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RASSF1 Ras association domain family member 1 [ Homo sapiens (human) ]

Gene ID: 11186, updated on 5-Mar-2024

Summary

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Official Symbol
RASSF1provided by HGNC
Official Full Name
Ras association domain family member 1provided by HGNC
Primary source
HGNC:HGNC:9882
See related
Ensembl:ENSG00000068028 MIM:605082; AllianceGenome:HGNC:9882
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
123F2; RDA32; NORE2A; RASSF1A; REH3P21
Summary
This gene encodes a protein similar to the RAS effector proteins. Loss or altered expression of this gene has been associated with the pathogenesis of a variety of cancers, which suggests the tumor suppressor function of this gene. The inactivation of this gene was found to be correlated with the hypermethylation of its CpG-island promoter region. The encoded protein was found to interact with DNA repair protein XPA. The protein was also shown to inhibit the accumulation of cyclin D1, and thus induce cell cycle arrest. Several alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq, May 2011]
Expression
Ubiquitous expression in bone marrow (RPKM 19.8), spleen (RPKM 15.6) and 25 other tissues See more
Orthologs
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Genomic context

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See RASSF1 in Genome Data Viewer
Location:
3p21.31
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (50329788..50340836, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (50359511..50370560, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (50367219..50378267, complement)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:50357211-50357884 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14391 Neighboring gene hyaluronidase 2 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19900 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:50359913-50360586 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:50361369-50361870 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14392 Neighboring gene tumor suppressor 2, mitochondrial calcium regulator Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19901 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14393 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14394 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:50374977-50375548 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19903 Neighboring gene RASSF1 antisense RNA 1 Neighboring gene H3K27ac-H3K4me1 hESC enhancers GRCh37_chr3:50377372-50378195 and GRCh37_chr3:50378196-50379018 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:50380164-50380746 Neighboring gene zinc finger MYND-type containing 10 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:50382474-50383024 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:50383025-50383575 Neighboring gene NPR2 like, GATOR1 complex subunit

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. RASSF1A inhibits epithelial-mesenchymal transition of gastric cancer cells by downregulating P-JNK. Bin Y, et al. Cell Biol Int, 2023 Mar. PMID 36404583
  2. RASSF1A disrupts the NOTCH signaling axis via SNURF/RNF4-mediated ubiquitination of HES1. Papaspyropoulos A, et al. EMBO Rep, 2022 Feb 3. PMID 34897944, Free PMC Article
  3. RAS-association domain family 1A regulates the abnormal cell proliferation in psoriasis via inhibition of Yes-associated protein. Jia J, et al. J Cell Mol Med, 2021 Jun. PMID 33960627, Free PMC Article
  4. Impact of RASSF1A gene methylation on clinico-pathological features of tumor and non-tumor tissue of breast cancer. Gupta V, et al. Ann Diagn Pathol, 2021 Jun. PMID 33621744
  5. Epigenetically inactivated RASSF1A as a tumor biomarker. Raos D, et al. Bosn J Basic Med Sci, 2021 Aug 1. PMID 33175673, Free PMC Article

See all (509) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Expression of RASSF1A, DIRAS3, and AKAP9 Genes in Thyroid Lesions: Implications for Differential Diagnosis and Prognosis of Thyroid Carcinomas.
    Title: Expression of RASSF1A, DIRAS3, and AKAP9 Genes in Thyroid Lesions: Implications for Differential Diagnosis and Prognosis of Thyroid Carcinomas.
  2. RASSF1A promotes ATM signaling and RASSF1A methylation is a synthetic lethal marker for ATR inhibitors.
    Title: RASSF1A promotes ATM signaling and RASSF1A methylation is a synthetic lethal marker for ATR inhibitors.
  3. SEPT9, H4C6, and RASSF1A methylation in nasopharyngeal swabs: A reflection of potential minimally invasive biomarkers for early screening of nasopharyngeal cancer.
    Title: SEPT9, H4C6, and RASSF1A methylation in nasopharyngeal swabs: A reflection of potential minimally invasive biomarkers for early screening of nasopharyngeal cancer.
  4. WDR3 promotes stem cell-like properties in prostate cancer by inhibiting USF2-mediated transcription of RASSF1A.
    Title: WDR3 promotes stem cell-like properties in prostate cancer by inhibiting USF2-mediated transcription of RASSF1A.
  5. Promoter methylation levels of RASSF1 and ATIC genes are associated with lung cancer in Iranian patients.
    Title: Promoter methylation levels of RASSF1 and ATIC genes are associated with lung cancer in Iranian patients.
  6. RASSF1A inhibits epithelial-mesenchymal transition of gastric cancer cells by downregulating P-JNK.
    Title: RASSF1A inhibits epithelial-mesenchymal transition of gastric cancer cells by downregulating P-JNK.
  7. Exome sequencing identifies RASSF1 and KLK3 germline variants in an Iranian multiple-case breast cancer family.
    Title: Exome sequencing identifies RASSF1 and KLK3 germline variants in an Iranian multiple-case breast cancer family.
  8. RASSF1A disrupts the NOTCH signaling axis via SNURF/RNF4-mediated ubiquitination of HES1.
    Title: RASSF1A disrupts the NOTCH signaling axis via SNURF/RNF4-mediated ubiquitination of HES1.
  9. Dysregulated HIC1 and RassF1A expression in vitro alters the cell cytoskeleton and exosomal Piwi-interacting RNA.
    Title: Dysregulated HIC1 and RassF1A expression in vitro alters the cell cytoskeleton and exosomal Piwi-interacting RNA.
  10. REX-1 Represses RASSF1a and Activates the MEK/ERK Pathway to Promote Tumorigenesis in Prostate Cancer.
    Title: REX-1 Represses RASSF1a and Activates the MEK/ERK Pathway to Promote Tumorigenesis in Prostate Cancer.
Submit: New GeneRIF Correction See all GeneRIFs (454)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables zinc ion binding TAS
Traceable Author Statement
more info
 PubMed 
Process Evidence Code Pubs
involved_in Ras protein signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in Ras protein signal transduction IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in cell cycle IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in centrosome IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in microtubule IEA
Inferred from Electronic Annotation
more info
  
is_active_in microtubule cytoskeleton IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in microtubule cytoskeleton IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in spindle pole IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
ras association domain-containing protein 1
Names
Ras association (RalGDS/AF-6) domain family member 1
WUGSC:H_LUCA12.5
cardiac-specific ras association domain family 1 protein
pancreas-specific ras association domain family 1 protein
tumor suppressor protein RDA32

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_023270.1 RefSeqGene

    Range
    5101..16149
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001206957.2 → NP_001193886.1  ras association domain-containing protein 1 isoform B

    See identical proteins and their annotated locations for NP_001193886.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (H) lacks an alternate coding exon compared to variant D, that causes a frameshift. The resulting isoform (B) is shorter at the N-terminus compared to isoform D. Variants B and H both encode the same isoform (B).
    Source sequence(s)
    AF132677, AF286217
    Consensus CDS
    CCDS2822.1
    UniProtKB/Swiss-Prot
    Q9NS23
    Related
    ENSP00000482696.1, ENST00000616212.4
    Conserved Domains (2) summary
    pfam16517
    Location:145 → 183
    Nore1-SARAH; Novel Ras effector 1 C-terminal SARAH (Sav/Rassf/Hpo) domain
    cl28922
    Location:1 → 135
    Ubiquitin_like_fold; Beta-grasp ubiquitin-like fold

  2. NM_007182.5 → NP_009113.3  ras association domain-containing protein 1 isoform A

    See identical proteins and their annotated locations for NP_009113.3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (A) lacks an in-frame coding segment compared to variant D, resulting an isoform (A) that lacks an internal region, as compared to isoform D.
    Source sequence(s)
    AF132675, BC110412
    Consensus CDS
    CCDS43096.1
    UniProtKB/TrEMBL
    Q17RX7
    Related
    ENSP00000352323.4, ENST00000359365.9
    Conserved Domains (3) summary
    cd01778
    Location:194 → 289
    RASSF1_RA; Ubiquitin-like domain of RASSF1 tumour supproessor protein
    pfam00130
    Location:52 → 101
    C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
    pfam16517
    Location:295 → 334
    Nore1-SARAH; Novel Ras effector 1 C-terminal SARAH (Sav/Rassf/Hpo) domain

