ADCY3 adenylate cyclase 3 [Homo sapiens (human)] - Gene

Summary

Official Symbol: ADCY3provided by HGNC
Official Full Name: adenylate cyclase 3provided by HGNC
Primary source: HGNC:HGNC:234
See related: Ensembl:ENSG00000138031 MIM:600291; AllianceGenome:HGNC:234
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: AC3; AC-III; BMIQ19
Summary: This gene encodes adenylyl cyclase 3 which is a membrane-associated enzyme and catalyzes the formation of the secondary messenger cyclic adenosine monophosphate (cAMP). This protein appears to be widely expressed in various human tissues and may be involved in a number of physiological and pathophysiological metabolic processes. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2016]
Expression: Ubiquitous expression in placenta (RPKM 27.7), ovary (RPKM 14.8) and 23 other tissues See more
Orthologs: all
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Genomic context

Location:: 2p23.3

Exon count:: 28

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	2	NC_000002.12 (24819169..24920237, complement)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	2	NC_060926.1 (24853918..24954979, complement)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	2	NC_000002.11 (25042038..25143106, complement)

Chromosome 2 - NC_000002.12 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Postnatal Dynamic Ciliary ARL13B and ADCY3 Localization in the Mouse Brain.
Title: Postnatal Dynamic Ciliary ARL13B and ADCY3 Localization in the Mouse Brain.
Adenylate cyclase 3: a potential genetic link between obesity and major depressive disorder.
Title: Adenylate cyclase 3: a potential genetic link between obesity and major depressive disorder.
Molecular modelling of novel ADCY3 variant predicts a molecular target for tackling obesity.
Title: Molecular modelling of novel ADCY3 variant predicts a molecular target for tackling obesity.
ALDH2, ADCY3 and BCMO1 polymorphisms and lifestyle-induced traits are jointly associated with CAD risk in Chinese Han people.
Title: ALDH2, ADCY3 and BCMO1 polymorphisms and lifestyle-induced traits are jointly associated with CAD risk in Chinese Han people.
ADCY3 is an important mediator of energy homeostasis and an attractive pharmacological target in the treatment of obesity.
Title: Loss-of-function mutations in ADCY3 cause monogenic severe obesity.
An enrichment of rare ADCY3 loss-of-function variants among individuals with type 2 diabetes in trans-ancestry cohorts.
Title: Loss-of-function variants in ADCY3 increase risk of obesity and type 2 diabetes.
MC4R colocalizes with ADCY3 at the primary cilia of a subset of hypothalamic neurons; obesity-associated MC4R mutations impair ciliary localization and inhibition of adenylyl cyclase signaling at the primary cilia of these neurons increases body weight.
Title: Subcellular localization of MC4R with ADCY3 at neuronal primary cilia underlies a common pathway for genetic predisposition to obesity.
This study showed that subjects carrying the G allele of the rs10182181 polymorphism may benefit more in terms of weight loss and improvement of body composition measurements when undertaking a hypocaloric low-fat diet as compared to a moderately-high-protein diet.
Title: Interaction between an ADCY3 Genetic Variant and Two Weight-Lowering Diets Affecting Body Fatness and Body Composition Outcomes Depending on Macronutrient Distribution: A Randomized Trial.
In peripheral organs, AC3 is present mainly in primary cilia in cells of the mesenchymal lineage. In epithelia, the apical cilium of renal and pancreatic tubules and of ductal plate in liver is AC3-negative whereas the cilium of basal cells of stratified epithelia is AC3-positive. Using fibroblasts cell culture, we show that AC3 appears at the plasma membrane of the primary cilium as soon as this organelle develops.
Title: Adenylate Cyclase Type III Is Not a Ubiquitous Marker for All Primary Cilia during Development.
Similar results were obtained after sustained stimulation with NKH477 to directly activate adenylyl cyclase
Title: Sustained signalling by PTH modulates IP3 accumulation and IP3 receptors through cyclic AMP junctions.

