FGL2 fibrinogen like 2 [Homo sapiens (human)] - Gene

Summary

Official Symbol: FGL2provided by HGNC
Official Full Name: fibrinogen like 2provided by HGNC
Primary source: HGNC:HGNC:3696
See related: Ensembl:ENSG00000127951 MIM:605351; AllianceGenome:HGNC:3696
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: T49; pT49
Summary: The protein encoded by this gene is a secreted protein that is similar to the beta- and gamma-chains of fibrinogen. The carboxyl-terminus of the encoded protein consists of the fibrinogen-related domains (FRED). The encoded protein forms a tetrameric complex which is stabilized by interchain disulfide bonds. This protein may play a role in physiologic functions at mucosal sites. [provided by RefSeq, Jul 2008]
Expression: Broad expression in spleen (RPKM 83.3), appendix (RPKM 61.0) and 22 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 7q11.23

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	7	NC_000007.14 (77193369..77199819, complement)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	7	NC_060931.1 (78444483..78450933, complement)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	7	NC_000007.13 (76822686..76829136, complement)

Chromosome 7 - NC_000007.14 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Presence and activity of Fibrinogen like protein 2 in platelets.
Title: Presence and activity of Fibrinogen like protein 2 in platelets.
A homozygous truncating mutation of FGL2 is associated with immune dysregulation.
Title: A homozygous truncating mutation of FGL2 is associated with immune dysregulation.
Assessment of Fibrinogen-like 2 (FGL2) in Human Chronic Kidney Disease through Transcriptomics Data Analysis.
Title: Assessment of Fibrinogen-like 2 (FGL2) in Human Chronic Kidney Disease through Transcriptomics Data Analysis.
Fibrinogen-like protein 2 in gastrointestinal stromal tumour.
Title: Fibrinogen-like protein 2 in gastrointestinal stromal tumour.
Soluble fibrinogenlike protein 2 levels are decreased in patients with ischemic heart failure and associated with cardiac function.
Title: Soluble fibrinogen‑like protein 2 levels are decreased in patients with ischemic heart failure and associated with cardiac function.
Predictive value of soluble fibrinogen-like protein 2 for survival in traumatic patients with sepsis.
Title: Predictive value of soluble fibrinogen-like protein 2 for survival in traumatic patients with sepsis.
Regulatory T cells induce polarization of pro-repair macrophages by secreting sFGL2 into the endometriotic milieu.
Title: Regulatory T cells induce polarization of pro-repair macrophages by secreting sFGL2 into the endometriotic milieu.
Dabigatran activates inflammation resolution by promoting fibrinogen-like protein 2 shedding and RvD5n-3 DPA production.
Title: Dabigatran activates inflammation resolution by promoting fibrinogen-like protein 2 shedding and RvD5(n-3 DPA) production.
Soluble fibrinogen-like protein 2 in condyloma acuminatum lesions.
Title: Soluble fibrinogen-like protein 2 in condyloma acuminatum lesions.
Identifying novel genetic variants for brain amyloid deposition: a genome-wide association study in the Korean population.
Title: Identifying novel genetic variants for brain amyloid deposition: a genome-wide association study in the Korean population.

Submit: New GeneRIF Correction See all GeneRIFs (49)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Protein interactions

Protein	Gene	Interaction	Pubs
Envelope transmembrane glycoprotein gp41	env	A synthetic peptide corresponding to the immunosuppressive domain (amino acids 574-592) of HIV-1 gp41 downregulates the expression of fibrinogen-like 2 (FGL2) in peptide-treated PBMCs	PubMed
Tat	tat	HIV-1 Tat downregulates the expression of fibrinogen-like 2 (FGL2) in human primary T cells	PubMed
Vif	vif	HIV-1 Vif downregulates the expression of fibrinogen-like 2 (FGL2) in Vif-expression T cells	PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

STS-Z36531 (e-PCR)
- UniSTS:18693

D7S2907 (e-PCR)
- UniSTS:21513

SGC34766 (e-PCR)
- UniSTS:65039

RH79020 (e-PCR)
- UniSTS:41747

D10S275 (e-PCR)
- UniSTS:147992

A009V32 (e-PCR)
- UniSTS:36178

STS-R61236 (e-PCR)
- UniSTS:49548

RH17500 (e-PCR)
- UniSTS:53449

G32885 (e-PCR)
- UniSTS:117464

STS-F04943 (e-PCR)
- UniSTS:36848

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables extracellular matrix structural constituent	RCA inferred from Reviewed Computational Analysis more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of defense response to virus	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of dendritic cell antigen processing and presentation	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of macrophage antigen processing and presentation	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of memory T cell differentiation	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in collagen-containing extracellular matrix	HDA more info	PubMed
is_active_in collagen-containing extracellular matrix	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular exosome	HDA more info	PubMed
located_in extracellular region	TAS Traceable Author Statement more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
part_of fibrinogen complex	TAS Traceable Author Statement more info	PubMed
located_in ficolin-1-rich granule lumen	TAS Traceable Author Statement more info

General protein information

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Preferred Names: fibroleukin

Names: fibrinogen-like protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_006682.3 → NP_006673.1 fibroleukin precursor

See identical proteins and their annotated locations for NP_006673.1

Status: REVIEWED

Source sequence(s)

AC007000, BC033820

Consensus CDS

CCDS5591.1

UniProtKB/Swiss-Prot

Q14314

UniProtKB/TrEMBL

A4D1B8, Q53GD2

Related

ENSP00000248598.5, ENST00000248598.6

Conserved Domains (2) summary

cl00085
Location:209 → 435

FReD; Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is involved in blood clotting, being activated by thrombin to assemble into fibrin clots. The N-termini of 2 times 3 chains come together to form a globular ...

cl27170
Location:28 → 161

DUF460; Protein of unknown function (DUF460)