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ABI2 abl interactor 2 [ Homo sapiens (human) ]

Gene ID: 10152, updated on 11-Apr-2024

Summary

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Official Symbol
ABI2provided by HGNC
Official Full Name
abl interactor 2provided by HGNC
Primary source
HGNC:HGNC:24011
See related
Ensembl:ENSG00000138443 MIM:606442; AllianceGenome:HGNC:24011
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
AIP1; ABI-2; ABI2B; AIP-1; AblBP3; argBP1; SSH3BP2; argBPIA; argBPIB
Summary
Enables several functions, including SH3 domain binding activity; identical protein binding activity; and ubiquitin protein ligase binding activity. Contributes to small GTPase binding activity. Involved in Rac protein signal transduction; positive regulation of cellular component organization; and zonula adherens assembly. Acts upstream of or within peptidyl-tyrosine phosphorylation. Located in several cellular components, including filopodium tip; lamellipodium; and nucleoplasm. Part of SCAR complex. Is active in adherens junction. Colocalizes with actin filament. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in brain (RPKM 35.9), thyroid (RPKM 13.9) and 21 other tissues See more
Orthologs
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Genomic context

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See ABI2 in Genome Data Viewer
Location:
2q33.2
Exon count:
19
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (203328394..203432169)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (203810332..203914077)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (204193117..204296892)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene cytochrome P450 family 20 subfamily A member 1 Neighboring gene RNA, 7SL, cytoplasmic 670, pseudogene Neighboring gene H3K27ac hESC enhancer GRCh37_chr2:204192004-204192974 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12255 Neighboring gene mitochondrial ribosomal protein L50 pseudogene 2 Neighboring gene H3K27ac hESC enhancer GRCh37_chr2:204209822-204210322 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17011 Neighboring gene MPRA-validated peak4020 silencer Neighboring gene tRNA-Glu (anticodon TTC) 9-1 Neighboring gene Ras association (RalGDS/AF-6) and pleckstrin homology domains 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12256 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12257 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12258 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr2:204464991-204465874 Neighboring gene zinc finger protein 207 pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Association of Abl interactor 2, ABI2, with platelet/lymphocyte ratio in patients with renal cell carcinoma: A pilot study. Ergun S, et al. Int J Exp Pathol, 2020 Jun. PMID 32496656, Free PMC Article
  2. Bcr-Abl induces abnormal cytoskeleton remodeling, beta1 integrin clustering and increased cell adhesion to fibronectin through the Abl interactor 1 pathway. Li Y, et al. J Cell Sci, 2007 Apr 15. PMID 17389688, Free PMC Article
  3. The expression of Abl interactor 2 in leiomyoma and myometrium and regulation by GnRH analogue and transforming growth factor-beta. Luo X, et al. Hum Reprod, 2006 Jun. PMID 16488906
  4. Identification of ArgBP1, an Arg protein tyrosine kinase binding protein that is the human homologue of a CNS-specific Xenopus gene. Wang B, et al. Oncogene, 1996 May 2. PMID 8649853
  5. PIM1 phosphorylates ABI2 to enhance actin dynamics and promote tumor invasion. Jensen CC, et al. J Cell Biol, 2023 Jun 5. PMID 37042842, Free PMC Article

See all (69) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. PIM1 phosphorylates ABI2 to enhance actin dynamics and promote tumor invasion.
    Title: PIM1 phosphorylates ABI2 to enhance actin dynamics and promote tumor invasion.
  2. Association of Abl interactor 2, ABI2, with platelet/lymphocyte ratio in patients with renal cell carcinoma: A pilot study.
    Title: Association of Abl interactor 2, ABI2, with platelet/lymphocyte ratio in patients with renal cell carcinoma: A pilot study.
  3. TIS21 attenuated Doxorubicin-induced cancer cell senescence by inhibiting linear actin nucleation via Nox4-ROS-ABI2-DRF signal cascade
    Title: TIS21(/BTG2) inhibits doxorubicin-induced stress fiber-vimentin networks via Nox4-ROS-ABI2-DRF-linked signal cascade.
  4. Abl-interactor 2 (ABI2) is a novel MLL translocation partner in acute myeloid leukemia.
    Title: Abl-interactor 2 (ABI2): a novel MLL translocation partner in acute myeloid leukemia.
  5. These findings uncover a novel link between cadherin-mediated adhesion and the regulation of actin dynamics through the requirement for an Abi/Dia complex for the formation and stability of cell-cell junctions.
    Title: Regulation of cell-cell adhesion by Abi/Diaphanous complexes.
  6. TRIM32 is a novel oncogene that promotes tumor growth, metastasis, and resistance to anticancer drugs via degradation of Abl-interactor 2
    Title: Tripartite motif protein 32 facilitates cell growth and migration via degradation of Abl-interactor 2.
  7. disruption of the interaction between Bcr-Abl and Abi1 by mutations either in Bcr-Abl or Abi1 not only abolished tyrosine phosphorylation of Abi1 and membrane translocation of Abi1/WAVE2
    Title: Bcr-Abl induces abnormal cytoskeleton remodeling, beta1 integrin clustering and increased cell adhesion to fibronectin through the Abl interactor 1 pathway.
  8. Abi-2 may have a key regulatory function in leiomyomas cellular/tissue structural organization during growth and regression
    Title: The expression of Abl interactor 2 in leiomyoma and myometrium and regulation by GnRH analogue and transforming growth factor-beta.
  9. NESH (Abi-3), like Abi-1 and Abi-2, is a component of the Abi/WAVE complex, but likely plays a different role in the regulation of c-Abl.
    Title: NESH (Abi-3) is present in the Abi/WAVE complex but does not promote c-Abl-mediated phosphorylation.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Genome-wide association study for subclinical atherosclerosis in major arterial territories in the NHLBI's Framingham Heart Study.
EBI GWAS Catalog
GWAS of butyrylcholinesterase activity identifies four novel loci, independent effects within BCHE and secondary associations with metabolic risk factors.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables SH3 domain binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables SH3 domain binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables SH3 domain binding TAS
Traceable Author Statement
more info
 PubMed 
enables cytoskeletal anchor activity TAS
Traceable Author Statement
more info
 PubMed 
enables identical protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables kinase binding NAS
Non-traceable Author Statement
more info
 PubMed 
enables proline-rich region binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables signaling adaptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables signaling adaptor activity IDA
Inferred from Direct Assay
more info
 PubMed 
contributes_to small GTPase binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables ubiquitin protein ligase binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in Rac protein signal transduction IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in actin polymerization or depolymerization NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in cell migration TAS
Traceable Author Statement
more info
 PubMed 
involved_in cytoskeleton organization TAS
Traceable Author Statement
more info
 PubMed 
involved_in lens fiber cell morphogenesis ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in neuron migration IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within peptidyl-tyrosine phosphorylation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of Arp2/3 complex-mediated actin nucleation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of lamellipodium assembly IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of dendritic spine morphogenesis ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
part_of SCAR complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of SCAR complex IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in actin-based cell projection IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in adherens junction IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm TAS
Traceable Author Statement
more info
 PubMed 
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in dendritic spine ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in filopodium tip IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in lamellipodium IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in lamellipodium IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
abl interactor 2
Names
abelson interactor 2
abl binding protein 3
abl-interacting protein 1 (SH3-containing protein)
abl-interactor protein 2b
arg protein tyrosine kinase-binding protein
arg-binding protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001282925.3 → NP_001269854.1  abl interactor 2 isoform a