Submit: New GeneRIF Correction See all GeneRIFs (25)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description	Tests
BODY MASS INDEX QUANTITATIVE TRAIT LOCUS 19 MedGen: C4693522 OMIM: 617885 GeneReviews: Not available	Compare labs

EBI GWAS Catalog

Description
A genome-wide meta-analysis of six type 1 diabetes cohorts identifies multiple associated loci. EBI GWAS Catalog EBI GWAS CatalogPubMed
A meta-analysis identifies new loci associated with body mass index in individuals of African ancestry. EBI GWAS Catalog EBI GWAS CatalogPubMed
Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index. EBI GWAS Catalog EBI GWAS CatalogPubMed
Genome-wide association and longitudinal analyses reveal genetic loci linking pubertal height growth, pubertal timing and childhood adiposity. EBI GWAS Catalog EBI GWAS CatalogPubMed
Genome-wide association study of body mass index in 23 000 individuals with and without asthma. EBI GWAS Catalog EBI GWAS CatalogPubMed
Genome-wide association study of height-adjusted BMI in childhood identifies functional variant in ADCY3. EBI GWAS Catalog EBI GWAS CatalogPubMed
Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture. EBI GWAS Catalog EBI GWAS CatalogPubMed
Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease. EBI GWAS Catalog EBI GWAS CatalogPubMed
Many sequence variants affecting diversity of adult human height. EBI GWAS Catalog EBI GWAS CatalogPubMed
Meta-analysis identifies common variants associated with body mass index in east Asians. EBI GWAS Catalog EBI GWAS CatalogPubMed
Meta-analysis of genome-wide association studies in East Asian-ancestry populations identifies four new loci for body mass index. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Protein interactions

Protein	Gene	Interaction	Pubs
Envelope surface glycoprotein gp120	env	The addition of HIV-1 gp120 with TNF-alpha to human B-cells stimulates cAMP production in a dose-dependent manner	PubMed
Envelope transmembrane glycoprotein gp41	env	Secretion of IL-10 is upregulated by HIV-1 gp41 in monocytes through activation of cAMP/adenylate cyclase and p70 (S6)-kinase; up-regulation of IL-10 is paralleled by an enhanced expression of the chemokine receptor CCR5	PubMed
Nef	nef	HIV-1 induces the upregulation of complement factor C3 in astrocytes and neurons through signaling pathways that involve protein kinase C and adenylate cyclase activation, which is an effect that may contribute to the pathogenesis of AIDS in the brain	PubMed
Tat	tat	HIV-1 Tat inhibits adenylyl cyclase activity in microglia and astrocyte cultures from neonatal rat brain, suggesting that Tat inhibition of cAMP synthesis may contribute to neuronal degeneration and cell death associated with HIV infection	PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

WI-11275 (e-PCR)
- UniSTS:43780

RH80427 (e-PCR)
- UniSTS:91217

ADCY3_2051 (e-PCR)
- UniSTS:280433

RH36332 (e-PCR)
- UniSTS:16523

UniSTS:496038 (e-PCR)
- UniSTS:496038

Adcy3 (e-PCR), detects polymorphism
- UniSTS:496038

D5S2617 (e-PCR)
- UniSTS:2730

SHGC-150739 (e-PCR)
- UniSTS:173498

G32338 (e-PCR)
- UniSTS:116930

D17S757 (e-PCR), detects polymorphism
- UniSTS:147150

A006F11 (e-PCR)
- UniSTS:74459

ADCY3_1034 (e-PCR)
- UniSTS:276974

ADCY3_V295 (e-PCR)
- UniSTS:276974

D2S2168 (e-PCR), detects polymorphism
- UniSTS:66557

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables adenylate cyclase activity	IBA Inferred from Biological aspect of Ancestor more info
enables adenylate cyclase activity	ISS Inferred from Sequence or Structural Similarity more info
enables calmodulin binding	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in acrosome reaction	ISS Inferred from Sequence or Structural Similarity more info
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in cAMP biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in cAMP biosynthetic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in cellular response to forskolin	ISS Inferred from Sequence or Structural Similarity more info
involved_in flagellated sperm motility	ISS Inferred from Sequence or Structural Similarity more info
involved_in intracellular signal transduction	IEA Inferred from Electronic Annotation more info
involved_in olfactory learning	ISS Inferred from Sequence or Structural Similarity more info
involved_in sensory perception of smell	ISS Inferred from Sequence or Structural Similarity more info
involved_in signal transduction	TAS Traceable Author Statement more info	PubMed
involved_in single fertilization	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in Golgi apparatus	ISS Inferred from Sequence or Structural Similarity more info
located_in ciliary membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in cilium	ISS Inferred from Sequence or Structural Similarity more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	HDA more info	PubMed
located_in membrane	ISS Inferred from Sequence or Structural Similarity more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	TAS Traceable Author Statement more info

