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Ezh2 enhancer of zeste 2 polycomb repressive complex 2 subunit [ Cricetulus griseus (Chinese hamster) ]

Gene ID: 100758055, updated on 8-Mar-2024

Summary

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Gene symbol
Ezh2
Gene description
enhancer of zeste 2 polycomb repressive complex 2 subunit
See related
Ensembl:ENSCGRG00015024408
Gene type
protein coding
RefSeq status
MODEL
Organism
Cricetulus griseus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Cricetidae; Cricetinae; Cricetulus
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 1
Exon count:
21
Annotation release Status Assembly Chr Location
104 current CriGri_1.0 (GCF_000223135.1) Unplaced Scaffold NW_003613638.1 (1298164..1345551, complement)
104 current CriGri-PICRH-1.0 (GCF_003668045.3) 1 Unlocalized Scaffold NW_023276806.1 (222348193..222417081)

NW_003613638.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC118238024 Neighboring gene cullin 1 Neighboring gene lanosterol 14-alpha demethylase Neighboring gene leucine rich repeats and death domain containing 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Unraveling the Chinese hamster ovary cell line transcriptome by next-generation sequencing. Becker J, et al. J Biotechnol, 2011 Dec 10. PMID 21945585

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables histone H3K27 methyltransferase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables protein binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in chromatin remodeling IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
histone-lysine N-methyltransferase EZH2
Names
Histone-lysine N-methyltransferase EZH2
enhancer of zeste homolog 2

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Cricetulus griseus Annotation Release 104 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference CriGri_1.0 Primary Assembly

Genomic

  1. NW_003613638.1 Reference CriGri_1.0 Primary Assembly

    Range
    1298164..1345551 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_016963722.3 → XP_016819211.1  histone-lysine N-methyltransferase EZH2 isoform X7

    UniProtKB/TrEMBL
    A0A8C2LRE5, A0A9J7HAF1
    Conserved Domains (4) summary
    cd19218
    Location:572 → 691
    SET_EZH2; SET domain found in enhancer of zeste homolog 2 (EZH2) and similar proteins
    pfam11616
    Location:39 → 68
    EZH2_WD-Binding; WD repeat binding protein EZH2
    pfam18118
    Location:158 → 249
    PRC2_HTH_1; Polycomb repressive complex 2 tri-helical domain
    pfam18264
    Location:522 → 553
    preSET_CXC; CXC domain

  2. XM_016963719.3 → XP_016819208.1  histone-lysine N-methyltransferase EZH2 isoform X6

    UniProtKB/TrEMBL
    A0A8C2LXC8, A0A9J7HB97
    Conserved Domains (4) summary
    COG2940
    Location:522 → 703
    SET; SET domain-containing protein (function unknown) [General function prediction only]
    cl40432
    Location:614 → 703
    SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain superfamily
    pfam11616
    Location:39 → 68
    EZH2_WD-Binding; WD repeat binding protein EZH2
    pfam18118
    Location:158 → 249
    PRC2_HTH_1; Polycomb repressive complex 2 tri-helical domain

  3. XM_027385962.2 → XP_027241763.1  histone-lysine N-methyltransferase EZH2 isoform X3

    UniProtKB/TrEMBL
    A0A8C2LXC8, A0A9J7HB45
    Conserved Domains (4) summary
    cd19218
    Location:605 → 724
    SET_EZH2; SET domain found in enhancer of zeste homolog 2 (EZH2) and similar proteins
    pfam11616
    Location:39 → 68
    EZH2_WD-Binding; WD repeat binding protein EZH2
    pfam18118
    Location:149 → 240
    PRC2_HTH_1; Polycomb repressive complex 2 tri-helical domain
    pfam18264
    Location:555 → 586
    preSET_CXC; CXC domain

  4. XM_007654470.4 → XP_007652660.1  histone-lysine N-methyltransferase EZH2 isoform X1

    UniProtKB/TrEMBL
    A0A8C2LXC8, A0A9J7J921
    Conserved Domains (2) summary
    smart00317
    Location:617 → 738
    SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain
    pfam11616
    Location:39 → 67
    EZH2_WD-Binding; WD repeat binding protein EZH2