    See identical proteins and their annotated locations for NP_001269854.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes isoform a.
    Source sequence(s)
    AC018891, AC080075
    Consensus CDS
    CCDS63093.1
    UniProtKB/Swiss-Prot
    B4DSN1, Q13147, Q13249, Q13801, Q9BV70, Q9NYB9
    UniProtKB/TrEMBL
    A0A7D9NKC8
    Related
    ENSP00000295851.4, ENST00000295851.10
    Conserved Domains (3) summary
    cd11972
    Location:452 → 512
    SH3_Abi2; Src homology 3 domain of Abl Interactor 2
    PHA03247
    Location:270 → 397
    PHA03247; large tegument protein UL36; Provisional
    pfam07815
    Location:93 → 156
    Abi_HHR; Abl-interactor HHR

  2. NM_001282926.3 → NP_001269855.1  abl interactor 2 isoform b

    See identical proteins and their annotated locations for NP_001269855.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 5' coding region, compared to variant 1, resulting in an isoform (b) that is shorter than isoform a.
    Source sequence(s)
    AC018891, AC080075
    Consensus CDS
    CCDS63094.1
    UniProtKB/Swiss-Prot
    B4DSN1, Q13147, Q13249, Q13801, Q9BV70, Q9NYB9
    UniProtKB/TrEMBL
    A0A0C4DG21
    Related
    ENSP00000391433.1, ENST00000424558.5
    Conserved Domains (3) summary
    cd11972
    Location:446 → 506
    SH3_Abi2; Src homology 3 domain of Abl Interactor 2
    PHA03247
    Location:264 → 391
    PHA03247; large tegument protein UL36; Provisional
    pfam07815
    Location:93 → 156
    Abi_HHR; Abl-interactor HHR

  3. NM_001282927.2 → NP_001269856.1  abl interactor 2 isoform d

    See identical proteins and their annotated locations for NP_001269856.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in its 5' UTR, differs in the presence and absence of exons in the 5' coding region, initiates translation at an alternate start codon, and lacks an in-frame exon in the central coding region, compared to variant 1. The encoded isoform (d) has a distinct N-terminus and is shorter than isoform a. Variants 4 and 6 both encode the same isoform (d).
    Source sequence(s)
    AC018891, AC080075
    UniProtKB/Swiss-Prot
    Q9NYB9
    Conserved Domains (2) summary
    cd11972
    Location:340 → 400
    SH3_Abi2; Src homology 3 domain of Abl Interactor 2
    pfam07815
    Location:48 → 118
    Abi_HHR; Abl-interactor HHR

  4. NM_001282932.2 → NP_001269861.1  abl interactor 2 isoform e

    See identical proteins and their annotated locations for NP_001269861.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) differs in its 5' UTR, differs in the presence and absence of exons in the 5' coding region, initiates translation at an alternate start codon, and lacks an in-frame exon in the central coding region, compared to variant 1. The encoded isoform (e) has a distinct N-terminus and is shorter than isoform a.
    Source sequence(s)
    AC018891, AC080075
    UniProtKB/TrEMBL
    B7Z836, E7EW77
    Conserved Domains (2) summary
    cd11972
    Location:329 → 389
    SH3_Abi2; Src homology 3 domain of Abl Interactor 2
    pfam07815
    Location:37 → 107
    Abi_HHR; Abl-interactor HHR

  5. NM_001375662.1 → NP_001362591.1  abl interactor 2 isoform f

    Status: VALIDATED

    Description
    Transcript Variant: This variant (7), as well as variant 8, encodes isoform f.
    Source sequence(s)
    AC018891, AC080075
    UniProtKB/Swiss-Prot
    B4DSN1, Q13147, Q13249, Q13801, Q9BV70, Q9NYB9
    Conserved Domains (3) summary
    cd11972
    Location:407 → 467
    SH3_Abi2; Src homology 3 domain of Abl Interactor 2
    PHA03247
    Location:196 → 332
    PHA03247; large tegument protein UL36; Provisional
    pfam07815
    Location:19 → 82
    Abi_HHR; Abl-interactor HHR

  6. NM_001375663.1 → NP_001362592.1  abl interactor 2 isoform f

    Status: VALIDATED

    Description
    Transcript Variant: This variant (8), as well as variant 7, encodes isoform f.
    Source sequence(s)
    AC018891, AC080075
    UniProtKB/Swiss-Prot
    B4DSN1, Q13147, Q13249, Q13801, Q9BV70, Q9NYB9
    Conserved Domains (3) summary
    cd11972
    Location:407 → 467
    SH3_Abi2; Src homology 3 domain of Abl Interactor 2
    PHA03247
    Location:196 → 332
    PHA03247; large tegument protein UL36; Provisional
    pfam07815
    Location:19 → 82
    Abi_HHR; Abl-interactor HHR

  7. NM_001375664.1 → NP_001362593.1  abl interactor 2 isoform g

    Status: VALIDATED

    Description
    Transcript Variant: This variant (9), as well as variant 10, encodes isoform g.
    Source sequence(s)
    AC018891, AC080075
    Conserved Domains (3) summary
    cd11972
    Location:329 → 389
    SH3_Abi2; Src homology 3 domain of Abl Interactor 2
    PHA03247
    Location:147 → 274
    PHA03247; large tegument protein UL36; Provisional
    pfam07815
    Location:19 → 82
    Abi_HHR; Abl-interactor HHR

  8. NM_001375665.1 → NP_001362594.1  abl interactor 2 isoform g

    Status: VALIDATED

    Description
    Transcript Variant: This variant (10), as well as variant 9, encodes isoform g.
    Source sequence(s)
    AC018891, AC080075
    Conserved Domains (3) summary
    cd11972
    Location:329 → 389
    SH3_Abi2; Src homology 3 domain of Abl Interactor 2
    PHA03247
    Location:147 → 274
    PHA03247; large tegument protein UL36; Provisional
    pfam07815
    Location:19 → 82
    Abi_HHR; Abl-interactor HHR

  9. NM_001375666.1 → NP_001362595.1  abl interactor 2 isoform h

    Status: VALIDATED

    Description
    Transcript Variant: This variant (11), as well as variant 12, encodes isoform h.
    Source sequence(s)
    AC018891, AC080075
    Conserved Domains (2) summary
    cd11972
    Location:311 → 371
    SH3_Abi2; Src homology 3 domain of Abl Interactor 2
    pfam07815
    Location:19 → 82
    Abi_HHR; Abl-interactor HHR

  10. NM_001375667.1 → NP_001362596.1  abl interactor 2 isoform h

    Status: VALIDATED

    Description
    Transcript Variant: This variant (12), as well as variant 11, encodes isoform h.
    Source sequence(s)
    AC018891, AC080075
    Conserved Domains (2) summary
    cd11972
    Location:311 → 371
    SH3_Abi2; Src homology 3 domain of Abl Interactor 2
    pfam07815
    Location:19 → 82
    Abi_HHR; Abl-interactor HHR

  11. NM_001375668.1 → NP_001362597.1  abl interactor 2 isoform i

    Status: VALIDATED

    Description
    Transcript Variant: This variant (13), as well as variant 14, encodes isoform i.
    Source sequence(s)
    AC018891, AC080075
    Conserved Domains (2) summary
    cd11972
    Location:291 → 351
    SH3_Abi2; Src homology 3 domain of Abl Interactor 2
    pfam07815
    Location:19 → 82
    Abi_HHR; Abl-interactor HHR

  12. NM_001375669.1 → NP_001362598.1  abl interactor 2 isoform i

    Status: VALIDATED

    Description
    Transcript Variant: This variant (14), as well as variant 13, encodes isoform i.
    Source sequence(s)
    AC018891, AC080075
    Conserved Domains (2) summary
    cd11972
    Location:291 → 351
    SH3_Abi2; Src homology 3 domain of Abl Interactor 2
    pfam07815
    Location:19 → 82
    Abi_HHR; Abl-interactor HHR

