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SLC34A2 solute carrier family 34 member 2 [ Homo sapiens (human) ]

Gene ID: 10568, updated on 4-Jan-2025

Summary

Official Symbol
SLC34A2provided by HGNC
Official Full Name
solute carrier family 34 member 2provided by HGNC
Primary source
HGNC:HGNC:11020
See related
Ensembl:ENSG00000157765 MIM:604217; AllianceGenome:HGNC:11020
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PULAM; NPTIIb; NaPi2b; NAPI-3B; NAPI-IIb
Summary
The protein encoded by this gene is a pH-sensitive sodium-dependent phosphate transporter. Phosphate uptake is increased at lower pH. Defects in this gene are a cause of pulmonary alveolar microlithiasis. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, May 2010]
Expression
Restricted expression toward lung (RPKM 380.9) See more
Orthologs
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Genomic context

See SLC34A2 in Genome Data Viewer
Location:
4p15.2
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 4 NC_000004.12 (25655851..25678748)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 4 NC_060928.1 (25637821..25660720)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (25657473..25680370)

Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124900687 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:25621229-25621730 Neighboring gene S-phase kinase associated protein 1 pseudogene Neighboring gene ReSE screen-validated silencer GRCh37_chr4:25647409-25647582 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:25656923-25657836 Neighboring gene ribosomal protein S29 pseudogene 11 Neighboring gene SLIRP. pseudogene 2

Genomic regions, transcripts, and products

Expression

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
PULMONARY ALVEOLAR MICROLITHIASIS
MedGen: C0155912 OMIM: 265100 GeneReviews: Not available
Compare labs

Pathways from PubChem

Interactions

General gene information

Clone Names

  • FLJ90534

Gene Ontology Provided by GOA

Component Evidence Code Pubs
is_active_in apical plasma membrane  
located_in apical plasma membrane PubMed 
located_in apical plasma membrane  
is_active_in brush border  
located_in brush border membrane  
located_in membrane PubMed 
located_in membrane PubMed 
located_in plasma membrane PubMed 
located_in plasma membrane  
located_in vesicle PubMed 
is_active_in vesicle  

General protein information

Preferred Names
sodium-dependent phosphate transport protein 2B
Names
sodium/phosphate cotransporter 2B
solute carrier family 34 (sodium phosphate), member 2
solute carrier family 34 (type II sodium/phosphate cotransporter), member 2
type II sodium-dependent phosphate transporter 3b

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_021185.2 RefSeqGene

    Range
    5002..27899
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001177998.2NP_001171469.2  sodium-dependent phosphate transport protein 2B isoform b

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice junction at the 5' end of an exon compared to variant 1. The resulting isoform (b) has the same N- and C-termini but is 1 aa shorter compared to isoform a. Variants 2 and 3 both encode the same isoform (b).
    Source sequence(s)
    AC092436
    Consensus CDS
    CCDS54750.1
    UniProtKB/TrEMBL
    A8K9G0
    Related
    ENSP00000425501.1, ENST00000504570.5
    Conserved Domains (1) summary
    TIGR01013
    Location:104603
    2a58; Phosphate:Na+ Symporter (PNaS) Family
  2. NM_001177999.2NP_001171470.2  sodium-dependent phosphate transport protein 2B isoform b

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and uses an alternate in-frame splice junction at the 5' end of an exon compared to variant 1. The resulting isoform (b) has the same N- and C-termini but is 1 aa shorter compared to isoform a. Variants 2 and 3 both encode the same isoform (b).
    Source sequence(s)
    AC092436
    Consensus CDS
    CCDS54750.1
    UniProtKB/TrEMBL
    A8K9G0
    Related
    ENSP00000423021.1, ENST00000503434.5
    Conserved Domains (1) summary
    TIGR01013
    Location:104603
    2a58; Phosphate:Na+ Symporter (PNaS) Family
  3. NM_006424.3NP_006415.3  sodium-dependent phosphate transport protein 2B isoform a

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (a).
    Source sequence(s)
    AC092436
    Consensus CDS
    CCDS3435.1
    UniProtKB/Swiss-Prot
    A5PL17, O95436, Q8N2K2, Q8WYA9, Q9P0V7
    UniProtKB/TrEMBL
    A0A0B5E3E9
    Related
    ENSP00000371483.3, ENST00000382051.8
    Conserved Domains (1) summary
    TIGR01013
    Location:105604
    2a58; Phosphate:Na+ Symporter (PNaS) Family

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000004.12 Reference GRCh38.p14 Primary Assembly

    Range
    25655851..25678748
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060928.1 Alternate T2T-CHM13v2.0

    Range
    25637821..25660720
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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