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ARHGAP33 Rho GTPase activating protein 33 [ Homo sapiens (human) ]

Gene ID: 115703, updated on 7-Apr-2024

Summary

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Official Symbol
ARHGAP33provided by HGNC
Official Full Name
Rho GTPase activating protein 33provided by HGNC
Primary source
HGNC:HGNC:23085
See related
Ensembl:ENSG00000004777 MIM:614902; AllianceGenome:HGNC:23085
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SNX26; TCGAP; NOMA-GAP
Summary
This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. Alternative splice variants encoding different isoforms have been identified in this gene. [provided by RefSeq, Feb 2010]
Expression
Broad expression in testis (RPKM 7.3), brain (RPKM 5.7) and 23 other tissues See more
Orthologs
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Genomic context

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Location:
19q13.12
Exon count:
24
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (35775564..35788822)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (38320866..38334124)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (36266466..36279724)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:36248182-36248753 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14500 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14501 Neighboring gene heat shock protein family B (small) member 6 Neighboring gene proline and serine rich 3 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:36257953-36258804 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14502 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10539 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:36268039-36268924 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:36268925-36269809 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:36275082-36275900 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14503 Neighboring gene long intergenic non-protein coding RNA 1529 Neighboring gene proline dehydrogenase 2 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:36297835-36298335

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Emerging roles of ARHGAP33 in intracellular trafficking of TrkB and pathophysiology of neuropsychiatric disorders. Nakazawa T, et al. Nat Commun, 2016 Feb 3. PMID 26839058, Free PMC Article
  2. The neurite outgrowth multiadaptor RhoGAP, NOMA-GAP, regulates neurite extension through SHP2 and Cdc42. Rosário M, et al. J Cell Biol, 2007 Jul 30. PMID 17664338, Free PMC Article
  3. The Phox homology (PX) domain, a new player in phosphoinositide signalling. Xu Y, et al. Biochem J, 2001 Dec 15. PMID 11736640, Free PMC Article
  4. Physical and functional interaction of Fyn tyrosine kinase with a brain-enriched Rho GTPase-activating protein TCGAP. Liu H, et al. J Biol Chem, 2006 Aug 18. PMID 16777849
  5. Human RhoGAP domain-containing proteins: structure, function and evolutionary relationships. Peck J, et al. FEBS Lett, 2002 Sep 25. PMID 12297274

See all (20) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. ARHGAP33 is associated with brain phenotypes of patients with schizophrenia.
    Title: Emerging roles of ARHGAP33 in intracellular trafficking of TrkB and pathophysiology of neuropsychiatric disorders.
  2. Results show that neurite outgrowth multiadaptor RhoGAP protein, NOMA-GAP, plays an essential role downstream of NGF in promoting neurite outgrowth and extension by recruiting SHP2 and activating Cdc42.
    Title: The neurite outgrowth multiadaptor RhoGAP, NOMA-GAP, regulates neurite extension through SHP2 and Cdc42.
  3. Observational study of gene-disease association. (HuGE Navigator)
    Title: Multiple genetic variants along candidate pathways influence plasma high-density lipoprotein cholesterol concentrations.
  4. TCGAP interacts with Fyn and is phosphorylated by Fyn, with tyrosine-406 in the GTPase-activating protein (GAP) domain as a major Fyn-mediated phosphorylation site.
    Title: Physical and functional interaction of Fyn tyrosine kinase with a brain-enriched Rho GTPase-activating protein TCGAP.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ39019

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables GTPase activator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables phosphatidylinositol binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein kinase binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in protein transport IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of dendritic spine morphogenesis IEA
Inferred from Electronic Annotation
more info
  
involved_in response to toxic substance IEA
Inferred from Electronic Annotation
more info
  
involved_in small GTPase-mediated signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in Golgi apparatus IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in actin cytoskeleton IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in cell cortex IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol TAS
Traceable Author Statement
more info
  
located_in dendritic spine IEA
Inferred from Electronic Annotation
more info
  
is_active_in fibrillar center IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nucleoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of protein-containing complex IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
rho GTPase-activating protein 33
Names
neurite outgrowth multiadaptor RhoGAP protein
rho-type GTPase-activating protein 33
sorting nexin 26
tc10/CDC42 GTPase-activating protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001172630.2 → NP_001166101.1  rho GTPase-activating protein 33 isoform 2