  13. NM_001375670.1 → NP_001362599.1  abl interactor 2 isoform j

    Status: VALIDATED

    Description
    Transcript Variant: This variant (15) encodes the longest isoform (j).
    Source sequence(s)
    AC018891, AC080075
    Consensus CDS
    CCDS92932.1
    UniProtKB/Swiss-Prot
    B4DSN1, Q13147, Q13249, Q13801, Q9BV70, Q9NYB9
    UniProtKB/TrEMBL
    F8WAL6, J3KNB2
    Related
    ENSP00000261018.9, ENST00000261018.12
    Conserved Domains (3) summary
    cd11972
    Location:481 → 541
    SH3_Abi2; Src homology 3 domain of Abl Interactor 2
    PHA03247
    Location:270 → 406
    PHA03247; large tegument protein UL36; Provisional
    pfam07815
    Location:93 → 156
    Abi_HHR; Abl-interactor HHR

  14. NM_001375671.1 → NP_001362600.1  abl interactor 2 isoform k

    Status: VALIDATED

    Source sequence(s)
    AC018891, AC080075
    UniProtKB/Swiss-Prot
    B4DSN1, Q13147, Q13249, Q13801, Q9BV70, Q9NYB9
    Conserved Domains (3) summary
    cd11972
    Location:480 → 540
    SH3_Abi2; Src homology 3 domain of Abl Interactor 2
    PHA03247
    Location:269 → 405
    PHA03247; large tegument protein UL36; Provisional
    pfam07815
    Location:93 → 156
    Abi_HHR; Abl-interactor HHR

  15. NM_001375672.1 → NP_001362601.1  abl interactor 2 isoform l

    Status: VALIDATED

    Source sequence(s)
    AC018891, AC080075
    UniProtKB/TrEMBL
    E7EP65
    Conserved Domains (3) summary
    PHA03247
    Location:270 → 406
    PHA03247; large tegument protein UL36; Provisional
    pfam07815
    Location:93 → 156
    Abi_HHR; Abl-interactor HHR
    cl17036
    Location:481 → 515
    SH3; Src Homology 3 domain superfamily

  16. NM_001375673.1 → NP_001362602.1  abl interactor 2 isoform m

    Status: VALIDATED

    Source sequence(s)
    AC018891, AC080075
    UniProtKB/Swiss-Prot
    B4DSN1, Q13147, Q13249, Q13801, Q9BV70, Q9NYB9
    Conserved Domains (3) summary
    cd11972
    Location:479 → 539
    SH3_Abi2; Src homology 3 domain of Abl Interactor 2
    PHA03247
    Location:270 → 406
    PHA03247; large tegument protein UL36; Provisional
    pfam07815
    Location:93 → 156
    Abi_HHR; Abl-interactor HHR

  17. NM_001375674.1 → NP_001362603.1  abl interactor 2 isoform n

    Status: VALIDATED

    Source sequence(s)
    AC018891, AC080075
    UniProtKB/TrEMBL
    E7EP65
    Conserved Domains (3) summary
    PHA03247
    Location:269 → 405
    PHA03247; large tegument protein UL36; Provisional
    pfam07815
    Location:93 → 156
    Abi_HHR; Abl-interactor HHR
    cl17036
    Location:480 → 514
    SH3; Src Homology 3 domain superfamily

  18. NM_001375675.1 → NP_001362604.1  abl interactor 2 isoform o

    Status: VALIDATED

    Source sequence(s)
    AC018891, AC080075
    UniProtKB/Swiss-Prot
    B4DSN1, Q13147, Q13249, Q13801, Q9BV70, Q9NYB9
    Conserved Domains (3) summary
    cd11972
    Location:475 → 535
    SH3_Abi2; Src homology 3 domain of Abl Interactor 2
    PHA03247
    Location:264 → 400
    PHA03247; large tegument protein UL36; Provisional
    pfam07815
    Location:93 → 156
    Abi_HHR; Abl-interactor HHR

  19. NM_001375676.1 → NP_001362605.1  abl interactor 2 isoform p

    Status: VALIDATED

    Source sequence(s)
    AC018891, AC080075
    Conserved Domains (2) summary
    PHA03247
    Location:270 → 399
    PHA03247; large tegument protein UL36; Provisional
    pfam07815
    Location:93 → 169
    Abi_HHR; Abl-interactor HHR

  20. NM_001375677.1 → NP_001362606.1  abl interactor 2 isoform q

    Status: VALIDATED

    Source sequence(s)
    AC018891, AC080075
    UniProtKB/Swiss-Prot
    B4DSN1, Q13147, Q13249, Q13801, Q9BV70, Q9NYB9
    Conserved Domains (3) summary
    cd11972
    Location:451 → 511
    SH3_Abi2; Src homology 3 domain of Abl Interactor 2
    PHA03247
    Location:269 → 396
    PHA03247; large tegument protein UL36; Provisional
    pfam07815
    Location:93 → 156
    Abi_HHR; Abl-interactor HHR

  21. NM_001375678.1 → NP_001362607.1  abl interactor 2 isoform r

    Status: VALIDATED

    Source sequence(s)
    AC018891, AC080075
    UniProtKB/Swiss-Prot
    B4DSN1, Q13147, Q13249, Q13801, Q9BV70, Q9NYB9
    Conserved Domains (3) summary
    cd11972
    Location:447 → 507
    SH3_Abi2; Src homology 3 domain of Abl Interactor 2
    PHA03247
    Location:221 → 351
    PHA03247; large tegument protein UL36; Provisional
    pfam07815
    Location:93 → 169
    Abi_HHR; Abl-interactor HHR

  22. NM_001375679.1 → NP_001362608.1  abl interactor 2 isoform s

    Status: VALIDATED

    Source sequence(s)
    AC018891, AC080075
    UniProtKB/Swiss-Prot
    B4DSN1, Q13147, Q13249, Q13801, Q9BV70, Q9NYB9
    Conserved Domains (3) summary
    cd11972
    Location:436 → 496
    SH3_Abi2; Src homology 3 domain of Abl Interactor 2
    PHA03247
    Location:225 → 361
    PHA03247; large tegument protein UL36; Provisional
    pfam07815
    Location:48 → 124
    Abi_HHR; Abl-interactor HHR

  23. NM_001375680.1 → NP_001362609.1  abl interactor 2 isoform t

    Status: VALIDATED

    Source sequence(s)
    AC018891, AC080075
    UniProtKB/Swiss-Prot
    B4DSN1, Q13147, Q13249, Q13801, Q9BV70, Q9NYB9
    Conserved Domains (3) summary
    cd11972
    Location:432 → 492
    SH3_Abi2; Src homology 3 domain of Abl Interactor 2
    PHA03247
    Location:221 → 357
    PHA03247; large tegument protein UL36; Provisional
    pfam07815
    Location:93 → 156
    Abi_HHR; Abl-interactor HHR

  24. NM_001375681.1 → NP_001362610.1  abl interactor 2 isoform u

    Status: VALIDATED

    Source sequence(s)
    AC018891, AC080075
    UniProtKB/Swiss-Prot
    B4DSN1, Q13147, Q13249, Q13801, Q9BV70, Q9NYB9
    Conserved Domains (3) summary
    cd11972
    Location:431 → 491
    SH3_Abi2; Src homology 3 domain of Abl Interactor 2
    PHA03247
    Location:220 → 356
    PHA03247; large tegument protein UL36; Provisional
    pfam07815
    Location:93 → 156
    Abi_HHR; Abl-interactor HHR

