RAPGEF4 Rap guanine nucleotide exchange factor 4 [Homo sapiens (human)] - Gene

Summary

Official Symbol: RAPGEF4provided by HGNC
Official Full Name: Rap guanine nucleotide exchange factor 4provided by HGNC
Primary source: HGNC:HGNC:16626
See related: Ensembl:ENSG00000091428 MIM:606058; AllianceGenome:HGNC:16626
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: EPAC; CGEF2; EPAC2; EPAC 2; Nbla00496; CAMP-GEFII
Summary: Enables guanyl-nucleotide exchange factor activity. Predicted to be involved in regulation of neurotransmitter receptor localization to postsynaptic specialization membrane and regulation of postsynapse organization. Predicted to act upstream of or within adenylate cyclase-activating G protein-coupled receptor signaling pathway; regulation of exocytosis; and secretion by cell. Predicted to be located in plasma membrane. Predicted to be active in glutamatergic synapse; hippocampal mossy fiber to CA3 synapse; and postsynaptic density. Implicated in autistic disorder. [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in brain (RPKM 37.0), adrenal (RPKM 17.3) and 12 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 2q31.1

Exon count:: 37

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	2	NC_000002.12 (172735318..173052893)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	2	NC_060926.1 (173221758..173539439)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	2	NC_000002.11 (173600573..173917621)

Chromosome 2 - NC_000002.12 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

EPAC Regulates Melanoma Growth by Stimulating mTORC1 Signaling and Loss of EPAC Signaling Dependence Correlates with Melanoma Progression.
Title: EPAC Regulates Melanoma Growth by Stimulating mTORC1 Signaling and Loss of EPAC Signaling Dependence Correlates with Melanoma Progression.
Pancreatic cancer-derived exosomal microRNA-19a induces beta-cell dysfunction by targeting ADCY1 and EPAC2.
Title: Pancreatic cancer-derived exosomal microRNA-19a induces β-cell dysfunction by targeting ADCY1 and EPAC2.
Origin and Isoform Specific Functions of Exchange Proteins Directly Activated by cAMP: A Phylogenetic Analysis.
Title: Origin and Isoform Specific Functions of Exchange Proteins Directly Activated by cAMP: A Phylogenetic Analysis.
Epac: new emerging cAMP-binding protein.
Title: Epac: new emerging cAMP-binding protein.
Broad Impact of Exchange Protein Directly Activated by cAMP 2 (EPAC2) on Respiratory Viral Infections.
Title: Broad Impact of Exchange Protein Directly Activated by cAMP 2 (EPAC2) on Respiratory Viral Infections.
The Epac2 coding gene (RAPGEF4) rs3769219 polymorphism is associated with protection against major depressive disorder in the Chinese Han population.
Title: The Epac2 coding gene (RAPGEF4) rs3769219 polymorphism is associated with protection against major depressive disorder in the Chinese Han population.
The authors conclude that Epac2/cAMP controls fusion pore expansion and thus the balance of hormone and transmitter release during insulin granule exocytosis.
Title: Fusion pore regulation by cAMP/Epac2 controls cargo release during insulin exocytosis.
Through isoform-specific gene knockdown, the authors found that EPAC2, but not EPAC1, plays a dominant role in controlling RSV replication and virus-induced host responses.
Title: Exchange Proteins Directly Activated by cAMP and Their Roles in Respiratory Syncytial Virus Infection.
Cyclic AMP (cAMP), a secondary messenger responsible for various physiological processes regulates cell metabolism by activating Protein kinase A (PKA) and by targeting exchange protein directly activated by cAMP (EPAC). EPAC is present in two isoforms EPAC1 and EPAC2, which exhibit different tissue distribution and is involved in GDP/GTP exchange along with activating Rap1- and Rap2-mediated signaling pathways.
Title: Insights into exchange factor directly activated by cAMP (EPAC) as potential target for cancer treatment.
Study identifies Epac2-Rap1 signaling as a novel feedback mechanism in the heart, which controls mitochondrial reactive oxygen species production.
Title: Epac2-Rap1 Signaling Regulates Reactive Oxygen Species Production and Susceptibility to Cardiac Arrhythmias.

