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Pik3c2a phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 alpha [ Cricetulus griseus (Chinese hamster) ]

Gene ID: 100756350, updated on 8-Mar-2024

Summary

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Gene symbol
Pik3c2a
Gene description
phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 alpha
Locus tag
I79_011924
See related
Ensembl:ENSCGRG00015010391
Gene type
protein coding
RefSeq status
MODEL
Organism
Cricetulus griseus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Cricetidae; Cricetinae; Cricetulus
Orthologs
human mouse all
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Genomic context

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See Pik3c2a in Genome Data Viewer
Location:
chromosome: 3
Exon count:
35
Annotation release Status Assembly Chr Location
104 current CriGri_1.0 (GCF_000223135.1) Unplaced Scaffold NW_003614088.1 (1092214..1186884, complement)
104 current CriGri-PICRH-1.0 (GCF_003668045.3) 3 NC_048596.1 (84208486..84302298)

NW_003614088.1Genomic Context describing neighboring genes Neighboring gene U6 spliceosomal RNA Neighboring gene ribosomal protein S13

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Unraveling the Chinese hamster ovary cell line transcriptome by next-generation sequencing. Becker J, et al. J Biotechnol, 2011 Dec 10. PMID 21945585

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables 1-phosphatidylinositol-3-kinase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables 1-phosphatidylinositol-4-phosphate 3-kinase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables phosphatidylinositol binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in cell migration IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in phosphatidylinositol 3-kinase/protein kinase B signal transduction IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in phosphatidylinositol-3-phosphate biosynthetic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in phosphatidylinositol-mediated signaling IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 PubMed 
part_of phosphatidylinositol 3-kinase complex IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha
Names
Phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing alpha polypeptide
phosphatidylinositol 3-kinase, C2 domain containing, alpha polypeptide

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Cricetulus griseus Annotation Release 104 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference CriGri_1.0 Primary Assembly

Genomic

  1. NW_003614088.1 Reference CriGri_1.0 Primary Assembly

    Range
    1092214..1186884 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_007645313.3 → XP_007643503.1  phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha

    See identical proteins and their annotated locations for XP_007643503.1

    UniProtKB/TrEMBL
    A0A061IAB7, A0A8C2LR00
    Conserved Domains (6) summary
    cd07289
    Location:1426 → 1534
    PX_PI3K_C2_alpha; The phosphoinositide binding Phox Homology Domain of the Alpha Isoform of Class II Phosphoinositide 3-Kinases
    cd04012
    Location:678 → 850
    C2A_PI3K_class_II; C2 domain first repeat present in class II phosphatidylinositol 3-kinases (PI3Ks)
    cd08381
    Location:1560 → 1681
    C2B_PI3K_class_II; C2 domain second repeat present in class II phosphatidylinositol 3-kinases (PI3Ks)
    cd00869
    Location:870 → 1038
    PI3Ka_II; Phosphoinositide 3-kinase (PI3K) class II, accessory domain (PIK domain); PIK domain is conserved in all PI3 and PI4-kinases. Its role is unclear but it has been suggested to be involved in substrate presentation. In general, class II PI3-kinases ...
    cd05176
    Location:1043 → 1395
    PI3Kc_C2_alpha; Catalytic domain of Class II Phosphoinositide 3-kinase alpha
    pfam00794
    Location:421 → 514
    PI3K_rbd; PI3-kinase family, ras-binding domain

  2. XM_007645314.3 → XP_007643504.1  phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha

    See identical proteins and their annotated locations for XP_007643504.1

    UniProtKB/TrEMBL
    A0A061IAB7, A0A8C2LR00
    Conserved Domains (6) summary
    cd07289
    Location:1426 → 1534
    PX_PI3K_C2_alpha; The phosphoinositide binding Phox Homology Domain of the Alpha Isoform of Class II Phosphoinositide 3-Kinases
    cd04012
    Location:678 → 850
    C2A_PI3K_class_II; C2 domain first repeat present in class II phosphatidylinositol 3-kinases (PI3Ks)
    cd08381
    Location:1560 → 1681
    C2B_PI3K_class_II; C2 domain second repeat present in class II phosphatidylinositol 3-kinases (PI3Ks)
    cd00869
    Location:870 → 1038
    PI3Ka_II; Phosphoinositide 3-kinase (PI3K) class II, accessory domain (PIK domain); PIK domain is conserved in all PI3 and PI4-kinases. Its role is unclear but it has been suggested to be involved in substrate presentation. In general, class II PI3-kinases ...
    cd05176
    Location:1043 → 1395
    PI3Kc_C2_alpha; Catalytic domain of Class II Phosphoinositide 3-kinase alpha
    pfam00794
    Location:421 → 514
    PI3K_rbd; PI3-kinase family, ras-binding domain

