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Kmt2a lysine methyltransferase 2A [ Cricetulus griseus (Chinese hamster) ]

Gene ID: 100760424, updated on 8-Mar-2024

Summary

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Gene symbol
Kmt2a
Gene description
lysine methyltransferase 2A
Locus tag
I79_018830
See related
Ensembl:ENSCGRG00015016752
Gene type
protein coding
RefSeq status
MODEL
Organism
Cricetulus griseus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Cricetidae; Cricetinae; Cricetulus
Also known as
Mll1
Annotation information
Annotation category: partial on reference assembly
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 4
Exon count:
36
Annotation release Status Assembly Chr Location
104 current CriGri_1.0 (GCF_000223135.1) Unplaced Scaffold NW_003614897.1 (97856..181814)
104 current CriGri-PICRH-1.0 (GCF_003668045.3) 4 NC_048597.1 (156480711..156564993, complement)

NW_003614897.1Genomic Context describing neighboring genes Neighboring gene ATP synthase F(0) complex subunit C2, mitochondrial-like Neighboring gene U6atac minor spliceosomal RNA Neighboring gene U6 spliceosomal RNA Neighboring gene tetratricopeptide repeat domain 36 Neighboring gene transmembrane protein 25

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Unraveling the Chinese hamster ovary cell line transcriptome by next-generation sequencing. Becker J, et al. J Biotechnol, 2011 Dec 10. PMID 21945585

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables histone H3K4 methyltransferase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables protein binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in positive regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
part_of histone methyltransferase complex IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
histone-lysine N-methyltransferase 2A
Names
Histone-lysine N-methyltransferase HRX
lysine (K)-specific methyltransferase 2A
myeloid/lymphoid or mixed-lineage leukemia 1

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Cricetulus griseus Annotation Release 104 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference CriGri_1.0 Primary Assembly

Genomic

  1. NW_003614897.1 Reference CriGri_1.0 Primary Assembly

    Range
    97856..181814
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_035461230.1 → XP_035317121.1  histone-lysine N-methyltransferase 2A isoform X1

    UniProtKB/TrEMBL
    A0A8C2MM69
    Conserved Domains (11) summary
    cd05493
    Location:1561 → 1691
    Bromo_ALL-1; Bromodomain, ALL-1 like proteins. ALL-1 is a vertebrate homologue of Drosophila trithorax and is often affected in chromosomal rearrangements that are linked to acute leukemias, such as acute lymphocytic leukemia (ALL). Bromodomains are found in many ...
    smart00542
    Location:3584 → 3667
    FYRC; FY-rich domain, C-terminal region
    PLN02744
    Location:1158 → 1211
    PLN02744; dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex
    cd15588
    Location:1347 → 1393
    PHD1_KMT2A; PHD finger 1 found in histone-lysine N-methyltransferase 2A (KMT2A)
    cd15590
    Location:1395 → 1444
    PHD2_KMT2A; PHD finger 2 found in histone-lysine N-methyltransferase 2A (KMT2A)
    cd15592
    Location:1482 → 1538
    PHD3_KMT2A; PHD finger 3 found in histone-lysine N-methyltransferase 2A (KMT2A)
    cd15693
    Location:1785 → 1897
    ePHD_KMT2A; Extended PHD finger found in histone-lysine N-methyltransferase 2A (KMT2A)
    pfam05109
    Location:3048 → 3277
    Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
    pfam02008
    Location:1060 → 1107
    zf-CXXC; CXXC zinc finger domain
    cd19170
    Location:3731 → 3884
    SET_KMT2A_2B; SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 2A (KMT2A), 2B (KMT2B) and similar proteins
    pfam05964
    Location:1938 → 1985
    FYRN; F/Y-rich N-terminus

Alternate CriGri-PICRH-1.0

Genomic

  1. NC_048597.1 Alternate CriGri-PICRH-1.0

    Range
    156480711..156564993 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_035443626.1 → XP_035299517.1  histone-lysine N-methyltransferase 2A isoform X6

