Auh AU RNA binding protein/enoyl-coenzyme A hydratase [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Auhprovided by MGI
Official Full Name: AU RNA binding protein/enoyl-coenzyme A hydrataseprovided by MGI
Primary source: MGI:MGI:1338011
See related: Ensembl:ENSMUSG00000021460 AllianceGenome:MGI:1338011
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary: Enables RNA binding activity and enoyl-CoA hydratase activity. Predicted to be involved in fatty acid beta-oxidation. Predicted to act upstream of or within branched-chain amino acid catabolic process. Located in mitochondrion. Human ortholog(s) of this gene implicated in 3-methylglutaconic aciduria type 1 and renal tubular transport disease. Orthologous to human AUH (AU RNA binding methylglutaconyl-CoA hydratase). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in cerebellum adult (RPKM 10.0), kidney adult (RPKM 9.4) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 13 A5- B1; 13 27.68 cM

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	13	NC_000079.7 (52989155..53083742, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	13	NC_000079.6 (52835107..52929704, complement)

Chromosome 13 - NC_000079.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (4)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH126105 (e-PCR)
- UniSTS:162817

RH125304 (e-PCR)
- UniSTS:162126

Auh (e-PCR), detects polymorphism
- UniSTS:546676

NoName (e-PCR)
- UniSTS:237018

D13Mit140 (e-PCR), detects polymorphism
- UniSTS:126963

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables RNA binding	IDA Inferred from Direct Assay more info	PubMed
enables catalytic activity	IEA Inferred from Electronic Annotation more info
enables enoyl-CoA hydratase activity	IBA Inferred from Biological aspect of Ancestor more info
enables enoyl-CoA hydratase activity	IDA Inferred from Direct Assay more info	PubMed
enables enoyl-CoA hydratase activity	ISO Inferred from Sequence Orthology more info
enables itaconyl-CoA hydratase activity	IEA Inferred from Electronic Annotation more info
enables lyase activity	IEA Inferred from Electronic Annotation more info
enables mRNA 3'-UTR binding	ISO Inferred from Sequence Orthology more info
enables methylglutaconyl-CoA hydratase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within branched-chain amino acid catabolic process	IEA Inferred from Electronic Annotation more info
involved_in fatty acid beta-oxidation	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in mitochondrion	HDA more info	PubMed
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrion	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: methylglutaconyl-CoA hydratase, mitochondrial

Names: 3-MG-CoA hydratase; AU-binding enoyl-CoA hydratase; AU-specific RNA-binding enoyl-CoA hydratase; itaconyl-CoA hydratase; muAUH

NP_001413039.1

EC 4.2.1.18

EC 4.2.1.56

NP_001413040.1

EC 4.2.1.18

EC 4.2.1.56

NP_001413041.1

EC 4.2.1.18

EC 4.2.1.56

NP_001413042.1

EC 4.2.1.18

EC 4.2.1.56

NP_001413043.1

EC 4.2.1.18

EC 4.2.1.56

NP_001413044.1

EC 4.2.1.18

EC 4.2.1.56

NP_001413045.1

EC 4.2.1.18

EC 4.2.1.56

NP_001413046.1

EC 4.2.1.18

EC 4.2.1.56

NP_001413047.1

EC 4.2.1.18

EC 4.2.1.56

NP_001413048.1

EC 4.2.1.18

EC 4.2.1.56

NP_001413049.1

EC 4.2.1.18

EC 4.2.1.56

NP_001413050.1

EC 4.2.1.18

EC 4.2.1.56

NP_001413051.1

EC 4.2.1.18

EC 4.2.1.56

NP_057918.2

EC 4.2.1.18

EC 4.2.1.56

XP_006516909.1

EC 4.2.1.18

EC 4.2.1.56

XP_017170862.1

EC 4.2.1.18

EC 4.2.1.56

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001426110.1 → NP_001413039.1 methylglutaconyl-CoA hydratase, mitochondrial isoform 2

Status: VALIDATED

Source sequence(s)

AC140443, AC160765
NM_001426111.1 → NP_001413040.1 methylglutaconyl-CoA hydratase, mitochondrial isoform 3

Status: VALIDATED

Source sequence(s)

AC140443, AC160765
NM_001426112.1 → NP_001413041.1 methylglutaconyl-CoA hydratase, mitochondrial isoform 4

Status: VALIDATED

Source sequence(s)

AC140443, AC160765
NM_001426113.1 → NP_001413042.1 methylglutaconyl-CoA hydratase, mitochondrial isoform 5

Status: VALIDATED

Source sequence(s)

AC140443, AC160765
NM_001426114.1 → NP_001413043.1 methylglutaconyl-CoA hydratase, mitochondrial isoform 6

Status: VALIDATED

Source sequence(s)

AC140443, AC160765
NM_001426115.1 → NP_001413044.1 methylglutaconyl-CoA hydratase, mitochondrial isoform 7

Status: VALIDATED

Source sequence(s)

AC140443, AC160765
NM_001426116.1 → NP_001413045.1 methylglutaconyl-CoA hydratase, mitochondrial isoform 8

Status: VALIDATED

Source sequence(s)

AC140443, AC160765
NM_001426117.1 → NP_001413046.1 methylglutaconyl-CoA hydratase, mitochondrial isoform 9

Status: VALIDATED

Source sequence(s)

AC140443, AC160765
NM_001426118.1 → NP_001413047.1 methylglutaconyl-CoA hydratase, mitochondrial isoform 10

Status: VALIDATED

Source sequence(s)

AC140443, AC160765
NM_001426119.1 → NP_001413048.1 methylglutaconyl-CoA hydratase, mitochondrial isoform 11

Status: VALIDATED

Source sequence(s)

AC140443, AC160765
NM_001426120.1 → NP_001413049.1 methylglutaconyl-CoA hydratase, mitochondrial isoform 12

Status: VALIDATED

Source sequence(s)

AC140443, AC160765
NM_001426121.1 → NP_001413050.1 methylglutaconyl-CoA hydratase, mitochondrial isoform 13

Status: VALIDATED

Source sequence(s)

AC140443, AC160765
NM_001426122.1 → NP_001413051.1 methylglutaconyl-CoA hydratase, mitochondrial isoform 13

Status: VALIDATED

Source sequence(s)

AC140443, AC160765
NM_016709.3 → NP_057918.2 methylglutaconyl-CoA hydratase, mitochondrial isoform 1

See identical proteins and their annotated locations for NP_057918.2

Status: VALIDATED

Source sequence(s)

AC140443, AC160765

Consensus CDS

CCDS26518.1

UniProtKB/Swiss-Prot

Q80YD7, Q8QZS0, Q9CY78, Q9D155, Q9JLZ3

UniProtKB/TrEMBL

A0A0R4J023

Related

ENSMUSP00000021913.10, ENSMUST00000021913.16

Conserved Domains (1) summary

cl23717
Location:61 → 314

crotonase-like; Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase. ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000079.7 Reference GRCm39 C57BL/6J

Range

52989155..53083742 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017315373.3 → XP_017170862.1 methylglutaconyl-CoA hydratase, mitochondrial isoform X2

UniProtKB/TrEMBL

E9QMT1

Conserved Domains (1) summary

cl23717
Location:61 → 114

crotonase-like; Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase. ...
XM_006516846.5 → XP_006516909.1 methylglutaconyl-CoA hydratase, mitochondrial isoform X2

UniProtKB/TrEMBL

E9QMT1

Related

ENSMUSP00000105658.4, ENSMUST00000110031.4

Conserved Domains (1) summary

cl23717
Location:61 → 114

crotonase-like; Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase. ...