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KLF12 KLF transcription factor 12 [ Homo sapiens (human) ]

Gene ID: 11278, updated on 3-Apr-2024

Summary

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Official Symbol
KLF12provided by HGNC
Official Full Name
KLF transcription factor 12provided by HGNC
Primary source
HGNC:HGNC:6346
See related
Ensembl:ENSG00000118922 MIM:607531; AllianceGenome:HGNC:6346
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
AP2REP; AP-2rep; HSPC122
Summary
Activator protein-2 alpha (AP-2 alpha) is a developmentally-regulated transcription factor and important regulator of gene expression during vertebrate development and carcinogenesis. The protein encoded by this gene is a member of the Kruppel-like zinc finger protein family and can repress expression of the AP-2 alpha gene by binding to a specific site in the AP-2 alpha gene promoter. Repression by the encoded protein requires binding with a corepressor, CtBP1. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in lymph node (RPKM 6.4), spleen (RPKM 4.4) and 24 other tissues See more
Orthologs
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Genomic context

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See KLF12 in Genome Data Viewer
Location:
13q22.1
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 13 NC_000013.11 (73686089..74306045, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 13 NC_060937.1 (72907694..73528039, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 13 NC_000013.10 (74260226..74880182, complement)

Chromosome 13 - NC_000013.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC128966561 Neighboring gene long intergenic non-protein coding RNA 393 Neighboring gene uncharacterized LOC105370256 Neighboring gene long intergenic non-protein coding RNA 392 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr13:74214267-74214908 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr13:74214909-74215550 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr13:74289066-74290265 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr13:74305638-74306208 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr13:74340128-74340628 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr13:74341622-74342257 Neighboring gene uncharacterized LOC124903182 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_33299 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_33300 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_33301 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_33303 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7817 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr13:74609849-74610779 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr13:74610780-74611709 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7818 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7819 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5399 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7820 Neighboring gene NANOG hESC enhancer GRCh37_chr13:74749652-74750153 Neighboring gene Sharpr-MPRA regulatory region 11269 Neighboring gene HNF1 motif-containing MPRA enhancer 52 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr13:74815323-74815876 Neighboring gene long intergenic non-protein coding RNA 402 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr13:74861026-74861526 Neighboring gene Sharpr-MPRA regulatory region 2285 Neighboring gene uncharacterized LOC105370259 Neighboring gene NANOG hESC enhancer GRCh37_chr13:74875892-74876393 Neighboring gene RNY1 pseudogene 5 Neighboring gene uncharacterized LOC100288208 Neighboring gene ribosomal protein L21 pseudogene 108

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. KLF12 promotes the proliferation of breast cancer cells by reducing the transcription of p21 in a p53-dependent and p53-independent manner. Li Y, et al. Cell Death Dis, 2023 May 8. PMID 37156774, Free PMC Article
  2. Krüppel-like factor 12 suppresses bladder cancer growth through transcriptionally inhibition of enolase 2. Tang C, et al. Gene, 2021 Feb 15. PMID 33279628
  3. Circ_0005273 induces the aggravation of pancreatic cancer by targeting KLF12. Hou YS, et al. Eur Rev Med Pharmacol Sci, 2020 Nov. PMID 33275224
  4. Tumour-suppression function of KLF12 through regulation of anoikis. Godin-Heymann N, et al. Oncogene, 2016 Jun 23. PMID 26455320, Free PMC Article
  5. Krüppel-like factor 12 negatively regulates human endometrial stromal cell decidualization. Shen X, et al. Biochem Biophys Res Commun, 2013 Mar 29. PMID 23458459

