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Atp5mc1 ATP synthase membrane subunit c locus 1 [ Mus musculus (house mouse) ]

Gene ID: 11951, updated on 11-Apr-2024

Summary

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Official Symbol
Atp5mc1provided by MGI
Official Full Name
ATP synthase membrane subunit c locus 1provided by MGI
Primary source
MGI:MGI:107653
See related
Ensembl:ENSMUSG00000006057 AllianceGenome:MGI:107653
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Atp5g1
Summary
Predicted to enable ligand-gated channel activity. Predicted to be involved in several processes, including ATP synthesis coupled proton transport; cellular response to L-glutamate; and negative regulation of mitochondrial membrane potential. Predicted to act upstream of or within ion transport. Located in mitochondrial inner membrane. Is expressed in several structures, including alimentary system; genitourinary system; hemolymphoid system; liver; and nervous system. Orthologous to human ATP5MC1 (ATP synthase membrane subunit c locus 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in heart adult (RPKM 958.8), duodenum adult (RPKM 383.7) and 27 other tissues See more
Orthologs
human all
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Genomic context

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Location:
11 D; 11 59.33 cM
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (95963619..95966520, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (96072793..96075694, complement)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene SNF8, ESCRT-II complex subunit, homolog (S. cerevisiae) Neighboring gene ubiquitin-conjugating enzyme E2Z Neighboring gene STARR-seq mESC enhancer starr_30532 Neighboring gene predicted gene, 22423 Neighboring gene calcium binding and coiled-coil domain 2 Neighboring gene STARR-seq mESC enhancer starr_30533 Neighboring gene tubulin tyrosine ligase-like family, member 6

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Mitochondrial ATP synthase levels in brown adipose tissue are governed by the c-Fo subunit P1 isoform. Kramarova TV, et al. FASEB J, 2008 Jan. PMID 17666453
  2. Sequence of a mouse embryo cDNA clone encoding proteolipid subunit 9 (P1) of the mitochondrial H(+)-ATP synthase. Pikó L, et al. Biochim Biophys Acta, 1994 Feb 8. PMID 8305451
  3. Patterns of mRNA prevalence and expression of B1 and B2 transcripts in early mouse embryos. Taylor KD, et al. Development, 1987 Dec. PMID 3503701
  4. Mitochondrial biogenesis in early mouse embryos: expression of the mRNAs for subunits IV, Vb, and VIIc of cytochrome c oxidase and subunit 9 (P1) of H(+)-ATP synthase. Taylor KD, et al. Mol Reprod Dev, 1995 Jan. PMID 7535541
  5. Stress-Induced Cyclin C Translocation Regulates Cardiac Mitochondrial Dynamics. Ponce JM, et al. J Am Heart Assoc, 2020 Apr 7. PMID 32248761, Free PMC Article

See all (34) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ligand-gated channel activity ISO
Inferred from Sequence Orthology
more info
  
enables lipid binding IEA
Inferred from Electronic Annotation
more info
  
enables proton transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within monoatomic ion transport IEA
Inferred from Electronic Annotation
more info
  
involved_in proton motive force-driven ATP synthesis IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within proton transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in proton transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of cation channel complex ISO
Inferred from Sequence Orthology
more info
  
located_in distal axon ISO
Inferred from Sequence Orthology
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrial inner membrane HDA PubMed 
part_of mitochondrial proton-transporting ATP synthase complex ISO
Inferred from Sequence Orthology
more info
  
part_of mitochondrial proton-transporting ATP synthase complex, coupling factor F(o) IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of mitochondrial proton-transporting ATP synthase complex, coupling factor F(o) ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrion HDA PubMed 
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  
located_in neuronal cell body ISO
Inferred from Sequence Orthology
more info
  
part_of proton-transporting ATP synthase complex, coupling factor F(o) IEA
Inferred from Electronic Annotation
more info
  
part_of proton-transporting two-sector ATPase complex, proton-transporting domain IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
ATP synthase F(0) complex subunit C1, mitochondrial
Names
ATP synthase lipid-binding protein, mitochondrial
ATP synthase proteolipid P1
ATP synthase, H+ transporting, mitochondrial F0 complex, subunit C1 (subunit 9)
ATPase protein 9
ATPase subunit c

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001161419.1 → NP_001154891.1  ATP synthase F(0) complex subunit C1, mitochondrial

    See identical proteins and their annotated locations for NP_001154891.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) has an alternate 5' UTR exon, as compared to variant 1.
    Source sequence(s)
    AK009883, BY276643, CF749235
    Consensus CDS
    CCDS25289.1
    UniProtKB/Swiss-Prot
    Q3TIE9, Q9CR84
    Related
    ENSMUSP00000103312.2, ENSMUST00000107684.2
    Conserved Domains (1) summary
    MTH00222
    Location:62 → 136
    ATP9; ATP synthase F0 subunit 9; Provisional

  2. NM_001417327.1 → NP_001404256.1  ATP synthase F(0) complex subunit C1, mitochondrial

    Status: VALIDATED

    Source sequence(s)
    AL603682
    UniProtKB/Swiss-Prot
    Q3TIE9, Q9CR84
    Related
    ENSMUSP00000103314.2, ENSMUST00000107686.8

  3. NM_007506.6 → NP_031532.2  ATP synthase F(0) complex subunit C1, mitochondrial

    See identical proteins and their annotated locations for NP_031532.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) and variant 2 encode the same protein.
    Source sequence(s)
    AK010868, BY297329, CF749235
    Consensus CDS
    CCDS25289.1
    UniProtKB/Swiss-Prot
    Q3TIE9, Q9CR84
    Related
    ENSMUSP00000088029.6, ENSMUST00000090541.12
    Conserved Domains (1) summary
    MTH00222
    Location:62 → 136
    ATP9; ATP synthase F0 subunit 9; Provisional

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    95963619..95966520 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9CR84.1 GenPept UniProtKB/Swiss-Prot:Q9CR84

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