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ACOT7 acyl-CoA thioesterase 7 [ Homo sapiens (human) ]

Gene ID: 11332, updated on 11-Apr-2024

Summary

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Official Symbol
ACOT7provided by HGNC
Official Full Name
acyl-CoA thioesterase 7provided by HGNC
Primary source
HGNC:HGNC:24157
See related
Ensembl:ENSG00000097021 MIM:602587; AllianceGenome:HGNC:24157
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ACT; ACH1; BACH; LACH; LACH1; hBACH; CTE-II
Summary
This gene encodes a member of the acyl coenzyme family. The encoded protein hydrolyzes the CoA thioester of palmitoyl-CoA and other long-chain fatty acids. Decreased expression of this gene may be associated with mesial temporal lobe epilepsy. Alternatively spliced transcript variants encoding distinct isoforms with different subcellular locations have been characterized. [provided by RefSeq, Jul 2008]
Expression
Broad expression in brain (RPKM 26.5), kidney (RPKM 21.3) and 22 other tissues See more
Orthologs
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Genomic context

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See ACOT7 in Genome Data Viewer
Location:
1p36.31
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (6264272..6393767, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (5789916..5919409, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (6324332..6453827, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:6304377-6304934 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:6305171-6305522 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 144 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 145 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 146 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:6309743-6310284 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 147 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 148 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 149 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 150 Neighboring gene G protein-coupled receptor 153 Neighboring gene hes family bHLH transcription factor 3 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:6329739-6330330 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:6330331-6330921 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:6333683-6333849 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:6335064-6335654 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:6339577-6340442 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:6340686-6341235 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 76 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr1:6361272-6362471 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:6396158-6396892 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:6397980-6398642 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:6398643-6399303 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:6399966-6400626 Neighboring gene Sharpr-MPRA regulatory region 5603 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:6417160-6418127 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 77 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 78 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 79 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 80 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:6424607-6425106 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:6427779-6428559 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:6434479-6434978 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:6445825-6446810 Neighboring gene H3K27ac hESC enhancers GRCh37_chr1:6453176-6453687 and GRCh37_chr1:6453688-6454200 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:6454201-6454711 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:6455464-6455988 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr1:6474153-6474654 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr1:6474655-6475154 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:6483551-6484165 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:6484166-6484779 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 153 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 154 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 82 Neighboring gene hes family bHLH transcription factor 2 Neighboring gene microRNA 4252 Neighboring gene espin

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Expression level of ACOT7 influences the prognosis in acute myeloid leukemia patients. Zhang X, et al. Cancer Biomark, 2019. PMID 31640082
  2. Long-chain acyl-CoA hydrolase in the brain. Yamada J. Amino Acids, 2005 May. PMID 15731883
  3. Aberrant cytosolic acyl-CoA thioester hydrolase in hippocampus of patients with mesial temporal lobe epilepsy. Yang JW, et al. Amino Acids, 2004 Dec. PMID 15592755
  4. Interaction between ACOT7 and LncRNA NMRAL2P via Methylation Regulates Gastric Cancer Progression. Feng H, et al. Yonsei Med J, 2020 Jun. PMID 32469171, Free PMC Article
  5. Purification, molecular cloning, and genomic organization of human brain long-chain acyl-CoA hydrolase. Yamada J, et al. J Biochem, 1999 Dec. PMID 10578051

See all (66) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Acyl-Coa Thioesterases: A Rheostat That Controls Activated Fatty Acids Modulates Dengue Virus Serotype 2 Replication.
    Title: Acyl-Coa Thioesterases: A Rheostat That Controls Activated Fatty Acids Modulates Dengue Virus Serotype 2 Replication.
  2. NMRAL2P activation suppresses ACOT7 expression in gastric cancer.
    Title: Interaction between ACOT7 and LncRNA NMRAL2P via Methylation Regulates Gastric Cancer Progression.
  3. Patients in high ACOT7 group had a significant lower EFS and OS, while patients in high versus low expression levels of other types of ACOT showed no significant difference on the outcome
    Title: Expression level of ACOT7 influences the prognosis in acute myeloid leukemia patients.
  4. PKCzeta was specifically involved in ACOT7 depletion-mediated cell cycle arrest as an upstream molecule of the p53-p21 signaling pathway in MCF7 human breast carcinoma and A549 human lung carcinoma cells.
    Title: Acyl-CoA thioesterase 7 is involved in cell cycle progression via regulation of PKCζ-p53-p21 signaling pathway.
  5. WIG1 governs the miRNA-dependent and the miRNA-independent recruitment of AGO2 to lower the stability of and suppress the translation of ACOT7 mRNA.
    Title: WIG1 is crucial for AGO2-mediated ACOT7 mRNA silencing via miRNA-dependent and -independent mechanisms.
  6. Observational study of gene-disease association. (HuGE Navigator)
    Title: Association of genetic variants with hemorrhagic stroke in Japanese individuals.
  7. the human BACH gene can express long-chain acyl-CoA hydrolase activity in multiple intracellular compartments by generating BACH isoforms with differential localization signals to affect various cellular functions that involve acyl-CoAs
    Title: Human brain acyl-CoA hydrolase isoforms encoded by a single gene.
  8. BACH was deranged in hippocampus of mesial temporal lobe epilepsy patients.
    Title: Aberrant cytosolic acyl-CoA thioester hydrolase in hippocampus of patients with mesial temporal lobe epilepsy.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Common variants at ten loci influence QT interval duration in the QTGEN Study.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC1126

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables carboxylic ester hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables fatty-acyl-CoA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables long-chain fatty acyl-CoA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables long-chain fatty acyl-CoA hydrolase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables long-chain fatty acyl-CoA hydrolase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein homodimerization activity IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in acyl-CoA metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in coenzyme A biosynthetic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in fatty acid catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in long-chain fatty-acyl-CoA catabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in medium-chain fatty acid biosynthetic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in medium-chain fatty-acyl-CoA catabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in palmitic acid biosynthetic process IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytosol TAS
Traceable Author Statement
more info
  
located_in extracellular exosome HDA PubMed 
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
  

General protein information

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Preferred Names
cytosolic acyl coenzyme A thioester hydrolase
Names
CTE-IIa
acyl-CoA thioesterase 2
acyl-CoA thioesterase, long chain
brain acyl-CoA hydrolase
long chain acyl-CoA thioester hydrolase
NP_009205.3
NP_863654.1
NP_863655.1
NP_863656.1
XP_047299355.1
XP_054190023.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_007274.4 → NP_009205.3  cytosolic acyl coenzyme A thioester hydrolase isoform hBACHa

    See identical proteins and their annotated locations for NP_009205.3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (hBACHa) differs in the 5' UTR and 5' coding region, compared to variant hBACHb. It encodes isoform hBACHa that has a shorter and distinct N-terminus lacking a mitochondrial targetting sequence, compared to isoform hBACHb.
    Source sequence(s)
    AL031847, AL031848
    Consensus CDS
    CCDS30573.1
    UniProtKB/Swiss-Prot
    O00154
    Related
    ENSP00000354615.4, ENST00000361521.9
    Conserved Domains (1) summary
    cd03442
    Location:212 → 335
    BFIT_BACH; Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis, ...

  2. NM_181864.3 → NP_863654.1  cytosolic acyl coenzyme A thioester hydrolase isoform hBACHb

    See identical proteins and their annotated locations for NP_863654.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (hBACHb) encodes the longest isoform (hBACHb), which may be targetted to the mitochondria.
    Source sequence(s)
    AL031847, AL031848, BC017365, BM807217
    Consensus CDS
    CCDS65.1
    UniProtKB/Swiss-Prot
    A8K0K7, A8K232, A8K6B8, A8K837, B3KQ12, O00154, O43703, Q53Y78, Q5JYL2, Q5JYL3, Q5JYL4, Q5JYL5, Q5JYL6, Q5TGR4, Q9UJM9, Q9Y539, Q9Y540
    Related
    ENSP00000367086.2, ENST00000377855.6
    Conserved Domains (1) summary
    cd03442
    Location:222 → 345
    BFIT_BACH; Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis, ...

  3. NM_181865.3 → NP_863655.1  cytosolic acyl coenzyme A thioester hydrolase isoform hBACHc

    See identical proteins and their annotated locations for NP_863655.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (hBACHc) differs in the 5' UTR and 5' coding region, compared to variant hBACHb. It encodes isoform hBACHc that has a shorter and distinct N-terminus, compared to isoform hBACHb, and may also be targetted to the mitochondria.
    Source sequence(s)
    AB074418, AL031848, BC017365, BU594651
    Consensus CDS
    CCDS66.1
    UniProtKB/Swiss-Prot
    O00154
    Related
    ENSP00000367076.3, ENST00000377845.7
    Conserved Domains (1) summary
    cd03442
    Location:192 → 315
    BFIT_BACH; Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis, ...

  4. NM_181866.3 → NP_863656.1  cytosolic acyl coenzyme A thioester hydrolase isoform hBACHd

    See identical proteins and their annotated locations for NP_863656.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (hBACHd) differs in the 5' UTR and 5' coding region, compared to variant hBACHb. It encodes isoform hBACHd that has a shorter and distinct N-terminus lacking a mitochondrial targetting sequence, compared to isoform hBACHb.
    Source sequence(s)
    AB074419, BC017365, BQ067921
    Consensus CDS
    CCDS67.1
    UniProtKB/TrEMBL
    K7EKP8
    Related
    ENSP00000367073.3, ENST00000377842.7
    Conserved Domains (2) summary
    cd03442
    Location:171 → 294
    BFIT_BACH; Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis, ...
    pfam16136
    Location:134 → 156
    NINJA_B; Putative nuclear localization signal

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    6264272..6393767 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047443399.1 → XP_047299355.1  cytosolic acyl coenzyme A thioester hydrolase isoform X1

    Related
    ENSP00000465719.1, ENST00000473466.2

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    5789916..5919409 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054334048.1 → XP_054190023.1  cytosolic acyl coenzyme A thioester hydrolase isoform X1

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_181862.2: Suppressed sequence

    Description
    NM_181862.2: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.

  2. NM_181863.2: Suppressed sequence

    Description
    NM_181863.2: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O00154.3 GenPept UniProtKB/Swiss-Prot:O00154

Gene LinkOut

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