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Pikfyve phosphoinositide kinase, FYVE-type zinc finger containing [ Cricetulus griseus (Chinese hamster) ]

Gene ID: 100758487, updated on 8-Mar-2024

Summary

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Gene symbol
Pikfyve
Gene description
phosphoinositide kinase, FYVE-type zinc finger containing
Locus tag
I79_014453
See related
Ensembl:ENSCGRG00015028893
Gene type
protein coding
RefSeq status
MODEL
Organism
Cricetulus griseus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Cricetidae; Cricetinae; Cricetulus
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 2
Exon count:
43
Annotation release Status Assembly Chr Location
104 current CriGri_1.0 (GCF_000223135.1) Unplaced Scaffold NW_003614305.1 (17376..110683, complement)
104 current CriGri-PICRH-1.0 (GCF_003668045.3) 2 NC_048595.1 (419156244..419251392)

NW_003614305.1Genomic Context describing neighboring genes Neighboring gene transfer RNA serine (anticodon GCU) Neighboring gene uncharacterized LOC103163833 Neighboring gene isocitrate dehydrogenase (NADP(+)) 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Unraveling the Chinese hamster ovary cell line transcriptome by next-generation sequencing. Becker J, et al. J Biotechnol, 2011 Dec 10. PMID 21945585

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables 1-phosphatidylinositol-3-phosphate 5-kinase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in intracellular signal transduction IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in phosphatidylinositol metabolic process IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
1-phosphatidylinositol 3-phosphate 5-kinase
Names
1-phosphatidylinositol-3-phosphate 5-kinase
phosphoinositide kinase, FYVE finger containing

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Cricetulus griseus Annotation Release 104 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference CriGri_1.0 Primary Assembly

Genomic

  1. NW_003614305.1 Reference CriGri_1.0 Primary Assembly

    Range
    17376..110683 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_003506909.4 → XP_003506957.1  1-phosphatidylinositol 3-phosphate 5-kinase isoform X3

    See identical proteins and their annotated locations for XP_003506957.1

    UniProtKB/TrEMBL
    A0A8C2MP20
    Conserved Domains (5) summary
    cd00139
    Location:1772 → 2085
    PIPKc; Phosphatidylinositol phosphate kinases (PIPK) catalyze the phosphorylation of phosphatidylinositol phosphate on the fourth or fifth hydroxyl of the inositol ring, to form phosphatidylinositol bisphosphate. CD alignment includes type II ...
    cd03334
    Location:617 → 877
    Fab1_TCP; TCP-1 like domain of the eukaryotic phosphatidylinositol 3-phosphate (PtdIns3P) 5-kinase Fab1. Fab1p is important for vacuole size regulation, presumably by modulating PtdIns(3,5)P2 effector activity. In the human homolog p235/PIKfyve deletion of this ...
    cd04448
    Location:357 → 438
    DEP_PIKfyve; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in fungal RhoGEF (GDP/GTP exchange factor) PIKfyve-like proteins. PIKfyve contains N-terminal Fyve finger and DEP domains, a central chaperonin-like domain and a C-terminal PIPK (phosphatidylinositol ...
    cd15725
    Location:154 → 215
    FYVE_PIKfyve_Fab1; FYVE domain found in metazoan PIKfyve, fungal and plant Fab1, and similar proteins
    cl12013
    Location:1399 → 1446
    BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

  2. XM_003506910.4 → XP_003506958.1  1-phosphatidylinositol 3-phosphate 5-kinase isoform X5

    See identical proteins and their annotated locations for XP_003506958.1

    UniProtKB/TrEMBL
    A0A8C2QLP7
    Conserved Domains (5) summary
    cd00139
    Location:1727 → 2040
    PIPKc; Phosphatidylinositol phosphate kinases (PIPK) catalyze the phosphorylation of phosphatidylinositol phosphate on the fourth or fifth hydroxyl of the inositol ring, to form phosphatidylinositol bisphosphate. CD alignment includes type II ...
    cd03334
    Location:572 → 832
    Fab1_TCP; TCP-1 like domain of the eukaryotic phosphatidylinositol 3-phosphate (PtdIns3P) 5-kinase Fab1. Fab1p is important for vacuole size regulation, presumably by modulating PtdIns(3,5)P2 effector activity. In the human homolog p235/PIKfyve deletion of this ...
    cd04448
    Location:368 → 449
    DEP_PIKfyve; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in fungal RhoGEF (GDP/GTP exchange factor) PIKfyve-like proteins. PIKfyve contains N-terminal Fyve finger and DEP domains, a central chaperonin-like domain and a C-terminal PIPK (phosphatidylinositol ...
    cd15725
    Location:165 → 226
    FYVE_PIKfyve_Fab1; FYVE domain found in metazoan PIKfyve, fungal and plant Fab1, and similar proteins
    cl12013
    Location:1354 → 1401
    BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