Submit: New GeneRIF Correction See all GeneRIFs (34)

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Genome-wide association meta-analysis identifies novel variants associated with fasting plasma glucose in East Asians. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Protein interactions

Protein	Gene	Interaction	Pubs
capsid	gag	Prostaglandin E2-mediated HIV-1 inhibition requires the EPAC/RAP/RhoA signaling pathway by downregulation of HIV-1 CA production	PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

WI-15265 (e-PCR)
- UniSTS:25858

SHGC-148065 (e-PCR)
- UniSTS:176174

SHGC-86333 (e-PCR)
- UniSTS:104057

SHGC-13676 (e-PCR)
- UniSTS:30330

SHGC-84070 (e-PCR)
- UniSTS:104656

Rapgef4 (e-PCR), detects polymorphism
- UniSTS:507860

RH118446 (e-PCR)
- UniSTS:109273

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables cAMP binding	ISS Inferred from Sequence or Structural Similarity more info
enables guanyl-nucleotide exchange factor activity	EXP Inferred from Experiment more info	PubMed
enables guanyl-nucleotide exchange factor activity	IBA Inferred from Biological aspect of Ancestor more info
enables guanyl-nucleotide exchange factor activity	ISS Inferred from Sequence or Structural Similarity more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein-macromolecule adaptor activity	IEA Inferred from Electronic Annotation more info
enables small GTPase binding	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor signaling pathway	TAS Traceable Author Statement more info	PubMed
involved_in Ras protein signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in adaptive immune response	TAS Traceable Author Statement more info
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in calcium-ion regulated exocytosis	IEA Inferred from Electronic Annotation more info
involved_in insulin secretion	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of insulin secretion	IEA Inferred from Electronic Annotation more info
involved_in regulation of exocytosis	IEA Inferred from Electronic Annotation more info
involved_in regulation of synaptic vesicle cycle	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in hippocampal mossy fiber to CA3 synapse	IEA Inferred from Electronic Annotation more info
located_in membrane	TAS Traceable Author Statement more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	TAS Traceable Author Statement more info

General protein information

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Preferred Names: rap guanine nucleotide exchange factor 4

Names: RAP guanine-nucleotide-exchange factor (GEF) 4; Rap guanine nucleotide exchange factor (GEF) 4; cAMP-regulated guanine nucleotide exchange factor II; exchange factor directly activated by cAMP 2; exchange protein directly activated by cAMP 2; putative protein product of Nbla00496

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001100397.2 → NP_001093867.1 rap guanine nucleotide exchange factor 4 isoform b

See identical proteins and their annotated locations for NP_001093867.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in its 5' UTR, lacks several exons in the 5' coding region, and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (b) has a distinct N-terminus and is shorter than isoform a.

Source sequence(s)

AC009484, AC019046, AC104086

Consensus CDS

CCDS42776.1

UniProtKB/TrEMBL

B7Z9P9

Related

ENSP00000380276.3, ENST00000397087.7

Conserved Domains (4) summary

smart00147
Location:624 → 865

RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases

cd00038
Location:212 → 323

CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...

cd04437
Location:62 → 190

DEP_Epac; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in Epac-like proteins. Epac (exchange proteins directly activated by cAMP) proteins are GEFs (guanine-nucleotide-exchange factors) for the small GTPases, Rap1 and Rap2. They are directly regulated by ...

pfam00618
Location:355 → 461

RasGEF_N; RasGEF N-terminal motif
NM_001282899.2 → NP_001269828.1 rap guanine nucleotide exchange factor 4 isoform c

See identical proteins and their annotated locations for NP_001269828.1

Status: VALIDATED

Description

Transcript Variant: This variant (3) differs in its 5' UTR, lacks several exons in the 5' coding region, and initiates translation at a downstream in-frame start codon, compared to variant 1. The encoded isoform (c) is shorter at the N-terminus, compared to isoform a.

