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Setd1a SET domain containing 1A, histone lysine methyltransferase [ Cricetulus griseus (Chinese hamster) ]

Gene ID: 100753962, updated on 8-Mar-2024

Summary

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Gene symbol
Setd1a
Gene description
SET domain containing 1A, histone lysine methyltransferase
See related
Ensembl:ENSCGRG00015024152
Gene type
protein coding
RefSeq status
MODEL
Organism
Cricetulus griseus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Cricetidae; Cricetinae; Cricetulus
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 3
Exon count:
19
Annotation release Status Assembly Chr Location
104 current CriGri_1.0 (GCF_000223135.1) Unplaced Scaffold NW_003615000.1 (36280..60620)
104 current CriGri-PICRH-1.0 (GCF_003668045.3) 3 NC_048596.1 (72972437..72996912, complement)

NW_003615000.1Genomic Context describing neighboring genes Neighboring gene F-box and leucine rich repeat protein 19 Neighboring gene ORAI calcium release-activated calcium modulator 3 Neighboring gene hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 7 Neighboring gene syntaxin 1B

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Unraveling the Chinese hamster ovary cell line transcriptome by next-generation sequencing. Becker J, et al. J Biotechnol, 2011 Dec 10. PMID 21945585

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables RNA binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables histone H3K4 methyltransferase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables protein binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
part_of Set1C/COMPASS complex IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
histone-lysine N-methyltransferase SETD1A
Names
Histone-lysine N-methyltransferase SETD1A

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Cricetulus griseus Annotation Release 104 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference CriGri_1.0 Primary Assembly

Genomic

  1. NW_003615000.1 Reference CriGri_1.0 Primary Assembly

    Range
    36280..60620
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_007651552.4 → XP_007649742.1  histone-lysine N-methyltransferase SETD1A isoform X1

    See identical proteins and their annotated locations for XP_007649742.1

    UniProtKB/TrEMBL
    A0A8C2MVA0, G3I7C4
    Conserved Domains (7) summary
    smart00317
    Location:1584 → 1707
    SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain
    smart00508
    Location:1707 → 1723
    PostSET; Cysteine-rich motif following a subset of SET domains
    COG0724
    Location:100 → 191
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
    COG2940
    Location:1487 → 1723
    SET; SET domain-containing protein (function unknown) [General function prediction only]
    cd12548
    Location:92 → 186
    RRM_Set1A; RNA recognition motif in vertebrate histone-lysine N-methyltransferase Setd1A (Set1A)
    pfam11764
    Location:1441 → 1574
    N-SET; COMPASS (Complex proteins associated with Set1p) component N
    cl02774
    Location:834 → 882
    Topoisomer_IB_N; Topoisomer_IB_N: N-terminal DNA binding fragment found in eukaryotic DNA topoisomerase (topo) IB proteins similar to the monomeric yeast and human topo I and heterodimeric topo I from Leishmania donvanni. Topo I enzymes are divided into: topo type IA ...

  2. XM_016979947.3 → XP_016835436.1  histone-lysine N-methyltransferase SETD1A isoform X2

    UniProtKB/TrEMBL
    A0A8C2MVA0

  3. XM_003510979.5 → XP_003511027.1  histone-lysine N-methyltransferase SETD1A isoform X1

    See identical proteins and their annotated locations for XP_003511027.1

    UniProtKB/TrEMBL
    A0A8C2MVA0, G3I7C4
    Conserved Domains (7) summary
    smart00317
    Location:1584 → 1707
    SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain
    smart00508
    Location:1707 → 1723
    PostSET; Cysteine-rich motif following a subset of SET domains
    COG0724
    Location:100 → 191
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
    COG2940
    Location:1487 → 1723
    SET; SET domain-containing protein (function unknown) [General function prediction only]
    cd12548
    Location:92 → 186
    RRM_Set1A; RNA recognition motif in vertebrate histone-lysine N-methyltransferase Setd1A (Set1A)
    pfam11764
    Location:1441 → 1574
    N-SET; COMPASS (Complex proteins associated with Set1p) component N
    cl02774
    Location:834 → 882
    Topoisomer_IB_N; Topoisomer_IB_N: N-terminal DNA binding fragment found in eukaryotic DNA topoisomerase (topo) IB proteins similar to the monomeric yeast and human topo I and heterodimeric topo I from Leishmania donvanni. Topo I enzymes are divided into: topo type IA ...