  3. XM_007647458.3 → XP_007645648.1  1-phosphatidylinositol 3-phosphate 5-kinase isoform X2

    See identical proteins and their annotated locations for XP_007645648.1

    UniProtKB/TrEMBL
    A0A9J7F7C9
    Conserved Domains (5) summary
    cd00139
    Location:1783 → 2096
    PIPKc; Phosphatidylinositol phosphate kinases (PIPK) catalyze the phosphorylation of phosphatidylinositol phosphate on the fourth or fifth hydroxyl of the inositol ring, to form phosphatidylinositol bisphosphate. CD alignment includes type II ...
    cd03334
    Location:628 → 888
    Fab1_TCP; TCP-1 like domain of the eukaryotic phosphatidylinositol 3-phosphate (PtdIns3P) 5-kinase Fab1. Fab1p is important for vacuole size regulation, presumably by modulating PtdIns(3,5)P2 effector activity. In the human homolog p235/PIKfyve deletion of this ...
    cd04448
    Location:368 → 449
    DEP_PIKfyve; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in fungal RhoGEF (GDP/GTP exchange factor) PIKfyve-like proteins. PIKfyve contains N-terminal Fyve finger and DEP domains, a central chaperonin-like domain and a C-terminal PIPK (phosphatidylinositol ...
    cd15725
    Location:165 → 226
    FYVE_PIKfyve_Fab1; FYVE domain found in metazoan PIKfyve, fungal and plant Fab1, and similar proteins
    cl12013
    Location:1410 → 1457
    BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

  4. XM_007647459.3 → XP_007645649.1  1-phosphatidylinositol 3-phosphate 5-kinase isoform X4

    See identical proteins and their annotated locations for XP_007645649.1

    UniProtKB/TrEMBL
    A0A9J7JE03
    Conserved Domains (5) summary
    cd00139
    Location:1728 → 2041
    PIPKc; Phosphatidylinositol phosphate kinases (PIPK) catalyze the phosphorylation of phosphatidylinositol phosphate on the fourth or fifth hydroxyl of the inositol ring, to form phosphatidylinositol bisphosphate. CD alignment includes type II ...
    cd03334
    Location:573 → 833
    Fab1_TCP; TCP-1 like domain of the eukaryotic phosphatidylinositol 3-phosphate (PtdIns3P) 5-kinase Fab1. Fab1p is important for vacuole size regulation, presumably by modulating PtdIns(3,5)P2 effector activity. In the human homolog p235/PIKfyve deletion of this ...
    cd04448
    Location:369 → 450
    DEP_PIKfyve; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in fungal RhoGEF (GDP/GTP exchange factor) PIKfyve-like proteins. PIKfyve contains N-terminal Fyve finger and DEP domains, a central chaperonin-like domain and a C-terminal PIPK (phosphatidylinositol ...
    cd15725
    Location:166 → 227
    FYVE_PIKfyve_Fab1; FYVE domain found in metazoan PIKfyve, fungal and plant Fab1, and similar proteins
    cl12013
    Location:1355 → 1402
    BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

