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Synj1 synaptojanin 1 [ Mus musculus (house mouse) ]

Gene ID: 104015, updated on 21-Apr-2024

Summary

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Official Symbol
Synj1provided by MGI
Official Full Name
synaptojanin 1provided by MGI
Primary source
MGI:MGI:1354961
See related
Ensembl:ENSMUSG00000022973 AllianceGenome:MGI:1354961
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
mKIAA0910; A930006D20Rik
Summary
Enables phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity. Involved in postsynaptic neurotransmitter receptor internalization; regulation of postsynaptic neurotransmitter receptor internalization; and synaptic vesicle uncoating. Acts upstream of or within several processes, including dephosphorylation; synaptic vesicle cycle; and synaptic vesicle transport. Located in Schaffer collateral - CA1 synapse and glutamatergic synapse. Part of membrane coat. Is expressed in several structures, including central nervous system; genitourinary system; peripheral nervous system; respiratory system; and sensory organ. Human ortholog(s) of this gene implicated in Parkinson's disease; Parkinson's disease 20; and developmental and epileptic encephalopathy 53. Orthologous to human SYNJ1 (synaptojanin 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in frontal lobe adult (RPKM 17.6), cortex adult (RPKM 16.9) and 26 other tissues See more
Orthologs
human all
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Genomic context

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Location:
16 C3.3; 16 52.18 cM
Exon count:
36
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (90732980..90810543, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (90936092..91013727, complement)

Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene eva-1 homolog C Neighboring gene predicted gene, 36363 Neighboring gene STARR-seq mESC enhancer starr_41466 Neighboring gene STARR-seq mESC enhancer starr_41467 Neighboring gene STARR-seq mESC enhancer starr_41468 Neighboring gene predicted gene, 53919 Neighboring gene STARR-positive B cell enhancer ABC_E4188 Neighboring gene cilia and flagella associate protien 298 Neighboring gene RIKEN cDNA 4930404I05 gene Neighboring gene STARR-positive B cell enhancer mm9_chr16:91012148-91012449 Neighboring gene STARR-seq mESC enhancer starr_41471 Neighboring gene PAX3 and PAX7 binding protein 1 Neighboring gene exosomal polycystin 1 interacting protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Synaptojanin1 Modifies Endolysosomal Parameters in Cultured Ventral Midbrain Neurons. Zhu X, et al. eNeuro, 2023 May. PMID 37072173, Free PMC Article
  2. Synaptojanin1 deficiency upregulates basal autophagosome formation in astrocytes. Pan PY, et al. J Biol Chem, 2021 Jul. PMID 34126070, Free PMC Article
  3. Synaptojanin 1-mediated PI(4,5)P2 hydrolysis is modulated by membrane curvature and facilitates membrane fission. Chang-Ileto B, et al. Dev Cell, 2011 Feb 15. PMID 21316588, Free PMC Article
  4. Oligomeric amyloid-beta peptide disrupts phosphatidylinositol-4,5-bisphosphate metabolism. Berman DE, et al. Nat Neurosci, 2008 May. PMID 18391946, Free PMC Article
  5. Absence of Sac2/INPP5F enhances the phenotype of a Parkinson's disease mutation of synaptojanin 1. Cao M, et al. Proc Natl Acad Sci U S A, 2020 Jun 2. PMID 32424101, Free PMC Article

See all (75) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. SYNJ1 rescues motor functions in hereditary and sporadic Parkinson's disease mice by upregulating TSP-1 expression.
    Title: SYNJ1 rescues motor functions in hereditary and sporadic Parkinson's disease mice by upregulating TSP-1 expression.
  2. Synaptojanin1 Modifies Endolysosomal Parameters in Cultured Ventral Midbrain Neurons.
    Title: Synaptojanin1 Modifies Endolysosomal Parameters in Cultured Ventral Midbrain Neurons.
  3. These data uncover a previously unidentified mechanism that links ApoE4-induced phospholipid changes to the pathogenic nature of ApoE4 in Alzheimer's disease.
    Title: Phospholipid dysregulation contributes to ApoE4-associated cognitive deficits in Alzheimer's disease pathogenesis.
  4. Synaptojanin1 deficiency upregulates basal autophagosome formation in astrocytes.
    Title: Synaptojanin1 deficiency upregulates basal autophagosome formation in astrocytes.
  5. Synj1 haploinsufficiency causes dopamine neuron vulnerability and alpha-synuclein accumulation in mice.
    Title: Synj1 haploinsufficiency causes dopamine neuron vulnerability and alpha-synuclein accumulation in mice.
  6. SYNJ1 contributes to memory deficits in the aging hippocampus in all forms of Alzheimer's disease.
    Title: Excess Synaptojanin 1 Contributes to Place Cell Dysfunction and Memory Deficits in the Aging Hippocampus in Three Types of Alzheimer's Disease.
  7. report showing expression, location and isoforms of Synj1 and Synj2 in the small and large intestine and that they might participate in intestinal pathology.
    Title: The Synaptojanins in the murine small and large intestine.
  8. Parkinson Sac Domain Mutation in Synaptojanin 1 Impairs Clathrin Uncoating at Synapses
    Title: Parkinson Sac Domain Mutation in Synaptojanin 1 Impairs Clathrin Uncoating at Synapses and Triggers Dystrophic Changes in Dopaminergic Axons.
  9. a novel mechanism by which reduction of a PI(4,5)P2-degrading enzyme, synj1, improves amyloid-induced neuropathology and behavior deficits through accelerating cellular Abeta clearance.
    Title: Reduction of synaptojanin 1 accelerates Aβ clearance and attenuates cognitive deterioration in an Alzheimer mouse model.
  10. These results implicate Pak5 in Pacsin1- and Synaptojanin1-mediated synaptic vesicle trafficking.
    Title: Identification of neuronal substrates implicates Pak5 in synaptic vesicle trafficking.
Submit: New GeneRIF Correction See all GeneRIFs (15)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables EH domain binding ISO
Inferred from Sequence Orthology
more info
  
enables SH3 domain binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables SH3 domain binding ISO
Inferred from Sequence Orthology
more info
  
enables inositol-1,4,5-trisphosphate 5-phosphatase activity ISO
Inferred from Sequence Orthology
more info
  
enables phosphatidylinositol phosphate 5-phosphatase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables phosphatidylinositol phosphate 5-phosphatase activity ISO
Inferred from Sequence Orthology
more info
  
enables phosphatidylinositol-3-phosphate phosphatase activity ISO
Inferred from Sequence Orthology
more info
  
enables phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity ISO
Inferred from Sequence Orthology
more info
  
enables phosphatidylinositol-4-phosphate phosphatase activity ISO
Inferred from Sequence Orthology
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein-containing complex binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within learning IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in learning ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within neurotransmitter transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in phosphatidylinositol dephosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within phosphatidylinositol dephosphorylation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in phosphatidylinositol dephosphorylation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within phosphatidylinositol metabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within phosphatidylinositol metabolic process TAS
Traceable Author Statement
more info
 PubMed 
acts_upstream_of_or_within phosphatidylinositol-mediated signaling TAS
Traceable Author Statement
more info
 PubMed 
involved_in positive regulation of endosome organization ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of gliogenesis ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of receptor-mediated endocytosis ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of synaptic vesicle recycling TAS
Traceable Author Statement
more info
 PubMed 
involved_in postsynaptic neurotransmitter receptor internalization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of postsynaptic neurotransmitter receptor internalization IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of postsynaptic neurotransmitter receptor internalization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in response to cytokine ISO
Inferred from Sequence Orthology
more info
  
involved_in response to retinoic acid ISO
Inferred from Sequence Orthology
more info
  
involved_in synaptic vesicle endocytosis IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within synaptic vesicle endocytosis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in synaptic vesicle endocytosis ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within synaptic vesicle priming IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within synaptic vesicle transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in synaptic vesicle uncoating IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within synaptic vesicle uncoating IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in synaptic vesicle uncoating IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in Schaffer collateral - CA1 synapse IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in Schaffer collateral - CA1 synapse IMP
Inferred from Mutant Phenotype
more info
 PubMed 
part_of clathrin coat TAS
Traceable Author Statement
more info
 PubMed 
part_of clathrin coat of coated pit ISO
Inferred from Sequence Orthology
more info
  
is_active_in glutamatergic synapse IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in glutamatergic synapse IMP
Inferred from Mutant Phenotype
more info
 PubMed 
located_in membrane ISO
Inferred from Sequence Orthology
more info
  
part_of membrane coat IDA
Inferred from Direct Assay
more info
 PubMed 
colocalizes_with microtubule ISO
Inferred from Sequence Orthology
more info
  
is_active_in parallel fiber to Purkinje cell synapse ISO
Inferred from Sequence Orthology
more info
  
is_active_in perinuclear region of cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in presynapse IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in presynapse ISO
Inferred from Sequence Orthology
more info
  
located_in presynapse ISO
Inferred from Sequence Orthology
more info
  
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
  
located_in synaptic membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
synaptojanin-1
Names
synaptic inositol 1,4,5-trisphosphate 5-phosphatase 1
NP_001038980.1
NP_001157955.1
NP_001392321.1
NP_001392322.1
NP_001392323.1
NP_001392324.1
NP_001392325.1
NP_001392326.1
NP_001392328.1
NP_001392329.1
NP_001392330.1
NP_001392331.1
NP_001392332.1
NP_001392333.1
NP_001392334.1
NP_001392335.1
NP_001392336.1
NP_001392337.1
NP_001392339.1
XP_006522900.1
XP_006522909.1
XP_011244377.1
XP_011244378.1
XP_011244379.1
XP_011244380.1
XP_011244381.1
XP_011244382.1
XP_011244383.1
XP_011244384.1
XP_011244385.1
XP_011244386.1
XP_011244387.1
XP_011244389.1
XP_011244391.1
XP_017172325.1
XP_017172326.1
XP_017172328.1
XP_017172329.1
XP_017172330.1
XP_030104762.1
XP_030104763.1
XP_030104765.1
XP_030104766.1
XP_030104768.1
XP_030104769.1
XP_030104770.1
XP_036015603.1
XP_036015605.1
XP_036015606.1
XP_036015610.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001045515.2 → NP_001038980.1  synaptojanin-1 isoform b

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) represents use of an alternate promoter and 5' UTR, uses a downstream start codon, and includes an alternate exon in the 3' coding region resulting in a frameshift, compared to variant 1. The resulting isoform (b) has a shorter N-terminus and a shorter and distinct C-terminus, compared to isoform a.
    Source sequence(s)
    AC134560, AC141885
    Consensus CDS
    CCDS49906.1
    UniProtKB/TrEMBL
    E9Q7S0, F7BQW7
    Related
    ENSMUSP00000128997.2, ENSMUST00000170853.8
    Conserved Domains (3) summary
    cd09098
    Location:533 → 868
    INPP5c_Synj1; Catalytic inositol polyphosphate 5-phosphatase (INPP5c) domain of synaptojanin 1
    pfam02383
    Location:60 → 340
    Syja_N; SacI homology domain
    cl17169
    Location:867 → 1008
    RRM_SF; RNA recognition motif (RRM) superfamily

  2. NM_001164483.2 → NP_001157955.1  synaptojanin-1 isoform a

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (a).
    Source sequence(s)
    AC134560, AC141885
    Consensus CDS
    CCDS49907.1
    UniProtKB/Swiss-Prot
    Q8CHC4
    UniProtKB/TrEMBL
    D3Z656
    Related
    ENSMUSP00000113308.2, ENSMUST00000121759.8
    Conserved Domains (3) summary
    cd09098
    Location:573 → 908
    INPP5c_Synj1; Catalytic inositol polyphosphate 5-phosphatase (INPP5c) domain of synaptojanin 1
    pfam02383
    Location:100 → 380
    Syja_N; SacI homology domain
    cl17169
    Location:907 → 1048
    RRM_SF; RNA recognition motif (RRM) superfamily

  3. NM_001405392.1 → NP_001392321.1  synaptojanin-1 isoform c

    Status: VALIDATED

    Source sequence(s)
    AC134560, AC141885

  4. NM_001405393.1 → NP_001392322.1  synaptojanin-1 isoform d

    Status: VALIDATED

    Source sequence(s)
    AC134560, AC141885

  5. NM_001405394.1 → NP_001392323.1  synaptojanin-1 isoform e

    Status: VALIDATED

    Source sequence(s)
    AC134560, AC141885

  6. NM_001405395.1 → NP_001392324.1  synaptojanin-1 isoform f

    Status: VALIDATED

    Source sequence(s)
    AC134560, AC141885
    Related
    ENSMUSP00000113518.3, ENSMUST00000118390.10

  7. NM_001405396.1 → NP_001392325.1  synaptojanin-1 isoform g

    Status: VALIDATED

    Source sequence(s)
    AC134560, AC141885

  8. NM_001405397.1 → NP_001392326.1  synaptojanin-1 isoform h

    Status: VALIDATED

    Source sequence(s)
    AC134560, AC141885

  9. NM_001405399.1 → NP_001392328.1  synaptojanin-1 isoform i

    Status: VALIDATED

    Source sequence(s)
    AC134560, AC141885

  10. NM_001405400.1 → NP_001392329.1  synaptojanin-1 isoform j

    Status: VALIDATED

    Source sequence(s)
    AC134560, AC141885

  11. NM_001405401.1 → NP_001392330.1  synaptojanin-1 isoform k

    Status: VALIDATED

    Source sequence(s)
    AC134560, AC141885

  12. NM_001405402.1 → NP_001392331.1  synaptojanin-1 isoform l

    Status: VALIDATED

    Source sequence(s)
    AC134560, AC141885

  13. NM_001405403.1 → NP_001392332.1  synaptojanin-1 isoform m

    Status: VALIDATED

    Source sequence(s)
    AC134560, AC141885

  14. NM_001405404.1 → NP_001392333.1  synaptojanin-1 isoform n

    Status: VALIDATED

    Source sequence(s)
    AC134560, AC141885

  15. NM_001405405.1 → NP_001392334.1  synaptojanin-1 isoform o

    Status: VALIDATED

    Source sequence(s)
    AC134560, AC141885

  16. NM_001405406.1 → NP_001392335.1  synaptojanin-1 isoform p

    Status: VALIDATED

    Source sequence(s)
    AC134560, AC141885

  17. NM_001405407.1 → NP_001392336.1  synaptojanin-1 isoform q

    Status: VALIDATED

    Source sequence(s)
    AC134560, AC141885

  18. NM_001405408.1 → NP_001392337.1  synaptojanin-1 isoform r

    Status: VALIDATED

    Source sequence(s)
    AC134560, AC141885

  19. NM_001405410.1 → NP_001392339.1  synaptojanin-1 isoform s

    Status: VALIDATED

    Source sequence(s)
    AC134560, AC141885

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000082.7 Reference GRCm39 C57BL/6J

    Range
    90732980..90810543 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030248902.2 → XP_030104762.1  synaptojanin-1 isoform X3

    UniProtKB/Swiss-Prot
    Q8CHC4
    Conserved Domains (4) summary
    cd09098
    Location:669 → 1004
    INPP5c_Synj1; Catalytic inositol polyphosphate 5-phosphatase (INPP5c) domain of synaptojanin 1
    PHA03247
    Location:1196 → 1598
    PHA03247; large tegument protein UL36; Provisional
    COG5329
    Location:204 → 624
    COG5329; Phosphoinositide polyphosphatase (Sac family) [Signal transduction mechanisms]
    cl17169
    Location:1003 → 1144
    RRM_SF; RNA recognition motif (RRM) superfamily

  2. XM_036159712.1 → XP_036015605.1  synaptojanin-1 isoform X14

    UniProtKB/Swiss-Prot
    Q8CHC4
    Conserved Domains (4) summary
    cd09098
    Location:677 → 1012
    INPP5c_Synj1; Catalytic inositol polyphosphate 5-phosphatase (INPP5c) domain of synaptojanin 1
    COG5329
    Location:204 → 624
    COG5329; Phosphoinositide polyphosphatase (Sac family) [Signal transduction mechanisms]
    pfam03154
    Location:1154 → 1544
    Atrophin-1; Atrophin-1 family
    cl17169
    Location:1011 → 1152
    RRM_SF; RNA recognition motif (RRM) superfamily

  3. XM_017316840.3 → XP_017172329.1  synaptojanin-1 isoform X37

    UniProtKB/TrEMBL
    F7BQW7
    Conserved Domains (4) summary
    cd09098
    Location:677 → 1012
    INPP5c_Synj1; Catalytic inositol polyphosphate 5-phosphatase (INPP5c) domain of synaptojanin 1
    COG5329
    Location:204 → 624
    COG5329; Phosphoinositide polyphosphatase (Sac family) [Signal transduction mechanisms]
    pfam03154
    Location:1154 → 1378
    Atrophin-1; Atrophin-1 family
    cl17169
    Location:1011 → 1152
    RRM_SF; RNA recognition motif (RRM) superfamily

  4. XM_030248903.2 → XP_030104763.1  synaptojanin-1 isoform X9

    UniProtKB/Swiss-Prot
    Q8CHC4
    Conserved Domains (4) summary
    cd09098
    Location:677 → 1012
    INPP5c_Synj1; Catalytic inositol polyphosphate 5-phosphatase (INPP5c) domain of synaptojanin 1
    COG5329
    Location:204 → 624
    COG5329; Phosphoinositide polyphosphatase (Sac family) [Signal transduction mechanisms]
    pfam03154
    Location:1154 → 1557
    Atrophin-1; Atrophin-1 family
    cl17169
    Location:1011 → 1152
    RRM_SF; RNA recognition motif (RRM) superfamily

  5. XM_017316836.3 → XP_017172325.1  synaptojanin-1 isoform X10

    UniProtKB/Swiss-Prot
    Q8CHC4
    Conserved Domains (4) summary
    cd09098
    Location:677 → 1012
    INPP5c_Synj1; Catalytic inositol polyphosphate 5-phosphatase (INPP5c) domain of synaptojanin 1
    PHA03247
    Location:1204 → 1577
    PHA03247; large tegument protein UL36; Provisional
    COG5329
    Location:204 → 624
    COG5329; Phosphoinositide polyphosphatase (Sac family) [Signal transduction mechanisms]
    cl17169
    Location:1011 → 1152
    RRM_SF; RNA recognition motif (RRM) superfamily

  6. XM_006522837.5 → XP_006522900.1  synaptojanin-1 isoform X6

    UniProtKB/Swiss-Prot
    Q8CHC4
    Conserved Domains (4) summary
    cd09098
    Location:677 → 1012
    INPP5c_Synj1; Catalytic inositol polyphosphate 5-phosphatase (INPP5c) domain of synaptojanin 1
    COG5329
    Location:204 → 624
    COG5329; Phosphoinositide polyphosphatase (Sac family) [Signal transduction mechanisms]
    pfam03154
    Location:1154 → 1570
    Atrophin-1; Atrophin-1 family
    cl17169
    Location:1011 → 1152
    RRM_SF; RNA recognition motif (RRM) superfamily

  7. XM_011246082.4 → XP_011244384.1  synaptojanin-1 isoform X15

    UniProtKB/Swiss-Prot
    Q8CHC4
    Conserved Domains (4) summary
    cd09098
    Location:672 → 1007
    INPP5c_Synj1; Catalytic inositol polyphosphate 5-phosphatase (INPP5c) domain of synaptojanin 1
    COG5329
    Location:204 → 627
    COG5329; Phosphoinositide polyphosphatase (Sac family) [Signal transduction mechanisms]
    pfam03154
    Location:1149 → 1539
    Atrophin-1; Atrophin-1 family
    cl17169
    Location:1006 → 1147
    RRM_SF; RNA recognition motif (RRM) superfamily

  8. XM_017316841.3 → XP_017172330.1  synaptojanin-1 isoform X38

    UniProtKB/TrEMBL
    F7BQW7
    Conserved Domains (4) summary
    cd09098
    Location:672 → 1007
    INPP5c_Synj1; Catalytic inositol polyphosphate 5-phosphatase (INPP5c) domain of synaptojanin 1
    COG5329
    Location:204 → 627
    COG5329; Phosphoinositide polyphosphatase (Sac family) [Signal transduction mechanisms]
    pfam03154
    Location:1149 → 1373
    Atrophin-1; Atrophin-1 family
    cl17169
    Location:1006 → 1147
    RRM_SF; RNA recognition motif (RRM) superfamily

  9. XM_036159710.1 → XP_036015603.1  synaptojanin-1 isoform X11

    UniProtKB/Swiss-Prot
    Q8CHC4
    Conserved Domains (4) summary
    cd09098
    Location:672 → 1007
    INPP5c_Synj1; Catalytic inositol polyphosphate 5-phosphatase (INPP5c) domain of synaptojanin 1
    COG5329
    Location:204 → 627
    COG5329; Phosphoinositide polyphosphatase (Sac family) [Signal transduction mechanisms]
    pfam03154
    Location:1172 → 1552
    Atrophin-1; Atrophin-1 family
    cl17169
    Location:1006 → 1147
    RRM_SF; RNA recognition motif (RRM) superfamily

  10. XM_011246076.4 → XP_011244378.1  synaptojanin-1 isoform X2

    UniProtKB/Swiss-Prot
    Q8CHC4
    Conserved Domains (4) summary
    cd09098
    Location:672 → 1007
    INPP5c_Synj1; Catalytic inositol polyphosphate 5-phosphatase (INPP5c) domain of synaptojanin 1
    PHA03247
    Location:1199 → 1601
    PHA03247; large tegument protein UL36; Provisional
    COG5329
    Location:204 → 627
    COG5329; Phosphoinositide polyphosphatase (Sac family) [Signal transduction mechanisms]
    cl17169
    Location:1006 → 1147
    RRM_SF; RNA recognition motif (RRM) superfamily

  11. XM_011246081.4 → XP_011244383.1  synaptojanin-1 isoform X13

    UniProtKB/Swiss-Prot
    Q8CHC4
    Conserved Domains (4) summary
    cd09098
    Location:680 → 1015
    INPP5c_Synj1; Catalytic inositol polyphosphate 5-phosphatase (INPP5c) domain of synaptojanin 1
    COG5329
    Location:204 → 627
    COG5329; Phosphoinositide polyphosphatase (Sac family) [Signal transduction mechanisms]
    pfam03154
    Location:1157 → 1547
    Atrophin-1; Atrophin-1 family
    cl17169
    Location:1014 → 1155
    RRM_SF; RNA recognition motif (RRM) superfamily

  12. XM_030248910.2 → XP_030104770.1  synaptojanin-1 isoform X36

    UniProtKB/TrEMBL
    F7BQW7
    Conserved Domains (4) summary
    cd09098
    Location:680 → 1015
    INPP5c_Synj1; Catalytic inositol polyphosphate 5-phosphatase (INPP5c) domain of synaptojanin 1
    COG5329
    Location:204 → 627
    COG5329; Phosphoinositide polyphosphatase (Sac family) [Signal transduction mechanisms]
    pfam03154
    Location:1157 → 1381
    Atrophin-1; Atrophin-1 family
    cl17169
    Location:1014 → 1155
    RRM_SF; RNA recognition motif (RRM) superfamily

  13. XM_017316839.3 → XP_017172328.1  synaptojanin-1 isoform X35

    UniProtKB/TrEMBL
    F7BQW7
    Conserved Domains (4) summary
    cd09098
    Location:680 → 1015
    INPP5c_Synj1; Catalytic inositol polyphosphate 5-phosphatase (INPP5c) domain of synaptojanin 1
    COG5329
    Location:204 → 627
    COG5329; Phosphoinositide polyphosphatase (Sac family) [Signal transduction mechanisms]
    pfam03154
    Location:1157 → 1381
    Atrophin-1; Atrophin-1 family
    cl17169
    Location:1014 → 1155
    RRM_SF; RNA recognition motif (RRM) superfamily

  14. XM_011246079.4 → XP_011244381.1  synaptojanin-1 isoform X7

    UniProtKB/Swiss-Prot
    Q8CHC4
    Conserved Domains (4) summary
    cd09098
    Location:680 → 1015
    INPP5c_Synj1; Catalytic inositol polyphosphate 5-phosphatase (INPP5c) domain of synaptojanin 1
    COG5329
    Location:204 → 627
    COG5329; Phosphoinositide polyphosphatase (Sac family) [Signal transduction mechanisms]
    pfam03154
    Location:1157 → 1560
    Atrophin-1; Atrophin-1 family
    cl17169
    Location:1014 → 1155
    RRM_SF; RNA recognition motif (RRM) superfamily

  15. XM_030248908.2 → XP_030104768.1  synaptojanin-1 isoform X31

    UniProtKB/TrEMBL
    F7BQW7
    Conserved Domains (4) summary
    cd09098
    Location:680 → 1015
    INPP5c_Synj1; Catalytic inositol polyphosphate 5-phosphatase (INPP5c) domain of synaptojanin 1
    COG5329
    Location:204 → 627
    COG5329; Phosphoinositide polyphosphatase (Sac family) [Signal transduction mechanisms]
    PRK07764
    Location:1200 → 1394
    PRK07764; DNA polymerase III subunits gamma and tau; Validated
    cl17169
    Location:1014 → 1155
    RRM_SF; RNA recognition motif (RRM) superfamily

  16. XM_011246077.4 → XP_011244379.1  synaptojanin-1 isoform X4

    UniProtKB/Swiss-Prot
    Q8CHC4
    Conserved Domains (4) summary
    cd09098
    Location:680 → 1015
    INPP5c_Synj1; Catalytic inositol polyphosphate 5-phosphatase (INPP5c) domain of synaptojanin 1
    COG5329
    Location:204 → 627
    COG5329; Phosphoinositide polyphosphatase (Sac family) [Signal transduction mechanisms]
    pfam03154
    Location:1157 → 1576
    Atrophin-1; Atrophin-1 family
    cl17169
    Location:1014 → 1155
    RRM_SF; RNA recognition motif (RRM) superfamily

  17. XM_011246080.4 → XP_011244382.1  synaptojanin-1 isoform X8

    UniProtKB/Swiss-Prot
    Q8CHC4
    Conserved Domains (4) summary
    cd09098
    Location:680 → 1015
    INPP5c_Synj1; Catalytic inositol polyphosphate 5-phosphatase (INPP5c) domain of synaptojanin 1
    PHA03247
    Location:1207 → 1580
    PHA03247; large tegument protein UL36; Provisional
    COG5329
    Location:204 → 627
    COG5329; Phosphoinositide polyphosphatase (Sac family) [Signal transduction mechanisms]
    cl17169
    Location:1014 → 1155
    RRM_SF; RNA recognition motif (RRM) superfamily

  18. XM_036159717.1 → XP_036015610.1  synaptojanin-1 isoform X33

    UniProtKB/TrEMBL
    F7BQW7
    Conserved Domains (4) summary
    cd09098
    Location:680 → 1015
    INPP5c_Synj1; Catalytic inositol polyphosphate 5-phosphatase (INPP5c) domain of synaptojanin 1
    PHA03247
    Location:1201 → 1424
    PHA03247; large tegument protein UL36; Provisional
    COG5329
    Location:204 → 627
    COG5329; Phosphoinositide polyphosphatase (Sac family) [Signal transduction mechanisms]
    cl17169
    Location:1014 → 1155
    RRM_SF; RNA recognition motif (RRM) superfamily

  19. XM_030248909.2 → XP_030104769.1  synaptojanin-1 isoform X32

    UniProtKB/TrEMBL
    F7BQW7
    Conserved Domains (4) summary
    cd09098
    Location:680 → 1015
    INPP5c_Synj1; Catalytic inositol polyphosphate 5-phosphatase (INPP5c) domain of synaptojanin 1
    PHA03247
    Location:1201 → 1397
    PHA03247; large tegument protein UL36; Provisional
    COG5329
    Location:204 → 627
    COG5329; Phosphoinositide polyphosphatase (Sac family) [Signal transduction mechanisms]
    cl17169
    Location:1014 → 1155
    RRM_SF; RNA recognition motif (RRM) superfamily

  20. XM_011246078.4 → XP_011244380.1  synaptojanin-1 isoform X5

    UniProtKB/Swiss-Prot
    Q8CHC4
    Conserved Domains (4) summary
    cd09098
    Location:680 → 1015
    INPP5c_Synj1; Catalytic inositol polyphosphate 5-phosphatase (INPP5c) domain of synaptojanin 1
    COG5329
    Location:204 → 627
    COG5329; Phosphoinositide polyphosphatase (Sac family) [Signal transduction mechanisms]
    pfam03154
    Location:1157 → 1573
    Atrophin-1; Atrophin-1 family
    cl17169
    Location:1014 → 1155
    RRM_SF; RNA recognition motif (RRM) superfamily

  21. XM_011246075.4 → XP_011244377.1  synaptojanin-1 isoform X1

    UniProtKB/Swiss-Prot
    Q8CHC4
    Conserved Domains (4) summary
    cd09098
    Location:680 → 1015
    INPP5c_Synj1; Catalytic inositol polyphosphate 5-phosphatase (INPP5c) domain of synaptojanin 1
    PHA03247
    Location:1207 → 1609
    PHA03247; large tegument protein UL36; Provisional
    COG5329
    Location:204 → 627
    COG5329; Phosphoinositide polyphosphatase (Sac family) [Signal transduction mechanisms]
    cl17169
    Location:1014 → 1155
    RRM_SF; RNA recognition motif (RRM) superfamily

  22. XM_011246085.4 → XP_011244387.1  synaptojanin-1 isoform X24

    See identical proteins and their annotated locations for XP_011244387.1

    UniProtKB/TrEMBL
    F7BQW7
    Conserved Domains (4) summary
    cd09098
    Location:680 → 1015
    INPP5c_Synj1; Catalytic inositol polyphosphate 5-phosphatase (INPP5c) domain of synaptojanin 1
    PHA03378
    Location:1119 → 1423
    PHA03378; EBNA-3B; Provisional
    COG5329
    Location:204 → 627
    COG5329; Phosphoinositide polyphosphatase (Sac family) [Signal transduction mechanisms]
    cl17169
    Location:1014 → 1155
    RRM_SF; RNA recognition motif (RRM) superfamily

  23. XM_017316837.3 → XP_017172326.1  synaptojanin-1 isoform X23

    UniProtKB/TrEMBL
    F7BQW7
    Conserved Domains (4) summary
    cd09098
    Location:680 → 1015
    INPP5c_Synj1; Catalytic inositol polyphosphate 5-phosphatase (INPP5c) domain of synaptojanin 1
    PHA03378
    Location:1119 → 1423
    PHA03378; EBNA-3B; Provisional
    COG5329
    Location:204 → 627
    COG5329; Phosphoinositide polyphosphatase (Sac family) [Signal transduction mechanisms]
    cl17169
    Location:1014 → 1155
    RRM_SF; RNA recognition motif (RRM) superfamily

  24. XM_030248905.2 → XP_030104765.1  synaptojanin-1 isoform X18

    UniProtKB/Swiss-Prot
    Q8CHC4
    Conserved Domains (4) summary
    cd09098
    Location:533 → 868
    INPP5c_Synj1; Catalytic inositol polyphosphate 5-phosphatase (INPP5c) domain of synaptojanin 1
    PHA03247
    Location:1060 → 1462
    PHA03247; large tegument protein UL36; Provisional
    COG5329
    Location:60 → 480
    COG5329; Phosphoinositide polyphosphatase (Sac family) [Signal transduction mechanisms]
    cl17169
    Location:867 → 1008
    RRM_SF; RNA recognition motif (RRM) superfamily