  3. NM_170712.3 → NP_733830.1  ras association domain-containing protein 1 isoform B

    See identical proteins and their annotated locations for NP_733830.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (B) differs in the 5' end region compared to variant D. The resulting isoform (B) has a shorter N-terminus, as compared to isoform D. Variants B and H both encode the same isoform (B).
    Source sequence(s)
    AC002481, BC110412
    Consensus CDS
    CCDS2822.1
    UniProtKB/Swiss-Prot
    Q9NS23
    Related
    ENSP00000378558.3, ENST00000395126.7
    Conserved Domains (2) summary
    pfam16517
    Location:145 → 183
    Nore1-SARAH; Novel Ras effector 1 C-terminal SARAH (Sav/Rassf/Hpo) domain
    cl28922
    Location:1 → 135
    Ubiquitin_like_fold; Beta-grasp ubiquitin-like fold

  4. NM_170713.3 → NP_733831.1  ras association domain-containing protein 1 isoform C

    See identical proteins and their annotated locations for NP_733831.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (C) differs in the 5' end region compared to variant D. The resulting isoform (C) has a distinct and shorter N-terminus, as compared to isoform D.
    Source sequence(s)
    AF132677, BI915594
    Consensus CDS
    CCDS2821.1
    UniProtKB/TrEMBL
    A8K9C3
    Related
    ENSP00000333327.3, ENST00000327761.7
    Conserved Domains (2) summary
    cd17218
    Location:60 → 216
    RA_RASSF1; Ras-associating (RA) domain found in Ras-association domain-containing protein 1 (RASSF1)
    pfam16517
    Location:226 → 264
    Nore1-SARAH; Novel Ras effector 1 C-terminal SARAH (Sav/Rassf/Hpo) domain

  5. NM_170714.2 → NP_733832.1  ras association domain-containing protein 1 isoform D

    See identical proteins and their annotated locations for NP_733832.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (D) encodes isoform D, which is one of the two longest isoforms.
    Source sequence(s)
    AF102771, BC110412
    Consensus CDS
    CCDS2820.1
    UniProtKB/Swiss-Prot
    B7ZLL1, O14571, O60539, O60710, Q0VGC6, Q5TZT2, Q9HB04, Q9HB18, Q9NS22, Q9NS23, Q9UND4, Q9UND5
    UniProtKB/TrEMBL
    Q17RX7
    Related
    ENSP00000349547.2, ENST00000357043.6
    Conserved Domains (3) summary
    cd01778
    Location:198 → 293
    RASSF1_RA; Ubiquitin-like domain of RASSF1 tumour supproessor protein
    pfam00130
    Location:52 → 105
    C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
    pfam16517
    Location:299 → 338
    Nore1-SARAH; Novel Ras effector 1 C-terminal SARAH (Sav/Rassf/Hpo) domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

    Range
    50329788..50340836 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047447372.1 → XP_047303328.1  ras association domain-containing protein 1 isoform X1

  2. XM_011533316.3 → XP_011531618.1  ras association domain-containing protein 1 isoform X1

    See identical proteins and their annotated locations for XP_011531618.1

    UniProtKB/Swiss-Prot
    Q9NS23
    Conserved Domains (2) summary
    pfam16517
    Location:145 → 183
    Nore1-SARAH; Novel Ras effector 1 C-terminal SARAH (Sav/Rassf/Hpo) domain
    cl28922
    Location:1 → 135
    Ubiquitin_like_fold; Beta-grasp ubiquitin-like fold

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060927.1 Alternate T2T-CHM13v2.0

    Range
    50359511..50370560 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054345089.1 → XP_054201064.1  ras association domain-containing protein 1 isoform X2

  2. XM_054345090.1 → XP_054201065.1  ras association domain-containing protein 1 isoform X1

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_170715.1: Suppressed sequence

    Description
    NM_170715.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.

  2. NM_170716.1: Suppressed sequence

    Description
    NM_170716.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.

  3. NM_170717.1: Suppressed sequence

    Description
    NM_170717.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9NS23.1 GenPept UniProtKB/Swiss-Prot:Q9NS23

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