  25. NM_001375682.1 → NP_001362611.1  abl interactor 2 isoform v

    Status: VALIDATED

    Source sequence(s)
    AC018891, AC080075
    UniProtKB/Swiss-Prot
    B4DSN1, Q13147, Q13249, Q13801, Q9BV70, Q9NYB9
    Conserved Domains (3) summary
    cd11972
    Location:430 → 490
    SH3_Abi2; Src homology 3 domain of Abl Interactor 2
    PHA03247
    Location:221 → 357
    PHA03247; large tegument protein UL36; Provisional
    pfam07815
    Location:93 → 156
    Abi_HHR; Abl-interactor HHR

  26. NM_001375683.1 → NP_001362612.1  abl interactor 2 isoform w

    Status: VALIDATED

    Source sequence(s)
    AC018891, AC080075
    UniProtKB/Swiss-Prot
    B4DSN1, Q13147, Q13249, Q13801, Q9BV70, Q9NYB9
    Conserved Domains (3) summary
    cd11972
    Location:426 → 486
    SH3_Abi2; Src homology 3 domain of Abl Interactor 2
    PHA03247
    Location:215 → 351
    PHA03247; large tegument protein UL36; Provisional
    pfam07815
    Location:93 → 156
    Abi_HHR; Abl-interactor HHR

  27. NM_001375684.1 → NP_001362613.1  abl interactor 2 isoform x

    Status: VALIDATED

    Source sequence(s)
    AC018891, AC080075
    UniProtKB/Swiss-Prot
    B4DSN1, Q13147, Q13249, Q13801, Q9BV70, Q9NYB9
    Conserved Domains (3) summary
    cd11972
    Location:425 → 485
    SH3_Abi2; Src homology 3 domain of Abl Interactor 2
    PHA03247
    Location:214 → 350
    PHA03247; large tegument protein UL36; Provisional
    pfam07815
    Location:93 → 156
    Abi_HHR; Abl-interactor HHR

  28. NM_001375685.1 → NP_001362614.1  abl interactor 2 isoform y

    Status: VALIDATED

    Source sequence(s)
    AC018891, AC080075
    UniProtKB/Swiss-Prot
    B4DSN1, Q13147, Q13249, Q13801, Q9BV70, Q9NYB9
    Conserved Domains (3) summary
    cd11972
    Location:418 → 478
    SH3_Abi2; Src homology 3 domain of Abl Interactor 2
    PHA03247
    Location:221 → 351
    PHA03247; large tegument protein UL36; Provisional
    pfam07815
    Location:93 → 156
    Abi_HHR; Abl-interactor HHR

  29. NM_001375686.1 → NP_001362615.1  abl interactor 2 isoform z

    Status: VALIDATED

    Source sequence(s)
    AC018891, AC080075
    UniProtKB/TrEMBL
    E7EW77
    Conserved Domains (2) summary
    pfam07815
    Location:93 → 156
    Abi_HHR; Abl-interactor HHR
    cl17036
    Location:414 → 448
    SH3; Src Homology 3 domain superfamily

  30. NM_001375687.1 → NP_001362616.1  abl interactor 2 isoform aa

    Status: VALIDATED

    Source sequence(s)
    AC018891, AC080075
    UniProtKB/TrEMBL
    E7EW77
    Conserved Domains (2) summary
    cd11972
    Location:413 → 473
    SH3_Abi2; Src homology 3 domain of Abl Interactor 2
    pfam07815
    Location:93 → 156
    Abi_HHR; Abl-interactor HHR

  31. NM_001375688.1 → NP_001362617.1  abl interactor 2 isoform bb

    Status: VALIDATED

    Source sequence(s)
    AC018891, AC080075
    UniProtKB/TrEMBL
    E7EW77
    Conserved Domains (2) summary
    cd11972
    Location:412 → 472
    SH3_Abi2; Src homology 3 domain of Abl Interactor 2
    pfam07815
    Location:93 → 156
    Abi_HHR; Abl-interactor HHR

  32. NM_001375689.1 → NP_001362618.1  abl interactor 2 isoform cc

    Status: VALIDATED

    Source sequence(s)
    AC018891, AC080075
    UniProtKB/TrEMBL
    E7EW77
    Conserved Domains (2) summary
    pfam07815
    Location:93 → 156
    Abi_HHR; Abl-interactor HHR
    cl17036
    Location:413 → 447
    SH3; Src Homology 3 domain superfamily

  33. NM_001375690.1 → NP_001362619.1  abl interactor 2 isoform dd

    Status: VALIDATED

    Source sequence(s)
    AC018891, AC080075
    UniProtKB/TrEMBL
    E7EW77
    Conserved Domains (2) summary
    cd11972
    Location:411 → 471
    SH3_Abi2; Src homology 3 domain of Abl Interactor 2
    pfam07815
    Location:93 → 156
    Abi_HHR; Abl-interactor HHR

  34. NM_001375691.1 → NP_001362620.1  abl interactor 2 isoform ee

    Status: VALIDATED

    Source sequence(s)
    AC018891, AC080075
    UniProtKB/Swiss-Prot
    B4DSN1, Q13147, Q13249, Q13801, Q9BV70, Q9NYB9
    Conserved Domains (3) summary
    cd11972
    Location:407 → 467
    SH3_Abi2; Src homology 3 domain of Abl Interactor 2
    PHA03247
    Location:225 → 352
    PHA03247; large tegument protein UL36; Provisional
    pfam07815
    Location:48 → 124
    Abi_HHR; Abl-interactor HHR

  35. NM_001375692.1 → NP_001362621.1  abl interactor 2 isoform ff

    Status: VALIDATED

    Source sequence(s)
    AC018891, AC080075
    UniProtKB/Swiss-Prot
    B4DSN1, Q13147, Q13249, Q13801, Q9BV70, Q9NYB9
    Conserved Domains (3) summary
    cd11972
    Location:403 → 463
    SH3_Abi2; Src homology 3 domain of Abl Interactor 2
    PHA03247
    Location:221 → 348
    PHA03247; large tegument protein UL36; Provisional
    pfam07815
    Location:93 → 156
    Abi_HHR; Abl-interactor HHR

  36. NM_001375693.1 → NP_001362622.1  abl interactor 2 isoform gg

    Status: VALIDATED

    Source sequence(s)
    AC018891, AC080075
    UniProtKB/Swiss-Prot
    B4DSN1, Q13147, Q13249, Q13801, Q9BV70, Q9NYB9
    Conserved Domains (3) summary
    cd11972
    Location:402 → 462
    SH3_Abi2; Src homology 3 domain of Abl Interactor 2
    PHA03247
    Location:220 → 347
    PHA03247; large tegument protein UL36; Provisional
    pfam07815
    Location:93 → 156
    Abi_HHR; Abl-interactor HHR

  37. NM_001375695.1 → NP_001362624.1  abl interactor 2 isoform hh

    Status: VALIDATED

    Source sequence(s)
    AC018891, AC080075
    UniProtKB/Swiss-Prot
    B4DSN1, Q13147, Q13249, Q13801, Q9BV70, Q9NYB9
    Conserved Domains (3) summary
    cd11972
    Location:401 → 461
    SH3_Abi2; Src homology 3 domain of Abl Interactor 2
    PHA03247
    Location:190 → 326
    PHA03247; large tegument protein UL36; Provisional
    pfam07815
    Location:19 → 82
    Abi_HHR; Abl-interactor HHR