    UniProtKB/TrEMBL
    A0A8C2MM69, A0A9J7GVZ7
    Conserved Domains (10) summary
    cd05493
    Location:1640 → 1770
    Bromo_ALL-1; Bromodomain, ALL-1 like proteins. ALL-1 is a vertebrate homologue of Drosophila trithorax and is often affected in chromosomal rearrangements that are linked to acute leukemias, such as acute lymphocytic leukemia (ALL). Bromodomains are found in many ...
    smart00542
    Location:3397 → 3480
    FYRC; FY-rich domain, C-terminal region
    PLN02744
    Location:1234 → 1287
    PLN02744; dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex
    cd15588
    Location:1423 → 1469
    PHD1_KMT2A; PHD finger 1 found in histone-lysine N-methyltransferase 2A (KMT2A)
    cd15590
    Location:1471 → 1520
    PHD2_KMT2A; PHD finger 2 found in histone-lysine N-methyltransferase 2A (KMT2A)
    cd15592
    Location:1558 → 1617
    PHD3_KMT2A; PHD finger 3 found in histone-lysine N-methyltransferase 2A (KMT2A)
    cd15693
    Location:1864 → 1976
    ePHD_KMT2A; Extended PHD finger found in histone-lysine N-methyltransferase 2A (KMT2A)
    pfam02008
    Location:1136 → 1183
    zf-CXXC; CXXC zinc finger domain
    cd19170
    Location:3544 → 3697
    SET_KMT2A_2B; SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 2A (KMT2A), 2B (KMT2B) and similar proteins
    pfam05964
    Location:2017 → 2064
    FYRN; F/Y-rich N-terminus

  2. XM_027411979.2 → XP_027267780.1  histone-lysine N-methyltransferase 2A isoform X3

    UniProtKB/TrEMBL
    A0A8C2MM69, A0A9J7JKF0

  3. XM_027411980.2 → XP_027267781.1  histone-lysine N-methyltransferase 2A isoform X4

    UniProtKB/TrEMBL
    A0A8C2MM69, A0A9J7FTI3

  4. XM_027411978.2 → XP_027267779.1  histone-lysine N-methyltransferase 2A isoform X2

    UniProtKB/TrEMBL
    A0A8C2MM69, A0A9J7FTH9
    Related
    ENSCGRP00015022207.2, ENSCGRT00015027250.2

  5. XM_027411982.2 → XP_027267783.1  histone-lysine N-methyltransferase 2A isoform X7

    UniProtKB/TrEMBL
    A0A9J7JFW5

  6. XM_035443625.1 → XP_035299516.1  histone-lysine N-methyltransferase 2A isoform X5

    UniProtKB/TrEMBL
    A0A8C2MM69, A0A9J7K6I2
    Conserved Domains (11) summary
    cd05493
    Location:1640 → 1770
    Bromo_ALL-1; Bromodomain, ALL-1 like proteins. ALL-1 is a vertebrate homologue of Drosophila trithorax and is often affected in chromosomal rearrangements that are linked to acute leukemias, such as acute lymphocytic leukemia (ALL). Bromodomains are found in many ...
    smart00542
    Location:3663 → 3746
    FYRC; FY-rich domain, C-terminal region
    PLN02744
    Location:1234 → 1287
    PLN02744; dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex
    cd15588
    Location:1423 → 1469
    PHD1_KMT2A; PHD finger 1 found in histone-lysine N-methyltransferase 2A (KMT2A)
    cd15590
    Location:1471 → 1520
    PHD2_KMT2A; PHD finger 2 found in histone-lysine N-methyltransferase 2A (KMT2A)
    cd15592
    Location:1558 → 1617
    PHD3_KMT2A; PHD finger 3 found in histone-lysine N-methyltransferase 2A (KMT2A)
    cd15693
    Location:1864 → 1976
    ePHD_KMT2A; Extended PHD finger found in histone-lysine N-methyltransferase 2A (KMT2A)
    pfam05109
    Location:3127 → 3356
    Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
    pfam02008
    Location:1136 → 1183
    zf-CXXC; CXXC zinc finger domain
    cl40432
    Location:3810 → 3873
    SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain superfamily
    pfam05964
    Location:2017 → 2064
    FYRN; F/Y-rich N-terminus
Nucleotide Protein Strain
Heading Accession and Version

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