See all (72) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. KLF12 transcriptionally regulates PD-L1 expression in non-small cell lung cancer.
    Title: KLF12 transcriptionally regulates PD-L1 expression in non-small cell lung cancer.
  2. Circ_0084188 promotes colorectal cancer progression by sponging miR-654-3p and regulating kruppel-like factor 12.
    Title: Circ_0084188 promotes colorectal cancer progression by sponging miR-654-3p and regulating kruppel-like factor 12.
  3. Kruppel-like factor 12 regulates aging ovarian granulosa cell apoptosis by repressing SPHK1 transcription and sphingosine-1-phosphate (S1P) production.
    Title: Krüppel-like factor 12 regulates aging ovarian granulosa cell apoptosis by repressing SPHK1 transcription and sphingosine-1-phosphate (S1P) production.
  4. MiR-17-5p promoter methylation regulated by DNA methyltransferase 3 beta (DNMT3B) expedites endometriosis via the Kruppel-like factor 12 (KLF12)/Wnt/beta-catenin axis.
    Title: MiR-17-5p promoter methylation regulated by DNA methyltransferase 3 beta (DNMT3B) expedites endometriosis via the Krüppel-like factor 12 (KLF12)/Wnt/β-catenin axis.
  5. KLF12 promotes the proliferation of breast cancer cells by reducing the transcription of p21 in a p53-dependent and p53-independent manner.
    Title: KLF12 promotes the proliferation of breast cancer cells by reducing the transcription of p21 in a p53-dependent and p53-independent manner.
  6. MicroRNA-650 suppresses KLF12 expression to regulate growth and metastasis of human ovarian cancer cells.
    Title: MicroRNA-650 suppresses KLF12 expression to regulate growth and metastasis of human ovarian cancer cells.
  7. Potentiated lung adenocarcinoma (LUAD) cell growth, migration and invasion by lncRNA DARS-AS1 via miR-188-5p/ KLF12 axis.
    Title: Potentiated lung adenocarcinoma (LUAD) cell growth, migration and invasion by lncRNA DARS-AS1 via miR-188-5p/ KLF12 axis.
  8. Circ-RNF111 aggravates the malignancy of gastric cancer through miR-876-3p-dependent regulation of KLF12.
    Title: Circ-RNF111 aggravates the malignancy of gastric cancer through miR-876-3p-dependent regulation of KLF12.
  9. Knockdown of circ_0075503 suppresses cell migration and invasion by regulating miR-15a-5p and KLF12 in endometriosis.
    Title: Knockdown of circ_0075503 suppresses cell migration and invasion by regulating miR-15a-5p and KLF12 in endometriosis.
  10. Circ_0005273 induces the aggravation of pancreatic cancer by targeting KLF12.
    Title: Circ_0005273 induces the aggravation of pancreatic cancer by targeting KLF12.
Submit: New GeneRIF Correction See all GeneRIFs (33)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
A genome-wide association study (GWAS) for bronchopulmonary dysplasia.
EBI GWAS Catalog
A genome-wide association study identifies pancreatic cancer susceptibility loci on chromosomes 13q22.1, 1q32.1 and 5p15.33.
EBI GWAS Catalog
A genome-wide search for quantitative trait loci affecting the cortical surface area and thickness of Heschl's gyrus.
EBI GWAS Catalog
Common variants in 22 loci are associated with QRS duration and cardiac ventricular conduction.
EBI GWAS Catalog
Genetic association study of QT interval highlights role for calcium signaling pathways in myocardial repolarization.
EBI GWAS Catalog
Genome-wide association study identifies multiple susceptibility loci for pancreatic cancer.
EBI GWAS Catalog
Genome-wide association study identifies novel loci associated with circulating phospho- and sphingolipid concentrations.
EBI GWAS Catalog
Parent-of-origin-specific allelic associations among 106 genomic loci for age at menarche.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables DNA-binding transcription factor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables DNA-binding transcription factor activity, RNA polymerase II-specific ISA
Inferred from Sequence Alignment
more info
  
enables DNA-binding transcription repressor activity, RNA polymerase II-specific IDA
Inferred from Direct Assay
more info
 PubMed 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables sequence-specific double-stranded DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of chromatin ISA
Inferred from Sequence Alignment
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
  
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
  

General protein information

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Preferred Names
Krueppel-like factor 12
Names
AP-2 repressor
AP-2rep transcription factor
KLF12 zinc finger transcriptional repressor
Kruppel like factor 12
transcriptional repressor AP-2rep

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001400136.1 → NP_001387065.1  Krueppel-like factor 12 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AL138713, AL139036, AL159972, AL160032, AL356319
    Consensus CDS
    CCDS9449.1
    UniProtKB/Swiss-Prot
    A8K5T2, L0R3J4, Q5VZM7, Q9UHZ0, Q9Y4X4
    Related
    ENSP00000515592.1, ENST00000703967.1

  2. NM_001400139.1 → NP_001387068.1  Krueppel-like factor 12 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AL138713, AL139036, AL159972, AL160032, AL353660
    Consensus CDS
    CCDS9449.1
    UniProtKB/Swiss-Prot
    A8K5T2, L0R3J4, Q5VZM7, Q9UHZ0, Q9Y4X4

  3. NM_001400141.1 → NP_001387070.1  Krueppel-like factor 12 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AL138713, AL139036, AL159972, AL160032
    Consensus CDS
    CCDS9449.1
    UniProtKB/Swiss-Prot
    A8K5T2, L0R3J4, Q5VZM7, Q9UHZ0, Q9Y4X4

  4. NM_001400146.1 → NP_001387075.1  Krueppel-like factor 12 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL138713, AL139036, AL159972, AL160032, AL356319

  5. NM_001400147.1 → NP_001387076.1  Krueppel-like factor 12 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AL138713, AL159972, AL160032, AL356319

  6. NM_001400148.1 → NP_001387077.1  Krueppel-like factor 12 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AL138713, AL159972, AL160032, AL356319

  7. NM_001400149.1 → NP_001387078.1  Krueppel-like factor 12 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AL138713, AL139036, AL159972, AL160032, AL356319

  8. NM_001400150.1 → NP_001387079.1  Krueppel-like factor 12 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AL138713, AL139036, AL159972, AL160032, AL356319

  9. NM_001400151.1 → NP_001387080.1  Krueppel-like factor 12 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AL138713, AL139036, AL159972, AL160032, AL356319