Source sequence(s)

AC009484, AC019046, AC104086

Consensus CDS

CCDS63060.1

UniProtKB/TrEMBL

B7Z9P9

Related

ENSP00000440250.1, ENST00000540783.5

Conserved Domains (4) summary

smart00147
Location:615 → 856

RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases

cd00038
Location:203 → 314

CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...

cd04437
Location:53 → 181

DEP_Epac; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in Epac-like proteins. Epac (exchange proteins directly activated by cAMP) proteins are GEFs (guanine-nucleotide-exchange factors) for the small GTPases, Rap1 and Rap2. They are directly regulated by ...

pfam00618
Location:346 → 452

RasGEF_N; RasGEF N-terminal motif
NM_001282900.2 → NP_001269829.1 rap guanine nucleotide exchange factor 4 isoform d

See identical proteins and their annotated locations for NP_001269829.1

Status: VALIDATED

Description

Transcript Variant: This variant (4) differs in its 5' UTR, lacks several exons in the 5' coding region, initiates translation at a downstream in-frame start codon, and lacks an additional in-frame exon in the 5' coding region, compared to variant 1. The encoded isoform (d) is shorter at the N-terminus, compared to isoform a.

Source sequence(s)

AC009484, AC019046, AC104086

Consensus CDS

CCDS63061.1

UniProtKB/TrEMBL

B7Z9P9

Related

ENSP00000440135.1, ENST00000538974.5

Conserved Domains (4) summary

smart00147
Location:597 → 838

RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases

cd00038
Location:185 → 296

CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...

cd04437
Location:35 → 163

DEP_Epac; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in Epac-like proteins. Epac (exchange proteins directly activated by cAMP) proteins are GEFs (guanine-nucleotide-exchange factors) for the small GTPases, Rap1 and Rap2. They are directly regulated by ...

pfam00618
Location:328 → 434

RasGEF_N; RasGEF N-terminal motif
NM_001282901.2 → NP_001269830.1 rap guanine nucleotide exchange factor 4 isoform e

See identical proteins and their annotated locations for NP_001269830.1

Status: VALIDATED

Description

Transcript Variant: This variant (5) differs in its 5' UTR, lacks several exons in the 5' coding region, and initiates translation at a downstream in-frame start codon, compared to variant 1. The encoded isoform (e) is shorter at the N-terminus, compared to isoform a.

Source sequence(s)

AC009484, AC019046, AC104086

Consensus CDS

CCDS74604.1

UniProtKB/TrEMBL

B7Z278, B7Z9P9

Related

ENSP00000438011.1, ENST00000535187.5

Conserved Domains (4) summary

smart00147
Location:548 → 789

RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases

cd00038
Location:136 → 247

CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...

cd04437
Location:1 → 114

DEP_Epac; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in Epac-like proteins. Epac (exchange proteins directly activated by cAMP) proteins are GEFs (guanine-nucleotide-exchange factors) for the small GTPases, Rap1 and Rap2. They are directly regulated by ...

pfam00618
Location:279 → 385

RasGEF_N; RasGEF N-terminal motif
NM_001375864.1 → NP_001362793.1 rap guanine nucleotide exchange factor 4 isoform f

Status: VALIDATED

Source sequence(s)

AC009484, AC018712, AC019046, AC104086

UniProtKB/TrEMBL

X5D9F4

Conserved Domains (4) summary

cd06224
Location:494 → 619

REM; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal domain (RasGef_N), also called REM domain (Ras exchanger motif). This domain is common in nucleotide exchange factors for Ras-like small GTPases and is typically found immediately ...

smart00147
Location:758 → 999

RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases

cd00038
Location:33 → 148

CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...

cd04437
Location:196 → 324

DEP_Epac; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in Epac-like proteins. Epac (exchange proteins directly activated by cAMP) proteins are GEFs (guanine-nucleotide-exchange factors) for the small GTPases, Rap1 and Rap2. They are directly regulated by ...
NM_001375865.1 → NP_001362794.1 rap guanine nucleotide exchange factor 4 isoform g

Status: VALIDATED

Source sequence(s)

AC009484, AC018712, AC019046, AC104086

UniProtKB/TrEMBL

X5D9F4

Conserved Domains (4) summary

smart00147
Location:757 → 998

RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases

cd00038
Location:43 → 158

CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...

cd04437
Location:206 → 334

DEP_Epac; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in Epac-like proteins. Epac (exchange proteins directly activated by cAMP) proteins are GEFs (guanine-nucleotide-exchange factors) for the small GTPases, Rap1 and Rap2. They are directly regulated by ...