    See identical proteins and their annotated locations for NP_001166101.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in 5' and 3' coding regions, as compared to variant 1. The resulting isoform (2) is shorter at the N-terminus, has a bigger additional segment and also lacks a smaller segment in the C-terminal region, as compared to isoform 1.
    Source sequence(s)
    AK127255, BC014084
    Consensus CDS
    CCDS54254.1
    UniProtKB/TrEMBL
    B3KU02
    Related
    ENSP00000368227.5, ENST00000378944.9
    Conserved Domains (3) summary
    cd11835
    Location:54 → 107
    SH3_ARHGAP32_33; Src homology 3 domain of Rho GTPase-activating proteins 32 and 33, and similar proteins
    cd04384
    Location:175 → 369
    RhoGAP_CdGAP; RhoGAP_CdGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of CdGAP-like proteins; CdGAP contains an N-terminal RhoGAP domain and a C-terminal proline-rich region, and it is active on both Cdc42 and Rac1 but not RhoA. CdGAP ...
    cl02563
    Location:1 → 32
    PX_domain; The Phox Homology domain, a phosphoinositide binding module

  2. NM_001366178.1 → NP_001353107.1  rho GTPase-activating protein 33 isoform 3

    Status: REVIEWED

    Source sequence(s)
    AC002398
    Consensus CDS
    CCDS92599.1
    UniProtKB/Swiss-Prot
    O14552, O14559, O14560, Q6ZSP6, Q96CP3, Q9NT23
    UniProtKB/TrEMBL
    B3KU02
    Related
    ENSP00000007510.6, ENST00000007510.9
    Conserved Domains (5) summary
    cd11835
    Location:190 → 243
    SH3_ARHGAP32_33; Src homology 3 domain of Rho GTPase-activating proteins 32 and 33, and similar proteins
    cd04384
    Location:311 → 505
    RhoGAP_CdGAP; RhoGAP_CdGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of CdGAP-like proteins; CdGAP contains an N-terminal RhoGAP domain and a C-terminal proline-rich region, and it is active on both Cdc42 and Rac1 but not RhoA. CdGAP ...
    cl02563
    Location:56 → 168
    PX_domain; The Phox Homology domain, a phosphoinositide binding module
    cl26464
    Location:709 → 1226
    Atrophin-1; Atrophin-1 family
    cl28033
    Location:521 → 869
    Herpes_ICP4_C; Herpesvirus ICP4-like protein C-terminal region

  3. NM_052948.4 → NP_443180.2  rho GTPase-activating protein 33 isoform 1

    See identical proteins and their annotated locations for NP_443180.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes isoform 1.
    Source sequence(s)
    AK096338, AK127255, AL137579, BC014084, BC128586
    Consensus CDS
    CCDS12477.1
    UniProtKB/TrEMBL
    B3KU02
    Related
    ENSP00000320038.4, ENST00000314737.9
    Conserved Domains (3) summary
    cd07299
    Location:56 → 168
    PX_TCGAP; The phosphoinositide binding Phox Homology domain of Tc10/Cdc42 GTPase-activating protein
    cd11835
    Location:190 → 243
    SH3_ARHGAP32_33; Src homology 3 domain of Rho GTPase-activating proteins 32 and 33, and similar proteins
    cd04384
    Location:311 → 505
    RhoGAP_CdGAP; RhoGAP_CdGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of CdGAP-like proteins; CdGAP contains an N-terminal RhoGAP domain and a C-terminal proline-rich region, and it is active on both Cdc42 and Rac1 but not RhoA. CdGAP ...

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

    Range
    35775564..35788822
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006722999.3 → XP_006723062.1  rho GTPase-activating protein 33 isoform X2

    UniProtKB/TrEMBL
    B3KU02
    Conserved Domains (3) summary
    cd11835
    Location:190 → 243
    SH3_ARHGAP32_33; Src homology 3 domain of Rho GTPase-activating proteins 32 and 33, and similar proteins
    cd04384
    Location:312 → 506
    RhoGAP_CdGAP; RhoGAP_CdGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of CdGAP-like proteins; CdGAP contains an N-terminal RhoGAP domain and a C-terminal proline-rich region, and it is active on both Cdc42 and Rac1 but not RhoA. CdGAP ...
    cl02563
    Location:56 → 168
    PX_domain; The Phox Homology domain, a phosphoinositide binding module

  2. XM_011526417.2 → XP_011524719.2  rho GTPase-activating protein 33 isoform X4

  3. XM_047438129.1 → XP_047294085.1  rho GTPase-activating protein 33 isoform X5

  4. XM_011526416.2 → XP_011524718.2  rho GTPase-activating protein 33 isoform X3

  5. XM_047438130.1 → XP_047294086.1  rho GTPase-activating protein 33 isoform X6

  6. XM_011526420.2 → XP_011524722.1  rho GTPase-activating protein 33 isoform X7

    UniProtKB/TrEMBL
    B3KU02
    Conserved Domains (3) summary
    cd11835
    Location:54 → 107
    SH3_ARHGAP32_33; Src homology 3 domain of Rho GTPase-activating proteins 32 and 33, and similar proteins
    cd04384
    Location:176 → 370
    RhoGAP_CdGAP; RhoGAP_CdGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of CdGAP-like proteins; CdGAP contains an N-terminal RhoGAP domain and a C-terminal proline-rich region, and it is active on both Cdc42 and Rac1 but not RhoA. CdGAP ...
    cl02563
    Location:1 → 32
    PX_domain; The Phox Homology domain, a phosphoinositide binding module