General protein information

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Preferred Names: adenylate cyclase type 3

Names: ATP pyrophosphate-lyase 3; adenylate cyclase type III; adenylate cyclase, olfactive type; adenylyl cyclase 3; adenylyl cyclase, type III

NP_001307542.1

EC 4.6.1.1

NP_001364057.1

EC 4.6.1.1

NP_001364058.1

EC 4.6.1.1

NP_001364059.1

EC 4.6.1.1

NP_001364060.1

EC 4.6.1.1

NP_001364061.1

EC 4.6.1.1

NP_004027.2

EC 4.6.1.1

XP_006711988.1

EC 4.6.1.1

XP_011530791.1

EC 4.6.1.1

XP_011530792.1

EC 4.6.1.1

XP_011530793.1

EC 4.6.1.1

XP_011530794.1

EC 4.6.1.1

XP_011530795.1

EC 4.6.1.1

XP_011530796.1

EC 4.6.1.1

XP_016858676.1

EC 4.6.1.1

XP_016858677.1

EC 4.6.1.1

XP_016858678.1

EC 4.6.1.1

XP_016858680.1

EC 4.6.1.1

XP_047298961.1

EC 4.6.1.1

XP_047298962.1

EC 4.6.1.1

XP_047298963.1

EC 4.6.1.1

XP_047298964.1

EC 4.6.1.1

XP_047298965.1

EC 4.6.1.1

XP_047298966.1

EC 4.6.1.1

XP_047298967.1

EC 4.6.1.1

XP_047298968.1

EC 4.6.1.1

XP_047298969.1

EC 4.6.1.1

XP_047298970.1

EC 4.6.1.1

XP_047298971.1

EC 4.6.1.1

XP_047298972.1

EC 4.6.1.1

XP_054196202.1

EC 4.6.1.1

XP_054196203.1

EC 4.6.1.1

XP_054196204.1

EC 4.6.1.1

XP_054196205.1

EC 4.6.1.1

XP_054196206.1

EC 4.6.1.1

XP_054196207.1

EC 4.6.1.1

XP_054196208.1

EC 4.6.1.1

XP_054196209.1

EC 4.6.1.1

XP_054196210.1

EC 4.6.1.1

XP_054196211.1

EC 4.6.1.1

XP_054196212.1

EC 4.6.1.1

XP_054196213.1

EC 4.6.1.1

XP_054196214.1

EC 4.6.1.1

XP_054196215.1

EC 4.6.1.1

XP_054196216.1

EC 4.6.1.1

XP_054196217.1

EC 4.6.1.1

XP_054196218.1

EC 4.6.1.1

XP_054196219.1

EC 4.6.1.1

XP_054196220.1

EC 4.6.1.1

XP_054196221.1

EC 4.6.1.1

XP_054196222.1

EC 4.6.1.1

XP_054196223.1

EC 4.6.1.1

XP_054196224.1

EC 4.6.1.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001320613.2 → NP_001307542.1 adenylate cyclase type 3 isoform 1

Status: REVIEWED

Description

Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).

