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Camk4 calcium/calmodulin-dependent protein kinase IV [ Mus musculus (house mouse) ]

Gene ID: 12326, updated on 11-Apr-2024

Summary

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Official Symbol
Camk4provided by MGI
Official Full Name
calcium/calmodulin-dependent protein kinase IVprovided by MGI
Primary source
MGI:MGI:88258
See related
Ensembl:ENSMUSG00000038128 AllianceGenome:MGI:88258
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
CaMKIV; CaMKIV/Gr; D18Bwg0362e; A430110E23Rik
Summary
Predicted to enable calcium-dependent protein serine/threonine kinase activity; calmodulin binding activity; and calmodulin-dependent protein kinase activity. Involved in postsynapse to nucleus signaling pathway. Acts upstream of or within several processes, including neuron-neuron synaptic transmission; nucleocytoplasmic transport; and positive regulation of protein export from nucleus. Located in several cellular components, including GABA-ergic synapse; glutamatergic synapse; and nucleus. Is expressed in several structures, including alimentary system; brain; eye; hemolymphoid system gland; and reproductive system. Orthologous to human CAMK4 (calcium/calmodulin dependent protein kinase IV). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in cerebellum adult (RPKM 21.8), cortex adult (RPKM 9.3) and 6 other tissues See more
Orthologs
human all
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Genomic context

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Location:
18 B1; 18 18.15 cM
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 18 NC_000084.7 (33067995..33328820)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 18 NC_000084.6 (32934941..33195767)

Chromosome 18 - NC_000084.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 4930455D15 gene Neighboring gene WD repeat domain 36 Neighboring gene RIKEN cDNA 2310026I22 gene Neighboring gene microRNA 6361 Neighboring gene CapStarr-seq enhancer MGSCv37_chr18:33100529-33100712 Neighboring gene CapStarr-seq enhancer MGSCv37_chr18:33105060-33105243 Neighboring gene STARR-seq mESC enhancer starr_44161 Neighboring gene STARR-seq mESC enhancer starr_44162 Neighboring gene STARR-seq mESC enhancer starr_44163 Neighboring gene STARR-seq mESC enhancer starr_44164 Neighboring gene STARR-seq mESC enhancer starr_44165 Neighboring gene predicted gene, 54015 Neighboring gene STARR-positive B cell enhancer ABC_E775 Neighboring gene StAR related lipid transfer domain containing 4 Neighboring gene predicted gene, 41683 Neighboring gene predicted gene, 46640

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Calcium/calmodulin dependent protein kinase IV in trophoblast cells under insulin resistance: functional and metabolomic analyses. Li L, et al. Mol Med, 2023 Jun 29. PMID 37386367, Free PMC Article
  2. CaMK4 Promotes Acute Lung Injury Through NLRP3 Inflammasome Activation in Type II Alveolar Epithelial Cell. Zhang T, et al. Front Immunol, 2022. PMID 35734175, Free PMC Article
  3. Calcium/calmodulin-dependent protein kinase IV regulates vascular autophagy and insulin signaling through Akt/mTOR/CREB pathway in ob/ob mice. Liu J, et al. J Physiol Biochem, 2022 Feb. PMID 34741274
  4. Attenuated β-adrenergic response in calcium/calmodulin-dependent protein kinase IV-knockout mice. Murakami M, et al. PLoS One, 2021. PMID 33857227, Free PMC Article
  5. CaMKIV regulates mitochondrial dynamics during sepsis. Zhang X, et al. Cell Calcium, 2020 Dec. PMID 32932146, Free PMC Article

See all (128) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. CaMK4 controls follicular helper T cell expansion and function during normal and autoimmune T-dependent B cell responses.
    Title: CaMK4 controls follicular helper T cell expansion and function during normal and autoimmune T-dependent B cell responses.
  2. Calcium/calmodulin dependent protein kinase IV in trophoblast cells under insulin resistance: functional and metabolomic analyses.
    Title: Calcium/calmodulin dependent protein kinase IV in trophoblast cells under insulin resistance: functional and metabolomic analyses.
  3. CaMK4 overexpression in polycystic kidney disease promotes mTOR-mediated cell proliferation.
    Title: CaMK4 overexpression in polycystic kidney disease promotes mTOR-mediated cell proliferation.
  4. CaMK4 Promotes Acute Lung Injury Through NLRP3 Inflammasome Activation in Type II Alveolar Epithelial Cell.
    Title: CaMK4 Promotes Acute Lung Injury Through NLRP3 Inflammasome Activation in Type II Alveolar Epithelial Cell.
  5. Calcium/calmodulin-dependent protein kinase IV regulates vascular autophagy and insulin signaling through Akt/mTOR/CREB pathway in ob/ob mice.
    Title: Calcium/calmodulin-dependent protein kinase IV regulates vascular autophagy and insulin signaling through Akt/mTOR/CREB pathway in ob/ob mice.
  6. Aberrantly glycosylated IgG elicits pathogenic signaling in podocytes and signifies lupus nephritis.
    Title: Aberrantly glycosylated IgG elicits pathogenic signaling in podocytes and signifies lupus nephritis.
  7. CaMKIV regulates mitochondrial dynamics during sepsis.
    Title: CaMKIV regulates mitochondrial dynamics during sepsis.
  8. CAMKK2-CAMK4 signaling regulates transferrin trafficking, turnover, and iron homeostasis.
    Title: CAMKK2-CAMK4 signaling regulates transferrin trafficking, turnover, and iron homeostasis.
  9. CaMK4-dependent phosphorylation of Akt/mTOR underlies Th17 excessive activation in experimental autoimmune prostatitis.
    Title: CaMK4-dependent phosphorylation of Akt/mTOR underlies Th17 excessive activation in experimental autoimmune prostatitis.
  10. CaMKIV limits metabolic damage through induction of hepatic autophagy by CREB in obese mice.
    Title: CaMKIV limits metabolic damage through induction of hepatic autophagy by CREB in obese mice.
Submit: New GeneRIF Correction See all GeneRIFs (52)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (5)  1 citation
  • Endonuclease-mediated (5) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables calcium-dependent protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables calmodulin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables calmodulin-dependent protein kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables calmodulin-dependent protein kinase activity ISO
Inferred from Sequence Orthology
more info
  
