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Slc33a1 solute carrier family 33 (acetyl-CoA transporter), member 1 [ Mus musculus (house mouse) ]

Gene ID: 11416, updated on 14-May-2024

Summary

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Official Symbol
Slc33a1provided by MGI
Official Full Name
solute carrier family 33 (acetyl-CoA transporter), member 1provided by MGI
Primary source
MGI:MGI:1332247
See related
Ensembl:ENSMUSG00000027822 AllianceGenome:MGI:1332247
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Acatn; D630022N01Rik
Summary
Predicted to enable solute:proton symporter activity. Predicted to be involved in BMP signaling pathway and SMAD protein signal transduction. Predicted to be located in endoplasmic reticulum and membrane. Predicted to be integral component of membrane. Is expressed in several structures, including brain; heart; liver; metanephros; and spleen. Human ortholog(s) of this gene implicated in hereditary spastic paraplegia 42. Orthologous to human SLC33A1 (solute carrier family 33 member 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in kidney adult (RPKM 15.9), adrenal adult (RPKM 12.8) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
3 E1; 3 30.08 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (63849744..63872154, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (63942323..63964733, complement)

Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA E130311K13 gene Neighboring gene predicted gene, 34379 Neighboring gene CapStarr-seq enhancer MGSCv37_chr3:63768480-63768744 Neighboring gene STARR-positive B cell enhancer ABC_E2666 Neighboring gene STARR-seq mESC enhancer starr_07841 Neighboring gene guanine monophosphate synthetase Neighboring gene vomeronasal 2, receptor, pseudogene 3 Neighboring gene vomeronasal 2, receptor 1 Neighboring gene predicted gene, 22165

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Deficient Endoplasmic Reticulum Acetyl-CoA Import in Pancreatic Acinar Cells Leads to Chronic Pancreatitis. Cooley MM, et al. Cell Mol Gastroenterol Hepatol, 2021. PMID 33080365, Free PMC Article
  2. S113R mutation in SLC33A1 leads to neurodegeneration and augmented BMP signaling in a mouse model. Liu P, et al. Dis Model Mech, 2017 Jan 1. PMID 27935820, Free PMC Article
  3. Genomic structure and promoter analysis of putative mouse acetyl-CoA transporter gene. Bora RS, et al. FEBS Lett, 2000 May 12. PMID 10812068
  4. Assignment1 of a putative acetyl-CoA transporter gene (Acatn) to mouse chromosome band 3E1-E3 by in situ hybridization. Bora RS, et al. Cytogenet Cell Genet, 1998. PMID 9925934
  5. ATG9A regulates proteostasis through reticulophagy receptors FAM134B and SEC62 and folding chaperones CALR and HSPB1. Sheehan BK, et al. iScience, 2021 Apr 23. PMID 33870132, Free PMC Article

See all (33) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Deficient Endoplasmic Reticulum Acetyl-CoA Import in Pancreatic Acinar Cells Leads to Chronic Pancreatitis.
    Title: Deficient Endoplasmic Reticulum Acetyl-CoA Import in Pancreatic Acinar Cells Leads to Chronic Pancreatitis.
  2. Results suggest that solute carrier family 33 (acetyl-CoA transporter) member 1 (AT-1) acts as an important metabolic regulator that maintains acetyl-CoA homeostasis by promoting functional crosstalk between different intracellular organelles.
    Title: Acetyl-CoA flux regulates the proteome and acetyl-proteome to maintain intracellular metabolic crosstalk.
  3. SLC33A1 can negatively regulate BMP signaling in mice.
    Title: S113R mutation in SLC33A1 leads to neurodegeneration and augmented BMP signaling in a mouse model.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Targeted (3)  1 citation

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables acetyl-CoA transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
  
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in acetyl-CoA transmembrane transport ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  
located_in endoplasmic reticulum membrane ISO
Inferred from Sequence Orthology
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
acetyl-coenzyme A transporter 1
Names
AT-1
acetyl-CoA transporter 1
solute carrier family 33 member 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001272035.1 → NP_001258964.1  acetyl-coenzyme A transporter 1 isoform 1

    See identical proteins and their annotated locations for NP_001258964.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 3' UTR compared to variant 1. Both variants 1 and 2 encode the same isoform (1).
    Source sequence(s)
    AC116732, AW519598
    Consensus CDS
    CCDS17382.1
    UniProtKB/Swiss-Prot
    Q99J27, Q9WTN1
    Related
    ENSMUSP00000125713.2, ENSMUST00000160883.2
    Conserved Domains (1) summary
    TIGR00901
    Location:86 → 459
    2A0125; AmpG-like permease

  2. NM_001331067.1 → NP_001317996.1  acetyl-coenzyme A transporter 1 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR, lacks a portion of the 5' coding region, and uses an alternate translation start site compared to variant 1. The encoded isoform (2) has a shorter and distinct N-terminus compared to isoform 1.
    Source sequence(s)
    AC116732

  3. NM_015728.5 → NP_056543.2  acetyl-coenzyme A transporter 1 isoform 1

    See identical proteins and their annotated locations for NP_056543.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same isoform (1).
    Source sequence(s)
    AC116732, AW519598
    Consensus CDS
    CCDS17382.1
    UniProtKB/Swiss-Prot
    Q99J27, Q9WTN1
    Related
    ENSMUSP00000029402.9, ENSMUST00000029402.15
    Conserved Domains (1) summary
    TIGR00901
    Location:86 → 459
    2A0125; AmpG-like permease

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000069.7 Reference GRCm39 C57BL/6J

    Range
    63849744..63872154 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q99J27.1 GenPept UniProtKB/Swiss-Prot:Q99J27

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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