  3. XM_003504810.4 → XP_003504858.1  phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha

    See identical proteins and their annotated locations for XP_003504858.1

    UniProtKB/TrEMBL
    A0A061IAB7, A0A8C2LR00
    Conserved Domains (6) summary
    cd07289
    Location:1426 → 1534
    PX_PI3K_C2_alpha; The phosphoinositide binding Phox Homology Domain of the Alpha Isoform of Class II Phosphoinositide 3-Kinases
    cd04012
    Location:678 → 850
    C2A_PI3K_class_II; C2 domain first repeat present in class II phosphatidylinositol 3-kinases (PI3Ks)
    cd08381
    Location:1560 → 1681
    C2B_PI3K_class_II; C2 domain second repeat present in class II phosphatidylinositol 3-kinases (PI3Ks)
    cd00869
    Location:870 → 1038
    PI3Ka_II; Phosphoinositide 3-kinase (PI3K) class II, accessory domain (PIK domain); PIK domain is conserved in all PI3 and PI4-kinases. Its role is unclear but it has been suggested to be involved in substrate presentation. In general, class II PI3-kinases ...
    cd05176
    Location:1043 → 1395
    PI3Kc_C2_alpha; Catalytic domain of Class II Phosphoinositide 3-kinase alpha
    pfam00794
    Location:421 → 514
    PI3K_rbd; PI3-kinase family, ras-binding domain

  4. XM_035457355.1 → XP_035313246.1  phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha

    UniProtKB/TrEMBL
    A0A061IAB7, A0A8C2LR00
    Conserved Domains (6) summary
    cd07289
    Location:1426 → 1534
    PX_PI3K_C2_alpha; The phosphoinositide binding Phox Homology Domain of the Alpha Isoform of Class II Phosphoinositide 3-Kinases
    cd04012
    Location:678 → 850
    C2A_PI3K_class_II; C2 domain first repeat present in class II phosphatidylinositol 3-kinases (PI3Ks)
    cd08381
    Location:1560 → 1681
    C2B_PI3K_class_II; C2 domain second repeat present in class II phosphatidylinositol 3-kinases (PI3Ks)
    cd00869
    Location:870 → 1038
    PI3Ka_II; Phosphoinositide 3-kinase (PI3K) class II, accessory domain (PIK domain); PIK domain is conserved in all PI3 and PI4-kinases. Its role is unclear but it has been suggested to be involved in substrate presentation. In general, class II PI3-kinases ...
    cd05176
    Location:1043 → 1395
    PI3Kc_C2_alpha; Catalytic domain of Class II Phosphoinositide 3-kinase alpha
    pfam00794
    Location:421 → 514
    PI3K_rbd; PI3-kinase family, ras-binding domain

Alternate CriGri-PICRH-1.0

Genomic

  1. NC_048596.1 Alternate CriGri-PICRH-1.0

    Range
    84208486..84302298
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_027410146.1 → XP_027265947.1  phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha

    UniProtKB/TrEMBL
    A0A061IAB7, A0A8C2LR00
    Conserved Domains (6) summary
    cd07289
    Location:1426 → 1534
    PX_PI3K_C2_alpha; The phosphoinositide binding Phox Homology Domain of the Alpha Isoform of Class II Phosphoinositide 3-Kinases
    cd04012
    Location:678 → 850
    C2A_PI3K_class_II; C2 domain first repeat present in class II phosphatidylinositol 3-kinases (PI3Ks)
    cd08381
    Location:1560 → 1681
    C2B_PI3K_class_II; C2 domain second repeat present in class II phosphatidylinositol 3-kinases (PI3Ks)
    cd00869
    Location:870 → 1038
    PI3Ka_II; Phosphoinositide 3-kinase (PI3K) class II, accessory domain (PIK domain); PIK domain is conserved in all PI3 and PI4-kinases. Its role is unclear but it has been suggested to be involved in substrate presentation. In general, class II PI3-kinases ...
    cd05176
    Location:1043 → 1395
    PI3Kc_C2_alpha; Catalytic domain of Class II Phosphoinositide 3-kinase alpha
    pfam00794
    Location:421 → 514
    PI3K_rbd; PI3-kinase family, ras-binding domain