  10. NM_001400152.1 → NP_001387081.1  Krueppel-like factor 12 isoform 6

    Status: VALIDATED

    Source sequence(s)
    AL138713, AL139036, AL159972, AL160032, AL356319

  11. NM_001400153.1 → NP_001387082.1  Krueppel-like factor 12 isoform 6

    Status: VALIDATED

    Source sequence(s)
    AL138713, AL139036, AL159972, AL160032, AL353660

  12. NM_007249.5 → NP_009180.3  Krueppel-like factor 12 isoform 1

    See identical proteins and their annotated locations for NP_009180.3

    Status: VALIDATED

    Source sequence(s)
    AF330041, AL160032, AL356319, DB125574
    Consensus CDS
    CCDS9449.1
    UniProtKB/Swiss-Prot
    A8K5T2, L0R3J4, Q5VZM7, Q9UHZ0, Q9Y4X4
    UniProtKB/TrEMBL
    Q8WWI3
    Related
    ENSP00000366897.2, ENST00000377669.7
    Conserved Domains (4) summary
    COG5048
    Location:228 → 401
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:319 → 341
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:363 → 388
    zf-H2C2_2; Zinc-finger double domain
    cd21441
    Location:27 → 224
    KLF12_N; N-terminal domain of Kruppel-like factor 12

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000013.11 Reference GRCh38.p14 Primary Assembly

    Range
    73686089..74306045 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011534909.3 → XP_011533211.1  Krueppel-like factor 12 isoform X3

    See identical proteins and their annotated locations for XP_011533211.1

    UniProtKB/Swiss-Prot
    A8K5T2, L0R3J4, Q5VZM7, Q9UHZ0, Q9Y4X4
    UniProtKB/TrEMBL
    Q8WWI3
    Conserved Domains (4) summary
    COG5048
    Location:228 → 401
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:319 → 341
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:363 → 388
    zf-H2C2_2; Zinc-finger double domain
    cd21441
    Location:27 → 224
    KLF12_N; N-terminal domain of Kruppel-like factor 12

  2. XM_047430082.1 → XP_047286038.1  Krueppel-like factor 12 isoform X5

  3. XM_047430083.1 → XP_047286039.1  Krueppel-like factor 12 isoform X6

  4. XM_047430084.1 → XP_047286040.1  Krueppel-like factor 12 isoform X6

  5. XM_011534907.3 → XP_011533209.1  Krueppel-like factor 12 isoform X1

    UniProtKB/TrEMBL
    Q8WWI3
    Conserved Domains (4) summary
    COG5048
    Location:241 → 414
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:332 → 354
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:330 → 354
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:376 → 401
    zf-H2C2_2; Zinc-finger double domain

  6. XM_011534908.4 → XP_011533210.1  Krueppel-like factor 12 isoform X2

    UniProtKB/TrEMBL
    Q8WWI3
    Conserved Domains (2) summary
    sd00017
    Location:332 → 354
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:330 → 354
    zf-C2H2; Zinc finger, C2H2 type

  7. XM_011534910.3 → XP_011533212.1  Krueppel-like factor 12 isoform X4

    UniProtKB/TrEMBL
    Q8WWI3
    Conserved Domains (4) summary
    COG5048
    Location:226 → 399
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:317 → 339
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:361 → 386
    zf-H2C2_2; Zinc-finger double domain
    cd21441
    Location:25 → 222
    KLF12_N; N-terminal domain of Kruppel-like factor 12

  8. XM_011534911.3 → XP_011533213.1  Krueppel-like factor 12 isoform X6

    See identical proteins and their annotated locations for XP_011533213.1

    UniProtKB/TrEMBL
    Q8WWI3
    Conserved Domains (4) summary
    COG5048
    Location:209 → 382
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:300 → 322
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:344 → 369
    zf-H2C2_2; Zinc-finger double domain
    cd21441
    Location:8 → 205
    KLF12_N; N-terminal domain of Kruppel-like factor 12

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060937.1 Alternate T2T-CHM13v2.0

    Range
    72907694..73528039 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054374085.1 → XP_054230060.1  Krueppel-like factor 12 isoform X3

    UniProtKB/Swiss-Prot
    A8K5T2, L0R3J4, Q5VZM7, Q9UHZ0, Q9Y4X4

  2. XM_054374087.1 → XP_054230062.1  Krueppel-like factor 12 isoform X5

  3. XM_054374089.1 → XP_054230064.1  Krueppel-like factor 12 isoform X6

  4. XM_054374090.1 → XP_054230065.1  Krueppel-like factor 12 isoform X6

  5. XM_054374083.1 → XP_054230058.1  Krueppel-like factor 12 isoform X1

  6. XM_054374084.1 → XP_054230059.1  Krueppel-like factor 12 isoform X2

  7. XM_054374086.1 → XP_054230061.1  Krueppel-like factor 12 isoform X4

  8. XM_054374088.1 → XP_054230063.1  Krueppel-like factor 12 isoform X6

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_016285.2: Suppressed sequence

    Description
    NM_016285.2: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9Y4X4.2 GenPept UniProtKB/Swiss-Prot:Q9Y4X4

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