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POC1B-GALNT4 POC1B-GALNT4 readthrough [ Homo sapiens (human) ]

Gene ID: 100528030, updated on 8-Mar-2024

Summary

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Official Symbol
POC1B-GALNT4provided by HGNC
Official Full Name
POC1B-GALNT4 readthroughprovided by HGNC
Primary source
HGNC:HGNC:42957
See related
Ensembl:ENSG00000259075 AllianceGenome:HGNC:42957
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
GALNT4; GalNAc-T4
Summary
This locus represents naturally occurring transcripts that splice the 5' exons of the POC1B (POC1 centriolar protein homolog B) gene on chromosome 12 to the GALNT4 (UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 4) gene, which is located within a POC1B intron. Alternative splicing results in two transcript variants, one of which encodes a fusion isoform that shares sequence identity with the products of each individual gene. [provided by RefSeq, Dec 2010]
Expression
Broad expression in stomach (RPKM 16.0), colon (RPKM 14.9) and 24 other tissues See more
Orthologs
all
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Genomic context

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Location:
12q21.33
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 12 NC_000012.12 (89519412..89526262, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 12 NC_060936.1 (89501268..89508118, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (89913189..89920039, complement)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124902981 Neighboring gene POC1 centriolar protein B Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4692 Neighboring gene ReSE screen-validated silencer GRCh37_chr12:89874798-89874988 Neighboring gene H3K27ac hESC enhancer GRCh37_chr12:89897120-89897793 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6707 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4694 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4693 Neighboring gene centromere protein C pseudogene 1 Neighboring gene POC1B antisense RNA 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4695 Neighboring gene polypeptide N-acetylgalactosaminyltransferase 4 Neighboring gene ATPase plasma membrane Ca2+ transporting 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6708 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6709 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6710 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4696 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4697 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4698 Neighboring gene uncharacterized LOC107984543 Neighboring gene ATP2B1 antisense RNA 1 Neighboring gene RNA, 5S ribosomal pseudogene 365

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Expression of conjoined genes: another mechanism for gene regulation in eukaryotes. Prakash T, et al. PLoS One, 2010 Oct 12. PMID 20967262, Free PMC Article
  2. TRIM67 drives tumorigenesis in oligodendrogliomas through Rho GTPase-dependent membrane blebbing. Demirdizen E, et al. Neuro Oncol, 2023 Jun 2. PMID 36215168, Free PMC Article
  3. Architecture of the human interactome defines protein communities and disease networks. Huttlin EL, et al. Nature, 2017 May 25. PMID 28514442, Free PMC Article
  4. Dual proteome-scale networks reveal cell-specific remodeling of the human interactome. Huttlin EL, et al. Cell, 2021 May 27. PMID 33961781, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See Variation Viewer (GRCh37.p13)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ58458, DKFZp686D0362

General protein information

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Preferred Names
POC1B-GALNT4 protein
Names
POC1B-GALNT4 fusion
Polypeptide GalNAc transferase 4
Polypeptide N-acetylgalactosaminyltransferase 4
Protein-UDP acetylgalactosaminyltransferase 4
UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 4
pp-GaNTase 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_054725.1 RefSeqGene

    Range
    5216..11851
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001199781.2 → NP_001186710.1  POC1B-GALNT4 protein isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1), which shares sequence identity with the products of both the POC1B and GALNT4 genes.
    Source sequence(s)
    AC010201, AC025034, BX647258, KF455691
    UniProtKB/TrEMBL
    F8VUJ3
    Related
    ENSP00000447852.1, ENST00000548729.5
    Conserved Domains (4) summary
    cd02510
    Location:135 → 429
    pp-GalNAc-T; pp-GalNAc-T initiates the formation of mucin-type O-linked glycans
    COG0463
    Location:131 → 427
    WcaA; Glycosyltransferase involved in cell wall bisynthesis [Cell wall/membrane/envelope biogenesis]
    cd00161
    Location:443 → 573
    RICIN; Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific ...
    pfam00652
    Location:443 → 571
    Ricin_B_lectin; Ricin-type beta-trefoil lectin domain

  2. NM_001199782.1 → NP_001186711.1  POC1B-GALNT4 protein isoform 2

    See identical proteins and their annotated locations for NP_001186711.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate upstream start codon, differs in the 5' coding region, and uses an alternate splice site in the 3' coding region, compared to variant 1. The encoded isoform (2) shares sequence identity with the GALNT4 gene product only, has a distinct N-terminus, and is shorter than isoform 1.
    Source sequence(s)
    AC010201, AC025034, AK297677, BX647258, KF455691
    UniProtKB/Swiss-Prot
    Q8N4A0
    Conserved Domains (3) summary
    cd00161
    Location:274 → 404
    RICIN; Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific ...
    pfam00652
    Location:274 → 402
    Ricin_B_lectin; Ricin-type beta-trefoil lectin domain
    cl11394
    Location:121 → 260
    Glyco_tranf_GTA_type; Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p14 Primary Assembly

    Range
    89519412..89526262 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060936.1 Alternate T2T-CHM13v2.0

    Range
    89501268..89508118 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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