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Acad11 acyl-Coenzyme A dehydrogenase family, member 11 [ Mus musculus (house mouse) ]

Gene ID: 102632, updated on 12-May-2024

Summary

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Official Symbol
Acad11provided by MGI
Official Full Name
acyl-Coenzyme A dehydrogenase family, member 11provided by MGI
Primary source
MGI:MGI:2143169
See related
Ensembl:ENSMUSG00000090150 AllianceGenome:MGI:2143169
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
5730439E10Rik
Summary
Predicted to enable medium-chain-acyl-CoA dehydrogenase activity and very-long-chain-acyl-CoA dehydrogenase activity. Predicted to be involved in fatty acid beta-oxidation using acyl-CoA dehydrogenase. Predicted to act upstream of or within fatty acid metabolic process. Located in mitochondrion. Is expressed in central nervous system and retina. Orthologous to human ACAD11 (acyl-CoA dehydrogenase family member 11). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in liver adult (RPKM 65.5), kidney adult (RPKM 50.8) and 23 other tissues See more
Orthologs
human all
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Genomic context

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Location:
9 F1; 9 56.25 cM
Exon count:
20
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (103940923..104004855)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (104063724..104127656)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene NSA2 ribosome biogenesis homolog pseudogene Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:103965595-103965778 Neighboring gene STARR-seq mESC enhancer starr_25105 Neighboring gene ubiquitin-like modifier activating enzyme 5 Neighboring gene STARR-seq mESC enhancer starr_25106 Neighboring gene atypical chemokine receptor 4 Neighboring gene STARR-seq mESC enhancer starr_25110 Neighboring gene DnaJ heat shock protein family (Hsp40) member C13 Neighboring gene high mobility group box 1, related sequence 16 Neighboring gene predicted gene, 46130

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Mutations in a novel gene, NPHP3, cause adolescent nephronophthisis, tapeto-retinal degeneration and hepatic fibrosis. Olbrich H, et al. Nat Genet, 2003 Aug. PMID 12872122
  2. Toward understanding the genetics of alcohol drinking through transcriptome meta-analysis. Mulligan MK, et al. Proc Natl Acad Sci U S A, 2006 Apr 18. PMID 16618939, Free PMC Article
  3. Proteomic analysis of rat liver peroxisome: presence of peroxisome-specific isozyme of Lon protease. Kikuchi M, et al. J Biol Chem, 2004 Jan 2. PMID 14561759
  4. Substrate and functional diversity of lysine acetylation revealed by a proteomics survey. Kim SC, et al. Mol Cell, 2006 Aug. PMID 16916647
  5. A mitochondrial protein compendium elucidates complex I disease biology. Pagliarini DJ, et al. Cell, 2008 Jul 11. PMID 18614015, Free PMC Article

See all (24) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (4) 
  • Gene trapped (1) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Potential readthrough

Included gene: Nphp3

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables acyl-CoA dehydrogenase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables flavin adenine dinucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables long-chain fatty acyl-CoA dehydrogenase activity ISO
Inferred from Sequence Orthology
more info
  
enables medium-chain fatty acyl-CoA dehydrogenase activity ISO
Inferred from Sequence Orthology
more info
  
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity, acting on the CH-CH group of donors IEA
Inferred from Electronic Annotation
more info
  
enables very-long-chain fatty acyl-CoA dehydrogenase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in fatty acid beta-oxidation using acyl-CoA dehydrogenase IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in fatty acid beta-oxidation using acyl-CoA dehydrogenase ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within fatty acid metabolic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within lipid metabolic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrial membrane ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrion HDA PubMed 
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
located_in peroxisome ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
acyl-CoA dehydrogenase family member 11
NP_780533.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_175324.4 → NP_780533.2  acyl-CoA dehydrogenase family member 11

    See identical proteins and their annotated locations for NP_780533.2

    Status: VALIDATED

    Source sequence(s)
    AI843434, AK077531
    Consensus CDS
    CCDS23458.1
    UniProtKB/Swiss-Prot
    Q80XL6, Q8BK19
    UniProtKB/TrEMBL
    A0A0R4J0I6
    Related
    ENSMUSP00000043424.6, ENSMUST00000047799.13
    Conserved Domains (3) summary
    cd01155
    Location:376 → 769
    ACAD_FadE2; Acyl-CoA dehydrogenases similar to fadE2
    PLN02876
    Location:6 → 769
    PLN02876; acyl-CoA dehydrogenase
    cd05154
    Location:42 → 292
    ACAD10_11_N-like; N-terminal domain of Acyl-CoA dehydrogenase (ACAD) 10 and 11, and similar proteins

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    103940923..104004855
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q80XL6.2 GenPept UniProtKB/Swiss-Prot:Q80XL6

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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