Source sequence(s)

AC012073, BC020148, BC126235, BC144119, BM148122, HY136273

Consensus CDS

CCDS82424.1

UniProtKB/TrEMBL

A0A0A0MSC1, B7ZLX9

Related

ENSP00000384484.2, ENST00000405392.6

Conserved Domains (3) summary

smart00044
Location:884 → 1102

CYCc; Adenylyl- / guanylyl cyclase, catalytic domain

pfam00211
Location:915 → 1122

Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain

pfam16214
Location:44 → 303

AC_N; Adenylyl cyclase N-terminal extracellular and transmembrane region
NM_001377128.1 → NP_001364057.1 adenylate cyclase type 3 isoform 3

Status: REVIEWED

Source sequence(s)

AC012073

UniProtKB/TrEMBL

B7ZLX9

Conserved Domains (2) summary

pfam00211
Location:936 → 1143

Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain

pfam16214
Location:44 → 303

AC_N; Adenylyl cyclase N-terminal extracellular and transmembrane region
NM_001377129.1 → NP_001364058.1 adenylate cyclase type 3 isoform 4

Status: REVIEWED

Source sequence(s)

AC012073

UniProtKB/TrEMBL

B3KNM3

Conserved Domains (2) summary

pfam00211
Location:868 → 1075

Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain

pfam16214
Location:44 → 303

AC_N; Adenylyl cyclase N-terminal extracellular and transmembrane region
NM_001377130.1 → NP_001364059.1 adenylate cyclase type 3 isoform 5

Status: REVIEWED

Source sequence(s)

AC012073

UniProtKB/TrEMBL

B3KNM3

Conserved Domains (3) summary

pfam00211
Location:310 → 494

Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain

pfam16214
Location:44 → 303

AC_N; Adenylyl cyclase N-terminal extracellular and transmembrane region

cl11967
Location:757 → 900

Nucleotidyl_cyc_III; Class III nucleotidyl cyclases
NM_001377131.1 → NP_001364060.1 adenylate cyclase type 3 isoform 6

Status: REVIEWED

Source sequence(s)

AC012073

UniProtKB/TrEMBL

U3KQ91

Related

ENSP00000475652.1, ENST00000606682.5

Conserved Domains (2) summary

pfam00211
Location:673 → 880

Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain

pfam16214
Location:2 → 62

AC_N; Adenylyl cyclase N-terminal extracellular and transmembrane region
NM_001377132.1 → NP_001364061.1 adenylate cyclase type 3 isoform 2

Status: REVIEWED

Source sequence(s)

AC012073

Consensus CDS

CCDS1715.1

UniProtKB/Swiss-Prot

B3KT86, O60266, Q53T54, Q9UDB1

UniProtKB/TrEMBL

B7ZLX9

Related

ENSP00000260600.5, ENST00000260600.9

Conserved Domains (2) summary

pfam00211
Location:914 → 1121

Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain

pfam16214
Location:44 → 303

AC_N; Adenylyl cyclase N-terminal extracellular and transmembrane region
NM_004036.5 → NP_004027.2 adenylate cyclase type 3 isoform 2

See identical proteins and their annotated locations for NP_004027.2

Status: REVIEWED

Description

Transcript Variant: This variant (2) uses an alternate in-frame splice junction compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is 1 aa shorter compared to isoform 1.

Source sequence(s)

AC012073, BC020148, BC126235, BM148122, HY136273

Consensus CDS

CCDS1715.1

UniProtKB/Swiss-Prot

B3KT86, O60266, Q53T54, Q9UDB1

UniProtKB/TrEMBL

B7ZLX9

Related

ENSP00000505261.1, ENST00000679454.1

Conserved Domains (2) summary

pfam00211
Location:914 → 1121

Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain

pfam16214
Location:44 → 303

AC_N; Adenylyl cyclase N-terminal extracellular and transmembrane region

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000002.12 Reference GRCh38.p14 Primary Assembly

Range

24819169..24920237 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_047443014.1 → XP_047298970.1 adenylate cyclase type 3 isoform X20
XM_047443012.1 → XP_047298968.1 adenylate cyclase type 3 isoform X18
XM_047443009.1 → XP_047298965.1 adenylate cyclase type 3 isoform X15
XM_047443010.1 → XP_047298966.1 adenylate cyclase type 3 isoform X16
XM_047443008.1 → XP_047298964.1 adenylate cyclase type 3 isoform X14
XM_017003187.2 → XP_016858676.1 adenylate cyclase type 3 isoform X5

