sfrp5 secreted frizzled-related protein 5 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: sfrp5provided by ZNC
Official Full Name: secreted frizzled-related protein 5provided by ZNC
Primary source: ZFIN:ZDB-GENE-011108-2
See related: Ensembl:ENSDARG00000039041 AllianceGenome:ZFIN:ZDB-GENE-011108-2
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: D144; frp1; zgc:101849
Summary: Predicted to enable Wnt-protein binding activity. Acts upstream of with a negative effect on canonical Wnt signaling pathway and non-canonical Wnt signaling pathway. Acts upstream of or within animal organ development; endodermal digestive tract morphogenesis; and regulation of signal transduction. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Is expressed in several structures, including anterior neural keel; anterior neural rod; gut; immature eye; and nervous system. Orthologous to human SFRP5 (secreted frizzled related protein 5). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 13

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	13	NC_007124.7 (39911551..39947335, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	13	NC_007124.6 (39785661..39821445, complement)

Chromosome 13 - NC_007124.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

note an increase in BMP ligand expression in Sfrp1a/5 depleted embryos, a phenotype similar to that seen in embryos with inhibited BMP signaling
Title: Sfrp1a and Sfrp5 function as positive regulators of Wnt and BMP signaling during early retinal development.
Sfrp5 inhibits both canonical and non-canonical Wnt signaling during embryonic and endodermal development
Title: Sfrp5 modulates both Wnt and BMP signaling and regulates gastrointestinal organogenesis [corrected] in the zebrafish, Danio rerio.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables Wnt-protein binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within Wnt signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in canonical Wnt signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_negative_effect canonical Wnt signaling pathway	IMP Inferred from Mutant Phenotype more info
acts_upstream_of_or_within cell differentiation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within closure of optic fissure	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within embryonic retina morphogenesis in camera-type eye	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within endodermal digestive tract morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within eye development	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within forebrain development	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within liver morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in non-canonical Wnt signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_negative_effect non-canonical Wnt signaling pathway	IMP Inferred from Mutant Phenotype more info
acts_upstream_of_or_within positive regulation of BMP signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within positive regulation of Wnt signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within regulation of Wnt signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed

Component	Evidence Code	Pubs
located_in extracellular region	IEA Inferred from Electronic Annotation more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: secreted frizzled-related protein 5

Names: sfrp1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_131858.1 → NP_571933.1 secreted frizzled-related protein 5 precursor

See identical proteins and their annotated locations for NP_571933.1

Status: PROVISIONAL

Source sequence(s)

BC085455

UniProtKB/TrEMBL

Q6YNR8

Related

ENSDARP00000056995.4, ENSDART00000056996.5

Conserved Domains (2) summary

cd07444
Location:46 → 172

CRD_SFRP5; Cysteine-rich domain of the secreted frizzled-related protein 5 (SFRP5), a regulator of Wnt activity

cd03580
Location:177 → 302

NTR_Sfrp1_like; NTR domain, Secreted frizzled-related protein (Sfrp) 1-like subfamily; composed of proteins similar to human Sfrp1, Sfrp2 and Sfrp5. Sfrps are soluble proteins containing an NTR domain C-terminal to a cysteine-rich Frizzled domain. They show diverse ...