pfam00618
Location:499 → 605

RasGEF_N; RasGEF N-terminal motif
NM_001375866.1 → NP_001362795.1 rap guanine nucleotide exchange factor 4 isoform h

Status: VALIDATED

Source sequence(s)

AC009484, AC018712, AC019046, AC104086

UniProtKB/TrEMBL

X5D7N4, X5D9F4

Conserved Domains (4) summary

smart00147
Location:750 → 991

RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases

cd00038
Location:43 → 158

CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...

cd04437
Location:188 → 316

DEP_Epac; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in Epac-like proteins. Epac (exchange proteins directly activated by cAMP) proteins are GEFs (guanine-nucleotide-exchange factors) for the small GTPases, Rap1 and Rap2. They are directly regulated by ...

pfam00618
Location:481 → 587

RasGEF_N; RasGEF N-terminal motif
NM_001375867.1 → NP_001362796.1 rap guanine nucleotide exchange factor 4 isoform i

Status: VALIDATED

Source sequence(s)

AC009484, AC018712, AC019046, AC104086

UniProtKB/TrEMBL

X5D9F4

Conserved Domains (4) summary

smart00147
Location:737 → 978

RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases

cd00038
Location:325 → 436

CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...

cd04437
Location:175 → 303

DEP_Epac; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in Epac-like proteins. Epac (exchange proteins directly activated by cAMP) proteins are GEFs (guanine-nucleotide-exchange factors) for the small GTPases, Rap1 and Rap2. They are directly regulated by ...

pfam00618
Location:468 → 574

RasGEF_N; RasGEF N-terminal motif
NM_001375868.1 → NP_001362797.1 rap guanine nucleotide exchange factor 4 isoform j

Status: VALIDATED

Source sequence(s)

AC009484, AC018712, AC019046, AC104086

UniProtKB/TrEMBL

X5D9F4

Conserved Domains (4) summary

smart00147
Location:719 → 960

RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases

cd00038
Location:43 → 158

CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...

cd04437
Location:206 → 334

DEP_Epac; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in Epac-like proteins. Epac (exchange proteins directly activated by cAMP) proteins are GEFs (guanine-nucleotide-exchange factors) for the small GTPases, Rap1 and Rap2. They are directly regulated by ...

pfam00618
Location:499 → 605

RasGEF_N; RasGEF N-terminal motif
NM_001375869.1 → NP_001362798.1 rap guanine nucleotide exchange factor 4 isoform k

Status: VALIDATED

Source sequence(s)

AC009484, AC018712, AC019046, AC104086

UniProtKB/TrEMBL

X5D9F4

Conserved Domains (4) summary

smart00147
Location:768 → 958

RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases

cd00038
Location:43 → 158

CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...

cd04437
Location:206 → 334

DEP_Epac; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in Epac-like proteins. Epac (exchange proteins directly activated by cAMP) proteins are GEFs (guanine-nucleotide-exchange factors) for the small GTPases, Rap1 and Rap2. They are directly regulated by ...

pfam00618
Location:499 → 605

RasGEF_N; RasGEF N-terminal motif
NM_001375870.1 → NP_001362799.1 rap guanine nucleotide exchange factor 4 isoform l

Status: VALIDATED

Source sequence(s)

AC009484, AC018712, AC019046, AC104086

UniProtKB/TrEMBL

X5D9F4

Conserved Domains (4) summary

smart00147
Location:768 → 929

RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases

cd00038
Location:43 → 158

CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...

cd04437
Location:206 → 334

DEP_Epac; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in Epac-like proteins. Epac (exchange proteins directly activated by cAMP) proteins are GEFs (guanine-nucleotide-exchange factors) for the small GTPases, Rap1 and Rap2. They are directly regulated by ...

pfam00618
Location:499 → 605

RasGEF_N; RasGEF N-terminal motif
NM_001375871.1 → NP_001362800.1 rap guanine nucleotide exchange factor 4 isoform m

Status: VALIDATED

Source sequence(s)

AC009484, AC018712, AC019046, AC104086

UniProtKB/TrEMBL

X5D9F4

Conserved Domains (4) summary

smart00147
Location:701 → 942

RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases

cd00038
Location:43 → 158

CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...

