Gne glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase [Cricetulus griseus (Chinese hamster)] - Gene

Summary

Gene symbol: Gne
Gene description: glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase
Locus tag: I79_021968
See related: Ensembl:ENSCGRG00015028299
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Cricetulus griseus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Cricetidae; Cricetinae; Cricetulus
Also known as: Uae1; GLCNE
Annotation information: Annotation category: partial on reference assembly
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 2

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
104	current	CriGri_1.0 (GCF_000223135.1)	Unplaced Scaffold	NW_003615710.1 (59944..88362, complement)
104	current	CriGri-PICRH-1.0 (GCF_003668045.3)	2	NC_048595.1 (99431695..99465470)

NW_003615710.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

Gne (e-PCR), detects polymorphism
- UniSTS:506942

Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables N-acylmannosamine kinase activity	IEA Inferred from Electronic Annotation more info	PubMed
enables UDP-N-acetylglucosamine 2-epimerase activity	IEA Inferred from Electronic Annotation more info	PubMed
enables hydrolase activity, hydrolyzing O-glycosyl compounds	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in UDP-N-acetylglucosamine metabolic process	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: bifunctional UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase

Names: UDP-GlcNAc-2-epimerase/ManAc kinase; UDP-N-acetylglucosamine-2-epimerase/N- acetylmannosamine kinase

NP_001233638.1

EC 2.7.1.60

EC 3.2.1.183

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001246709.1 → NP_001233638.1 bifunctional UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase

See identical proteins and their annotated locations for NP_001233638.1

Status: PROVISIONAL

Source sequence(s)

AB107226

UniProtKB/Swiss-Prot

Q7TQ49

UniProtKB/TrEMBL

A0A061IDT0

Related

ENSCGRP00015037811.1, ENSCGRT00015046089.2

Conserved Domains (4) summary

cd03786
Location:11 → 375

GT1_UDP-GlcNAc_2-Epimerase; Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues ...

COG1940
Location:409 → 722

NagC; Sugar kinase of the NBD/HSP70 family, may contain an N-terminal HTH domain [Transcription, Carbohydrate transport and metabolism]

TIGR03568
Location:11 → 374

NeuC_NnaA; UDP-N-acetyl-D-glucosamine 2-epimerase, UDP-hydrolysing

cl17037
Location:410 → 669

NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily