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BATF basic leucine zipper ATF-like transcription factor [ Homo sapiens (human) ]

Gene ID: 10538, updated on 5-Mar-2024

Summary

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Official Symbol
BATFprovided by HGNC
Official Full Name
basic leucine zipper ATF-like transcription factorprovided by HGNC
Primary source
HGNC:HGNC:958
See related
Ensembl:ENSG00000156127 MIM:612476; AllianceGenome:HGNC:958
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SFA2; B-ATF; BATF1; SFA-2
Summary
The protein encoded by this gene is a nuclear basic leucine zipper protein that belongs to the AP-1/ATF superfamily of transcription factors. The leucine zipper of this protein mediates dimerization with members of the Jun family of proteins. This protein is thought to be a negative regulator of AP-1/ATF transcriptional events. [provided by RefSeq, Jul 2008]
Expression
Broad expression in lymph node (RPKM 11.0), appendix (RPKM 9.8) and 14 other tissues See more
Orthologs
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Genomic context

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See BATF in Genome Data Viewer
Location:
14q24.3
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 14 NC_000014.9 (75522469..75546992)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 14 NC_060938.1 (69731553..69756105)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (75988812..76013335)

Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8746 Neighboring gene H3K27ac hESC enhancer GRCh37_chr14:75894221-75894778 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5946 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5947 Neighboring gene JDP2 antisense RNA 1 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:75904146-75904649 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:75905657-75906159 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:75907363-75908346 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8748 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:75918700-75919214 Neighboring gene Jun dimerization protein 2 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:75919215-75919730 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:75919731-75920244 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:75925593-75926141 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:75941017-75941518 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:75946817-75947707 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8750 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:75980965-75981530 Neighboring gene uncharacterized LOC105370572 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8751 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8752 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8753 Neighboring gene ReSE screen-validated silencer GRCh37_chr14:76004983-76005197 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8756 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8755 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8754 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8757 Neighboring gene uncharacterized LOC107984653 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8758 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8759 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8760 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5949 Neighboring gene FLVCR2 antisense RNA 1 Neighboring gene FLVCR choline and putative heme transporter 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. BATF reprograms the tumor immune status. Fan T, et al. Med, 2023 Jan 13. PMID 36640752
  2. BATF epigenetically and transcriptionally controls the activation program of regulatory T cells in human tumors. Itahashi K, et al. Sci Immunol, 2022 Oct 14. PMID 36206353
  3. Increased BATF expression is associated with the severity of liver damage in patients with chronic hepatitis B. Wang LY, et al. Clin Exp Med, 2018 May. PMID 29164410
  4. Epstein-Barr virus nuclear antigen 3A partially coincides with EBNA3C genome-wide and is tethered to DNA through BATF complexes. Schmidt SC, et al. Proc Natl Acad Sci U S A, 2015 Jan 13. PMID 25540416, Free PMC Article
  5. Phosphorylation of BATF regulates DNA binding: a novel mechanism for AP-1 (activator protein-1) regulation. Deppmann CD, et al. Biochem J, 2003 Sep 1. PMID 12809553, Free PMC Article