cd04437
Location:188 → 316

DEP_Epac; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in Epac-like proteins. Epac (exchange proteins directly activated by cAMP) proteins are GEFs (guanine-nucleotide-exchange factors) for the small GTPases, Rap1 and Rap2. They are directly regulated by ...

pfam00618
Location:481 → 587

RasGEF_N; RasGEF N-terminal motif
NM_001375872.1 → NP_001362801.1 rap guanine nucleotide exchange factor 4 isoform n

Status: VALIDATED

Source sequence(s)

AC009484, AC018712, AC019046, AC104086

Consensus CDS

CCDS92899.1

UniProtKB/TrEMBL

E9PB94, X5D9F4

Related

ENSP00000387104.1, ENST00000409036.5

Conserved Domains (4) summary

smart00147
Location:768 → 941

RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases

cd00038
Location:43 → 158

CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...

cd04437
Location:206 → 334

DEP_Epac; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in Epac-like proteins. Epac (exchange proteins directly activated by cAMP) proteins are GEFs (guanine-nucleotide-exchange factors) for the small GTPases, Rap1 and Rap2. They are directly regulated by ...

pfam00618
Location:499 → 605

RasGEF_N; RasGEF N-terminal motif
NM_001375873.1 → NP_001362802.1 rap guanine nucleotide exchange factor 4 isoform o

Status: VALIDATED

Source sequence(s)

AC009484, AC018712, AC019046, AC104086

UniProtKB/TrEMBL

X5D9F4

Conserved Domains (4) summary

smart00147
Location:750 → 940

RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases

cd00038
Location:43 → 158

CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...

cd04437
Location:188 → 316

DEP_Epac; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in Epac-like proteins. Epac (exchange proteins directly activated by cAMP) proteins are GEFs (guanine-nucleotide-exchange factors) for the small GTPases, Rap1 and Rap2. They are directly regulated by ...

pfam00618
Location:481 → 587

RasGEF_N; RasGEF N-terminal motif
NM_001375874.1 → NP_001362803.1 rap guanine nucleotide exchange factor 4 isoform p

Status: VALIDATED

Source sequence(s)

AC009484, AC018712, AC019046, AC104086

UniProtKB/TrEMBL

X5D9F4

Conserved Domains (4) summary

smart00147
Location:750 → 911

RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases

cd00038
Location:43 → 158

CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...

cd04437
Location:188 → 316

DEP_Epac; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in Epac-like proteins. Epac (exchange proteins directly activated by cAMP) proteins are GEFs (guanine-nucleotide-exchange factors) for the small GTPases, Rap1 and Rap2. They are directly regulated by ...

pfam00618
Location:481 → 587

RasGEF_N; RasGEF N-terminal motif
NM_001375875.1 → NP_001362804.1 rap guanine nucleotide exchange factor 4 isoform q

Status: VALIDATED

Source sequence(s)

AC009484, AC018712, AC104086

UniProtKB/TrEMBL

B7Z2Q8

Conserved Domains (2) summary

cd00038
Location:43 → 158

CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...

cd04437
Location:206 → 334

DEP_Epac; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in Epac-like proteins. Epac (exchange proteins directly activated by cAMP) proteins are GEFs (guanine-nucleotide-exchange factors) for the small GTPases, Rap1 and Rap2. They are directly regulated by ...
NM_001375876.1 → NP_001362805.1 rap guanine nucleotide exchange factor 4 isoform r

Status: VALIDATED

Source sequence(s)

AC009484, AC018712, AC104086

Conserved Domains (2) summary

cd00038
Location:43 → 158

CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...

cd04437
Location:188 → 316

DEP_Epac; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in Epac-like proteins. Epac (exchange proteins directly activated by cAMP) proteins are GEFs (guanine-nucleotide-exchange factors) for the small GTPases, Rap1 and Rap2. They are directly regulated by ...
NM_007023.4 → NP_008954.2 rap guanine nucleotide exchange factor 4 isoform a

See identical proteins and their annotated locations for NP_008954.2

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a).

