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Ldha lactate dehydrogenase A [ Cricetulus griseus (Chinese hamster) ]

Gene ID: 100689064, updated on 8-Mar-2024

Summary

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Gene symbol
Ldha
Gene description
lactate dehydrogenase A
Locus tag
I79_017480
See related
Ensembl:ENSCGRG00015015898
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Cricetulus griseus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Cricetidae; Cricetinae; Cricetulus
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 3
Exon count:
9
Annotation release Status Assembly Chr Location
104 current CriGri_1.0 (GCF_000223135.1) Unplaced Scaffold NW_003614690.1 (175077..185715)
104 current CriGri-PICRH-1.0 (GCF_003668045.3) 3 NC_048596.1 (145001207..145009551)

NW_003614690.1Genomic Context describing neighboring genes Neighboring gene HPS5 biogenesis of lysosomal organelles complex 2 subunit 2 Neighboring gene general transcription factor IIH subunit 1 Neighboring gene L-lactate dehydrogenase C chain Neighboring gene tumor susceptibility 101

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Complete knockout of the lactate dehydrogenase A gene is lethal in pyruvate dehydrogenase kinase 1, 2, 3 down-regulated CHO cells. Yip SS, et al. Mol Biotechnol, 2014 Sep. PMID 24841241
  2. Down-regulation of lactate dehydrogenase-A by siRNAs for reduced lactic acid formation of Chinese hamster ovary cells producing thrombopoietin. Kim SH, et al. Appl Microbiol Biotechnol, 2007 Feb. PMID 17086415
  3. Unraveling the Chinese hamster ovary cell line transcriptome by next-generation sequencing. Becker J, et al. J Biotechnol, 2011 Dec 10. PMID 21945585

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Data show that a complete knockout of LDHA is lethal in CHO cells, despite simultaneous down-regulation of PDHK1, 2, and 3.
    Title: Complete knockout of the lactate dehydrogenase A gene is lethal in pyruvate dehydrogenase kinase 1, 2, 3 down-regulated CHO cells.
Submit: New GeneRIF Correction

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables L-lactate dehydrogenase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in carboxylic acid metabolic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
L-lactate dehydrogenase A chain
NP_001230979.1
XP_007648109.1
XP_007648110.1
XP_027297188.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001244050.1 → NP_001230979.1  L-lactate dehydrogenase A chain

    See identical proteins and their annotated locations for NP_001230979.1

    Status: PROVISIONAL

    Source sequence(s)
    DQ912661
    UniProtKB/TrEMBL
    G3I255, Q06BU8
    Related
    ENSCGRP00015020849.2, ENSCGRT00015025637.2
    Conserved Domains (2) summary
    cd05293
    Location:19 → 329
    LDH_1; A subgroup of L-lactate dehydrogenases
    TIGR01771
    Location:25 → 324
    L-LDH-NAD; L-lactate dehydrogenase

RefSeqs of Annotated Genomes: Cricetulus griseus Annotation Release 104 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference CriGri_1.0 Primary Assembly

Genomic

  1. NW_003614690.1 Reference CriGri_1.0 Primary Assembly

    Range
    175077..185715
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_007649920.3 → XP_007648110.1  L-lactate dehydrogenase A chain isoform X2

    See identical proteins and their annotated locations for XP_007648110.1

    UniProtKB/TrEMBL
    G3I255, Q06BU8
    Conserved Domains (2) summary
    cd05293
    Location:19 → 329
    LDH_1; A subgroup of L-lactate dehydrogenases
    TIGR01771
    Location:25 → 324
    L-LDH-NAD; L-lactate dehydrogenase

  2. XM_027441387.2 → XP_027297188.1  L-lactate dehydrogenase A chain isoform X3

    UniProtKB/TrEMBL
    G3I255

  3. XM_007649919.4 → XP_007648109.1  L-lactate dehydrogenase A chain isoform X1

    UniProtKB/TrEMBL
    A0A3L7HVN5, G3I255
    Conserved Domains (1) summary
    cd05293
    Location:48 → 358
    LDH_1; A subgroup of L-lactate dehydrogenases

Alternate CriGri-PICRH-1.0

Genomic

  1. NC_048596.1 Alternate CriGri-PICRH-1.0

    Range
    145001207..145009551
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

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