SLCO2B1 solute carrier organic anion transporter family member 2B1 [Homo sapiens (human)] - Gene

Summary

Official Symbol: SLCO2B1provided by HGNC
Official Full Name: solute carrier organic anion transporter family member 2B1provided by HGNC
Primary source: HGNC:HGNC:10962
See related: Ensembl:ENSG00000137491 MIM:604988; AllianceGenome:HGNC:10962
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: OATPB; OATP-B; OATP2B1; SLC21A9
Summary: This locus encodes a member of the organic anion-transporting polypeptide family of membrane proteins. The protein encoded by this locus may function in regulation of placental uptake of sulfated steroids. Alternatively spliced transcript variants have been described. [provided by RefSeq, Nov 2010]
Expression: Broad expression in liver (RPKM 44.0), lung (RPKM 34.3) and 23 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 11q13.4

Exon count:: 16

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	11	NC_000011.10 (75151107..75206549)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	11	NC_060935.1 (75080709..75136155)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	11	NC_000011.9 (74862152..74917594)

Chromosome 11 - NC_000011.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Roles of breast cancer resistance protein and organic anion transporting polypeptide 2B1 in gastrointestinal toxicity induced by SN-38 under inflammatory conditions.
Title: Roles of breast cancer resistance protein and organic anion transporting polypeptide 2B1 in gastrointestinal toxicity induced by SN-38 under inflammatory conditions.
SLCO1B3 and SLCO2B1 genotypes, androgen deprivation therapy, and prostate cancer outcomes: a prospective cohort study and meta-analysis.
Title: SLCO1B3 and SLCO2B1 genotypes, androgen deprivation therapy, and prostate cancer outcomes: a prospective cohort study and meta-analysis.
Genetic Polymorphisms in SLCO2B1 and ABCC1 Conjointly Modulate Atorvastatin Intracellular Accumulation in HEK293 Recombinant Cell Lines.
Title: Genetic Polymorphisms in SLCO2B1 and ABCC1 Conjointly Modulate Atorvastatin Intracellular Accumulation in HEK293 Recombinant Cell Lines.
Association of genetic polymorphisms with local steroid metabolism in human benign breasts.
Title: Association of genetic polymorphisms with local steroid metabolism in human benign breasts.
Differences in transport function of the human and rat orthologue of the Organic Anion Transporting Polypeptide 2B1 (OATP2B1).
Title: Differences in transport function of the human and rat orthologue of the Organic Anion Transporting Polypeptide 2B1 (OATP2B1).
Uptake Pathway of Apple-derived Nanoparticle by Intestinal Cells to Deliver its Cargo.
Title: Uptake Pathway of Apple-derived Nanoparticle by Intestinal Cells to Deliver its Cargo.
Functional Characterization Reveals the Significance of Rare Coding Variations in Human Organic Anion Transporting Polypeptide 2B1 (SLCO2B1).
Title: Functional Characterization Reveals the Significance of Rare Coding Variations in Human Organic Anion Transporting Polypeptide 2B1 (SLCO2B1).
Oral absorption of voriconazole is affected by SLCO2B1 c.*396T>C genetic polymorphism in CYP2C19 poor metabolizers.
Title: Oral absorption of voriconazole is affected by SLCO2B1 c.*396T>C genetic polymorphism in CYP2C19 poor metabolizers.
Post-transcriptional regulation of OATP2B1 transporter by a microRNA, miR-24.
Title: Post-transcriptional regulation of OATP2B1 transporter by a microRNA, miR-24.
Role of Oatp2b1 in Drug Absorption and Drug-Drug Interactions.
Title: Role of Oatp2b1 in Drug Absorption and Drug-Drug Interactions.

Submit: New GeneRIF Correction See all GeneRIFs (67)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D8S2278 (e-PCR)
- UniSTS:473906

STS-T26641 (e-PCR)
- UniSTS:32335

RH45548 (e-PCR)
- UniSTS:56149

D11S1073 (e-PCR)
- UniSTS:44636

D1S1425 (e-PCR)
- UniSTS:149621

SHGC-142426 (e-PCR)
- UniSTS:182390

D11S3488 (e-PCR)
- UniSTS:152728

D1S3693 (e-PCR)
- UniSTS:474271

SLC21A9_406.2 (e-PCR)
- UniSTS:468131

STS-T26641 (e-PCR)
- UniSTS:69036

NoName (e-PCR)
- UniSTS:489935

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables bile acid transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables organic anion transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed
enables organic anion transmembrane transporter activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables prostaglandin transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed
enables sodium-independent organic anion transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables sodium-independent organic anion transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed
enables sodium-independent organic anion transmembrane transporter activity	TAS Traceable Author Statement more info
enables transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in bile acid and bile salt transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in heme catabolic process	TAS Traceable Author Statement more info
involved_in monoatomic ion transport	IEA Inferred from Electronic Annotation more info
involved_in organic anion transport	IDA Inferred from Direct Assay more info	PubMed
involved_in prostaglandin transport	IEA Inferred from Electronic Annotation more info
involved_in sodium-independent organic anion transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in sodium-independent organic anion transport	TAS Traceable Author Statement more info
involved_in transmembrane transport	IDA Inferred from Direct Assay more info	PubMed
involved_in transmembrane transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in transport across blood-brain barrier	NAS Non-traceable Author Statement more info	PubMed
involved_in xenobiotic metabolic process	TAS Traceable Author Statement more info

Component	Evidence Code	Pubs
is_active_in apical plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in apical plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in apical plasma membrane	ISS Inferred from Sequence or Structural Similarity more info	PubMed
located_in basal plasma membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in basolateral plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	TAS Traceable Author Statement more info

General protein information

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Preferred Names: solute carrier organic anion transporter family member 2B1

Names: OATP-RP2; organic anion transporter B; organic anion transporter polypeptide-related protein 2; organic anion transporting polypeptide 2B1; solute carrier family 21 (organic anion transporter), member 9

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_027921.1 RefSeqGene

Range

5121..60563

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001145211.3 → NP_001138683.1 solute carrier organic anion transporter family member 2B1 isoform 2

See identical proteins and their annotated locations for NP_001138683.1

Status: REVIEWED

Description

Transcript Variant: This variant (2) contains an alternate 5' terminal exon compared to transcript variant 1. This results in translation initiation from an in-frame downstream AUG and an isoform (2) with a shorter N-terminus compared to isoform 1.

Source sequence(s)

AF205073, AP001972, BC041095, CK299190, DC362722

Consensus CDS

CCDS44683.1

UniProtKB/TrEMBL

E9PRW4

Related

ENSP00000388912.2, ENST00000428359.6

Conserved Domains (3) summary

cd06174
Location:34 → 230

MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...

cd01330
Location:463 → 520

KAZAL_SLC21; The kazal-type serine protease inhibitor domain has been detected in an extracellular loop region of solute carrier 21 (SLC21) family members (organic anion transporters) , which may regulate the specificity of anion uptake. The KAZAL_SLC21 domain is a ...

pfam03137
Location:28 → 625

OATP; Organic Anion Transporter Polypeptide (OATP) family
NM_001145212.3 → NP_001138684.1 solute carrier organic anion transporter family member 2B1 isoform 3

Status: REVIEWED

Description

Transcript Variant: This variant (3) is missing 3 consecutive coding exons from the 5' end compared to transcript variant 1. However, it maintains the reading frame and results in a shorter isoform (3) lacking a protein segment from the N-terminus compared to isoform 1.

Source sequence(s)

AP001972, BC041095, CK299190, DC343392

Consensus CDS

CCDS53679.1

UniProtKB/TrEMBL

A0A0A0MTF1, E9PRW4

Related

ENSP00000436324.1, ENST00000525650.5

Conserved Domains (1) summary

cl28910
Location:46 → 444

MFS; Major Facilitator Superfamily
NM_007256.5 → NP_009187.1 solute carrier organic anion transporter family member 2B1 isoform 1

See identical proteins and their annotated locations for NP_009187.1

Status: REVIEWED

Description

Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).

Source sequence(s)

AP001972, BC041095, CK299190, DC343392

Consensus CDS

CCDS8235.1

UniProtKB/Swiss-Prot

A0A024R5I4, A8K2G9, B4DGA9, B4DTB0, E7ERN5, E9PPU8, O94956, Q9H2Z0, Q9UFU1

UniProtKB/TrEMBL

E9PRW4

Related

ENSP00000289575.5, ENST00000289575.10

Conserved Domains (1) summary

pfam03137
Location:50 → 647

OATP; Organic Anion Transporter Polypeptide (OATP) family

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000011.10 Reference GRCh38.p14 Primary Assembly

Range

75151107..75206549

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017017157.2 → XP_016872646.2 solute carrier organic anion transporter family member 2B1 isoform X1
XM_047426333.1 → XP_047282289.1 solute carrier organic anion transporter family member 2B1 isoform X2
XM_047426334.1 → XP_047282290.1 solute carrier organic anion transporter family member 2B1 isoform X2

Alternate T2T-CHM13v2.0

Genomic

NC_060935.1 Alternate T2T-CHM13v2.0

Range

75080709..75136155

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_054367583.1 → XP_054223558.1 solute carrier organic anion transporter family member 2B1 isoform X2
XM_054367582.1 → XP_054223557.1 solute carrier organic anion transporter family member 2B1 isoform X2
XM_054367581.1 → XP_054223556.1 solute carrier organic anion transporter family member 2B1 isoform X2