  25. XM_030248906.1 → XP_030104766.1  synaptojanin-1 isoform X20

    UniProtKB/Swiss-Prot
    Q8CHC4
    Conserved Domains (4) summary
    cd09098
    Location:525 → 860
    INPP5c_Synj1; Catalytic inositol polyphosphate 5-phosphatase (INPP5c) domain of synaptojanin 1
    PHA03247
    Location:1052 → 1454
    PHA03247; large tegument protein UL36; Provisional
    COG5329
    Location:60 → 480
    COG5329; Phosphoinositide polyphosphatase (Sac family) [Signal transduction mechanisms]
    cl17169
    Location:859 → 1000
    RRM_SF; RNA recognition motif (RRM) superfamily

  26. XM_036159713.1 → XP_036015606.1  synaptojanin-1 isoform X21

    UniProtKB/Swiss-Prot
    Q8CHC4
    Conserved Domains (4) summary
    cd09098
    Location:528 → 863
    INPP5c_Synj1; Catalytic inositol polyphosphate 5-phosphatase (INPP5c) domain of synaptojanin 1
    COG5329
    Location:60 → 483
    COG5329; Phosphoinositide polyphosphatase (Sac family) [Signal transduction mechanisms]
    pfam03154
    Location:1005 → 1395
    Atrophin-1; Atrophin-1 family
    cl17169
    Location:862 → 1003
    RRM_SF; RNA recognition motif (RRM) superfamily

  27. XM_011246084.1 → XP_011244386.1  synaptojanin-1 isoform X19

    UniProtKB/Swiss-Prot
    Q8CHC4
    Conserved Domains (4) summary
    cd09098
    Location:528 → 863
    INPP5c_Synj1; Catalytic inositol polyphosphate 5-phosphatase (INPP5c) domain of synaptojanin 1
    PHA03247
    Location:1055 → 1457
    PHA03247; large tegument protein UL36; Provisional
    COG5329
    Location:60 → 483
    COG5329; Phosphoinositide polyphosphatase (Sac family) [Signal transduction mechanisms]
    cl17169
    Location:862 → 1003
    RRM_SF; RNA recognition motif (RRM) superfamily

  28. XM_011246083.1 → XP_011244385.1  synaptojanin-1 isoform X17

    UniProtKB/Swiss-Prot
    Q8CHC4
    Conserved Domains (4) summary
    cd09098
    Location:536 → 871
    INPP5c_Synj1; Catalytic inositol polyphosphate 5-phosphatase (INPP5c) domain of synaptojanin 1
    PHA03247
    Location:1063 → 1465
    PHA03247; large tegument protein UL36; Provisional
    COG5329
    Location:60 → 483
    COG5329; Phosphoinositide polyphosphatase (Sac family) [Signal transduction mechanisms]
    cl17169
    Location:870 → 1011
    RRM_SF; RNA recognition motif (RRM) superfamily

  29. XM_011246089.4 → XP_011244391.1  synaptojanin-1 isoform X43

    Conserved Domains (4) summary
    cd09098
    Location:86 → 421
    INPP5c_Synj1; Catalytic inositol polyphosphate 5-phosphatase (INPP5c) domain of synaptojanin 1
    PHA03247
    Location:607 → 1015
    PHA03247; large tegument protein UL36; Provisional
    COG5329
    Location:2 → 33
    COG5329; Phosphoinositide polyphosphatase (Sac family) [Signal transduction mechanisms]
    cl17169
    Location:420 → 561
    RRM_SF; RNA recognition motif (RRM) superfamily

  30. XM_006522846.4 → XP_006522909.1  synaptojanin-1 isoform X44

    Conserved Domains (3) summary
    cd09098
    Location:14 → 349
    INPP5c_Synj1; Catalytic inositol polyphosphate 5-phosphatase (INPP5c) domain of synaptojanin 1
    PHA03247
    Location:535 → 943
    PHA03247; large tegument protein UL36; Provisional
    cl17169
    Location:348 → 489
    RRM_SF; RNA recognition motif (RRM) superfamily

  31. XM_011246087.4 → XP_011244389.1  synaptojanin-1 isoform X25

    UniProtKB/TrEMBL
    F7BQW7
    Conserved Domains (4) summary
    cd09098
    Location:680 → 1015
    INPP5c_Synj1; Catalytic inositol polyphosphate 5-phosphatase (INPP5c) domain of synaptojanin 1
    PHA03378
    Location:1119 → 1423
    PHA03378; EBNA-3B; Provisional
    COG5329
    Location:204 → 627
    COG5329; Phosphoinositide polyphosphatase (Sac family) [Signal transduction mechanisms]
    cl17169
    Location:1014 → 1155
    RRM_SF; RNA recognition motif (RRM) superfamily

RNA

  1. XR_876128.4 RNA Sequence

  2. XR_004939141.1 RNA Sequence

  3. XR_004939140.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8CHC4.3 GenPept UniProtKB/Swiss-Prot:Q8CHC4

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