  2. XM_027410148.1 → XP_027265949.1  phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha

    UniProtKB/TrEMBL
    A0A061IAB7, A0A8C2LR00
    Conserved Domains (6) summary
    cd07289
    Location:1426 → 1534
    PX_PI3K_C2_alpha; The phosphoinositide binding Phox Homology Domain of the Alpha Isoform of Class II Phosphoinositide 3-Kinases
    cd04012
    Location:678 → 850
    C2A_PI3K_class_II; C2 domain first repeat present in class II phosphatidylinositol 3-kinases (PI3Ks)
    cd08381
    Location:1560 → 1681
    C2B_PI3K_class_II; C2 domain second repeat present in class II phosphatidylinositol 3-kinases (PI3Ks)
    cd00869
    Location:870 → 1038
    PI3Ka_II; Phosphoinositide 3-kinase (PI3K) class II, accessory domain (PIK domain); PIK domain is conserved in all PI3 and PI4-kinases. Its role is unclear but it has been suggested to be involved in substrate presentation. In general, class II PI3-kinases ...
    cd05176
    Location:1043 → 1395
    PI3Kc_C2_alpha; Catalytic domain of Class II Phosphoinositide 3-kinase alpha
    pfam00794
    Location:421 → 514
    PI3K_rbd; PI3-kinase family, ras-binding domain

  3. XM_027410147.1 → XP_027265948.1  phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha

    UniProtKB/TrEMBL
    A0A061IAB7, A0A8C2LR00
    Conserved Domains (6) summary
    cd07289
    Location:1426 → 1534
    PX_PI3K_C2_alpha; The phosphoinositide binding Phox Homology Domain of the Alpha Isoform of Class II Phosphoinositide 3-Kinases
    cd04012
    Location:678 → 850
    C2A_PI3K_class_II; C2 domain first repeat present in class II phosphatidylinositol 3-kinases (PI3Ks)
    cd08381
    Location:1560 → 1681
    C2B_PI3K_class_II; C2 domain second repeat present in class II phosphatidylinositol 3-kinases (PI3Ks)
    cd00869
    Location:870 → 1038
    PI3Ka_II; Phosphoinositide 3-kinase (PI3K) class II, accessory domain (PIK domain); PIK domain is conserved in all PI3 and PI4-kinases. Its role is unclear but it has been suggested to be involved in substrate presentation. In general, class II PI3-kinases ...
    cd05176
    Location:1043 → 1395
    PI3Kc_C2_alpha; Catalytic domain of Class II Phosphoinositide 3-kinase alpha
    pfam00794
    Location:421 → 514
    PI3K_rbd; PI3-kinase family, ras-binding domain

  4. XM_035442266.1 → XP_035298157.1  phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha

    UniProtKB/TrEMBL
    A0A061IAB7, A0A8C2LR00
    Related
    ENSCGRP00015013763.2, ENSCGRT00015016846.2
    Conserved Domains (6) summary
    cd07289
    Location:1426 → 1534
    PX_PI3K_C2_alpha; The phosphoinositide binding Phox Homology Domain of the Alpha Isoform of Class II Phosphoinositide 3-Kinases
    cd04012
    Location:678 → 850
    C2A_PI3K_class_II; C2 domain first repeat present in class II phosphatidylinositol 3-kinases (PI3Ks)
    cd08381
    Location:1560 → 1681
    C2B_PI3K_class_II; C2 domain second repeat present in class II phosphatidylinositol 3-kinases (PI3Ks)
    cd00869
    Location:870 → 1038
    PI3Ka_II; Phosphoinositide 3-kinase (PI3K) class II, accessory domain (PIK domain); PIK domain is conserved in all PI3 and PI4-kinases. Its role is unclear but it has been suggested to be involved in substrate presentation. In general, class II PI3-kinases ...
    cd05176
    Location:1043 → 1395
    PI3Kc_C2_alpha; Catalytic domain of Class II Phosphoinositide 3-kinase alpha
    pfam00794
    Location:421 → 514
    PI3K_rbd; PI3-kinase family, ras-binding domain
Nucleotide Protein Strain
Heading Accession and Version

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