Alternate CriGri-PICRH-1.0

Genomic

  1. NC_048596.1 Alternate CriGri-PICRH-1.0

    Range
    72972437..72996912 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_027404499.2 → XP_027260300.1  histone-lysine N-methyltransferase SETD1A isoform X2

    UniProtKB/TrEMBL
    A0A8C2MVA0, A0A9J7FH67

  2. XM_027404498.2 → XP_027260299.1  histone-lysine N-methyltransferase SETD1A isoform X1

    UniProtKB/TrEMBL
    A0A8C2MVA0, A0A9J7JHN1
    Conserved Domains (3) summary
    cd19169
    Location:1572 → 1719
    SET_SETD1; SET domain (including post-SET domain) found in SET domain-containing protein 1 (SETD1) and similar proteins
    pfam11764
    Location:1441 → 1578
    N-SET; COMPASS (Complex proteins associated with Set1p) component N
    cd12548
    Location:92 → 186
    RRM_Set1A; RNA recognition motif in vertebrate histone-lysine N-methyltransferase Setd1A (Set1A)

  3. XM_027404495.2 → XP_027260296.1  histone-lysine N-methyltransferase SETD1A isoform X1

    UniProtKB/TrEMBL
    A0A8C2MVA0, A0A9J7JHN1
    Conserved Domains (3) summary
    cd19169
    Location:1572 → 1719
    SET_SETD1; SET domain (including post-SET domain) found in SET domain-containing protein 1 (SETD1) and similar proteins
    pfam11764
    Location:1441 → 1578
    N-SET; COMPASS (Complex proteins associated with Set1p) component N
    cd12548
    Location:92 → 186
    RRM_Set1A; RNA recognition motif in vertebrate histone-lysine N-methyltransferase Setd1A (Set1A)

  4. XM_035442181.1 → XP_035298072.1  histone-lysine N-methyltransferase SETD1A isoform X1

    UniProtKB/TrEMBL
    A0A8C2MVA0, A0A9J7JHN1
    Conserved Domains (3) summary
    cd19169
    Location:1572 → 1719
    SET_SETD1; SET domain (including post-SET domain) found in SET domain-containing protein 1 (SETD1) and similar proteins
    pfam11764
    Location:1441 → 1578
    N-SET; COMPASS (Complex proteins associated with Set1p) component N
    cd12548
    Location:92 → 186
    RRM_Set1A; RNA recognition motif in vertebrate histone-lysine N-methyltransferase Setd1A (Set1A)

  5. XM_027404494.2 → XP_027260295.1  histone-lysine N-methyltransferase SETD1A isoform X1

    UniProtKB/TrEMBL
    A0A8C2MVA0, A0A9J7JHN1
    Related
    ENSCGRP00015032023.2, ENSCGRT00015039099.2
    Conserved Domains (3) summary
    cd19169
    Location:1572 → 1719
    SET_SETD1; SET domain (including post-SET domain) found in SET domain-containing protein 1 (SETD1) and similar proteins
    pfam11764
    Location:1441 → 1578
    N-SET; COMPASS (Complex proteins associated with Set1p) component N
    cd12548
    Location:92 → 186
    RRM_Set1A; RNA recognition motif in vertebrate histone-lysine N-methyltransferase Setd1A (Set1A)

  6. XM_027404493.2 → XP_027260294.1  histone-lysine N-methyltransferase SETD1A isoform X1

    UniProtKB/TrEMBL
    A0A8C2MVA0, A0A9J7JHN1
    Related
    ENSCGRP00015032007.2, ENSCGRT00015039076.2
    Conserved Domains (3) summary
    cd19169
    Location:1572 → 1719
    SET_SETD1; SET domain (including post-SET domain) found in SET domain-containing protein 1 (SETD1) and similar proteins
    pfam11764
    Location:1441 → 1578
    N-SET; COMPASS (Complex proteins associated with Set1p) component N
    cd12548
    Location:92 → 186
    RRM_Set1A; RNA recognition motif in vertebrate histone-lysine N-methyltransferase Setd1A (Set1A)

  7. XM_027404497.2 → XP_027260298.1  histone-lysine N-methyltransferase SETD1A isoform X1

    UniProtKB/TrEMBL
    A0A8C2MVA0, A0A9J7JHN1
    Conserved Domains (3) summary
    cd19169
    Location:1572 → 1719
    SET_SETD1; SET domain (including post-SET domain) found in SET domain-containing protein 1 (SETD1) and similar proteins
    pfam11764
    Location:1441 → 1578
    N-SET; COMPASS (Complex proteins associated with Set1p) component N
    cd12548
    Location:92 → 186
    RRM_Set1A; RNA recognition motif in vertebrate histone-lysine N-methyltransferase Setd1A (Set1A)
Nucleotide Protein Strain
Heading Accession and Version

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