Dpyd dihydropyrimidine dehydrogenase [Cricetulus griseus (Chinese hamster)] - Gene

Summary

Gene symbol: Dpyd
Gene description: dihydropyrimidine dehydrogenase
Locus tag: I79_017784
See related: Ensembl:ENSCGRG00015000372
Gene type: protein coding
RefSeq status: MODEL
Organism: Cricetulus griseus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Cricetidae; Cricetinae; Cricetulus
Annotation information: Annotation category: partial on reference assembly
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 1

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
104	current	CriGri_1.0 (GCF_000223135.1)	Unplaced Scaffold	NW_003614733.1 (5209..490939)
104	current	CriGri_1.0 (GCF_000223135.1)	Unplaced Scaffold	NW_003616651.1 (20871..86733)
104	current	CriGri_1.0 (GCF_000223135.1)	Unplaced Scaffold	NW_003617220.1 (35808..71562)
104	current	CriGri-PICRH-1.0 (GCF_003668045.3)	1 Unlocalized Scaffold	NW_023276806.1 (38950701..39780755, complement)

NW_003617220.1 Genomic Context describing neighboring genes

NW_003616651.1 Genomic Context describing neighboring genes

NW_003614733.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

stSG626535 (e-PCR)
- UniSTS:456662

Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables NADP binding	IEA Inferred from Electronic Annotation more info	PubMed
enables dihydropyrimidine dehydrogenase (NADP+) activity	IEA Inferred from Electronic Annotation more info	PubMed
enables iron-sulfur cluster binding	IEA Inferred from Electronic Annotation more info	PubMed
enables uracil binding	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in thymine catabolic process	IEA Inferred from Electronic Annotation more info	PubMed
involved_in uracil catabolic process	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info	PubMed
located_in cytosol	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: dihydropyrimidine dehydrogenase [NADP(+)]

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Cricetulus griseus Annotation Release 104 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference CriGri_1.0 Primary Assembly

Genomic

NW_003614733.1 Reference CriGri_1.0 Primary Assembly

Range

5209..490939

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_003509586.3 → XP_003509634.2 dihydropyrimidine dehydrogenase [NADP(+)] isoform X1

Conserved Domains (4) summary

PRK11749
Location:74 → 531

PRK11749; dihydropyrimidine dehydrogenase subunit A; Provisional

pfam13450
Location:215 → 259

NAD_binding_8; NAD(P)-binding Rossmann-like domain

pfam14691
Location:77 → 189

Fer4_20; Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster

cl21457
Location:552 → 656

TIM_phosphate_binding; TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate ...

Reference CriGri_1.0 Primary Assembly

Genomic

NW_003616651.1 Reference CriGri_1.0 Primary Assembly

Range

20871..86733

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_007654600.3 → XP_007652790.2 dihydropyrimidine dehydrogenase [NADP(+)] isoform X2

Reference CriGri_1.0 Primary Assembly

Genomic

NW_003617220.1 Reference CriGri_1.0 Primary Assembly

Range

35808..71562

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_007655019.3 → XP_007653209.3 dihydropyrimidine dehydrogenase [NADP(+)] isoform X3

Conserved Domains (1) summary

cl21457
Location:15 → 85

TIM; TIM-like beta/alpha barrel domains