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Arsb arylsulfatase B [ Mus musculus (house mouse) ]

Gene ID: 11881, updated on 5-Mar-2024

Summary

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Official Symbol
Arsbprovided by MGI
Official Full Name
arylsulfatase Bprovided by MGI
Primary source
MGI:MGI:88075
See related
Ensembl:ENSMUSG00000042082 AllianceGenome:MGI:88075
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
As1; As-1; As-1r; As-1s; As-1t; As1-r; As1-s; As1-t; Asr-1; Ast-1; 1110007C02Rik
Summary
Enables arylsulfatase activity. Acts upstream of or within anterior head development. Located in cell surface. Is expressed in skeleton. Used to study mucopolysaccharidosis VI. Human ortholog(s) of this gene implicated in mucopolysaccharidosis VI. Orthologous to human ARSB (arylsulfatase B). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in kidney adult (RPKM 45.3), ovary adult (RPKM 25.9) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Arsb in Genome Data Viewer
Location:
13 C3; 13 47.88 cM
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (93908187..94079524)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (93771679..93943016)

Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene dimethylglycine dehydrogenase precursor Neighboring gene expressed sequence AW495222 Neighboring gene predicted gene, 41021 Neighboring gene microRNA 5624 Neighboring gene STARR-seq mESC enhancer starr_35297 Neighboring gene predicted gene, 24737 Neighboring gene STARR-seq mESC enhancer starr_35299 Neighboring gene STARR-seq mESC enhancer starr_35300 Neighboring gene cytochrome c, pseudogene 3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Early enzyme replacement therapy prevents dental and craniofacial abnormalities in a mouse model of mucopolysaccharidosis type VI. Nagpal R, et al. Front Physiol, 2022. PMID 36213247, Free PMC Article
  2. Increased CHST15 follows decline in arylsulfatase B (ARSB) and disinhibition of non-canonical WNT signaling: potential impact on epithelial and mesenchymal identity. Bhattacharyya S, et al. Oncotarget, 2020 Jun 16. PMID 32595831, Free PMC Article
  3. Odiparcil, a potential glycosaminoglycans clearance therapy in mucopolysaccharidosis VI-Evidence from in vitro and in vivo models. Entchev E, et al. PLoS One, 2020. PMID 32413051, Free PMC Article
  4. Enzyme replacement therapy in mice lacking arylsulfatase B targets bone-remodeling cells, but not chondrocytes. Hendrickx G, et al. Hum Mol Genet, 2020 Mar 27. PMID 31943020, Free PMC Article
  5. Expression and Distribution of Arylsulfatase B are Closely Associated with Neuron Death in SOD1 G93A Transgenic Mice. Zhang J, et al. Mol Neurobiol, 2018 Feb. PMID 28124772

See all (59) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Arsb-deficient mice and the underlying bone cell deficits were fully corrected by enzyme replacement therapy in the trabecular compartment.
    Title: The Lysosomal Protein Arylsulfatase B Is a Key Enzyme Involved in Skeletal Turnover.
  2. Our data suggested that the abnormal expression and distribution of ARSB were closely associated with the neuron death in the SOD1 G93A transgenic mice.
    Title: Expression and Distribution of Arylsulfatase B are Closely Associated with Neuron Death in SOD1 G93A Transgenic Mice.
  3. Arylsulfatase B regulates versican expression by galectin-3 and AP-1 mediated transcriptional effects.
    Title: Arylsulfatase B regulates versican expression by galectin-3 and AP-1 mediated transcriptional effects.
  4. These studies reveal how carrageenan exposure can lead to transcriptional events in colonic epithelial cells through decline in arylsulfatase B activity, with subsequent impact on C4S, galectin-3, Sp1, and Wnt9A
    Title: Increased expression of colonic Wnt9A through Sp1-mediated transcriptional effects involving arylsulfatase B, chondroitin 4-sulfate, and galectin-3.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables N-acetylgalactosamine-4-sulfatase activity ISO
Inferred from Sequence Orthology
more info
 PubMed 
enables N-acetylgalactosamine-6-sulfatase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables arylsulfatase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables sulfuric ester hydrolase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within anterior head development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in autophagy ISO
Inferred from Sequence Orthology
more info
  
involved_in chondroitin sulfate catabolic process ISO
Inferred from Sequence Orthology
more info
 PubMed 
involved_in colon epithelial cell migration ISO
Inferred from Sequence Orthology
more info
  
involved_in dermatan sulfate catabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of neuron projection development ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of epithelial cell migration ISO
Inferred from Sequence Orthology
more info
  
involved_in response to estrogen ISO
Inferred from Sequence Orthology
more info
  
involved_in response to methylmercury ISO
Inferred from Sequence Orthology
more info
  
involved_in response to nutrient ISO
Inferred from Sequence Orthology
more info
  
involved_in response to pH ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cell surface IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cell surface ISO
Inferred from Sequence Orthology
more info
  
is_active_in lysosome IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
arylsulfatase B
Names
ASB
G4S
N-acetylgalactosamine-4-sulfatase
arylsulfatase B complex
arylsulfatase B regulation
arylsulfatase B structural
arylsulfatase B temporal regulation
NP_033842.3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_009712.3 → NP_033842.3  arylsulfatase B precursor

    See identical proteins and their annotated locations for NP_033842.3

    Status: VALIDATED

    Source sequence(s)
    AC136976, AK140163, AK158312
    Consensus CDS
    CCDS36749.1
    UniProtKB/Swiss-Prot
    P50429, Q32KJ1, Q3TYV7, Q3U4Q6, Q8C404
    UniProtKB/TrEMBL
    A0A0R4J138
    Related
    ENSMUSP00000088964.5, ENSMUST00000091403.6
    Conserved Domains (2) summary
    COG3119
    Location:42 → 490
    AslA; Arylsulfatase A or related enzyme [Inorganic ion transport and metabolism]
    cd16029
    Location:46 → 489
    4-S; N-acetylgalactosamine 4-sulfatase, also called arylsulftase B

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000079.7 Reference GRCm39 C57BL/6J

    Range
    93908187..94079524
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P50429.3 GenPept UniProtKB/Swiss-Prot:P50429

Gene LinkOut

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