CK621564, CN692679, CO043799, DV651580
    Consensus CDS
    CCDS84775.1
    UniProtKB/TrEMBL
    A0A0A6YXH3, F6UHR6
    Related
    ENSMUSP00000141991.2, ENSMUST00000194478.6
    Conserved Domains (2) summary
    cd13290
    Location:5 → 106
    PH_ORP9; Human Oxysterol binding protein related protein 9 Pleckstrin homology (PH) domain
    pfam01237
    Location:387 → 733
    Oxysterol_BP; Oxysterol-binding protein

  3. NM_001355190.1 → NP_001342119.1  oxysterol-binding protein-related protein 9 isoform e

    Status: VALIDATED

    Source sequence(s)
    AK035658, AL627406, BQ176735, BQ745311, BU706118, CD353630, CX563312, DV651580, DV657501
    Conserved Domains (1) summary
    pfam01237
    Location:199 → 545
    Oxysterol_BP; Oxysterol-binding protein

  4. NM_001355191.1 → NP_001342120.1  oxysterol-binding protein-related protein 9 isoform e

    Status: VALIDATED

    Source sequence(s)
    AK035658, AL627406, BQ176735, BQ745311, BU706118, CX563312, DV651580, DV657501
    Conserved Domains (1) summary
    pfam01237
    Location:199 → 545
    Oxysterol_BP; Oxysterol-binding protein

  5. NM_001368727.1 → NP_001355656.1  oxysterol-binding protein-related protein 9 isoform f

    Status: VALIDATED

    Source sequence(s)
    AL627103, AL627406
    Consensus CDS
    CCDS89802.1
    UniProtKB/Swiss-Prot
    A2A8Z1, A2A9Q8
    UniProtKB/TrEMBL
    F6UHR6
    Related
    ENSMUSP00000030288.8, ENSMUST00000030288.14
    Conserved Domains (2) summary
    cd13290
    Location:5 → 106
    PH_ORP9; Human Oxysterol binding protein related protein 9 Pleckstrin homology (PH) domain
    pfam01237
    Location:377 → 723
    Oxysterol_BP; Oxysterol-binding protein

  6. NM_133885.4 → NP_598646.4  oxysterol-binding protein-related protein 9 isoform a

    See identical proteins and their annotated locations for NP_598646.4

    Status: VALIDATED

    Description
    Transcript Variant: This variant (a) represents the longest transcript and encodes the longest isoform (a).
    Source sequence(s)
    AK075981, AK131984, AL627103, AL627406
    Consensus CDS
    CCDS38835.2
    UniProtKB/TrEMBL
    E9PXZ2, F6UHR6
    Related
    ENSMUSP00000124370.3, ENSMUST00000162787.9
    Conserved Domains (2) summary
    cd13290
    Location:5 → 106
    PH_ORP9; Human Oxysterol binding protein related protein 9 Pleckstrin homology (PH) domain
    pfam01237
    Location:364 → 710
    Oxysterol_BP; Oxysterol-binding protein

  7. NM_173350.3 → NP_775485.2  oxysterol-binding protein-related protein 9 isoform b

    Status: VALIDATED

    Description
    Transcript Variant: This variant (b) has multiple differences in the 5' UTR and 5' coding region, compared to variant a, resulting in a protein (isoform b) with a shorter and distinct N-terminus when compared to isoform a.
    Source sequence(s)
    AK035658, AL627406, CJ088630
    Consensus CDS
    CCDS51258.1
    UniProtKB/TrEMBL
    F6UHR6
    Related
    ENSMUSP00000081396.7, ENSMUST00000084366.13
    Conserved Domains (1) summary
    pfam01237
    Location:280 → 626
    Oxysterol_BP; Oxysterol-binding protein

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    108918342..109059469 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006502617.4 → XP_006502680.2  oxysterol-binding protein-related protein 9 isoform X1

    UniProtKB/TrEMBL
    F6UHR6
    Related
    ENSMUSP00000124742.2, ENSMUST00000160774.8
    Conserved Domains (2) summary
    cd13290
    Location:5 → 106
    PH_ORP9; Human Oxysterol binding protein related protein 9 Pleckstrin homology (PH) domain
    pfam01237
    Location:400 → 746
    Oxysterol_BP; Oxysterol-binding protein

  2. XM_036163549.1 → XP_036019442.1  oxysterol-binding protein-related protein 9 isoform X7

    UniProtKB/TrEMBL
    Q8R0G3
    Conserved Domains (1) summary
    pfam01237
    Location:212 → 558
    Oxysterol_BP; Oxysterol-binding protein

