Pten phosphatase and tensin homolog [Cricetulus griseus (Chinese hamster)] - Gene

Summary

Gene symbol: Pten
Gene description: phosphatase and tensin homolog
Locus tag: I79_018586
See related: Ensembl:ENSCGRG00015021424
Gene type: protein coding
RefSeq status: MODEL
Organism: Cricetulus griseus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Cricetidae; Cricetinae; Cricetulus
Orthologs: human mouse all
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Annotation release	Status	Assembly	Chr	Location
104	current	CriGri_1.0 (GCF_000223135.1)	Unplaced Scaffold	NW_003614860.1 (176541..244265, complement)
104	current	CriGri-PICRH-1.0 (GCF_003668045.3)	3	NC_048596.1 (28737150..28810194, complement)

NW_003614860.1 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

SIPL1 promotes AKT activation by decreasing the amount of PTEN protein in CHO-K1 cells.
Title: SIPL1 enhances the proliferation, attachment, and migration of CHO cells by inhibiting PTEN function.

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Function	Evidence Code	Pubs
enables inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity	IEA Inferred from Electronic Annotation more info	PubMed
enables phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity	IEA Inferred from Electronic Annotation more info	PubMed
enables phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity	IEA Inferred from Electronic Annotation more info	PubMed
enables protein tyrosine phosphatase activity	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in cell motility	IEA Inferred from Electronic Annotation more info	PubMed
involved_in negative regulation of cell population proliferation	IEA Inferred from Electronic Annotation more info	PubMed
involved_in phosphatidylinositol 3-kinase/protein kinase B signal transduction	IEA Inferred from Electronic Annotation more info	PubMed
involved_in phosphatidylinositol dephosphorylation	IEA Inferred from Electronic Annotation more info	PubMed
involved_in protein dephosphorylation	IEA Inferred from Electronic Annotation more info	PubMed
involved_in regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in cell projection	IEA Inferred from Electronic Annotation more info	PubMed
located_in cytosol	IEA Inferred from Electronic Annotation more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info	PubMed
located_in plasma membrane	IEA Inferred from Electronic Annotation more info	PubMed

Preferred Names: phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN

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The following sections contain reference sequences that belong to a specific genome build. Explain

XM_003510310.3 → XP_003510358.1 phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN isoform X2

See identical proteins and their annotated locations for XP_003510358.1

UniProtKB/TrEMBL

A0A061IBI8

Conserved Domains (2) summary

cd14509
Location:24 → 181

PTP_PTEN; protein tyrosine phosphatase-like catalytic domain of phosphatase and tensin homolog

pfam10409
Location:188 → 349

PTEN_C2; C2 domain of PTEN tumor-suppressor protein
XM_027442057.2 → XP_027297858.1 phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN isoform X1

UniProtKB/TrEMBL

A0A061IBI8, A0A9J7JGL0