See all (53) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Integrated BATF transcriptional network regulates suppressive intratumoral regulatory T cells.
    Title: Integrated BATF transcriptional network regulates suppressive intratumoral regulatory T cells.
  2. Relative Expression of BATF and CD112 in PBMC of Patients with Chronic Lymphocytic Leukemia.
    Title: Relative Expression of BATF and CD112 in PBMC of Patients with Chronic Lymphocytic Leukemia.
  3. BATF reprograms the tumor immune status.
    Title: BATF reprograms the tumor immune status.
  4. Depletion of BATF in CAR-T cells enhances antitumor activity by inducing resistance against exhaustion and formation of central memory cells.
    Title: Depletion of BATF in CAR-T cells enhances antitumor activity by inducing resistance against exhaustion and formation of central memory cells.
  5. BATF epigenetically and transcriptionally controls the activation program of regulatory T cells in human tumors.
    Title: BATF epigenetically and transcriptionally controls the activation program of regulatory T cells in human tumors.
  6. A systematic comparison of FOSL1, FOSL2 and BATF-mediated transcriptional regulation during early human Th17 differentiation.
    Title: A systematic comparison of FOSL1, FOSL2 and BATF-mediated transcriptional regulation during early human Th17 differentiation.
  7. Supervised machine learning algorithm identified KRT20, BATF and TP63 as biologically relevant biomarkers for bladder biopsy specimens from interstitial cystitis/bladder pain syndrome patients.
    Title: Supervised machine learning algorithm identified KRT20, BATF and TP63 as biologically relevant biomarkers for bladder biopsy specimens from interstitial cystitis/bladder pain syndrome patients.
  8. Prognostic Value of DNA Methylation-Driven Genes in Clear Cell Renal Cell Carcinoma: A Study Based on Methylation and Transcriptome Analyses.
    Title: Prognostic Value of DNA Methylation-Driven Genes in Clear Cell Renal Cell Carcinoma: A Study Based on Methylation and Transcriptome Analyses.
  9. results reveal that JunB, c-Jun, and Bach2 cooperate with BATF to contribute to the specificity of BATF-dependent cytokine induction in Th subsets.
    Title: BATF-Interacting Proteins Dictate Specificity in Th Subset Activity.
  10. BATF-dependent pathogenic GM-CSF+ effector T cells are critical promoters of intestinal inflammation in graft-versus-host disease
    Title: BATF-dependent IL-7RhiGM-CSF+ T cells control intestinal graft-versus-host disease.
Submit: New GeneRIF Correction See all GeneRIFs (22)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis.
EBI GWAS Catalog
Genome-wide association study meta-analysis identifies seven new rheumatoid arthritis risk loci.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA-binding transcription activator activity, RNA polymerase II-specific IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription factor activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables DNA-binding transcription factor activity, RNA polymerase II-specific ISA
Inferred from Sequence Alignment
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables sequence-specific DNA binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables sequence-specific double-stranded DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in DNA damage response ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in DNA damage response, signal transduction by p53 class mediator ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in T-helper 17 cell differentiation ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in T-helper 17 cell lineage commitment ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in T-helper 2 cell differentiation ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in defense response to protozoan ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in hematopoietic stem cell differentiation ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in integrated stress response signaling NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in isotype switching ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in lymphoid progenitor cell differentiation ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in myeloid dendritic cell differentiation ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of cytokine production ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of T-helper 17 cell differentiation NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of transcription by RNA polymerase II NAS
Non-traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
part_of RNA polymerase II transcription regulator complex IPI
Inferred from Physical Interaction
more info
 PubMed 
part_of chromatin ISA
Inferred from Sequence Alignment
more info
  
located_in cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
  
located_in nucleoplasm TAS
Traceable Author Statement
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in nucleus NAS
Non-traceable Author Statement
more info
 PubMed 

General protein information

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Preferred Names
basic leucine zipper transcriptional factor ATF-like
Names
B-cell-activating transcription factor
SF-HT-activated gene 2 protein
activating transcription factor B
basic leucine zipper transcription factor, ATF-like

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_006399.5 → NP_006390.1  basic leucine zipper transcriptional factor ATF-like

    See identical proteins and their annotated locations for NP_006390.1

    Status: REVIEWED

    Source sequence(s)
    BC032294, BP235761, U15460
    Consensus CDS
    CCDS9843.1
    UniProtKB/Swiss-Prot
    Q16520
    Related
    ENSP00000286639.6, ENST00000286639.8
    Conserved Domains (1) summary
    cd14701
    Location:26 → 83
    bZIP_BATF; Basic leucine zipper (bZIP) domain of BATF proteins: a DNA-binding and dimerization domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000014.9 Reference GRCh38.p14 Primary Assembly

    Range
    75522469..75546992
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060938.1 Alternate T2T-CHM13v2.0

    Range
    69731553..69756105
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q16520.1 GenPept UniProtKB/Swiss-Prot:Q16520

Gene LinkOut

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