  38. NM_001375696.1 → NP_001362625.1  abl interactor 2 isoform ii

    Status: VALIDATED

    Source sequence(s)
    AC018891, AC080075
    UniProtKB/TrEMBL
    E7EW77
    Conserved Domains (2) summary
    cd11972
    Location:400 → 460
    SH3_Abi2; Src homology 3 domain of Abl Interactor 2
    pfam07815
    Location:93 → 163
    Abi_HHR; Abl-interactor HHR

  39. NM_001375698.1 → NP_001362627.1  abl interactor 2 isoform jj

    Status: VALIDATED

    Source sequence(s)
    AC018891, AC080075
    Consensus CDS
    CCDS92933.1
    UniProtKB/Swiss-Prot
    B4DSN1, Q13147, Q13249, Q13801, Q9BV70, Q9NYB9
    UniProtKB/TrEMBL
    E9PEZ7
    Related
    ENSP00000408898.1, ENST00000430418.5
    Conserved Domains (3) summary
    cd11972
    Location:397 → 457
    SH3_Abi2; Src homology 3 domain of Abl Interactor 2
    PHA03247
    Location:215 → 342
    PHA03247; large tegument protein UL36; Provisional
    pfam07815
    Location:93 → 156
    Abi_HHR; Abl-interactor HHR

  40. NM_001375699.1 → NP_001362628.1  abl interactor 2 isoform kk

    Status: VALIDATED

    Source sequence(s)
    AC018891, AC080075
    UniProtKB/Swiss-Prot
    B4DSN1, Q13147, Q13249, Q13801, Q9BV70, Q9NYB9
    Conserved Domains (3) summary
    cd11972
    Location:396 → 456
    SH3_Abi2; Src homology 3 domain of Abl Interactor 2
    PHA03247
    Location:214 → 341
    PHA03247; large tegument protein UL36; Provisional
    pfam07815
    Location:93 → 156
    Abi_HHR; Abl-interactor HHR

  41. NM_001375702.1 → NP_001362631.1  abl interactor 2 isoform ll

    Status: VALIDATED

    Source sequence(s)
    AC018891, AC080075
    UniProtKB/Swiss-Prot
    B4DSN1, Q13147, Q13249, Q13801, Q9BV70, Q9NYB9
    Conserved Domains (3) summary
    cd11972
    Location:396 → 456
    SH3_Abi2; Src homology 3 domain of Abl Interactor 2
    PHA03247
    Location:214 → 341
    PHA03247; large tegument protein UL36; Provisional
    pfam07815
    Location:39 → 100
    Abi_HHR; Abl-interactor HHR

  42. NM_001375704.1 → NP_001362633.1  abl interactor 2 isoform mm

    Status: VALIDATED

    Source sequence(s)
    AC018891, AC080075
    UniProtKB/TrEMBL
    E7EW77
    Conserved Domains (2) summary
    pfam07815
    Location:93 → 163
    Abi_HHR; Abl-interactor HHR
    cl17036
    Location:414 → 449
    SH3; Src Homology 3 domain superfamily

  43. NM_001375706.1 → NP_001362635.1  abl interactor 2 isoform nn

    Status: VALIDATED

    Source sequence(s)
    AC018891, AC080075
    UniProtKB/TrEMBL
    E7EW77
    Conserved Domains (2) summary
    cd11972
    Location:385 → 445
    SH3_Abi2; Src homology 3 domain of Abl Interactor 2
    pfam07815
    Location:93 → 156
    Abi_HHR; Abl-interactor HHR

  44. NM_001375707.1 → NP_001362636.1  abl interactor 2 isoform oo

    Status: VALIDATED

    Source sequence(s)
    AC018891, AC080075
    UniProtKB/TrEMBL
    E7EW77
    Conserved Domains (2) summary
    cd11972
    Location:384 → 444
    SH3_Abi2; Src homology 3 domain of Abl Interactor 2
    pfam07815
    Location:93 → 156
    Abi_HHR; Abl-interactor HHR

  45. NM_001375708.1 → NP_001362637.1  abl interactor 2 isoform pp

    Status: VALIDATED

    Source sequence(s)
    AC018891, AC080075
    UniProtKB/TrEMBL
    E7EW77
    Conserved Domains (2) summary
    pfam07815
    Location:93 → 156
    Abi_HHR; Abl-interactor HHR
    cl17036
    Location:385 → 419
    SH3; Src Homology 3 domain superfamily

  46. NM_001375709.1 → NP_001362638.1  abl interactor 2 isoform qq

    Status: VALIDATED

    Source sequence(s)
    AC018891, AC080075
    UniProtKB/TrEMBL
    E7EW77
    Conserved Domains (2) summary
    pfam07815
    Location:93 → 156
    Abi_HHR; Abl-interactor HHR
    cl17036
    Location:384 → 418
    SH3; Src Homology 3 domain superfamily

  47. NM_001375710.1 → NP_001362639.1  abl interactor 2 isoform rr

    Status: VALIDATED

    Source sequence(s)
    AC018891, AC080075
    UniProtKB/TrEMBL
    E7EW77
    Conserved Domains (2) summary
    cd11972
    Location:383 → 443
    SH3_Abi2; Src homology 3 domain of Abl Interactor 2
    pfam07815
    Location:93 → 163
    Abi_HHR; Abl-interactor HHR

  48. NM_001375711.1 → NP_001362640.1  abl interactor 2 isoform ss

    Status: VALIDATED

    Source sequence(s)
    AC018891, AC080075
    UniProtKB/Swiss-Prot
    B4DSN1, Q13147, Q13249, Q13801, Q9BV70, Q9NYB9
    Conserved Domains (3) summary
    cd11972
    Location:378 → 438
    SH3_Abi2; Src homology 3 domain of Abl Interactor 2
    PHA03247
    Location:196 → 323
    PHA03247; large tegument protein UL36; Provisional
    pfam07815
    Location:19 → 82
    Abi_HHR; Abl-interactor HHR

  49. NM_001375712.1 → NP_001362641.1  abl interactor 2 isoform tt

    Status: VALIDATED

    Source sequence(s)
    AC018891, AC080075
    UniProtKB/TrEMBL
    E7EP65
    Conserved Domains (3) summary
    PHA03247
    Location:221 → 348
    PHA03247; large tegument protein UL36; Provisional
    pfam07815
    Location:93 → 156
    Abi_HHR; Abl-interactor HHR
    cl17036
    Location:403 → 438
    SH3; Src Homology 3 domain superfamily

  50. NM_001375714.1 → NP_001362643.1  abl interactor 2 isoform uu

    Status: VALIDATED

    Source sequence(s)
    AC018891, AC080075
    Conserved Domains (3) summary
    cd11972
    Location:376 → 436
    SH3_Abi2; Src homology 3 domain of Abl Interactor 2
    PHA03247
    Location:165 → 301
    PHA03247; large tegument protein UL36; Provisional
    pfam07815
    Location:39 → 100
    Abi_HHR; Abl-interactor HHR

  51. NM_001375717.1 → NP_001362646.1  abl interactor 2 isoform vv

    Status: VALIDATED

    Source sequence(s)
    AC018891, AC080075
    Conserved Domains (2) summary
    cd11972
    Location:374 → 434
    SH3_Abi2; Src homology 3 domain of Abl Interactor 2
    pfam07815
    Location:48 → 124
    Abi_HHR; Abl-interactor HHR

  52. NM_001375719.1 → NP_001362648.1  abl interactor 2 isoform ww

    Status: VALIDATED

    Source sequence(s)
    AC018891, AC080075
    UniProtKB/Swiss-Prot
    B4DSN1, Q13147, Q13249, Q13801, Q9BV70, Q9NYB9
    Conserved Domains (3) summary
    cd11972
    Location:373 → 433
    SH3_Abi2; Src homology 3 domain of Abl Interactor 2
    PHA03247
    Location:191 → 318
    PHA03247; large tegument protein UL36; Provisional
    pfam07815
    Location:63 → 139
    Abi_HHR; Abl-interactor HHR