UniProtKB/TrEMBL

B7ZLX9
XM_011532491.2 → XP_011530793.1 adenylate cyclase type 3 isoform X4

UniProtKB/TrEMBL

B7ZLX9

Conserved Domains (3) summary

smart00044
Location:903 → 1121

CYCc; Adenylyl- / guanylyl cyclase, catalytic domain

pfam00211
Location:934 → 1141

Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain

pfam16214
Location:44 → 303

AC_N; Adenylyl cyclase N-terminal extracellular and transmembrane region
XM_011532494.2 → XP_011530796.1 adenylate cyclase type 3 isoform X13

UniProtKB/TrEMBL

B3KNM3

Conserved Domains (3) summary

smart00044
Location:859 → 1077

CYCc; Adenylyl- / guanylyl cyclase, catalytic domain

pfam00211
Location:890 → 1097

Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain

pfam16214
Location:44 → 303

AC_N; Adenylyl cyclase N-terminal extracellular and transmembrane region
XM_047443013.1 → XP_047298969.1 adenylate cyclase type 3 isoform X19
XM_047443007.1 → XP_047298963.1 adenylate cyclase type 3 isoform X12
XM_006711925.2 → XP_006711988.1 adenylate cyclase type 3 isoform X3

UniProtKB/TrEMBL

B7ZLX9

Conserved Domains (3) summary

smart00044
Location:906 → 1124

CYCc; Adenylyl- / guanylyl cyclase, catalytic domain

pfam00211
Location:937 → 1144

Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain

pfam16214
Location:44 → 303

AC_N; Adenylyl cyclase N-terminal extracellular and transmembrane region
XM_047443006.1 → XP_047298962.1 adenylate cyclase type 3 isoform X11
XM_017003189.2 → XP_016858678.1 adenylate cyclase type 3 isoform X10

UniProtKB/TrEMBL

B3KNM3
XM_047443011.1 → XP_047298967.1 adenylate cyclase type 3 isoform X17
XM_011532493.2 → XP_011530795.1 adenylate cyclase type 3 isoform X9

UniProtKB/TrEMBL

B3KNM3

Conserved Domains (3) summary

smart00044
Location:879 → 1097

CYCc; Adenylyl- / guanylyl cyclase, catalytic domain

pfam00211
Location:910 → 1117

Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain

pfam16214
Location:44 → 303

AC_N; Adenylyl cyclase N-terminal extracellular and transmembrane region
XM_011532490.2 → XP_011530792.1 adenylate cyclase type 3 isoform X2

UniProtKB/TrEMBL

B7ZLX9

Conserved Domains (3) summary

smart00044
Location:924 → 1142

CYCc; Adenylyl- / guanylyl cyclase, catalytic domain

pfam00211
Location:955 → 1162

Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain

pfam16214
Location:44 → 303

AC_N; Adenylyl cyclase N-terminal extracellular and transmembrane region
XM_017003188.2 → XP_016858677.1 adenylate cyclase type 3 isoform X7

UniProtKB/TrEMBL

B7ZLX9
XM_011532489.2 → XP_011530791.1 adenylate cyclase type 3 isoform X1

UniProtKB/TrEMBL

B7ZLX9

Conserved Domains (3) summary

smart00044
Location:925 → 1143

CYCc; Adenylyl- / guanylyl cyclase, catalytic domain

pfam00211
Location:956 → 1163

Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain

pfam16214
Location:44 → 303

AC_N; Adenylyl cyclase N-terminal extracellular and transmembrane region
XM_011532492.3 → XP_011530794.1 adenylate cyclase type 3 isoform X6

UniProtKB/TrEMBL

B7ZLX9

Conserved Domains (3) summary

smart00044
Location:925 → 1126

CYCc; Adenylyl- / guanylyl cyclase, catalytic domain

pfam00211
Location:310 → 516

Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain

pfam16214
Location:44 → 303

AC_N; Adenylyl cyclase N-terminal extracellular and transmembrane region
XM_047443005.1 → XP_047298961.1 adenylate cyclase type 3 isoform X8
XM_047443016.1 → XP_047298972.1 adenylate cyclase type 3 isoform X23
XM_017003191.1 → XP_016858680.1 adenylate cyclase type 3 isoform X21

UniProtKB/TrEMBL

U3KQ91
XM_047443015.1 → XP_047298971.1 adenylate cyclase type 3 isoform X22