  7. XM_047438131.1 → XP_047294087.1  rho GTPase-activating protein 33 isoform X8

  8. XM_047438134.1 → XP_047294090.1  rho GTPase-activating protein 33 isoform X14

  9. XM_017026238.2 → XP_016881727.1  rho GTPase-activating protein 33 isoform X12

    UniProtKB/TrEMBL
    A0A0A0MQQ9, A1A5D2

  10. XM_011526421.3 → XP_011524723.1  rho GTPase-activating protein 33 isoform X13

    Conserved Domains (3) summary
    cd11835
    Location:227 → 280
    SH3_ARHGAP32_33; Src homology 3 domain of Rho GTPase-activating proteins 32 and 33, and similar proteins
    cd04384
    Location:349 → 543
    RhoGAP_CdGAP; RhoGAP_CdGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of CdGAP-like proteins; CdGAP contains an N-terminal RhoGAP domain and a C-terminal proline-rich region, and it is active on both Cdc42 and Rac1 but not RhoA. CdGAP ...
    cl02563
    Location:93 → 205
    PX_domain; The Phox Homology domain, a phosphoinositide binding module

  11. XM_047438135.1 → XP_047294091.1  rho GTPase-activating protein 33 isoform X15

  12. XM_011526418.2 → XP_011524720.1  rho GTPase-activating protein 33 isoform X1

    UniProtKB/TrEMBL
    B3KU02
    Conserved Domains (3) summary
    cd11835
    Location:54 → 107
    SH3_ARHGAP32_33; Src homology 3 domain of Rho GTPase-activating proteins 32 and 33, and similar proteins
    cd04384
    Location:176 → 370
    RhoGAP_CdGAP; RhoGAP_CdGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of CdGAP-like proteins; CdGAP contains an N-terminal RhoGAP domain and a C-terminal proline-rich region, and it is active on both Cdc42 and Rac1 but not RhoA. CdGAP ...
    cl02563
    Location:1 → 32
    PX_domain; The Phox Homology domain, a phosphoinositide binding module

  13. XM_006723003.2 → XP_006723066.1  rho GTPase-activating protein 33 isoform X9

    Conserved Domains (1) summary
    PHA03247
    Location:455 → 757
    PHA03247; large tegument protein UL36; Provisional

  14. XM_047438132.1 → XP_047294088.1  rho GTPase-activating protein 33 isoform X10

  15. XM_047438133.1 → XP_047294089.1  rho GTPase-activating protein 33 isoform X11

RNA

  1. XR_935731.3 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060943.1 Alternate T2T-CHM13v2.0

    Range
    38320866..38334124
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054319718.1 → XP_054175693.1  rho GTPase-activating protein 33 isoform X2

  2. XM_054319720.1 → XP_054175695.1  rho GTPase-activating protein 33 isoform X4

  3. XM_054319721.1 → XP_054175696.1  rho GTPase-activating protein 33 isoform X5

  4. XM_054319719.1 → XP_054175694.1  rho GTPase-activating protein 33 isoform X3

  5. XM_054319722.1 → XP_054175697.1  rho GTPase-activating protein 33 isoform X6

  6. XM_054319723.1 → XP_054175698.1  rho GTPase-activating protein 33 isoform X7

  7. XM_054319724.1 → XP_054175699.1  rho GTPase-activating protein 33 isoform X8

  8. XM_054319729.1 → XP_054175704.1  rho GTPase-activating protein 33 isoform X14

  9. XM_054319728.1 → XP_054175703.1  rho GTPase-activating protein 33 isoform X13

  10. XM_054319730.1 → XP_054175705.1  rho GTPase-activating protein 33 isoform X15

  11. XM_054319717.1 → XP_054175692.1  rho GTPase-activating protein 33 isoform X1

  12. XM_054319725.1 → XP_054175700.1  rho GTPase-activating protein 33 isoform X9

  13. XM_054319726.1 → XP_054175701.1  rho GTPase-activating protein 33 isoform X10

  14. XM_054319727.1 → XP_054175702.1  rho GTPase-activating protein 33 isoform X11

RNA

  1. XR_008485081.1 RNA Sequence

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O14559.2 GenPept UniProtKB/Swiss-Prot:O14559

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