  5. XM_007654486.4 → XP_007652676.1  histone-lysine N-methyltransferase EZH2 isoform X8

    UniProtKB/TrEMBL
    A0A8C2LRE5, A0A9J7H8A8
    Conserved Domains (4) summary
    cd19218
    Location:558 → 677
    SET_EZH2; SET domain found in enhancer of zeste homolog 2 (EZH2) and similar proteins
    pfam11616
    Location:39 → 68
    EZH2_WD-Binding; WD repeat binding protein EZH2
    pfam18118
    Location:149 → 240
    PRC2_HTH_1; Polycomb repressive complex 2 tri-helical domain
    pfam18264
    Location:508 → 539
    preSET_CXC; CXC domain

  6. XM_007654475.4 → XP_007652665.1  histone-lysine N-methyltransferase EZH2 isoform X4

    UniProtKB/TrEMBL
    A0A8C2LXC8, A0A9J7KE50
    Conserved Domains (4) summary
    cd19218
    Location:600 → 719
    SET_EZH2; SET domain found in enhancer of zeste homolog 2 (EZH2) and similar proteins
    pfam11616
    Location:39 → 68
    EZH2_WD-Binding; WD repeat binding protein EZH2
    pfam18118
    Location:149 → 240
    PRC2_HTH_1; Polycomb repressive complex 2 tri-helical domain
    pfam18264
    Location:550 → 581
    preSET_CXC; CXC domain

  7. XM_003496944.5 → XP_003496992.1  histone-lysine N-methyltransferase EZH2 isoform X2

    See identical proteins and their annotated locations for XP_003496992.1

    UniProtKB/TrEMBL
    A0A8C2LXC8, G3GXG1
    Conserved Domains (4) summary
    cd19218
    Location:609 → 728
    SET_EZH2; SET domain found in enhancer of zeste homolog 2 (EZH2) and similar proteins
    pfam11616
    Location:39 → 68
    EZH2_WD-Binding; WD repeat binding protein EZH2
    pfam18118
    Location:158 → 249
    PRC2_HTH_1; Polycomb repressive complex 2 tri-helical domain
    pfam18264
    Location:559 → 590
    preSET_CXC; CXC domain

  8. XM_027385967.2 → XP_027241768.1  histone-lysine N-methyltransferase EZH2 isoform X5

    UniProtKB/TrEMBL
    A0A8C2LXC8, A0A9J7F1T2

  9. XM_016963730.3 → XP_016819219.1  histone-lysine N-methyltransferase EZH2 isoform X9

    UniProtKB/TrEMBL
    A0A8C2LXC8, A0A9J7F2Y7

  10. XM_016963732.3 → XP_016819221.1  histone-lysine N-methyltransferase EZH2 isoform X9

    UniProtKB/TrEMBL
    A0A8C2LXC8, A0A9J7F2Y7

Alternate CriGri-PICRH-1.0

Genomic

  1. NW_023276806.1 Alternate CriGri-PICRH-1.0

    Range
    222348193..222417081
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_035450999.1 → XP_035306890.1  histone-lysine N-methyltransferase EZH2 isoform X7

    UniProtKB/TrEMBL
    A0A8C2LRE5, A0A9J7HAF1
    Related
    ENSCGRP00015041074.1, ENSCGRT00015065823.1
    Conserved Domains (4) summary
    cd19218
    Location:572 → 691
    SET_EZH2; SET domain found in enhancer of zeste homolog 2 (EZH2) and similar proteins
    pfam11616
    Location:39 → 68
    EZH2_WD-Binding; WD repeat binding protein EZH2
    pfam18118
    Location:158 → 249
    PRC2_HTH_1; Polycomb repressive complex 2 tri-helical domain
    pfam18264
    Location:522 → 553
    preSET_CXC; CXC domain

  2. XM_035450998.1 → XP_035306889.1  histone-lysine N-methyltransferase EZH2 isoform X6

    UniProtKB/TrEMBL
    A0A8C2LXC8, A0A9J7HB97
    Conserved Domains (4) summary
    COG2940
    Location:522 → 703
    SET; SET domain-containing protein (function unknown) [General function prediction only]
    cl40432
    Location:614 → 703
    SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain superfamily
    pfam11616
    Location:39 → 68
    EZH2_WD-Binding; WD repeat binding protein EZH2
    pfam18118
    Location:158 → 249
    PRC2_HTH_1; Polycomb repressive complex 2 tri-helical domain