  5. XM_007647456.3 → XP_007645646.1  1-phosphatidylinositol 3-phosphate 5-kinase isoform X1

    See identical proteins and their annotated locations for XP_007645646.1

    UniProtKB/TrEMBL
    A0A9J7F842
    Conserved Domains (4) summary
    cd03334
    Location:629 → 889
    Fab1_TCP; TCP-1 like domain of the eukaryotic phosphatidylinositol 3-phosphate (PtdIns3P) 5-kinase Fab1. Fab1p is important for vacuole size regulation, presumably by modulating PtdIns(3,5)P2 effector activity. In the human homolog p235/PIKfyve deletion of this ...
    cd04448
    Location:369 → 450
    DEP_PIKfyve; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in fungal RhoGEF (GDP/GTP exchange factor) PIKfyve-like proteins. PIKfyve contains N-terminal Fyve finger and DEP domains, a central chaperonin-like domain and a C-terminal PIPK (phosphatidylinositol ...
    cd15725
    Location:166 → 227
    FYVE_PIKfyve_Fab1; FYVE domain found in metazoan PIKfyve, fungal and plant Fab1, and similar proteins
    cd17300
    Location:1830 → 2096
    PIPKc_PIKfyve; Phosphatidylinositol phosphate kinase (PIPK) catalytic domain found in 1-phosphatidylinositol-3-phosphate 5-kinase and similar proteins

  6. XM_035458738.1 → XP_035314629.1  1-phosphatidylinositol 3-phosphate 5-kinase isoform X1

    UniProtKB/TrEMBL
    A0A9J7F842
    Conserved Domains (4) summary
    cd03334
    Location:629 → 889
    Fab1_TCP; TCP-1 like domain of the eukaryotic phosphatidylinositol 3-phosphate (PtdIns3P) 5-kinase Fab1. Fab1p is important for vacuole size regulation, presumably by modulating PtdIns(3,5)P2 effector activity. In the human homolog p235/PIKfyve deletion of this ...
    cd04448
    Location:369 → 450
    DEP_PIKfyve; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in fungal RhoGEF (GDP/GTP exchange factor) PIKfyve-like proteins. PIKfyve contains N-terminal Fyve finger and DEP domains, a central chaperonin-like domain and a C-terminal PIPK (phosphatidylinositol ...
    cd15725
    Location:166 → 227
    FYVE_PIKfyve_Fab1; FYVE domain found in metazoan PIKfyve, fungal and plant Fab1, and similar proteins
    cd17300
    Location:1830 → 2096
    PIPKc_PIKfyve; Phosphatidylinositol phosphate kinase (PIPK) catalytic domain found in 1-phosphatidylinositol-3-phosphate 5-kinase and similar proteins

  7. XM_007647457.4 → XP_007645647.1  1-phosphatidylinositol 3-phosphate 5-kinase isoform X1

    See identical proteins and their annotated locations for XP_007645647.1

    UniProtKB/TrEMBL
    A0A9J7F842
    Conserved Domains (4) summary
    cd03334
    Location:629 → 889
    Fab1_TCP; TCP-1 like domain of the eukaryotic phosphatidylinositol 3-phosphate (PtdIns3P) 5-kinase Fab1. Fab1p is important for vacuole size regulation, presumably by modulating PtdIns(3,5)P2 effector activity. In the human homolog p235/PIKfyve deletion of this ...
    cd04448
    Location:369 → 450
    DEP_PIKfyve; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in fungal RhoGEF (GDP/GTP exchange factor) PIKfyve-like proteins. PIKfyve contains N-terminal Fyve finger and DEP domains, a central chaperonin-like domain and a C-terminal PIPK (phosphatidylinositol ...
    cd15725
    Location:166 → 227
    FYVE_PIKfyve_Fab1; FYVE domain found in metazoan PIKfyve, fungal and plant Fab1, and similar proteins
    cd17300
    Location:1830 → 2096
    PIPKc_PIKfyve; Phosphatidylinositol phosphate kinase (PIPK) catalytic domain found in 1-phosphatidylinositol-3-phosphate 5-kinase and similar proteins

Alternate CriGri-PICRH-1.0

Genomic

  1. NC_048595.1 Alternate CriGri-PICRH-1.0

    Range
    419156244..419251392
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_027397108.1 → XP_027252909.1  1-phosphatidylinositol 3-phosphate 5-kinase isoform X1