enables calmodulin-dependent protein kinase activity TAS
Traceable Author Statement
more info
 PubMed 
enables kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within adaptive immune response IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within immune system process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within inflammatory response IEA
Inferred from Electronic Annotation
more info
  
involved_in intracellular signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in long-term memory ISO
Inferred from Sequence Orthology
more info
  
involved_in myeloid dendritic cell differentiation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within neuron-neuron synaptic transmission IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within nucleocytoplasmic transport IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in peptidyl-serine phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within phosphorylation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within positive regulation of DNA-templated transcription IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within positive regulation of protein export from nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in postsynapse to nucleus signaling pathway IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in postsynapse to nucleus signaling pathway IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in postsynapse to nucleus signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in postsynaptic modulation of chemical synaptic transmission IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in postsynaptic modulation of chemical synaptic transmission IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in postsynaptic modulation of chemical synaptic transmission IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein autophosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within protein phosphorylation IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within protein phosphorylation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within signal transduction IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
is_active_in GABA-ergic synapse IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in GABA-ergic synapse IEP
Inferred from Expression Pattern
more info
 PubMed 
is_active_in GABA-ergic synapse IMP
Inferred from Mutant Phenotype
more info
 PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytosol TAS
Traceable Author Statement
more info
  
located_in fibrillar center ISO
Inferred from Sequence Orthology
more info
  
is_active_in glutamatergic synapse IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in glutamatergic synapse IEP
Inferred from Expression Pattern
more info
 PubMed 
is_active_in glutamatergic synapse IMP
Inferred from Mutant Phenotype
more info
 PubMed 
is_active_in glutamatergic synapse ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm TAS
Traceable Author Statement
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in postsynapse ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
calcium/calmodulin-dependent protein kinase type IV
Names
CAM kinase-GR
Ca2+/calmodulin-dependent protein kinase type IV/Gr
caMK IV
NP_033923.2
XP_006525606.1
XP_006525607.1
XP_006525609.1
XP_030106157.1
XP_030106158.1
XP_036016846.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_009793.3 → NP_033923.2  calcium/calmodulin-dependent protein kinase type IV

    See identical proteins and their annotated locations for NP_033923.2

    Status: VALIDATED

    Source sequence(s)
    AC114919, BC070420, CJ104330
    Consensus CDS
    CCDS29122.1
    UniProtKB/Swiss-Prot
    P08414, Q61381
    UniProtKB/TrEMBL
    Q8BGR3
    Related
    ENSMUSP00000046539.5, ENSMUST00000042868.6
    Conserved Domains (1) summary
    cd14085
    Location:38 → 331
    STKc_CaMKIV; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type IV

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000084.7 Reference GRCm39 C57BL/6J

    Range
    33067995..33328820
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006525544.5 → XP_006525607.1  calcium/calmodulin-dependent protein kinase type IV isoform X2

    See identical proteins and their annotated locations for XP_006525607.1

    UniProtKB/Swiss-Prot
    P08414, Q61381
    UniProtKB/TrEMBL
    Q8BGR3
    Related
    ENSMUSP00000157216.2, ENSMUST00000234654.2
    Conserved Domains (1) summary
    cd14085
    Location:38 → 331
    STKc_CaMKIV; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type IV

  2. XM_030250297.2 → XP_030106157.1  calcium/calmodulin-dependent protein kinase type IV isoform X2

    UniProtKB/Swiss-Prot
    P08414, Q61381
    UniProtKB/TrEMBL
    Q8BGR3
    Conserved Domains (1) summary
    cd14085
    Location:38 → 331
    STKc_CaMKIV; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type IV

  3. XM_006525543.3 → XP_006525606.1  calcium/calmodulin-dependent protein kinase type IV isoform X1

    UniProtKB/Swiss-Prot
    P08414, Q61381
    Conserved Domains (1) summary
    cd14085
    Location:66 → 359
    STKc_CaMKIV; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type IV

  4. XM_030250298.2 → XP_030106158.1  calcium/calmodulin-dependent protein kinase type IV isoform X3

    Conserved Domains (2) summary
    pfam04698
    Location:200 → 251
    Rab_eff_C; Rab effector MyRIP/melanophilin C-terminus
    cl21453
    Location:1 → 138
    PKc_like; Protein Kinases, catalytic domain

  5. XM_006525546.5 → XP_006525609.1  calcium/calmodulin-dependent protein kinase type IV isoform X2

    See identical proteins and their annotated locations for XP_006525609.1

    UniProtKB/Swiss-Prot
    P08414, Q61381
    UniProtKB/TrEMBL
    Q8BGR3
    Conserved Domains (1) summary
    cd14085
    Location:38 → 331
    STKc_CaMKIV; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type IV

  6. XM_036160953.1 → XP_036016846.1  calcium/calmodulin-dependent protein kinase type IV isoform X3

    Conserved Domains (2) summary
    pfam04698
    Location:200 → 251
    Rab_eff_C; Rab effector MyRIP/melanophilin C-terminus
    cl21453
    Location:1 → 138
    PKc_like; Protein Kinases, catalytic domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P08414.2 GenPept UniProtKB/Swiss-Prot:P08414

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