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Aox1 aldehyde oxidase 1 [ Mus musculus (house mouse) ]

Gene ID: 11761, updated on 5-Mar-2024

Summary

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Official Symbol
Aox1provided by MGI
Official Full Name
aldehyde oxidase 1provided by MGI
Primary source
MGI:MGI:88035
See related
Ensembl:ENSMUSG00000063558 AllianceGenome:MGI:88035
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Ao; Ro; Aox2; Moro; Aox-1; Aox-2
Summary
Enables aldehyde oxidase activity; protein homodimerization activity; and retinal oxidase activity. Involved in xenobiotic metabolic process. Located in cytosol. Is expressed in retina. Human ortholog(s) of this gene implicated in amyotrophic lateral sclerosis. Orthologous to human AOX1 (aldehyde oxidase 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in bladder adult (RPKM 8.7), subcutaneous fat pad adult (RPKM 8.5) and 14 other tissues See more
Orthologs
human all
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Genomic context

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See Aox1 in Genome Data Viewer
Location:
1 C1.3; 1 28.86 cM
Exon count:
36
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (58068963..58145569)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (58029809..58106410)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene potassium channel tetramerisation domain containing 18 Neighboring gene STARR-positive B cell enhancer ABC_E7730 Neighboring gene STARR-seq mESC enhancer starr_01001 Neighboring gene shugoshin 2A Neighboring gene STARR-seq mESC enhancer starr_01003 Neighboring gene STARR-seq mESC enhancer starr_01004 Neighboring gene STARR-seq mESC enhancer starr_01005 Neighboring gene predicted gene, 39643 Neighboring gene aldehyde oxidase 3 Neighboring gene predicted gene, 24548

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Expressional studies of the aldehyde oxidase (AOX1) gene during myogenic differentiation in C2C12 cells. Kamli MR, et al. Biochem Biophys Res Commun, 2014 Aug 8. PMID 24996175
  2. Small-interference RNA-mediated knock-down of aldehyde oxidase 1 in 3T3-L1 cells impairs adipogenesis and adiponectin release. Weigert J, et al. FEBS Lett, 2008 Aug 20. PMID 18671973
  3. The mouse aldehyde oxidase gene: molecular cloning, chromosomal mapping and functional characterization of the 5'-flanking region. Demontis S, et al. Biochim Biophys Acta, 1999 Dec 23. PMID 10673024
  4. Selective localization of mouse aldehyde oxidase mRNA in the choroid plexus and motor neurons. Bendotti C, et al. Neuroreport, 1997 Jul 7. PMID 9243637
  5. Genetic variations of an oxidase in mammals. Gluecksohn-Waelsch S, et al. J Biol Chem, 1967 Mar 25. PMID 4225774

See all (42) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Although mAOX2 and mAOX3 are very similar to each other, we propose the following pairs of overlapping substrate specificities: mAOX2/mAOX4 and mAOX3/mAXO1.
    Title: Insights into the structural determinants of substrate specificity and activity in mouse aldehyde oxidases.
  2. findings suggest that AOX1 acts as a contributor to the process of myogenesis by influencing the level of H2O2
    Title: Expressional studies of the aldehyde oxidase (AOX1) gene during myogenic differentiation in C2C12 cells.
  3. only Glu1265 is essential for catalytic activity by initiating the base-catalyzed mechanism of substrate oxidation
    Title: Site directed mutagenesis of amino acid residues at the active site of mouse aldehyde oxidase AOX1.
  4. These data indicate that AOX1 is essential for adipogenesis and may link energy and drug metabolism.
    Title: Small-interference RNA-mediated knock-down of aldehyde oxidase 1 in 3T3-L1 cells impairs adipogenesis and adiponectin release.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1) 
  • Endonuclease-mediated (2) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC13774

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables 2 iron, 2 sulfur cluster binding ISO
Inferred from Sequence Orthology
more info
  
enables FAD binding IEA
Inferred from Electronic Annotation
more info
  
enables NAD binding IEA
Inferred from Electronic Annotation
more info
  
enables aldehyde oxidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables aldehyde oxidase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables aldehyde oxidase activity ISO
Inferred from Sequence Orthology
more info
  
enables flavin adenine dinucleotide binding ISO
Inferred from Sequence Orthology
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables iron ion binding ISO
Inferred from Sequence Orthology
more info
  
enables iron-sulfur cluster binding IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables molybdopterin cofactor binding ISO
Inferred from Sequence Orthology
more info
  
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein homodimerization activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within lipid metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in xenobiotic metabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in xenobiotic metabolic process ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
aldehyde oxidase 1
Names
aldehyde oxidase 2
azaheterocycle hydroxylase 1
retinal oxidase
NP_033806.2
XP_006495693.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_009676.2 → NP_033806.2  aldehyde oxidase 1

    See identical proteins and their annotated locations for NP_033806.2

    Status: VALIDATED

    Source sequence(s)
    AB017482, AC025116, AC117562
    Consensus CDS
    CCDS35575.1
    UniProtKB/TrEMBL
    G3X8P9, Q8R387
    Related
    ENSMUSP00000001027.7, ENSMUST00000001027.7
    Conserved Domains (6) summary
    TIGR02969
    Location:5 → 1333
    mam_aldehyde_ox; aldehyde oxidase
    pfam00941
    Location:238 → 418
    FAD_binding_5; FAD binding domain in molybdopterin dehydrogenase
    pfam01315
    Location:593 → 695
    Ald_Xan_dh_C; Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain
    pfam01799
    Location:87 → 160
    Fer2_2; [2Fe-2S] binding domain
    pfam02738
    Location:708 → 1240
    Ald_Xan_dh_C2; Molybdopterin-binding domain of aldehyde dehydrogenase
    pfam03450
    Location:425 → 529
    CO_deh_flav_C; CO dehydrogenase flavoprotein C-terminal domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    58068963..58145569
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006495630.5 → XP_006495693.1  aldehyde oxidase 1 isoform X1

    Conserved Domains (1) summary
    TIGR02969
    Location:5 → 703
    mam_aldehyde_ox; aldehyde oxidase
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O54754.2 GenPept UniProtKB/Swiss-Prot:O54754

Gene LinkOut

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