Source sequence(s)

AC009484, AC018712, AC019046, AC104086

Consensus CDS

CCDS42775.1

UniProtKB/Swiss-Prot

B2R7R3, B7Z283, B7Z3T6, B7Z912, O95636, Q8IXK6, Q8TAA4, Q8WZA2

UniProtKB/TrEMBL

X5D9F4

Related

ENSP00000380271.3, ENST00000397081.8

Conserved Domains (4) summary

smart00147
Location:768 → 1009

RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases

cd00038
Location:43 → 158

CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...

cd04437
Location:206 → 334

DEP_Epac; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in Epac-like proteins. Epac (exchange proteins directly activated by cAMP) proteins are GEFs (guanine-nucleotide-exchange factors) for the small GTPases, Rap1 and Rap2. They are directly regulated by ...

pfam00618
Location:499 → 605

RasGEF_N; RasGEF N-terminal motif

RNA

NR_164739.1 RNA Sequence

Status: VALIDATED

Source sequence(s)

AC009484, AC018712, AC019046, AC104086
NR_164740.1 RNA Sequence

Status: VALIDATED

Source sequence(s)

AC009484, AC018712, AC019046, AC104086
NR_164741.1 RNA Sequence

Status: VALIDATED

Source sequence(s)

AC009484, AC018712, AC019046, AC104086

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000002.12 Reference GRCh38.p14 Primary Assembly

Range

172735318..173052893

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_047443030.1 → XP_047298986.1 rap guanine nucleotide exchange factor 4 isoform X4
XM_006712205.4 → XP_006712268.1 rap guanine nucleotide exchange factor 4 isoform X6

See identical proteins and their annotated locations for XP_006712268.1

UniProtKB/TrEMBL

B7Z9P9

Conserved Domains (4) summary

smart00147
Location:597 → 838

RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases

cd00038
Location:185 → 296

CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...

cd04437
Location:35 → 163

DEP_Epac; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in Epac-like proteins. Epac (exchange proteins directly activated by cAMP) proteins are GEFs (guanine-nucleotide-exchange factors) for the small GTPases, Rap1 and Rap2. They are directly regulated by ...

pfam00618
Location:328 → 434

RasGEF_N; RasGEF N-terminal motif
XM_017003196.3 → XP_016858685.1 rap guanine nucleotide exchange factor 4 isoform X1

UniProtKB/TrEMBL

X5D9F4
XM_047443028.1 → XP_047298984.1 rap guanine nucleotide exchange factor 4 isoform X2
XM_017003197.2 → XP_016858686.1 rap guanine nucleotide exchange factor 4 isoform X5

UniProtKB/TrEMBL

B7Z9P9
XM_047443029.1 → XP_047298985.1 rap guanine nucleotide exchange factor 4 isoform X3
XM_047443032.1 → XP_047298988.1 rap guanine nucleotide exchange factor 4 isoform X8
XM_047443033.1 → XP_047298989.1 rap guanine nucleotide exchange factor 4 isoform X9

UniProtKB/TrEMBL

B7Z278
XM_047443031.1 → XP_047298987.1 rap guanine nucleotide exchange factor 4 isoform X7

Alternate T2T-CHM13v2.0

Genomic

NC_060926.1 Alternate T2T-CHM13v2.0

Range

173221758..173539439

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_054340254.1 → XP_054196229.1 rap guanine nucleotide exchange factor 4 isoform X4
XM_054340256.1 → XP_054196231.1 rap guanine nucleotide exchange factor 4 isoform X6
XM_054340251.1 → XP_054196226.1 rap guanine nucleotide exchange factor 4 isoform X1
XM_054340252.1 → XP_054196227.1 rap guanine nucleotide exchange factor 4 isoform X2
XM_054340255.1 → XP_054196230.1 rap guanine nucleotide exchange factor 4 isoform X5
XM_054340253.1 → XP_054196228.1 rap guanine nucleotide exchange factor 4 isoform X3
XM_054340258.1 → XP_054196233.1 rap guanine nucleotide exchange factor 4 isoform X8
XM_054340257.1 → XP_054196232.1 rap guanine nucleotide exchange factor 4 isoform X7
XM_054340259.1 → XP_054196234.1 rap guanine nucleotide exchange factor 4 isoform X9

UniProtKB/TrEMBL

B7Z278