  53. NM_001375721.1 → NP_001362650.1  abl interactor 2 isoform xx

    Status: VALIDATED

    Source sequence(s)
    AC018891, AC080075
    Conserved Domains (2) summary
    cd11972
    Location:369 → 429
    SH3_Abi2; Src homology 3 domain of Abl Interactor 2
    pfam07815
    Location:48 → 118
    Abi_HHR; Abl-interactor HHR

  54. NM_001375722.1 → NP_001362651.1  abl interactor 2 isoform yy

    Status: VALIDATED

    Source sequence(s)
    AC018891, AC080075
    Conserved Domains (2) summary
    cd11972
    Location:368 → 428
    SH3_Abi2; Src homology 3 domain of Abl Interactor 2
    pfam07815
    Location:48 → 118
    Abi_HHR; Abl-interactor HHR

  55. NM_001375723.1 → NP_001362652.1  abl interactor 2 isoform zz

    Status: VALIDATED

    Source sequence(s)
    AC018891, AC080075
    UniProtKB/TrEMBL
    E7EW77
    Conserved Domains (2) summary
    cd11972
    Location:365 → 425
    SH3_Abi2; Src homology 3 domain of Abl Interactor 2
    pfam07815
    Location:93 → 156
    Abi_HHR; Abl-interactor HHR

  56. NM_001375724.1 → NP_001362653.1  abl interactor 2 isoform aaa

    Status: VALIDATED

    Source sequence(s)
    AC018891, AC080075
    UniProtKB/TrEMBL
    E7EW77
    Conserved Domains (2) summary
    cd11972
    Location:364 → 424
    SH3_Abi2; Src homology 3 domain of Abl Interactor 2
    pfam07815
    Location:93 → 156
    Abi_HHR; Abl-interactor HHR

  57. NM_001375725.1 → NP_001362654.1  abl interactor 2 isoform bbb

    Status: VALIDATED

    Source sequence(s)
    AC018891, AC080075
    UniProtKB/TrEMBL
    E7EW77
    Conserved Domains (2) summary
    cd11972
    Location:363 → 423
    SH3_Abi2; Src homology 3 domain of Abl Interactor 2
    pfam07815
    Location:93 → 156
    Abi_HHR; Abl-interactor HHR

  58. NM_001375726.1 → NP_001362655.1  abl interactor 2 isoform ccc

    Status: VALIDATED

    Source sequence(s)
    AC018891, AC080075
    UniProtKB/TrEMBL
    E7EW77
    Conserved Domains (2) summary
    cd11972
    Location:362 → 422
    SH3_Abi2; Src homology 3 domain of Abl Interactor 2
    pfam07815
    Location:93 → 156
    Abi_HHR; Abl-interactor HHR

  59. NM_001375727.1 → NP_001362656.1  abl interactor 2 isoform ddd

    Status: VALIDATED

    Source sequence(s)
    AC018891, AC080075
    Conserved Domains (3) summary
    cd11972
    Location:358 → 418
    SH3_Abi2; Src homology 3 domain of Abl Interactor 2
    PHA03247
    Location:147 → 283
    PHA03247; large tegument protein UL36; Provisional
    pfam07815
    Location:19 → 95
    Abi_HHR; Abl-interactor HHR

  60. NM_001375728.1 → NP_001362657.1  abl interactor 2 isoform eee

    Status: VALIDATED

    Source sequence(s)
    AC018891, AC080075
    UniProtKB/TrEMBL
    E7EW77
    Conserved Domains (2) summary
    cd11972
    Location:358 → 418
    SH3_Abi2; Src homology 3 domain of Abl Interactor 2
    pfam07815
    Location:39 → 100
    Abi_HHR; Abl-interactor HHR

  61. NM_001375729.1 → NP_001362658.1  abl interactor 2 isoform fff

    Status: VALIDATED

    Source sequence(s)
    AC018891, AC080075
    Conserved Domains (3) summary
    cd11972
    Location:357 → 417
    SH3_Abi2; Src homology 3 domain of Abl Interactor 2
    PHA03247
    Location:146 → 282
    PHA03247; large tegument protein UL36; Provisional
    pfam07815
    Location:19 → 95
    Abi_HHR; Abl-interactor HHR

  62. NM_001375730.1 → NP_001362659.1  abl interactor 2 isoform ggg

    Status: VALIDATED

    Source sequence(s)
    AC018891, AC080075
    UniProtKB/TrEMBL
    E7EW77
    Conserved Domains (2) summary
    cd11972
    Location:357 → 417
    SH3_Abi2; Src homology 3 domain of Abl Interactor 2
    pfam07815
    Location:39 → 100
    Abi_HHR; Abl-interactor HHR

  63. NM_001375731.1 → NP_001362660.1  abl interactor 2 isoform hhh

    Status: VALIDATED

    Source sequence(s)
    AC018891, AC080075
    UniProtKB/TrEMBL
    E7EW77
    Conserved Domains (2) summary
    cd11972
    Location:356 → 416
    SH3_Abi2; Src homology 3 domain of Abl Interactor 2
    pfam07815
    Location:39 → 100
    Abi_HHR; Abl-interactor HHR

  64. NM_001375732.1 → NP_001362661.1  abl interactor 2 isoform iii

    Status: VALIDATED

    Source sequence(s)
    AC018891, AC080075
    Conserved Domains (3) summary
    cd11972
    Location:347 → 407
    SH3_Abi2; Src homology 3 domain of Abl Interactor 2
    PHA03247
    Location:165 → 292
    PHA03247; large tegument protein UL36; Provisional
    pfam07815
    Location:39 → 100
    Abi_HHR; Abl-interactor HHR

  65. NM_001375733.1 → NP_001362662.1  abl interactor 2 isoform jjj

    Status: VALIDATED

    Source sequence(s)
    AC018891, AC080075
    Conserved Domains (3) summary
    cd11972
    Location:341 → 401
    SH3_Abi2; Src homology 3 domain of Abl Interactor 2
    PHA03247
    Location:159 → 286
    PHA03247; large tegument protein UL36; Provisional
    pfam07815
    Location:39 → 100
    Abi_HHR; Abl-interactor HHR

  66. NM_001375734.1 → NP_001362663.1  abl interactor 2 isoform kkk

    Status: VALIDATED

    Source sequence(s)
    AC018891, AC080075
    UniProtKB/TrEMBL
    Q53SH3
    Conserved Domains (2) summary
    cd11972
    Location:340 → 400
    SH3_Abi2; Src homology 3 domain of Abl Interactor 2
    pfam07815
    Location:19 → 82
    Abi_HHR; Abl-interactor HHR

  67. NM_001375735.1 → NP_001362664.1  abl interactor 2 isoform lll

    Status: VALIDATED

    Source sequence(s)
    AC018891, AC080075
    Conserved Domains (2) summary
    cd11972
    Location:338 → 398
    SH3_Abi2; Src homology 3 domain of Abl Interactor 2
    pfam07815
    Location:19 → 89
    Abi_HHR; Abl-interactor HHR

  68. NM_001375736.1 → NP_001362665.1  abl interactor 2 isoform mmm

    Status: VALIDATED

    Source sequence(s)
    AC018891, AC080075
    Conserved Domains (2) summary
    cd11972
    Location:338 → 398
    SH3_Abi2; Src homology 3 domain of Abl Interactor 2
    PHA03247
    Location:156 → 283
    PHA03247; large tegument protein UL36; Provisional

