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Duox2 dual oxidase 2 [ Cricetulus griseus (Chinese hamster) ]

Gene ID: 100764526, updated on 8-Mar-2024

Summary

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Gene symbol
Duox2
Gene description
dual oxidase 2
Locus tag
I79_003741
See related
Ensembl:ENSCGRG00015018797
Gene type
protein coding
RefSeq status
MODEL
Organism
Cricetulus griseus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Cricetidae; Cricetinae; Cricetulus
Orthologs
human mouse all
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Genomic context

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See Duox2 in Genome Data Viewer
Location:
chromosome: 6
Exon count:
32
Annotation release Status Assembly Chr Location
104 current CriGri_1.0 (GCF_000223135.1) Unplaced Scaffold NW_003613677.1 (21592..39644)
104 current CriGri-PICRH-1.0 (GCF_003668045.3) 6 NC_048599.1 (56131301..56149534)

NW_003613677.1Genomic Context describing neighboring genes Neighboring gene dual oxidase maturation factor 1 Neighboring gene dual oxidase maturation factor 2 Neighboring gene sorbitol dehydrogenase Neighboring gene telomere repeat binding bouquet formation protein 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables heme binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables peroxidase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables superoxide-generating NAD(P)H oxidase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in defense response IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in response to oxidative stress IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in superoxide anion generation IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
part_of NADPH oxidase complex IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
dual oxidase 2

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Cricetulus griseus Annotation Release 104 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference CriGri_1.0 Primary Assembly

Genomic

  1. NW_003613677.1 Reference CriGri_1.0 Primary Assembly

    Range
    21592..39644
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_035444990.1 → XP_035300881.1  dual oxidase 2 isoform X1

    UniProtKB/TrEMBL
    A0A8C2N3H0
    Conserved Domains (6) summary
    cd06186
    Location:1161 → 1435
    NOX_Duox_like_FAD_NADP; NADPH oxidase (NOX) catalyzes the generation of reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. ROS were originally identified as bactericidal agents in phagocytes, but are now also implicated in cell signaling and metabolism. NOX ...
    cd00051
    Location:714 → 775
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    cd15898
    Location:713 → 742
    EFh_PI-PLC; EF-hand motif [structural motif]
    cl28895
    Location:713 → 838
    EFh_PI-PLC; EF-hand motif found in eukaryotic phosphoinositide-specific phospholipase C (PI-PLC, EC 3.1.4.11) isozymes
    cl14561
    Location:38 → 484
    An_peroxidase_like; Animal heme peroxidases and related proteins
    pfam01794
    Location:975 → 1119
    Ferric_reduct; Ferric reductase like transmembrane component

Alternate CriGri-PICRH-1.0

Genomic

  1. NC_048599.1 Alternate CriGri-PICRH-1.0

    Range
    56131301..56149534
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_027421994.2 → XP_027277795.1  dual oxidase 2 isoform X2

    UniProtKB/TrEMBL
    A0A8C2N3H0, A0A9J7G8W2
    Related
    ENSCGRP00015043797.1, ENSCGRT00015066786.1
Nucleotide Protein Strain
Heading Accession and Version

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