  3. XM_035450996.1 → XP_035306887.1  histone-lysine N-methyltransferase EZH2 isoform X3

    UniProtKB/TrEMBL
    A0A8C2LXC8, A0A9J7HB45
    Conserved Domains (4) summary
    cd19218
    Location:605 → 724
    SET_EZH2; SET domain found in enhancer of zeste homolog 2 (EZH2) and similar proteins
    pfam11616
    Location:39 → 68
    EZH2_WD-Binding; WD repeat binding protein EZH2
    pfam18118
    Location:149 → 240
    PRC2_HTH_1; Polycomb repressive complex 2 tri-helical domain
    pfam18264
    Location:555 → 586
    preSET_CXC; CXC domain

  4. XM_027389803.2 → XP_027245604.1  histone-lysine N-methyltransferase EZH2 isoform X1

    UniProtKB/TrEMBL
    A0A8C2LXC8, A0A9J7J921

  5. XM_035451000.1 → XP_035306891.1  histone-lysine N-methyltransferase EZH2 isoform X8

    UniProtKB/TrEMBL
    A0A8C2LRE5, A0A9J7H8A8
    Conserved Domains (4) summary
    cd19218
    Location:558 → 677
    SET_EZH2; SET domain found in enhancer of zeste homolog 2 (EZH2) and similar proteins
    pfam11616
    Location:39 → 68
    EZH2_WD-Binding; WD repeat binding protein EZH2
    pfam18118
    Location:149 → 240
    PRC2_HTH_1; Polycomb repressive complex 2 tri-helical domain
    pfam18264
    Location:508 → 539
    preSET_CXC; CXC domain

  6. XM_035450997.1 → XP_035306888.1  histone-lysine N-methyltransferase EZH2 isoform X4

    UniProtKB/TrEMBL
    A0A8C2LXC8, A0A9J7KE50
    Related
    ENSCGRP00015045843.1, ENSCGRT00015059456.1
    Conserved Domains (4) summary
    cd19218
    Location:600 → 719
    SET_EZH2; SET domain found in enhancer of zeste homolog 2 (EZH2) and similar proteins
    pfam11616
    Location:39 → 68
    EZH2_WD-Binding; WD repeat binding protein EZH2
    pfam18118
    Location:149 → 240
    PRC2_HTH_1; Polycomb repressive complex 2 tri-helical domain
    pfam18264
    Location:550 → 581
    preSET_CXC; CXC domain

  7. XM_035450995.1 → XP_035306886.1  histone-lysine N-methyltransferase EZH2 isoform X2

    UniProtKB/TrEMBL
    A0A8C2LXC8, G3GXG1
    Related
    ENSCGRP00015032372.2, ENSCGRT00015039506.2
    Conserved Domains (4) summary
    cd19218
    Location:609 → 728
    SET_EZH2; SET domain found in enhancer of zeste homolog 2 (EZH2) and similar proteins
    pfam11616
    Location:39 → 68
    EZH2_WD-Binding; WD repeat binding protein EZH2
    pfam18118
    Location:158 → 249
    PRC2_HTH_1; Polycomb repressive complex 2 tri-helical domain
    pfam18264
    Location:559 → 590
    preSET_CXC; CXC domain

  8. XM_027389802.2 → XP_027245603.1  histone-lysine N-methyltransferase EZH2 isoform X1

    UniProtKB/TrEMBL
    A0A8C2LXC8, A0A9J7J921

  9. XM_027389807.2 → XP_027245608.1  histone-lysine N-methyltransferase EZH2 isoform X5

    UniProtKB/TrEMBL
    A0A8C2LXC8, A0A9J7F1T2

  10. XM_027389811.2 → XP_027245612.1  histone-lysine N-methyltransferase EZH2 isoform X9

    UniProtKB/TrEMBL
    A0A8C2LXC8, A0A9J7F2Y7

  11. XM_027389812.2 → XP_027245613.1  histone-lysine N-methyltransferase EZH2 isoform X9

    UniProtKB/TrEMBL
    A0A8C2LXC8, A0A9J7F2Y7
Nucleotide Protein Strain
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