  69. NM_001375737.1 → NP_001362666.1  abl interactor 2 isoform nnn

    Status: VALIDATED

    Source sequence(s)
    AC018891, AC080075
    Conserved Domains (2) summary
    pfam07815
    Location:93 → 163
    Abi_HHR; Abl-interactor HHR
    cl17036
    Location:364 → 399
    SH3; Src Homology 3 domain superfamily

  70. NM_001375738.1 → NP_001362667.1  abl interactor 2 isoform ooo

    Status: VALIDATED

    Source sequence(s)
    AC018891, AC080075
    UniProtKB/TrEMBL
    E7EW77
    Conserved Domains (2) summary
    cd11972
    Location:336 → 396
    SH3_Abi2; Src homology 3 domain of Abl Interactor 2
    pfam07815
    Location:93 → 156
    Abi_HHR; Abl-interactor HHR

  71. NM_001375739.1 → NP_001362668.1  abl interactor 2 isoform ppp

    Status: VALIDATED

    Source sequence(s)
    AC018891, AC080075
    UniProtKB/TrEMBL
    E7EW77
    Conserved Domains (2) summary
    cd11972
    Location:335 → 395
    SH3_Abi2; Src homology 3 domain of Abl Interactor 2
    pfam07815
    Location:93 → 156
    Abi_HHR; Abl-interactor HHR

  72. NM_001375740.1 → NP_001362669.1  abl interactor 2 isoform rrr

    Status: VALIDATED

    Source sequence(s)
    AC018891, AC080075
    UniProtKB/TrEMBL
    E7EW77
    Conserved Domains (2) summary
    cd11972
    Location:334 → 394
    SH3_Abi2; Src homology 3 domain of Abl Interactor 2
    pfam07815
    Location:93 → 163
    Abi_HHR; Abl-interactor HHR

  73. NM_001375741.1 → NP_001362670.1  abl interactor 2 isoform sss

    Status: VALIDATED

    Source sequence(s)
    AC018891, AC080075
    UniProtKB/TrEMBL
    E7EW77
    Conserved Domains (2) summary
    cd11972
    Location:329 → 389
    SH3_Abi2; Src homology 3 domain of Abl Interactor 2
    pfam07815
    Location:39 → 100
    Abi_HHR; Abl-interactor HHR

  74. NM_001375742.1 → NP_001362671.1  abl interactor 2 isoform ttt

    Status: VALIDATED

    Source sequence(s)
    AC018891, AC080075
    Conserved Domains (3) summary
    cd11972
    Location:328 → 388
    SH3_Abi2; Src homology 3 domain of Abl Interactor 2
    PHA03247
    Location:146 → 273
    PHA03247; large tegument protein UL36; Provisional
    pfam07815
    Location:19 → 82
    Abi_HHR; Abl-interactor HHR

  75. NM_001375743.1 → NP_001362672.1  abl interactor 2 isoform uuu

    Status: VALIDATED

    Source sequence(s)
    AC018891, AC080075
    Conserved Domains (2) summary
    pfam07815
    Location:39 → 100
    Abi_HHR; Abl-interactor HHR
    cl17036
    Location:329 → 363
    SH3; Src Homology 3 domain superfamily

  76. NM_001375744.1 → NP_001362673.1  abl interactor 2 isoform vvv

    Status: VALIDATED

    Source sequence(s)
    AC018891, AC080075
    UniProtKB/TrEMBL
    E7EW77
    Conserved Domains (1) summary
    cd11972
    Location:326 → 386
    SH3_Abi2; Src homology 3 domain of Abl Interactor 2

  77. NM_001375745.1 → NP_001362674.1  abl interactor 2 isoform www

    Status: VALIDATED

    Source sequence(s)
    AC018891, AC080075
    Conserved Domains (3) summary
    cd11972
    Location:326 → 386
    SH3_Abi2; Src homology 3 domain of Abl Interactor 2
    PHA03247
    Location:146 → 273
    PHA03247; large tegument protein UL36; Provisional
    pfam07815
    Location:19 → 95
    Abi_HHR; Abl-interactor HHR

  78. NM_001375746.1 → NP_001362675.1  abl interactor 2 isoform xxx

    Status: VALIDATED

    Source sequence(s)
    AC018891, AC080075
    UniProtKB/TrEMBL
    E7EW77
    Conserved Domains (1) summary
    cd11972
    Location:325 → 385
    SH3_Abi2; Src homology 3 domain of Abl Interactor 2

  79. NM_001375747.1 → NP_001362676.1  abl interactor 2 isoform yyy

    Status: VALIDATED

    Source sequence(s)
    AC018891, AC080075
    Conserved Domains (3) summary
    cd11972
    Location:319 → 379
    SH3_Abi2; Src homology 3 domain of Abl Interactor 2
    PHA03247
    Location:168 → 253
    PHA03247; large tegument protein UL36; Provisional
    pfam07815
    Location:48 → 118
    Abi_HHR; Abl-interactor HHR

  80. NM_001375748.1 → NP_001362677.1  abl interactor 2 isoform zzz

    Status: VALIDATED

    Source sequence(s)
    AC018891, AC080075
    Conserved Domains (2) summary
    cd11972
    Location:309 → 369
    SH3_Abi2; Src homology 3 domain of Abl Interactor 2
    pfam07815
    Location:19 → 89
    Abi_HHR; Abl-interactor HHR

  81. NM_001375749.1 → NP_001362678.1  abl interactor 2 isoform aaaa

    Status: VALIDATED

    Source sequence(s)
    AC018891, AC080075
    Conserved Domains (1) summary
    cd11972
    Location:306 → 366
    SH3_Abi2; Src homology 3 domain of Abl Interactor 2

  82. NM_001375750.1 → NP_001362679.1  abl interactor 2 isoform bbbb

    Status: VALIDATED

    Source sequence(s)
    AC018891, AC080075
    Conserved Domains (3) summary
    cd11972
    Location:303 → 363
    SH3_Abi2; Src homology 3 domain of Abl Interactor 2
    PHA03247
    Location:147 → 274
    PHA03247; large tegument protein UL36; Provisional
    pfam07815
    Location:19 → 95
    Abi_HHR; Abl-interactor HHR

  83. NM_001375751.1 → NP_001362680.1  abl interactor 2 isoform cccc

    Status: VALIDATED

    Source sequence(s)
    AC018891, AC080075
    Conserved Domains (2) summary
    cd11972
    Location:290 → 350
    SH3_Abi2; Src homology 3 domain of Abl Interactor 2
    pfam07815
    Location:19 → 82
    Abi_HHR; Abl-interactor HHR

  84. NM_001375752.1 → NP_001362681.1  abl interactor 2 isoform dddd

    Status: VALIDATED

    Source sequence(s)
    AC018891, AC080075
    Conserved Domains (2) summary
    cd11972
    Location:280 → 340
    SH3_Abi2; Src homology 3 domain of Abl Interactor 2
    pfam07815
    Location:39 → 100
    Abi_HHR; Abl-interactor HHR

  85. NM_001375753.1 → NP_001362682.1  abl interactor 2 isoform eeee

    Status: VALIDATED

    Source sequence(s)
    AC018891, AC080075
    Conserved Domains (2) summary
    pfam07815
    Location:19 → 89
    Abi_HHR; Abl-interactor HHR
    cl17036
    Location:262 → 296
    SH3; Src Homology 3 domain superfamily

  86. NM_001375754.1 → NP_001362683.1  abl interactor 2 isoform d

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6), as well as variant 4, encodes isoform d.
    Source sequence(s)
    AC018891, AC080075
    Conserved Domains (2) summary
    cd11972
    Location:340 → 400
    SH3_Abi2; Src homology 3 domain of Abl Interactor 2
    pfam07815
    Location:48 → 118
    Abi_HHR; Abl-interactor HHR

  87. NM_001375755.1 → NP_001362684.1  abl interactor 2 isoform qqq

    Status: VALIDATED

    Source sequence(s)
    AC018891, AC080075
    Conserved Domains (2) summary
    pfam07815
    Location:93 → 156
    Abi_HHR; Abl-interactor HHR
    cl17036
    Location:336 → 370
    SH3; Src Homology 3 domain superfamily

  88. NM_005759.7 → NP_005750.4  abl interactor 2 isoform c

    See identical proteins and their annotated locations for NP_005750.4

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks an alternate in-frame exon in both the 5' and central coding regions, but includes an additional in-frame exon in the 3' coding region, compared to variant 1. The encoded isoform (c) is shorter than isoform a.
    Source sequence(s)
    AC018891, AC080075
    Consensus CDS
    CCDS2358.1
    UniProtKB/TrEMBL
    E7EW77
    Related
    ENSP00000261017.5, ENST00000261017.9
    Conserved Domains (2) summary
    cd11972
    Location:414 → 474
    SH3_Abi2; Src homology 3 domain of Abl Interactor 2
    pfam07815
    Location:93 → 156
    Abi_HHR; Abl-interactor HHR

RNA

  1. NR_164704.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC018891, AC080075

  2. NR_164705.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC018891, AC080075

  3. NR_164706.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC018891, AC080075

  4. NR_164707.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC018891, AC080075

  5. NR_164708.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC018891, AC080075

  6. NR_164709.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC018891, AC080075

  7. NR_164710.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC018891, AC080075

  8. NR_164711.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC018891, AC080075

  9. NR_164712.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC018891, AC080075

  10. NR_164713.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC018891, AC080075
    Related
    ENST00000261016.11

  11. NR_164714.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC018891, AC080075

  12. NR_164715.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC018891, AC080075

  13. NR_164716.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC018891, AC080075

  14. NR_164717.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC018891, AC080075

  15. NR_164718.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC018891, AC080075

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

    Range
    203328394..203432169
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047442823.1 → XP_047298779.1  abl interactor 2 isoform X1

  2. XM_047442826.1 → XP_047298782.1  abl interactor 2 isoform X4

  3. XM_006712180.4 → XP_006712243.1  abl interactor 2 isoform X9

    See identical proteins and their annotated locations for XP_006712243.1

    UniProtKB/TrEMBL
    E7EW77
    Conserved Domains (2) summary
    cd11972
    Location:420 → 480
    SH3_Abi2; Src homology 3 domain of Abl Interactor 2
    pfam07815
    Location:93 → 156
    Abi_HHR; Abl-interactor HHR

  4. XM_047442831.1 → XP_047298787.1  abl interactor 2 isoform X10

  5. XM_006712181.4 → XP_006712244.1  abl interactor 2 isoform X12

    See identical proteins and their annotated locations for XP_006712244.1

    UniProtKB/TrEMBL
    E7EW77
    Conserved Domains (2) summary
    cd11972
    Location:391 → 451
    SH3_Abi2; Src homology 3 domain of Abl Interactor 2
    pfam07815
    Location:93 → 156
    Abi_HHR; Abl-interactor HHR

  6. XM_017003132.3 → XP_016858621.1  abl interactor 2 isoform X14

    UniProtKB/TrEMBL
    E7EW77

  7. XM_047442832.1 → XP_047298788.1  abl interactor 2 isoform X11

  8. XM_006712182.4 → XP_006712245.1  abl interactor 2 isoform X13

    See identical proteins and their annotated locations for XP_006712245.1

    UniProtKB/TrEMBL
    E7EW77
    Conserved Domains (2) summary
    cd11972
    Location:390 → 450
    SH3_Abi2; Src homology 3 domain of Abl Interactor 2
    pfam07815
    Location:93 → 156
    Abi_HHR; Abl-interactor HHR

  9. XM_047442834.1 → XP_047298790.1  abl interactor 2 isoform X15

  10. XM_047442835.1 → XP_047298791.1  abl interactor 2 isoform X16

  11. XM_017003144.3 → XP_016858633.1  abl interactor 2 isoform X19

    UniProtKB/TrEMBL
    E7EW77
    Conserved Domains (2) summary
    cd11972
    Location:342 → 402
    SH3_Abi2; Src homology 3 domain of Abl Interactor 2
    pfam07815
    Location:93 → 169
    Abi_HHR; Abl-interactor HHR

  12. XM_017003138.3 → XP_016858627.1  abl interactor 2 isoform X17

    UniProtKB/TrEMBL
    E7EW77
    Conserved Domains (3) summary
    cd11972
    Location:370 → 430
    SH3_Abi2; Src homology 3 domain of Abl Interactor 2
    PHA03247
    Location:219 → 304
    PHA03247; large tegument protein UL36; Provisional
    pfam07815
    Location:93 → 156
    Abi_HHR; Abl-interactor HHR

  13. XM_047442824.1 → XP_047298780.1  abl interactor 2 isoform X2

  14. XM_047442827.1 → XP_047298783.1  abl interactor 2 isoform X5

  15. XM_047442825.1 → XP_047298781.1  abl interactor 2 isoform X3

  16. XM_047442828.1 → XP_047298784.1  abl interactor 2 isoform X6

  17. XM_047442829.1 → XP_047298785.1  abl interactor 2 isoform X7

  18. XM_047442836.1 → XP_047298792.1  abl interactor 2 isoform X18

  19. XM_047442837.1 → XP_047298793.1  abl interactor 2 isoform X20

  20. XM_047442830.1 → XP_047298786.1  abl interactor 2 isoform X8

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060926.1 Alternate T2T-CHM13v2.0

    Range
    203810332..203914077
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054340092.1 → XP_054196067.1  abl interactor 2 isoform X1

  2. XM_054340100.1 → XP_054196075.1  abl interactor 2 isoform X9

  3. XM_054340101.1 → XP_054196076.1  abl interactor 2 isoform X10

  4. XM_054340103.1 → XP_054196078.1  abl interactor 2 isoform X12

  5. XM_054340105.1 → XP_054196080.1  abl interactor 2 isoform X14

  6. XM_054340102.1 → XP_054196077.1  abl interactor 2 isoform X11

  7. XM_054340104.1 → XP_054196079.1  abl interactor 2 isoform X13

  8. XM_054340106.1 → XP_054196081.1  abl interactor 2 isoform X15

  9. XM_054340107.1 → XP_054196082.1  abl interactor 2 isoform X16

  10. XM_054340110.1 → XP_054196085.1  abl interactor 2 isoform X19

  11. XM_054340108.1 → XP_054196083.1  abl interactor 2 isoform X17

  12. XM_054340093.1 → XP_054196068.1  abl interactor 2 isoform X2

  13. XM_054340095.1 → XP_054196070.1  abl interactor 2 isoform X21

  14. XM_054340096.1 → XP_054196071.1  abl interactor 2 isoform X22

  15. XM_054340097.1 → XP_054196072.1  abl interactor 2 isoform X5

  16. XM_054340094.1 → XP_054196069.1  abl interactor 2 isoform X3

  17. XM_054340098.1 → XP_054196073.1  abl interactor 2 isoform X6

  18. XM_054340099.1 → XP_054196074.1  abl interactor 2 isoform X7

  19. XM_054340109.1 → XP_054196084.1  abl interactor 2 isoform X18

  20. XM_054340111.1 → XP_054196086.1  abl interactor 2 isoform X20

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9NYB9.1 GenPept UniProtKB/Swiss-Prot:Q9NYB9

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