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PSMD14 proteasome 26S subunit, non-ATPase 14 [ Homo sapiens (human) ]

Gene ID: 10213, updated on 5-Mar-2024

Summary

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Official Symbol
PSMD14provided by HGNC
Official Full Name
proteasome 26S subunit, non-ATPase 14provided by HGNC
Primary source
HGNC:HGNC:16889
See related
Ensembl:ENSG00000115233 MIM:607173; AllianceGenome:HGNC:16889
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PAD1; POH1; RPN11
Summary
This gene encodes a component of the 26S proteasome. The 26S proteasome is a large multiprotein complex that catalyzes the degradation of ubiquitinated intracellular proteins. The encoded protein is a component of the 19S regulatory cap complex of the 26S proteasome and mediates substrate deubiquitination. A pseudogene of this gene is also located on the long arm of chromosome 2. [provided by RefSeq, Feb 2012]
Expression
Ubiquitous expression in brain (RPKM 24.9), testis (RPKM 22.1) and 25 other tissues See more
Orthologs
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Genomic context

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See PSMD14 in Genome Data Viewer
Location:
2q24.2
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (161308425..161411717)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (161766719..161870044)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (162164936..162268228)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene TANK antisense RNA 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16703 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12051 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12052 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12053 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16704 Neighboring gene H3K27ac hESC enhancer GRCh37_chr2:162016649-162017412 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_54722 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16705 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16706 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16707 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_54734 Neighboring gene TRAF family member associated NFKB activator Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_54744 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_54751 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_54752 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16708 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12054 Neighboring gene VISTA enhancer hs416 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12056 Neighboring gene PSMD14 divergent transcript Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16710 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16709 Neighboring gene H3K27ac hESC enhancer GRCh37_chr2:162101046-162101546 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12057 Neighboring gene long intergenic non-protein coding RNA 1806 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr2:162134920-162135556 Neighboring gene OCT4-H3K27ac hESC enhancer GRCh37_chr2:162135557-162136192 Neighboring gene Sharpr-MPRA regulatory region 15701 Neighboring gene Sharpr-MPRA regulatory region 9806 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16712 Neighboring gene MXRA7 pseudogene 1 Neighboring gene VISTA enhancer hs2337 Neighboring gene ReSE screen-validated silencer GRCh37_chr2:162254028-162254187 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16713 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12058 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12059 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:162272934-162273556 Neighboring gene NANOG hESC enhancer GRCh37_chr2:162279216-162279737 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12060 Neighboring gene RNA, 5S ribosomal pseudogene 108 Neighboring gene T-box brain transcription factor 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16714 Neighboring gene AT-hook containing transcription factor 1 pseudogene 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Novel insights into the non-canonical roles of PSMD14/POH1/Rpn11 in proteostasis and in the modulation of cancer progression. Bustamante HA, et al. Cell Signal, 2023 Jan. PMID 36241058
  2. The prognostic role of PSMD14 in head and neck squamous cell carcinoma. Schnoell J, et al. J Cancer Res Clin Oncol, 2023 Jun. PMID 35750900, Free PMC Article
  3. PSMD14 Targeting Triggers Paraptosis in Breast Cancer Cells by Inducing Proteasome Inhibition and Ca(2+) Imbalance. Lee HJ, et al. Int J Mol Sci, 2022 Feb 28. PMID 35269789, Free PMC Article
  4. Identification of PSMD14 as a potential novel prognosis biomarker and therapeutic target for osteosarcoma. Gong Y, et al. Cancer Rep (Hoboken), 2022 Jul. PMID 34383385, Free PMC Article
  5. Targeting PSMD14 inhibits melanoma growth through SMAD3 stabilization. Yokoyama S, et al. Sci Rep, 2020 Nov 5. PMID 33154524, Free PMC Article

See all (190) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. PSMD14 stabilizes estrogen signaling and facilitates breast cancer progression via deubiquitinating ERalpha.
    Title: PSMD14 stabilizes estrogen signaling and facilitates breast cancer progression via deubiquitinating ERα.
  2. POH1 induces Smad3 deubiquitination and promotes lung cancer metastasis.
    Title: POH1 induces Smad3 deubiquitination and promotes lung cancer metastasis.
  3. Regulation of Drp1 and enhancement of mitochondrial fission by the deubiquitinating enzyme PSMD14 facilitates the proliferation of bladder cancer cells.
    Title: Regulation of Drp1 and enhancement of mitochondrial fission by the deubiquitinating enzyme PSMD14 facilitates the proliferation of bladder cancer cells.
  4. POH1 facilitates pancreatic carcinogenesis through MYC-driven acinar-to-ductal metaplasia and is a potential therapeutic target.
    Title: POH1 facilitates pancreatic carcinogenesis through MYC-driven acinar-to-ductal metaplasia and is a potential therapeutic target.
  5. The prognostic role of PSMD14 in head and neck squamous cell carcinoma.
    Title: The prognostic role of PSMD14 in head and neck squamous cell carcinoma.
  6. Depletion of PSMD14 suppresses bladder cancer proliferation by regulating GPX4.
    Title: Depletion of PSMD14 suppresses bladder cancer proliferation by regulating GPX4.
  7. Deubiquitylase PSMD14 inhibits autophagy to promote ovarian cancer progression via stabilization of LRPPRC.
    Title: Deubiquitylase PSMD14 inhibits autophagy to promote ovarian cancer progression via stabilization of LRPPRC.
  8. Novel insights into the non-canonical roles of PSMD14/POH1/Rpn11 in proteostasis and in the modulation of cancer progression.
    Title: Novel insights into the non-canonical roles of PSMD14/POH1/Rpn11 in proteostasis and in the modulation of cancer progression.
  9. Identification of PSMD14 as a potential novel prognosis biomarker and therapeutic target for osteosarcoma.
    Title: Identification of PSMD14 as a potential novel prognosis biomarker and therapeutic target for osteosarcoma.
  10. PSMD14 Targeting Triggers Paraptosis in Breast Cancer Cells by Inducing Proteasome Inhibition and Ca(2+) Imbalance.
    Title: PSMD14 Targeting Triggers Paraptosis in Breast Cancer Cells by Inducing Proteasome Inhibition and Ca(2+) Imbalance.
Submit: New GeneRIF Correction See all GeneRIFs (31)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Common genetic variants associated with cognitive performance identified using the proxy-phenotype method.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables K63-linked deubiquitinase activity TAS
Traceable Author Statement
more info
  
enables endopeptidase activator activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables metal-dependent deubiquitinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal-dependent deubiquitinase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables metal-dependent deubiquitinase activity TAS
Traceable Author Statement
more info
 PubMed 
enables metallopeptidase activity TAS
Traceable Author Statement
more info
 PubMed 
enables proteasome binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables proteasome binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in double-strand break repair via homologous recombination IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in double-strand break repair via nonhomologous end joining IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in protein K63-linked deubiquitination IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein K63-linked deubiquitination TAS
Traceable Author Statement
more info
 PubMed 
involved_in protein deubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of proteasomal protein catabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in response to ethanol IEA
Inferred from Electronic Annotation
more info
  
involved_in ubiquitin-dependent protein catabolic process TAS
Traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
located_in cytosol TAS
Traceable Author Statement
more info
  
part_of cytosolic proteasome complex IEA
Inferred from Electronic Annotation
more info
  
located_in extracellular region TAS
Traceable Author Statement
more info
  
located_in ficolin-1-rich granule lumen TAS
Traceable Author Statement
more info
  
located_in nucleoplasm TAS
Traceable Author Statement
more info
  
located_in nucleus HDA PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of proteasome accessory complex ISS
Inferred from Sequence or Structural Similarity
more info
  
part_of proteasome complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of proteasome complex NAS
Non-traceable Author Statement
more info
 PubMed 
part_of proteasome complex TAS
Traceable Author Statement
more info
 PubMed 
part_of proteasome regulatory particle, lid subcomplex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of proteasome regulatory particle, lid subcomplex IMP
Inferred from Mutant Phenotype
more info
 PubMed 
located_in secretory granule lumen TAS
Traceable Author Statement
more info
  

General protein information

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Preferred Names
26S proteasome non-ATPase regulatory subunit 14
Names
26S proteasome regulatory subunit rpn11
26S proteasome-associated PAD1 homolog 1
proteasome (prosome, macropain) 26S subunit, non-ATPase, 14
testis tissue sperm-binding protein Li 69n
NP_005796.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_005805.6 → NP_005796.1  26S proteasome non-ATPase regulatory subunit 14

    See identical proteins and their annotated locations for NP_005796.1

    Status: REVIEWED

    Source sequence(s)
    BC066336, BM978668, DA133201, U86782
    Consensus CDS
    CCDS46437.1
    UniProtKB/Swiss-Prot
    B3KNW2, O00176, O00487
    UniProtKB/TrEMBL
    A0A140VKF2
    Related
    ENSP00000386541.3, ENST00000409682.8
    Conserved Domains (1) summary
    cd08069
    Location:21 → 286
    MPN_RPN11_CSN5; Mov34/MPN/PAD-1 family: proteasomal regulatory protein Rpn11 and signalosome complex subunit CSN5

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

    Range
    161308425..161411717
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060926.1 Alternate T2T-CHM13v2.0

    Range
    161766719..161870044
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O00487.1 GenPept UniProtKB/Swiss-Prot:O00487

Gene LinkOut

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