    UniProtKB/TrEMBL
    A0A9J7F842
    Related
    ENSCGRP00015056573.1, ENSCGRT00015069087.1
    Conserved Domains (4) summary
    cd03334
    Location:629 → 889
    Fab1_TCP; TCP-1 like domain of the eukaryotic phosphatidylinositol 3-phosphate (PtdIns3P) 5-kinase Fab1. Fab1p is important for vacuole size regulation, presumably by modulating PtdIns(3,5)P2 effector activity. In the human homolog p235/PIKfyve deletion of this ...
    cd04448
    Location:369 → 450
    DEP_PIKfyve; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in fungal RhoGEF (GDP/GTP exchange factor) PIKfyve-like proteins. PIKfyve contains N-terminal Fyve finger and DEP domains, a central chaperonin-like domain and a C-terminal PIPK (phosphatidylinositol ...
    cd15725
    Location:166 → 227
    FYVE_PIKfyve_Fab1; FYVE domain found in metazoan PIKfyve, fungal and plant Fab1, and similar proteins
    cd17300
    Location:1830 → 2096
    PIPKc_PIKfyve; Phosphatidylinositol phosphate kinase (PIPK) catalytic domain found in 1-phosphatidylinositol-3-phosphate 5-kinase and similar proteins

  2. XM_027397112.1 → XP_027252913.1  1-phosphatidylinositol 3-phosphate 5-kinase isoform X4

    UniProtKB/TrEMBL
    A0A9J7JE03

  3. XM_027397110.1 → XP_027252911.1  1-phosphatidylinositol 3-phosphate 5-kinase isoform X2

    UniProtKB/TrEMBL
    A0A9J7F7C9

  4. XM_027397113.1 → XP_027252914.1  1-phosphatidylinositol 3-phosphate 5-kinase isoform X5

    UniProtKB/TrEMBL
    A0A8C2QLP7
    Related
    ENSCGRP00015038672.2, ENSCGRT00015047082.2

  5. XM_027397111.1 → XP_027252912.1  1-phosphatidylinositol 3-phosphate 5-kinase isoform X3

    UniProtKB/TrEMBL
    A0A8C2MP20
    Related
    ENSCGRP00015038671.1, ENSCGRT00015047081.2

  6. XM_035441004.1 → XP_035296895.1  1-phosphatidylinositol 3-phosphate 5-kinase isoform X1

    UniProtKB/TrEMBL
    A0A9J7F842
    Conserved Domains (4) summary
    cd03334
    Location:629 → 889
    Fab1_TCP; TCP-1 like domain of the eukaryotic phosphatidylinositol 3-phosphate (PtdIns3P) 5-kinase Fab1. Fab1p is important for vacuole size regulation, presumably by modulating PtdIns(3,5)P2 effector activity. In the human homolog p235/PIKfyve deletion of this ...
    cd04448
    Location:369 → 450
    DEP_PIKfyve; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in fungal RhoGEF (GDP/GTP exchange factor) PIKfyve-like proteins. PIKfyve contains N-terminal Fyve finger and DEP domains, a central chaperonin-like domain and a C-terminal PIPK (phosphatidylinositol ...
    cd15725
    Location:166 → 227
    FYVE_PIKfyve_Fab1; FYVE domain found in metazoan PIKfyve, fungal and plant Fab1, and similar proteins
    cd17300
    Location:1830 → 2096
    PIPKc_PIKfyve; Phosphatidylinositol phosphate kinase (PIPK) catalytic domain found in 1-phosphatidylinositol-3-phosphate 5-kinase and similar proteins

  7. XM_027397109.2 → XP_027252910.1  1-phosphatidylinositol 3-phosphate 5-kinase isoform X1

    UniProtKB/TrEMBL
    A0A9J7F842
    Conserved Domains (4) summary
    cd03334
    Location:629 → 889
    Fab1_TCP; TCP-1 like domain of the eukaryotic phosphatidylinositol 3-phosphate (PtdIns3P) 5-kinase Fab1. Fab1p is important for vacuole size regulation, presumably by modulating PtdIns(3,5)P2 effector activity. In the human homolog p235/PIKfyve deletion of this ...
    cd04448
    Location:369 → 450
    DEP_PIKfyve; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in fungal RhoGEF (GDP/GTP exchange factor) PIKfyve-like proteins. PIKfyve contains N-terminal Fyve finger and DEP domains, a central chaperonin-like domain and a C-terminal PIPK (phosphatidylinositol ...
    cd15725
    Location:166 → 227
    FYVE_PIKfyve_Fab1; FYVE domain found in metazoan PIKfyve, fungal and plant Fab1, and similar proteins
    cd17300
    Location:1830 → 2096
    PIPKc_PIKfyve; Phosphatidylinositol phosphate kinase (PIPK) catalytic domain found in 1-phosphatidylinositol-3-phosphate 5-kinase and similar proteins
Nucleotide Protein Strain
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