  3. XM_030253060.2 → XP_030108920.1  oxysterol-binding protein-related protein 9 isoform X8

    Conserved Domains (1) summary
    pfam01237
    Location:199 → 545
    Oxysterol_BP; Oxysterol-binding protein

  4. XM_036163548.1 → XP_036019441.1  oxysterol-binding protein-related protein 9 isoform X7

    UniProtKB/TrEMBL
    Q8R0G3
    Conserved Domains (1) summary
    pfam01237
    Location:212 → 558
    Oxysterol_BP; Oxysterol-binding protein

  5. XM_030253064.2 → XP_030108924.1  oxysterol-binding protein-related protein 9 isoform X9

    Conserved Domains (1) summary
    pfam01237
    Location:35 → 381
    Oxysterol_BP; Oxysterol-binding protein

  6. XM_030253061.2 → XP_030108921.1  oxysterol-binding protein-related protein 9 isoform X8

    Conserved Domains (1) summary
    pfam01237
    Location:199 → 545
    Oxysterol_BP; Oxysterol-binding protein

  7. XM_030253057.1 → XP_030108917.1  oxysterol-binding protein-related protein 9 isoform X2

    UniProtKB/TrEMBL
    F6UHR6
    Conserved Domains (2) summary
    pfam01237
    Location:359 → 705
    Oxysterol_BP; Oxysterol-binding protein
    cl17171
    Location:1 → 65
    PH-like; Pleckstrin homology-like domain

  8. XM_036163550.1 → XP_036019443.1  oxysterol-binding protein-related protein 9 isoform X9

    Conserved Domains (1) summary
    pfam01237
    Location:35 → 381
    Oxysterol_BP; Oxysterol-binding protein

  9. XM_030253062.1 → XP_030108922.1  oxysterol-binding protein-related protein 9 isoform X8

    Conserved Domains (1) summary
    pfam01237
    Location:199 → 545
    Oxysterol_BP; Oxysterol-binding protein

  10. XM_036163547.1 → XP_036019440.1  oxysterol-binding protein-related protein 9 isoform X5

    UniProtKB/TrEMBL
    F6UHR6
    Conserved Domains (2) summary
    pfam01237
    Location:310 → 656
    Oxysterol_BP; Oxysterol-binding protein
    cl17171
    Location:13 → 39
    PH-like; Pleckstrin homology-like domain

  11. XM_036163546.1 → XP_036019439.1  oxysterol-binding protein-related protein 9 isoform X3

    UniProtKB/TrEMBL
    F6UHR6
    Conserved Domains (2) summary
    pfam01237
    Location:333 → 679
    Oxysterol_BP; Oxysterol-binding protein
    cl17171
    Location:13 → 39
    PH-like; Pleckstrin homology-like domain

  12. XM_030253059.2 → XP_030108919.1  oxysterol-binding protein-related protein 9 isoform X6

    UniProtKB/TrEMBL
    E9Q6C1, F6UHR6
    Related
    ENSMUSP00000125714.2, ENSMUST00000161363.2
    Conserved Domains (2) summary
    pfam01237
    Location:297 → 643
    Oxysterol_BP; Oxysterol-binding protein
    cl17171
    Location:13 → 39
    PH-like; Pleckstrin homology-like domain

  13. XM_030253063.1 → XP_030108923.1  oxysterol-binding protein-related protein 9 isoform X8

    Conserved Domains (1) summary
    pfam01237
    Location:199 → 545
    Oxysterol_BP; Oxysterol-binding protein

  14. XM_011240378.1 → XP_011238680.1  oxysterol-binding protein-related protein 9 isoform X7

    See identical proteins and their annotated locations for XP_011238680.1

    UniProtKB/TrEMBL
    Q8R0G3
    Conserved Domains (1) summary
    pfam01237
    Location:212 → 558
    Oxysterol_BP; Oxysterol-binding protein

  15. XM_030253058.2 → XP_030108918.1  oxysterol-binding protein-related protein 9 isoform X4

    UniProtKB/TrEMBL
    F6UHR6
    Conserved Domains (2) summary
    pfam01237
    Location:320 → 666
    Oxysterol_BP; Oxysterol-binding protein
    cl17171
    Location:13 → 39
    PH-like; Pleckstrin homology-like domain

  16. XM_030253065.1 → XP_030108925.1  oxysterol-binding protein-related protein 9 isoform X9

    Conserved Domains (1) summary
    pfam01237
    Location:35 → 381
    Oxysterol_BP; Oxysterol-binding protein
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A2A8Z1.1 GenPept UniProtKB/Swiss-Prot:A2A8Z1

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous