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TNK2 tyrosine kinase non receptor 2 [ Homo sapiens (human) ]

Gene ID: 10188, updated on 11-Apr-2024

Summary

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Official Symbol
TNK2provided by HGNC
Official Full Name
tyrosine kinase non receptor 2provided by HGNC
Primary source
HGNC:HGNC:19297
See related
Ensembl:ENSG00000061938 MIM:606994; AllianceGenome:HGNC:19297
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ACK; ACK1; ACK-1; p21cdc42Hs
Summary
This gene encodes a tyrosine kinase that binds Cdc42Hs in its GTP-bound form and inhibits both the intrinsic and GTPase-activating protein (GAP)-stimulated GTPase activity of Cdc42Hs. This binding is mediated by a unique sequence of 47 amino acids C-terminal to an SH3 domain. The protein may be involved in a regulatory mechanism that sustains the GTP-bound active form of Cdc42Hs and which is directly linked to a tyrosine phosphorylation signal transduction pathway. Several alternatively spliced transcript variants have been identified from this gene, but the full-length nature of only two transcript variants has been determined. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in brain (RPKM 21.9), bone marrow (RPKM 14.7) and 24 other tissues See more
Orthologs
mouse all
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Genomic context

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See TNK2 in Genome Data Viewer
Location:
3q29
Exon count:
33
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (195863364..195908551, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (198449491..198494501)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (195590235..195635422, complement)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene vegetative cell wall protein gp1-like Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:195543301-195544106 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr3:195547535-195548734 Neighboring gene OCT4-H3K4me1 hESC enhancer GRCh37_chr3:195550530-195551217 Neighboring gene Neanderthal introgressed variant-containing enhancers experimental_67540 and experimental_67545 Neighboring gene Neanderthal introgressed variant-containing enhancers experimental_67549, experimental_67550 and experimental_67551 Neighboring gene MPRA-validated peak4987 silencer Neighboring gene uncharacterized LOC107984010 Neighboring gene long intergenic non-protein coding RNA 1983 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:195577694-195578194 Neighboring gene kinesin family member 3A pseudogene 1 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:195586662-195587186 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:195587187-195587709 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:195604399-195604953 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:195610157-195610657 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:195613501-195614264 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:195615031-195615794 Neighboring gene microRNA 6829 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15041 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15042 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21059 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:195623973-195624772 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:195625602-195626282 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21060 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21061 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21062 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15043 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15044 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15045 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21063 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:195641665-195642277 Neighboring gene TNK2 antisense RNA 1 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:195652784-195653752 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:195653753-195654721 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:195654722-195655690 Neighboring gene RNA, U2 small nuclear 11, pseudogene Neighboring gene mucin-5AC-like Neighboring gene serine/threonine-protein phosphatase 4 regulatory subunit 2-like

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. ACKnowledging the role of the Activated-Cdc42 associated kinase (ACK) in regulating protein stability in cancer. Hodder S, et al. Small GTPases, 2023 Dec. PMID 37194323, Free PMC Article
  2. Host factor TNK2 is required for influenza virus infection. Zhou A, et al. Genes Genomics, 2023 Jun. PMID 37133719
  3. Domain Architecture of the Nonreceptor Tyrosine Kinase Ack1. Kan Y, et al. Cells, 2023 Mar 15. PMID 36980241, Free PMC Article
  4. Identification of downstream signaling cascades of ACK1 and prognostic classifiers in non-small cell lung cancer. Zhu J, et al. Aging (Albany NY), 2021 Jan 20. PMID 33495411, Free PMC Article
  5. TNK2 promoted esophageal cancer progression via activating egfr-akt signaling. Zhang A, et al. J Clin Lab Anal, 2021 Mar. PMID 33484472, Free PMC Article

See all (137) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Activation of E3 ubiquitin ligase WWP2 by non-receptor tyrosine kinase ACK1.
    Title: Activation of E3 ubiquitin ligase WWP2 by non-receptor tyrosine kinase ACK1.
  2. Host factor TNK2 is required for influenza virus infection.
    Title: Host factor TNK2 is required for influenza virus infection.
  3. ACKnowledging the role of the Activated-Cdc42 associated kinase (ACK) in regulating protein stability in cancer.
    Title: ACKnowledging the role of the Activated-Cdc42 associated kinase (ACK) in regulating protein stability in cancer.
  4. Domain Architecture of the Nonreceptor Tyrosine Kinase Ack1.
    Title: Domain Architecture of the Nonreceptor Tyrosine Kinase Ack1.
  5. Biochemical Studies of Systemic Lupus Erythematosus-Associated Mutations in Nonreceptor Tyrosine Kinases Ack1 and Brk.
    Title: Biochemical Studies of Systemic Lupus Erythematosus-Associated Mutations in Nonreceptor Tyrosine Kinases Ack1 and Brk.
  6. Activity of the nonreceptor tyrosine kinase Ack1 is regulated by tyrosine phosphorylation of its Mig6 homology region.
    Title: Activity of the nonreceptor tyrosine kinase Ack1 is regulated by tyrosine phosphorylation of its Mig6 homology region.
  7. Assembly of nuclear dimers of PI3K regulatory subunits is regulated by the Cdc42-activated tyrosine kinase ACK.
    Title: Assembly of nuclear dimers of PI3K regulatory subunits is regulated by the Cdc42-activated tyrosine kinase ACK.
  8. Loss of ACK1 Upregulates EGFR and Mediates Resistance to BRAF Inhibition.
    Title: Loss of ACK1 Upregulates EGFR and Mediates Resistance to BRAF Inhibition.
  9. TNK2 promoted esophageal cancer progression via activating egfr-akt signaling.
    Title: TNK2 promoted esophageal cancer progression via activating egfr-akt signaling.
  10. Identification of downstream signaling cascades of ACK1 and prognostic classifiers in non-small cell lung cancer.
    Title: Identification of downstream signaling cascades of ACK1 and prognostic classifiers in non-small cell lung cancer.
Submit: New GeneRIF Correction See all GeneRIFs (71)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
A genome-wide association study (GWAS) for bronchopulmonary dysplasia.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ44758, FLJ45547

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables GTPase inhibitor activity TAS
Traceable Author Statement
more info
 PubMed 
enables WW domain binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables epidermal growth factor receptor binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables identical protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables non-membrane spanning protein tyrosine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein serine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine/tyrosine kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein tyrosine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein tyrosine kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables ubiquitin protein ligase binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in cell surface receptor signaling pathway TAS
Traceable Author Statement
more info
 PubMed 
involved_in endocytosis IEA
Inferred from Electronic Annotation
more info
  
involved_in phosphorylation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of peptidyl-tyrosine phosphorylation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of clathrin-dependent endocytosis IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in small GTPase-mediated signal transduction TAS
Traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
part_of Grb2-EGFR complex IDA
Inferred from Direct Assay
more info
 PubMed 
located_in adherens junction IEA
Inferred from Electronic Annotation
more info
  
located_in clathrin-coated pit IDA
Inferred from Direct Assay
more info
 PubMed 
located_in clathrin-coated vesicle IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoophidium IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasmic vesicle membrane IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in endosome ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in intracellular membrane-bounded organelle IDA
Inferred from Direct Assay
more info
  
located_in membrane HDA PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in perinuclear region of cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
activated CDC42 kinase 1
Names
activated Cdc42-associated kinase 1
activated p21cdc42Hs kinase
tyrosine kinase non-receptor protein 2
NP_001010938.2
NP_001294975.1
NP_001369200.1
NP_001369201.1
NP_001369202.1
NP_001369203.1
NP_001369204.1
NP_001373093.1
NP_001374636.1
NP_001374637.1
NP_001374638.1
NP_001374639.1
NP_001374640.1
NP_001374641.1
NP_001374642.1
NP_001374643.1
NP_001374644.1
NP_001374645.1
NP_001374646.1
NP_001374647.1
NP_001374648.1
NP_001374649.1
NP_001374650.1
NP_005772.3
XP_011510619.2
XP_011510620.2
XP_011510623.1
XP_016860998.1
XP_024309059.2
XP_024309060.1
XP_024309061.1
XP_024309063.1
XP_047303097.1
XP_047303098.1
XP_047303099.1
XP_047303100.1
XP_047303101.1
XP_047303102.1
XP_047303103.1
XP_047303104.1
XP_047303105.1
XP_047303106.1
XP_047303107.1
XP_047303108.1
XP_047303109.1
XP_047303110.1
XP_047303111.1
XP_047303112.1
XP_047303113.1
XP_047303114.1
XP_047303115.1
XP_047303116.1
XP_047303117.1
XP_047303118.1
XP_047303119.1
XP_047303120.1
XP_047303121.1
XP_047303122.1
XP_054200826.1
XP_054200827.1
XP_054200828.1
XP_054200829.1
XP_054200830.1
XP_054200831.1
XP_054200832.1
XP_054200833.1
XP_054200834.1
XP_054200835.1
XP_054200836.1
XP_054200837.1
XP_054200838.1
XP_054200839.1
XP_054200840.1
XP_054200841.1
XP_054200842.1
XP_054200843.1
XP_054200844.1
XP_054200845.1
XP_054200846.1
XP_054200847.1
XP_054200848.1
XP_054200849.1
XP_054200850.1
XP_054200851.1
XP_054200852.1
XP_054200853.1
XP_054200854.1
XP_054200855.1
XP_054200856.1
XP_054200857.1
XP_054200858.1
XP_054200859.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_029779.1 RefSeqGene

    Range
    5459..50646
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001010938.2 → NP_001010938.2  activated CDC42 kinase 1 isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) has a distinct 5' UTR and 5' coding region, lacks one alternate 3' coding exon, and contains a different alternate 3' coding exon, as compared to variant 1. The translation remains in-frame, and results in a longer isoform (2) that has a longer and distinct N-terminus, compared to isoform 1.
    Source sequence(s)
    AK127455, AK131539, BC020395, L13738
    Consensus CDS
    CCDS33927.2
    UniProtKB/TrEMBL
    A0A499FJ16
    Related
    ENSP00000499858.1, ENST00000671753.1
    Conserved Domains (7) summary
    cd09539
    Location:30 → 91
    SAM_TNK-like; SAM domain of TNK(ACK)-like non-receptor tyrosine-protein kinases
    PHA03247
    Location:582 → 888
    PHA03247; large tegument protein UL36; Provisional
    cd14328
    Location:998 → 1037
    UBA_TNK1; UBA domain found in non-receptor tyrosine-protein kinase TNK1 and similar proteins
    cd05040
    Location:154 → 411
    PTKc_Ack_like; Catalytic domain of the Protein Tyrosine Kinase, Activated Cdc42-associated kinase
    pfam09027
    Location:473 → 538
    GTPase_binding; GTPase binding
    pfam11555
    Location:813 → 879
    Inhibitor_Mig-6; EGFR receptor inhibitor Mig-6
    pfam14604
    Location:419 → 468
    SH3_9; Variant SH3 domain

  2. NM_001308046.2 → NP_001294975.1  activated CDC42 kinase 1 isoform 3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks an alternate 5' exon, contains an alternate 5' terminal exon, lacks one alternate 3' coding exon, and initiates translation at an alternate start codon, compared to variant 1. It encodes a shorter isoform (3) that has a shorter and distinct N-terminus, compared to isoform 1.
    Source sequence(s)
    AC124944
    Consensus CDS
    CCDS77875.1
    UniProtKB/TrEMBL
    A0A499FJ16, C9J1X3
    Related
    ENSP00000392546.1, ENST00000428187.7
    Conserved Domains (7) summary
    cd09539
    Location:38 → 99
    SAM_TNK-like; SAM domain of TNK(ACK)-like non-receptor tyrosine-protein kinases
    smart00221
    Location:158 → 417
    STYKc; Protein kinase; unclassified specificity
    cd14328
    Location:991 → 1030
    UBA_TNK1; UBA domain found in non-receptor tyrosine-protein kinase TNK1 and similar proteins
    cd05040
    Location:162 → 419
    PTKc_Ack_like; Catalytic domain of the Protein Tyrosine Kinase, Activated Cdc42-associated kinase
    pfam09027
    Location:479 → 546
    GTPase_binding; GTPase binding
    pfam11555
    Location:806 → 870
    Inhibitor_Mig-6; EGFR receptor inhibitor Mig-6
    pfam14604
    Location:427 → 476
    SH3_9; Variant SH3 domain

  3. NM_001382271.1 → NP_001369200.1  activated CDC42 kinase 1 isoform 4

    Status: REVIEWED

    Source sequence(s)
    AC124944
    Consensus CDS
    CCDS93443.1
    UniProtKB/TrEMBL
    A0A499FJ16, A0A5F9ZHJ2
    Related
    ENSP00000503221.1, ENST00000678220.1
    Conserved Domains (8) summary
    cd09539
    Location:38 → 99
    SAM_TNK-like; SAM domain of TNK(ACK)-like non-receptor tyrosine-protein kinases
    PHA03247
    Location:575 → 881
    PHA03247; large tegument protein UL36; Provisional
    cd14274
    Location:993 → 1036
    UBA_ACK1; UBA domain found in activated Cdc42 kinase 1 (ACK1) and similar proteins
    cd14328
    Location:1023 → 1062
    UBA_TNK1; UBA domain found in non-receptor tyrosine-protein kinase TNK1 and similar proteins
    cd05040
    Location:162 → 419
    PTKc_Ack_like; Catalytic domain of the Protein Tyrosine Kinase, Activated Cdc42-associated kinase
    pfam09027
    Location:481 → 546
    GTPase_binding; GTPase binding
    pfam11555
    Location:806 → 870
    Inhibitor_Mig-6; EGFR receptor inhibitor Mig-6
    pfam14604
    Location:427 → 476
    SH3_9; Variant SH3 domain

  4. NM_001382272.1 → NP_001369201.1  activated CDC42 kinase 1 isoform 5

    Status: REVIEWED

    Source sequence(s)
    AC124944
    UniProtKB/TrEMBL
    A0A499FJ16
    Conserved Domains (8) summary
    cd09539
    Location:30 → 91
    SAM_TNK-like; SAM domain of TNK(ACK)-like non-receptor tyrosine-protein kinases
    PHA03247
    Location:582 → 888
    PHA03247; large tegument protein UL36; Provisional
    cd14274
    Location:1000 → 1043
    UBA_ACK1; UBA domain found in activated Cdc42 kinase 1 (ACK1) and similar proteins
    cd14328
    Location:1030 → 1069
    UBA_TNK1; UBA domain found in non-receptor tyrosine-protein kinase TNK1 and similar proteins
    cd05040
    Location:154 → 411
    PTKc_Ack_like; Catalytic domain of the Protein Tyrosine Kinase, Activated Cdc42-associated kinase
    pfam09027
    Location:473 → 538
    GTPase_binding; GTPase binding
    pfam11555
    Location:813 → 877
    Inhibitor_Mig-6; EGFR receptor inhibitor Mig-6
    pfam14604
    Location:419 → 468
    SH3_9; Variant SH3 domain

  5. NM_001382273.1 → NP_001369202.1  activated CDC42 kinase 1 isoform 6

    Status: REVIEWED

    Source sequence(s)
    AC124944
    Consensus CDS
    CCDS93442.1
    UniProtKB/TrEMBL
    A0A499FJ16, A0A5F9ZGX5
    Related
    ENSP00000499899.1, ENST00000672887.2
    Conserved Domains (8) summary
    cd09539
    Location:6 → 67
    SAM_TNK-like; SAM domain of TNK(ACK)-like non-receptor tyrosine-protein kinases
    PHA03247
    Location:558 → 864
    PHA03247; large tegument protein UL36; Provisional
    cd14274
    Location:976 → 1019
    UBA_ACK1; UBA domain found in activated Cdc42 kinase 1 (ACK1) and similar proteins
    cd14328
    Location:1006 → 1045
    UBA_TNK1; UBA domain found in non-receptor tyrosine-protein kinase TNK1 and similar proteins
    cd05040
    Location:130 → 387
    PTKc_Ack_like; Catalytic domain of the Protein Tyrosine Kinase, Activated Cdc42-associated kinase
    pfam09027
    Location:449 → 514
    GTPase_binding; GTPase binding
    pfam11555
    Location:789 → 853
    Inhibitor_Mig-6; EGFR receptor inhibitor Mig-6
    pfam14604
    Location:395 → 444
    SH3_9; Variant SH3 domain

  6. NM_001382274.1 → NP_001369203.1  activated CDC42 kinase 1 isoform 6

    Status: REVIEWED

    Source sequence(s)
    AC124944
    Consensus CDS
    CCDS93442.1
    UniProtKB/TrEMBL
    A0A499FJ16, A0A5F9ZGX5
    Conserved Domains (8) summary
    cd09539
    Location:6 → 67
    SAM_TNK-like; SAM domain of TNK(ACK)-like non-receptor tyrosine-protein kinases
    PHA03247
    Location:558 → 864
    PHA03247; large tegument protein UL36; Provisional
    cd14274
    Location:976 → 1019
    UBA_ACK1; UBA domain found in activated Cdc42 kinase 1 (ACK1) and similar proteins
    cd14328
    Location:1006 → 1045
    UBA_TNK1; UBA domain found in non-receptor tyrosine-protein kinase TNK1 and similar proteins
    cd05040
    Location:130 → 387
    PTKc_Ack_like; Catalytic domain of the Protein Tyrosine Kinase, Activated Cdc42-associated kinase
    pfam09027
    Location:449 → 514
    GTPase_binding; GTPase binding
    pfam11555
    Location:789 → 853
    Inhibitor_Mig-6; EGFR receptor inhibitor Mig-6
    pfam14604
    Location:395 → 444
    SH3_9; Variant SH3 domain

  7. NM_001382275.1 → NP_001369204.1  activated CDC42 kinase 1 isoform 7

    Status: REVIEWED

    Source sequence(s)
    AC124944
    UniProtKB/TrEMBL
    A0A499FJ16
    Conserved Domains (7) summary
    cd09539
    Location:38 → 99
    SAM_TNK-like; SAM domain of TNK(ACK)-like non-receptor tyrosine-protein kinases
    PHA03247
    Location:590 → 896
    PHA03247; large tegument protein UL36; Provisional
    cd14328
    Location:1006 → 1045
    UBA_TNK1; UBA domain found in non-receptor tyrosine-protein kinase TNK1 and similar proteins
    cd05040
    Location:162 → 419
    PTKc_Ack_like; Catalytic domain of the Protein Tyrosine Kinase, Activated Cdc42-associated kinase
    pfam09027
    Location:481 → 546
    GTPase_binding; GTPase binding
    pfam11555
    Location:821 → 885
    Inhibitor_Mig-6; EGFR receptor inhibitor Mig-6
    pfam14604
    Location:427 → 476
    SH3_9; Variant SH3 domain

  8. NM_001386164.1 → NP_001373093.1  activated CDC42 kinase 1 isoform 8

    Status: REVIEWED

    Source sequence(s)
    AC124944
    Consensus CDS
    CCDS93441.1
    UniProtKB/TrEMBL
    A0A499FJ16, A0A5F9ZI29
    Related
    ENSP00000500887.1, ENST00000673420.1
    Conserved Domains (8) summary
    cd09539
    Location:6 → 67
    SAM_TNK-like; SAM domain of TNK(ACK)-like non-receptor tyrosine-protein kinases
    PHA03247
    Location:543 → 849
    PHA03247; large tegument protein UL36; Provisional
    cd14274
    Location:961 → 1004
    UBA_ACK1; UBA domain found in activated Cdc42 kinase 1 (ACK1) and similar proteins
    cd14328
    Location:991 → 1030
    UBA_TNK1; UBA domain found in non-receptor tyrosine-protein kinase TNK1 and similar proteins
    cd05040
    Location:130 → 387
    PTKc_Ack_like; Catalytic domain of the Protein Tyrosine Kinase, Activated Cdc42-associated kinase
    pfam09027
    Location:449 → 514
    GTPase_binding; GTPase binding
    pfam11555
    Location:774 → 838
    Inhibitor_Mig-6; EGFR receptor inhibitor Mig-6
    pfam14604
    Location:395 → 444
    SH3_9; Variant SH3 domain

  9. NM_001387707.1 → NP_001374636.1  activated CDC42 kinase 1 isoform 9

    Status: REVIEWED

    Source sequence(s)
    AC124944
    UniProtKB/TrEMBL
    A0A499FJ16
    Conserved Domains (8) summary
    cd09539
    Location:38 → 99
    SAM_TNK-like; SAM domain of TNK(ACK)-like non-receptor tyrosine-protein kinases
    PHA03247
    Location:590 → 896
    PHA03247; large tegument protein UL36; Provisional
    cd14274
    Location:1008 → 1051
    UBA_ACK1; UBA domain found in activated Cdc42 kinase 1 (ACK1) and similar proteins
    cd14328
    Location:1038 → 1077
    UBA_TNK1; UBA domain found in non-receptor tyrosine-protein kinase TNK1 and similar proteins
    cd05040
    Location:162 → 419
    PTKc_Ack_like; Catalytic domain of the Protein Tyrosine Kinase, Activated Cdc42-associated kinase
    pfam09027
    Location:481 → 546
    GTPase_binding; GTPase binding
    pfam11555
    Location:821 → 885
    Inhibitor_Mig-6; EGFR receptor inhibitor Mig-6
    pfam14604
    Location:427 → 476
    SH3_9; Variant SH3 domain

  10. NM_001387708.1 → NP_001374637.1  activated CDC42 kinase 1 isoform 10

    Status: REVIEWED

    Source sequence(s)
    AC124944
    UniProtKB/TrEMBL
    A0A499FJ16
    Conserved Domains (8) summary
    cd09539
    Location:30 → 91
    SAM_TNK-like; SAM domain of TNK(ACK)-like non-receptor tyrosine-protein kinases
    PHA03247
    Location:567 → 873
    PHA03247; large tegument protein UL36; Provisional
    cd14274
    Location:985 → 1028
    UBA_ACK1; UBA domain found in activated Cdc42 kinase 1 (ACK1) and similar proteins
    cd14328
    Location:1015 → 1054
    UBA_TNK1; UBA domain found in non-receptor tyrosine-protein kinase TNK1 and similar proteins
    cd05040
    Location:154 → 411
    PTKc_Ack_like; Catalytic domain of the Protein Tyrosine Kinase, Activated Cdc42-associated kinase
    pfam09027
    Location:473 → 538
    GTPase_binding; GTPase binding
    pfam11555
    Location:798 → 862
    Inhibitor_Mig-6; EGFR receptor inhibitor Mig-6
    pfam14604
    Location:419 → 468
    SH3_9; Variant SH3 domain

  11. NM_001387709.1 → NP_001374638.1  activated CDC42 kinase 1 isoform 8

    Status: REVIEWED

    Source sequence(s)
    AC124944
    Consensus CDS
    CCDS93441.1
    UniProtKB/TrEMBL
    A0A499FJ16, A0A5F9ZI29
    Conserved Domains (8) summary
    cd09539
    Location:6 → 67
    SAM_TNK-like; SAM domain of TNK(ACK)-like non-receptor tyrosine-protein kinases
    PHA03247
    Location:543 → 849
    PHA03247; large tegument protein UL36; Provisional
    cd14274
    Location:961 → 1004
    UBA_ACK1; UBA domain found in activated Cdc42 kinase 1 (ACK1) and similar proteins
    cd14328
    Location:991 → 1030
    UBA_TNK1; UBA domain found in non-receptor tyrosine-protein kinase TNK1 and similar proteins
    cd05040
    Location:130 → 387
    PTKc_Ack_like; Catalytic domain of the Protein Tyrosine Kinase, Activated Cdc42-associated kinase
    pfam09027
    Location:449 → 514
    GTPase_binding; GTPase binding
    pfam11555
    Location:774 → 838
    Inhibitor_Mig-6; EGFR receptor inhibitor Mig-6
    pfam14604
    Location:395 → 444
    SH3_9; Variant SH3 domain

  12. NM_001387710.1 → NP_001374639.1  activated CDC42 kinase 1 isoform 8

    Status: REVIEWED

    Source sequence(s)
    AC124944
    Consensus CDS
    CCDS93441.1
    UniProtKB/TrEMBL
    A0A499FJ16, A0A5F9ZI29
    Conserved Domains (8) summary
    cd09539
    Location:6 → 67
    SAM_TNK-like; SAM domain of TNK(ACK)-like non-receptor tyrosine-protein kinases
    PHA03247
    Location:543 → 849
    PHA03247; large tegument protein UL36; Provisional
    cd14274
    Location:961 → 1004
    UBA_ACK1; UBA domain found in activated Cdc42 kinase 1 (ACK1) and similar proteins
    cd14328
    Location:991 → 1030
    UBA_TNK1; UBA domain found in non-receptor tyrosine-protein kinase TNK1 and similar proteins
    cd05040
    Location:130 → 387
    PTKc_Ack_like; Catalytic domain of the Protein Tyrosine Kinase, Activated Cdc42-associated kinase
    pfam09027
    Location:449 → 514
    GTPase_binding; GTPase binding
    pfam11555
    Location:774 → 838
    Inhibitor_Mig-6; EGFR receptor inhibitor Mig-6
    pfam14604
    Location:395 → 444
    SH3_9; Variant SH3 domain

  13. NM_001387711.1 → NP_001374640.1  activated CDC42 kinase 1 isoform 8

    Status: REVIEWED

    Source sequence(s)
    AC124944
    Consensus CDS
    CCDS93441.1
    UniProtKB/TrEMBL
    A0A499FJ16, A0A5F9ZI29
    Conserved Domains (8) summary
    cd09539
    Location:6 → 67
    SAM_TNK-like; SAM domain of TNK(ACK)-like non-receptor tyrosine-protein kinases
    PHA03247
    Location:543 → 849
    PHA03247; large tegument protein UL36; Provisional
    cd14274
    Location:961 → 1004
    UBA_ACK1; UBA domain found in activated Cdc42 kinase 1 (ACK1) and similar proteins
    cd14328
    Location:991 → 1030
    UBA_TNK1; UBA domain found in non-receptor tyrosine-protein kinase TNK1 and similar proteins
    cd05040
    Location:130 → 387
    PTKc_Ack_like; Catalytic domain of the Protein Tyrosine Kinase, Activated Cdc42-associated kinase
    pfam09027
    Location:449 → 514
    GTPase_binding; GTPase binding
    pfam11555
    Location:774 → 838
    Inhibitor_Mig-6; EGFR receptor inhibitor Mig-6
    pfam14604
    Location:395 → 444
    SH3_9; Variant SH3 domain

  14. NM_001387712.1 → NP_001374641.1  activated CDC42 kinase 1 isoform 8

    Status: REVIEWED

    Source sequence(s)
    AC124944
    Consensus CDS
    CCDS93441.1
    UniProtKB/TrEMBL
    A0A499FJ16, A0A5F9ZI29
    Conserved Domains (8) summary
    cd09539
    Location:6 → 67
    SAM_TNK-like; SAM domain of TNK(ACK)-like non-receptor tyrosine-protein kinases
    PHA03247
    Location:543 → 849
    PHA03247; large tegument protein UL36; Provisional
    cd14274
    Location:961 → 1004
    UBA_ACK1; UBA domain found in activated Cdc42 kinase 1 (ACK1) and similar proteins
    cd14328
    Location:991 → 1030
    UBA_TNK1; UBA domain found in non-receptor tyrosine-protein kinase TNK1 and similar proteins
    cd05040
    Location:130 → 387
    PTKc_Ack_like; Catalytic domain of the Protein Tyrosine Kinase, Activated Cdc42-associated kinase
    pfam09027
    Location:449 → 514
    GTPase_binding; GTPase binding
    pfam11555
    Location:774 → 838
    Inhibitor_Mig-6; EGFR receptor inhibitor Mig-6
    pfam14604
    Location:395 → 444
    SH3_9; Variant SH3 domain

  15. NM_001387713.1 → NP_001374642.1  activated CDC42 kinase 1 isoform 1

    Status: REVIEWED

    Source sequence(s)
    AC124944
    Consensus CDS
    CCDS33928.1
    UniProtKB/Swiss-Prot
    Q07912, Q6ZMQ0, Q8N6U7, Q96H59
    UniProtKB/TrEMBL
    A0A499FJ16
    Conserved Domains (8) summary
    cd09539
    Location:6 → 67
    SAM_TNK-like; SAM domain of TNK(ACK)-like non-receptor tyrosine-protein kinases
    PHA03247
    Location:543 → 849
    PHA03247; large tegument protein UL36; Provisional
    cd14274
    Location:958 → 1002
    UBA_ACK1; UBA domain found in activated Cdc42 kinase 1 (ACK1) and similar proteins
    cd14328
    Location:989 → 1028
    UBA_TNK1; UBA domain found in non-receptor tyrosine-protein kinase TNK1 and similar proteins
    cd05040
    Location:130 → 387
    PTKc_Ack_like; Catalytic domain of the Protein Tyrosine Kinase, Activated Cdc42-associated kinase
    pfam09027
    Location:449 → 514
    GTPase_binding; GTPase binding
    pfam11555
    Location:774 → 838
    Inhibitor_Mig-6; EGFR receptor inhibitor Mig-6
    pfam14604
    Location:395 → 444
    SH3_9; Variant SH3 domain

  16. NM_001387714.1 → NP_001374643.1  activated CDC42 kinase 1 isoform 1

    Status: REVIEWED

    Source sequence(s)
    AC124944
    Consensus CDS
    CCDS33928.1
    UniProtKB/Swiss-Prot
    Q07912, Q6ZMQ0, Q8N6U7, Q96H59
    UniProtKB/TrEMBL
    A0A499FJ16
    Conserved Domains (8) summary
    cd09539
    Location:6 → 67
    SAM_TNK-like; SAM domain of TNK(ACK)-like non-receptor tyrosine-protein kinases
    PHA03247
    Location:543 → 849
    PHA03247; large tegument protein UL36; Provisional
    cd14274
    Location:958 → 1002
    UBA_ACK1; UBA domain found in activated Cdc42 kinase 1 (ACK1) and similar proteins
    cd14328
    Location:989 → 1028
    UBA_TNK1; UBA domain found in non-receptor tyrosine-protein kinase TNK1 and similar proteins
    cd05040
    Location:130 → 387
    PTKc_Ack_like; Catalytic domain of the Protein Tyrosine Kinase, Activated Cdc42-associated kinase
    pfam09027
    Location:449 → 514
    GTPase_binding; GTPase binding
    pfam11555
    Location:774 → 838
    Inhibitor_Mig-6; EGFR receptor inhibitor Mig-6
    pfam14604
    Location:395 → 444
    SH3_9; Variant SH3 domain

  17. NM_001387715.1 → NP_001374644.1  activated CDC42 kinase 1 isoform 11

    Status: REVIEWED

    Source sequence(s)
    AC124944
    UniProtKB/TrEMBL
    A0A499FJ16
    Conserved Domains (7) summary
    cd09539
    Location:30 → 91
    SAM_TNK-like; SAM domain of TNK(ACK)-like non-receptor tyrosine-protein kinases
    PHA03247
    Location:567 → 873
    PHA03247; large tegument protein UL36; Provisional
    cd14328
    Location:983 → 1022
    UBA_TNK1; UBA domain found in non-receptor tyrosine-protein kinase TNK1 and similar proteins
    cd05040
    Location:154 → 411
    PTKc_Ack_like; Catalytic domain of the Protein Tyrosine Kinase, Activated Cdc42-associated kinase
    pfam09027
    Location:473 → 538
    GTPase_binding; GTPase binding
    pfam11555
    Location:798 → 862
    Inhibitor_Mig-6; EGFR receptor inhibitor Mig-6
    pfam14604
    Location:419 → 468
    SH3_9; Variant SH3 domain

  18. NM_001387716.1 → NP_001374645.1  activated CDC42 kinase 1 isoform 12

    Status: REVIEWED

    Source sequence(s)
    AC124944
    UniProtKB/TrEMBL
    A0A499FJ16
    Conserved Domains (7) summary
    cd09539
    Location:6 → 67
    SAM_TNK-like; SAM domain of TNK(ACK)-like non-receptor tyrosine-protein kinases
    PHA03247
    Location:558 → 864
    PHA03247; large tegument protein UL36; Provisional
    cd14328
    Location:974 → 1013
    UBA_TNK1; UBA domain found in non-receptor tyrosine-protein kinase TNK1 and similar proteins
    cd05040
    Location:130 → 387
    PTKc_Ack_like; Catalytic domain of the Protein Tyrosine Kinase, Activated Cdc42-associated kinase
    pfam09027
    Location:449 → 514
    GTPase_binding; GTPase binding
    pfam11555
    Location:789 → 853
    Inhibitor_Mig-6; EGFR receptor inhibitor Mig-6
    pfam14604
    Location:395 → 444
    SH3_9; Variant SH3 domain

  19. NM_001387717.1 → NP_001374646.1  activated CDC42 kinase 1 isoform 12

    Status: REVIEWED

    Source sequence(s)
    AC124944
    UniProtKB/TrEMBL
    A0A499FJ16
    Conserved Domains (7) summary
    cd09539
    Location:6 → 67
    SAM_TNK-like; SAM domain of TNK(ACK)-like non-receptor tyrosine-protein kinases
    PHA03247
    Location:558 → 864
    PHA03247; large tegument protein UL36; Provisional
    cd14328
    Location:974 → 1013
    UBA_TNK1; UBA domain found in non-receptor tyrosine-protein kinase TNK1 and similar proteins
    cd05040
    Location:130 → 387
    PTKc_Ack_like; Catalytic domain of the Protein Tyrosine Kinase, Activated Cdc42-associated kinase
    pfam09027
    Location:449 → 514
    GTPase_binding; GTPase binding
    pfam11555
    Location:789 → 853
    Inhibitor_Mig-6; EGFR receptor inhibitor Mig-6
    pfam14604
    Location:395 → 444
    SH3_9; Variant SH3 domain

  20. NM_001387718.1 → NP_001374647.1  activated CDC42 kinase 1 isoform 12

    Status: REVIEWED

    Source sequence(s)
    AC124944
    UniProtKB/TrEMBL
    A0A499FJ16
    Conserved Domains (7) summary
    cd09539
    Location:6 → 67
    SAM_TNK-like; SAM domain of TNK(ACK)-like non-receptor tyrosine-protein kinases
    PHA03247
    Location:558 → 864
    PHA03247; large tegument protein UL36; Provisional
    cd14328
    Location:974 → 1013
    UBA_TNK1; UBA domain found in non-receptor tyrosine-protein kinase TNK1 and similar proteins
    cd05040
    Location:130 → 387
    PTKc_Ack_like; Catalytic domain of the Protein Tyrosine Kinase, Activated Cdc42-associated kinase
    pfam09027
    Location:449 → 514
    GTPase_binding; GTPase binding
    pfam11555
    Location:789 → 853
    Inhibitor_Mig-6; EGFR receptor inhibitor Mig-6
    pfam14604
    Location:395 → 444
    SH3_9; Variant SH3 domain

  21. NM_001387719.1 → NP_001374648.1  activated CDC42 kinase 1 isoform 13

    Status: REVIEWED

    Source sequence(s)
    AC124944
    Consensus CDS
    CCDS93440.1
    UniProtKB/TrEMBL
    A0A499FJ16, A0A5F9ZHP4
    Conserved Domains (7) summary
    cd09539
    Location:6 → 67
    SAM_TNK-like; SAM domain of TNK(ACK)-like non-receptor tyrosine-protein kinases
    PHA03247
    Location:543 → 849
    PHA03247; large tegument protein UL36; Provisional
    cd14328
    Location:959 → 998
    UBA_TNK1; UBA domain found in non-receptor tyrosine-protein kinase TNK1 and similar proteins
    cd05040
    Location:130 → 387
    PTKc_Ack_like; Catalytic domain of the Protein Tyrosine Kinase, Activated Cdc42-associated kinase
    pfam09027
    Location:449 → 514
    GTPase_binding; GTPase binding
    pfam11555
    Location:774 → 838
    Inhibitor_Mig-6; EGFR receptor inhibitor Mig-6
    pfam14604
    Location:395 → 444
    SH3_9; Variant SH3 domain

  22. NM_001387720.1 → NP_001374649.1  activated CDC42 kinase 1 isoform 13

    Status: REVIEWED

    Source sequence(s)
    AC124944
    Consensus CDS
    CCDS93440.1
    UniProtKB/TrEMBL
    A0A499FJ16, A0A5F9ZHP4
    Related
    ENSP00000500486.1, ENST00000672024.1
    Conserved Domains (7) summary
    cd09539
    Location:6 → 67
    SAM_TNK-like; SAM domain of TNK(ACK)-like non-receptor tyrosine-protein kinases
    PHA03247
    Location:543 → 849
    PHA03247; large tegument protein UL36; Provisional
    cd14328
    Location:959 → 998
    UBA_TNK1; UBA domain found in non-receptor tyrosine-protein kinase TNK1 and similar proteins
    cd05040
    Location:130 → 387
    PTKc_Ack_like; Catalytic domain of the Protein Tyrosine Kinase, Activated Cdc42-associated kinase
    pfam09027
    Location:449 → 514
    GTPase_binding; GTPase binding
    pfam11555
    Location:774 → 838
    Inhibitor_Mig-6; EGFR receptor inhibitor Mig-6
    pfam14604
    Location:395 → 444
    SH3_9; Variant SH3 domain

  23. NM_001387721.1 → NP_001374650.1  activated CDC42 kinase 1 isoform 13

    Status: REVIEWED

    Source sequence(s)
    AC124944
    Consensus CDS
    CCDS93440.1
    UniProtKB/TrEMBL
    A0A499FJ16, A0A5F9ZHP4
    Conserved Domains (7) summary
    cd09539
    Location:6 → 67
    SAM_TNK-like; SAM domain of TNK(ACK)-like non-receptor tyrosine-protein kinases
    PHA03247
    Location:543 → 849
    PHA03247; large tegument protein UL36; Provisional
    cd14328
    Location:959 → 998
    UBA_TNK1; UBA domain found in non-receptor tyrosine-protein kinase TNK1 and similar proteins
    cd05040
    Location:130 → 387
    PTKc_Ack_like; Catalytic domain of the Protein Tyrosine Kinase, Activated Cdc42-associated kinase
    pfam09027
    Location:449 → 514
    GTPase_binding; GTPase binding
    pfam11555
    Location:774 → 838
    Inhibitor_Mig-6; EGFR receptor inhibitor Mig-6
    pfam14604
    Location:395 → 444
    SH3_9; Variant SH3 domain

  24. NM_005781.5 → NP_005772.3  activated CDC42 kinase 1 isoform 1

    See identical proteins and their annotated locations for NP_005772.3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) is the more frequently occurring transcript and it encodes isoform 1.
    Source sequence(s)
    AC124944, AK127455, AK131539, BG742978, CN411136, L13738
    Consensus CDS
    CCDS33928.1
    UniProtKB/Swiss-Prot
    Q07912, Q6ZMQ0, Q8N6U7, Q96H59
    UniProtKB/TrEMBL
    A0A499FJ16
    Related
    ENSP00000329425.6, ENST00000333602.14
    Conserved Domains (8) summary
    cd09539
    Location:6 → 67
    SAM_TNK-like; SAM domain of TNK(ACK)-like non-receptor tyrosine-protein kinases
    PHA03247
    Location:543 → 849
    PHA03247; large tegument protein UL36; Provisional
    cd14274
    Location:958 → 1002
    UBA_ACK1; UBA domain found in activated Cdc42 kinase 1 (ACK1) and similar proteins
    cd14328
    Location:989 → 1028
    UBA_TNK1; UBA domain found in non-receptor tyrosine-protein kinase TNK1 and similar proteins
    cd05040
    Location:130 → 387
    PTKc_Ack_like; Catalytic domain of the Protein Tyrosine Kinase, Activated Cdc42-associated kinase
    pfam09027
    Location:449 → 514
    GTPase_binding; GTPase binding
    pfam11555
    Location:774 → 838
    Inhibitor_Mig-6; EGFR receptor inhibitor Mig-6
    pfam14604
    Location:395 → 444
    SH3_9; Variant SH3 domain

RNA

  1. NR_170678.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC124944

  2. NR_170679.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC124944

  3. NR_170680.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC124944

  4. NR_170681.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC124944

  5. NR_170682.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC124944

  6. NR_170683.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC124944

  7. NR_170684.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC124944

  8. NR_170685.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC124944

  9. NR_170686.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC124944

  10. NR_170687.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC124944

  11. NR_170688.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC124944

  12. NR_170689.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC124944

  13. NR_170690.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC124944

  14. NR_170691.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC124944

  15. NR_170692.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC124944

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

    Range
    195863364..195908551 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047447154.1 → XP_047303110.1  activated CDC42 kinase 1 isoform X15

  2. XM_047447157.1 → XP_047303113.1  activated CDC42 kinase 1 isoform X12

    UniProtKB/TrEMBL
    A0A5F9ZGX5

  3. XM_047447153.1 → XP_047303109.1  activated CDC42 kinase 1 isoform X5

    UniProtKB/TrEMBL
    A0A5F9ZHJ2

  4. XM_047447161.1 → XP_047303117.1  activated CDC42 kinase 1 isoform X19

  5. XM_047447143.1 → XP_047303099.1  activated CDC42 kinase 1 isoform X1

  6. XM_047447142.1 → XP_047303098.1  activated CDC42 kinase 1 isoform X1

  7. XM_047447162.1 → XP_047303118.1  activated CDC42 kinase 1 isoform X20

  8. XM_047447156.1 → XP_047303112.1  activated CDC42 kinase 1 isoform X17

  9. XM_024453292.2 → XP_024309060.1  activated CDC42 kinase 1 isoform X14

    UniProtKB/TrEMBL
    A0A499FJ16
    Conserved Domains (6) summary
    cd09539
    Location:23 → 84
    SAM_TNK-like; SAM domain of TNK(ACK)-like non-receptor tyrosine-protein kinases
    smart00326
    Location:410 → 461
    SH3; Src homology 3 domains
    PHA03247
    Location:575 → 881
    PHA03247; large tegument protein UL36; Provisional
    cd14274
    Location:993 → 1036
    UBA_ACK1; UBA domain found in activated Cdc42 kinase 1 (ACK1) and similar proteins
    cd14328
    Location:1023 → 1062
    UBA_TNK1; UBA domain found in non-receptor tyrosine-protein kinase TNK1 and similar proteins
    cd05040
    Location:147 → 404
    PTKc_Ack_like; Catalytic domain of the Protein Tyrosine Kinase, Activated Cdc42-associated kinase

  10. XM_047447150.1 → XP_047303106.1  activated CDC42 kinase 1 isoform X11

  11. XM_047447160.1 → XP_047303116.1  activated CDC42 kinase 1 isoform X13

    UniProtKB/Swiss-Prot
    Q07912, Q6ZMQ0, Q8N6U7, Q96H59

  12. XM_047447159.1 → XP_047303115.1  activated CDC42 kinase 1 isoform X18

    UniProtKB/TrEMBL
    A0A5F9ZI29

  13. XM_047447158.1 → XP_047303114.1  activated CDC42 kinase 1 isoform X12

    UniProtKB/TrEMBL
    A0A5F9ZGX5

  14. XM_024453295.2 → XP_024309063.1  activated CDC42 kinase 1 isoform X12

    UniProtKB/TrEMBL
    A0A499FJ16, A0A5F9ZGX5
    Conserved Domains (8) summary
    cd09539
    Location:6 → 67
    SAM_TNK-like; SAM domain of TNK(ACK)-like non-receptor tyrosine-protein kinases
    PHA03247
    Location:558 → 864
    PHA03247; large tegument protein UL36; Provisional
    cd14274
    Location:976 → 1019
    UBA_ACK1; UBA domain found in activated Cdc42 kinase 1 (ACK1) and similar proteins
    cd14328
    Location:1006 → 1045
    UBA_TNK1; UBA domain found in non-receptor tyrosine-protein kinase TNK1 and similar proteins
    cd05040
    Location:130 → 387
    PTKc_Ack_like; Catalytic domain of the Protein Tyrosine Kinase, Activated Cdc42-associated kinase
    pfam09027
    Location:449 → 514
    GTPase_binding; GTPase binding
    pfam11555
    Location:789 → 853
    Inhibitor_Mig-6; EGFR receptor inhibitor Mig-6
    pfam14604
    Location:395 → 444
    SH3_9; Variant SH3 domain

  15. XM_047447141.1 → XP_047303097.1  activated CDC42 kinase 1 isoform X1

  16. XM_047447151.1 → XP_047303107.1  activated CDC42 kinase 1 isoform X13

    UniProtKB/Swiss-Prot
    Q07912, Q6ZMQ0, Q8N6U7, Q96H59

  17. XM_024453291.2 → XP_024309059.2  activated CDC42 kinase 1 isoform X12

    UniProtKB/TrEMBL
    A0A5F9ZGX5

  18. XM_047447148.1 → XP_047303104.1  activated CDC42 kinase 1 isoform X9

    UniProtKB/TrEMBL
    C9J1X3

  19. XM_047447146.1 → XP_047303102.1  activated CDC42 kinase 1 isoform X6

  20. XM_047447145.1 → XP_047303101.1  activated CDC42 kinase 1 isoform X5

    UniProtKB/TrEMBL
    A0A5F9ZHJ2

  21. XM_047447147.1 → XP_047303103.1  activated CDC42 kinase 1 isoform X8

  22. XM_011512318.3 → XP_011510620.2  activated CDC42 kinase 1 isoform X4

    UniProtKB/TrEMBL
    A0A499FJ16

  23. XM_011512317.4 → XP_011510619.2  activated CDC42 kinase 1 isoform X2

  24. XM_047447152.1 → XP_047303108.1  activated CDC42 kinase 1 isoform X5

    UniProtKB/TrEMBL
    A0A5F9ZHJ2

  25. XM_024453293.2 → XP_024309061.1  activated CDC42 kinase 1 isoform X12

    UniProtKB/TrEMBL
    A0A499FJ16, A0A5F9ZGX5
    Conserved Domains (8) summary
    cd09539
    Location:6 → 67
    SAM_TNK-like; SAM domain of TNK(ACK)-like non-receptor tyrosine-protein kinases
    PHA03247
    Location:558 → 864
    PHA03247; large tegument protein UL36; Provisional
    cd14274
    Location:976 → 1019
    UBA_ACK1; UBA domain found in activated Cdc42 kinase 1 (ACK1) and similar proteins
    cd14328
    Location:1006 → 1045
    UBA_TNK1; UBA domain found in non-receptor tyrosine-protein kinase TNK1 and similar proteins
    cd05040
    Location:130 → 387
    PTKc_Ack_like; Catalytic domain of the Protein Tyrosine Kinase, Activated Cdc42-associated kinase
    pfam09027
    Location:449 → 514
    GTPase_binding; GTPase binding
    pfam11555
    Location:789 → 853
    Inhibitor_Mig-6; EGFR receptor inhibitor Mig-6
    pfam14604
    Location:395 → 444
    SH3_9; Variant SH3 domain

  26. XM_047447155.1 → XP_047303111.1  activated CDC42 kinase 1 isoform X16

  27. XM_047447163.1 → XP_047303119.1  activated CDC42 kinase 1 isoform X22

  28. XM_011512321.2 → XP_011510623.1  activated CDC42 kinase 1 isoform X21

    UniProtKB/TrEMBL
    A0A499FJ16
    Conserved Domains (7) summary
    smart00221
    Location:50 → 309
    STYKc; Protein kinase; unclassified specificity
    cd14274
    Location:900 → 943
    UBA_ACK1; UBA domain found in activated Cdc42 kinase 1 (ACK1) and similar proteins
    cd14328
    Location:930 → 969
    UBA_TNK1; UBA domain found in non-receptor tyrosine-protein kinase TNK1 and similar proteins
    cd05040
    Location:54 → 311
    PTKc_Ack_like; Catalytic domain of the Protein Tyrosine Kinase, Activated Cdc42-associated kinase
    pfam09027
    Location:371 → 438
    GTPase_binding; GTPase binding
    pfam11555
    Location:713 → 777
    Inhibitor_Mig-6; EGFR receptor inhibitor Mig-6
    pfam14604
    Location:319 → 368
    SH3_9; Variant SH3 domain

  29. XM_047447164.1 → XP_047303120.1  activated CDC42 kinase 1 isoform X23

  30. XM_047447165.1 → XP_047303121.1  activated CDC42 kinase 1 isoform X23

  31. XM_047447166.1 → XP_047303122.1  activated CDC42 kinase 1 isoform X24

    UniProtKB/TrEMBL
    B3KXJ4
    Related
    ENSP00000500238.1, ENST00000672548.1

  32. XM_047447149.1 → XP_047303105.1  activated CDC42 kinase 1 isoform X10

  33. XM_017005509.2 → XP_016860998.1  activated CDC42 kinase 1 isoform X7

    UniProtKB/TrEMBL
    A0A499FJ16

  34. XM_047447144.1 → XP_047303100.1  activated CDC42 kinase 1 isoform X3

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060927.1 Alternate T2T-CHM13v2.0

    Range
    198449491..198494501
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054344851.1 → XP_054200826.1  activated CDC42 kinase 1 isoform X1

  2. XM_054344852.1 → XP_054200827.1  activated CDC42 kinase 1 isoform X1

  3. XM_054344877.1 → XP_054200852.1  activated CDC42 kinase 1 isoform X19

  4. XM_054344867.1 → XP_054200842.1  activated CDC42 kinase 1 isoform X5

    UniProtKB/TrEMBL
    A0A5F9ZHJ2

  5. XM_054344872.1 → XP_054200847.1  activated CDC42 kinase 1 isoform X12

    UniProtKB/TrEMBL
    A0A5F9ZGX5

  6. XM_054344862.1 → XP_054200837.1  activated CDC42 kinase 1 isoform X11

  7. XM_054344865.1 → XP_054200840.1  activated CDC42 kinase 1 isoform X14

  8. XM_054344869.1 → XP_054200844.1  activated CDC42 kinase 1 isoform X17

  9. XM_054344878.1 → XP_054200853.1  activated CDC42 kinase 1 isoform X20

  10. XM_054344875.1 → XP_054200850.1  activated CDC42 kinase 1 isoform X18

    UniProtKB/TrEMBL
    A0A5F9ZI29

  11. XM_054344876.1 → XP_054200851.1  activated CDC42 kinase 1 isoform X13

    UniProtKB/Swiss-Prot
    Q07912, Q6ZMQ0, Q8N6U7, Q96H59

  12. XM_054344873.1 → XP_054200848.1  activated CDC42 kinase 1 isoform X12

    UniProtKB/TrEMBL
    A0A5F9ZGX5

  13. XM_054344874.1 → XP_054200849.1  activated CDC42 kinase 1 isoform X12

    UniProtKB/TrEMBL
    A0A5F9ZGX5

  14. XM_054344871.1 → XP_054200846.1  activated CDC42 kinase 1 isoform X12

    UniProtKB/TrEMBL
    A0A5F9ZGX5

  15. XM_054344855.1 → XP_054200830.1  activated CDC42 kinase 1 isoform X4

  16. XM_054344859.1 → XP_054200834.1  activated CDC42 kinase 1 isoform X8

  17. XM_054344856.1 → XP_054200831.1  activated CDC42 kinase 1 isoform X5

    UniProtKB/TrEMBL
    A0A5F9ZHJ2

  18. XM_054344857.1 → XP_054200832.1  activated CDC42 kinase 1 isoform X6

  19. XM_054344860.1 → XP_054200835.1  activated CDC42 kinase 1 isoform X9

    UniProtKB/TrEMBL
    C9J1X3

  20. XM_054344863.1 → XP_054200838.1  activated CDC42 kinase 1 isoform X12

    UniProtKB/TrEMBL
    A0A5F9ZGX5

  21. XM_054344864.1 → XP_054200839.1  activated CDC42 kinase 1 isoform X13

    UniProtKB/Swiss-Prot
    Q07912, Q6ZMQ0, Q8N6U7, Q96H59

  22. XM_054344854.1 → XP_054200829.1  activated CDC42 kinase 1 isoform X3

  23. XM_054344858.1 → XP_054200833.1  activated CDC42 kinase 1 isoform X7

  24. XM_054344861.1 → XP_054200836.1  activated CDC42 kinase 1 isoform X10

  25. XM_054344866.1 → XP_054200841.1  activated CDC42 kinase 1 isoform X5

    UniProtKB/TrEMBL
    A0A5F9ZHJ2

  26. XM_054344853.1 → XP_054200828.1  activated CDC42 kinase 1 isoform X2

  27. XM_054344870.1 → XP_054200845.1  activated CDC42 kinase 1 isoform X12

    UniProtKB/TrEMBL
    A0A5F9ZGX5

  28. XM_054344868.1 → XP_054200843.1  activated CDC42 kinase 1 isoform X16

  29. XM_054344879.1 → XP_054200854.1  activated CDC42 kinase 1 isoform X21

  30. XM_054344880.1 → XP_054200855.1  activated CDC42 kinase 1 isoform X22

  31. XM_054344881.1 → XP_054200856.1  activated CDC42 kinase 1 isoform X23

  32. XM_054344882.1 → XP_054200857.1  activated CDC42 kinase 1 isoform X23

  33. XM_054344883.1 → XP_054200858.1  activated CDC42 kinase 1 isoform X24

    UniProtKB/TrEMBL
    B3KXJ4

  34. XM_054344884.1 → XP_054200859.1  activated CDC42 kinase 1 isoform X24

    UniProtKB/TrEMBL
    B3KXJ4
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q07912.3 GenPept UniProtKB/Swiss-Prot:Q07912

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