U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Il1r2 interleukin 1 receptor type 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 117022, updated on 11-Apr-2024

Summary

Go to the top of the page Help
Official Symbol
Il1r2provided by RGD
Official Full Name
interleukin 1 receptor type 2provided by RGD
Primary source
RGD:621147
See related
Ensembl:ENSRNOG00000014378 AllianceGenome:RGD:621147
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable interleukin-1 binding activity and interleukin-1 receptor activity. Predicted to be involved in cytokine-mediated signaling pathway. Predicted to act upstream of or within negative regulation of gene expression and negative regulation of interleukin-1-mediated signaling pathway. Predicted to be located in cytoplasm. Human ortholog(s) of this gene implicated in aggressive periodontitis. Orthologous to human IL1R2 (interleukin 1 receptor type 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Thymus (RPKM 18.1), Lung (RPKM 9.2) and 5 other tissues See more
Orthologs
human mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See Il1r2 in Genome Data Viewer
Location:
9q22
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 9 NC_086027.1 (49879928..49920374)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 9 NC_051344.1 (42384280..42424726)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 9 NC_005108.4 (46840646..46881241)

Chromosome 9 - NC_086027.1Genomic Context describing neighboring genes Neighboring gene cytochrome c oxidase subunit 6A1, pseudogene 2 Neighboring gene mitogen-activated protein kinase kinase kinase kinase 4 Neighboring gene uncharacterized LOC120094675 Neighboring gene H3.3 histone A like 3

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. An Immune-Related Signature Predicts Survival in Patients With Lung Adenocarcinoma. Zhang M, et al. Front Oncol, 2019. PMID 31921619, Free PMC Article
  2. Global characterization of T cells in non-small-cell lung cancer by single-cell sequencing. Guo X, et al. Nat Med, 2018 Jul. PMID 29942094
  3. Evidence of associations between cytokine gene polymorphisms and quality of life in patients with cancer and their family caregivers. Alexander K, et al. Oncol Nurs Forum, 2014 Sep. PMID 25158664
  4. Interleukin-1 stimulates the expression of type I and type II interleukin-1 receptors in the rat insulinoma cell line Rinm5F; sequencing a rat type II interleukin-1 receptor cDNA. Bristulf J, et al. Eur Cytokine Netw, 1994 May-Jun. PMID 7524717
  5. Adipose-Derived Extract Suppresses IL-1β-Induced Inflammatory Signaling Pathways in Human Chondrocytes and Ameliorates the Cartilage Destruction of Experimental Osteoarthritis in Rats. Ohashi H, et al. Int J Mol Sci, 2021 Sep 10. PMID 34575945, Free PMC Article

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Cardiomyocyte IL-1R2 protects heart from ischemia/reperfusion injury by attenuating IL-17RA-mediated cardiomyocyte apoptosis.
    Title: Cardiomyocyte IL-1R2 protects heart from ischemia/reperfusion injury by attenuating IL-17RA-mediated cardiomyocyte apoptosis.
  2. Adipose-Derived Extract Suppresses IL-1beta-Induced Inflammatory Signaling Pathways in Human Chondrocytes and Ameliorates the Cartilage Destruction of Experimental Osteoarthritis in Rats.
    Title: Adipose-Derived Extract Suppresses IL-1β-Induced Inflammatory Signaling Pathways in Human Chondrocytes and Ameliorates the Cartilage Destruction of Experimental Osteoarthritis in Rats.
  3. Activity of Il-1 in parturition is regulated by progesterone via Il1R1/Il1R2/Il-1RAcp pathway.
    Title: Interleukin (IL)-1 in rat parturition: IL-1 receptors 1 and 2 and accessory proteins abundance in pregnant rat uterus at term - regulation by progesterone.
Submit: New GeneRIF Correction

Pathways from PubChem

Go to the top of the page

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables interleukin-1 binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables interleukin-1 binding IEA
Inferred from Electronic Annotation
more info
  
enables interleukin-1 binding ISO
Inferred from Sequence Orthology
more info
  
enables interleukin-1 receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables interleukin-1 receptor activity ISO
Inferred from Sequence Orthology
more info
  
enables interleukin-1, type II, blocking receptor activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in cytokine-mediated signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of cytokine production involved in inflammatory response IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within negative regulation of cytokine production involved in inflammatory response ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of interleukin-1 alpha production IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within negative regulation of interleukin-1 alpha production ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of interleukin-1-mediated signaling pathway IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within negative regulation of interleukin-1-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of protein processing IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within negative regulation of protein processing ISO
Inferred from Sequence Orthology
more info
  
involved_in protein processing IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of protein processing ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

Go to the top of the page Help
Preferred Names
interleukin-1 receptor type 2
Names
CD121 antigen-like family member B
IL-1 type II receptor
IL-1R-2
IL-1R-beta
IL-1RT-2
IL-1RT2
interleukin-1 receptor beta
interleukin-1 receptor type II

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_053953.2 → NP_446405.1  interleukin-1 receptor type 2 precursor

    See identical proteins and their annotated locations for NP_446405.1

    Status: PROVISIONAL

    Source sequence(s)
    JAXUCZ010000009
    UniProtKB/Swiss-Prot
    P43303, Q5BJ99
    UniProtKB/TrEMBL
    A0A0H2UHL7, A6INM7
    Related
    ENSRNOP00000019415.4, ENSRNOT00000019415.6
    Conserved Domains (1) summary
    PHA02785
    Location:41 → 340
    PHA02785; IL-beta-binding protein; Provisional

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086027.1 Reference GRCr8

    Range
    49879928..49920374
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039082947.2 → XP_038938875.1  interleukin-1 receptor type 2 isoform X1

    Conserved Domains (1) summary
    PHA02785
    Location:59 → 310
    PHA02785; IL-beta-binding protein; Provisional
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P43303.1 GenPept UniProtKB/Swiss-Prot:P43303

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous