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Paics phosphoribosylaminoimidazole carboxylase and phosphoribosylaminoimidazolesuccinocarboxamide synthase [ Cricetulus griseus (Chinese hamster) ]

Gene ID: 100758991, updated on 8-Mar-2024

Summary

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Gene symbol
Paics
Gene description
phosphoribosylaminoimidazole carboxylase and phosphoribosylaminoimidazolesuccinocarboxamide synthase
Locus tag
I79_022535
See related
Ensembl:ENSCGRG00015008011
Gene type
protein coding
RefSeq status
MODEL
Organism
Cricetulus griseus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Cricetidae; Cricetinae; Cricetulus
Orthologs
human all
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Genomic context

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Location:
chromosome: 1
Exon count:
10
Annotation release Status Assembly Chr Location
104 current CriGri_1.0 (GCF_000223135.1) Unplaced Scaffold NW_003615992.1 (47612..61610)
104 current CriGri-PICRH-1.0 (GCF_003668045.3) 1 Unlocalized Scaffold NW_023276807.1 (143371545..143385543)

NW_003615992.1Genomic Context describing neighboring genes Neighboring gene aminoadipate-semialdehyde dehydrogenase Neighboring gene phosphoribosyl pyrophosphate amidotransferase Neighboring gene uncharacterized LOC103163085 Neighboring gene signal recognition particle 72 Neighboring gene ADP ribosylation factor like GTPase 9

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Genetic and metabolomic analysis of AdeD and AdeI mutants of de novo purine biosynthesis: cellular models of de novo purine biosynthesis deficiency disorders. Duval N, et al. Mol Genet Metab, 2013 Mar. PMID 23394948, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables phosphoribosylaminoimidazolesuccinocarboxamide synthase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in 'de novo' IMP biosynthetic process IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
multifunctional protein ADE2
Names
Multifunctional protein ADE2
phosphoribosylaminoimidazole carboxylase; phosphoribosylaminoimidazolesuccinocarboxamide synthase

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Cricetulus griseus Annotation Release 104 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference CriGri_1.0 Primary Assembly

Genomic

  1. NW_003615992.1 Reference CriGri_1.0 Primary Assembly

    Range
    47612..61610
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_016963184.1 → XP_016818673.1  multifunctional protein ADE2 isoform X3

    UniProtKB/TrEMBL
    A0A8C2QN90
    Conserved Domains (2) summary
    cd01416
    Location:1 → 209
    SAICAR_synt_Ade5; Ade5_like 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase
    TIGR01162
    Location:219 → 372
    purE; phosphoribosylaminoimidazole carboxylase, PurE protein

  2. XM_007653814.4 → XP_007652004.1  multifunctional protein ADE2 isoform X3

    UniProtKB/TrEMBL
    A0A8C2QN90
    Conserved Domains (2) summary
    cd01416
    Location:1 → 209
    SAICAR_synt_Ade5; Ade5_like 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase
    TIGR01162
    Location:219 → 372
    purE; phosphoribosylaminoimidazole carboxylase, PurE protein

  3. XM_003513528.5 → XP_003513576.1  multifunctional protein ADE2 isoform X2

    UniProtKB/TrEMBL
    M1R995
    Conserved Domains (2) summary
    cd01416
    Location:7 → 258
    SAICAR_synt_Ade5; Ade5_like 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase
    TIGR01162
    Location:268 → 421
    purE; phosphoribosylaminoimidazole carboxylase, PurE protein

  4. XM_007653813.2 → XP_007652003.1  multifunctional protein ADE2 isoform X1

    UniProtKB/TrEMBL
    M1R995
    Conserved Domains (2) summary
    cd01416
    Location:50 → 301
    SAICAR_synt_Ade5; Ade5_like 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase
    TIGR01162
    Location:311 → 464
    purE; phosphoribosylaminoimidazole carboxylase, PurE protein

Alternate CriGri-PICRH-1.0

Genomic

  1. NW_023276807.1 Alternate CriGri-PICRH-1.0

    Range
    143371545..143385543
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_027390947.1 → XP_027246748.1  multifunctional protein ADE2 isoform X6

    UniProtKB/TrEMBL
    A0A8C2QN90, A0A9J7J9S3
    Related
    ENSCGRP00015010511.1, ENSCGRT00015012909.2

  2. XM_027390948.2 → XP_027246749.1  multifunctional protein ADE2 isoform X6

    UniProtKB/TrEMBL
    A0A8C2QN90, A0A9J7J9S3

  3. XM_027390946.2 → XP_027246747.1  multifunctional protein ADE2 isoform X5

    UniProtKB/TrEMBL
    M1R995, M1RNR0
    Related
    ENSCGRP00015010490.1, ENSCGRT00015012889.2

  4. XM_027390945.1 → XP_027246746.1  multifunctional protein ADE2 isoform X4

    UniProtKB/TrEMBL
    A0A9J7F414, M1R995
Nucleotide Protein Strain
Heading Accession and Version

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