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Ccna1 cyclin A1 [ Mus musculus (house mouse) ]

Gene ID: 12427, updated on 11-Apr-2024

Summary

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Official Symbol
Ccna1provided by MGI
Official Full Name
cyclin A1provided by MGI
Primary source
MGI:MGI:108042
See related
Ensembl:ENSMUSG00000027793 AllianceGenome:MGI:108042
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Predicted to enable cyclin-dependent protein serine/threonine kinase regulator activity. Predicted to be involved in mitotic cell cycle phase transition and regulation of cyclin-dependent protein serine/threonine kinase activity. Predicted to act upstream of or within several processes, including cell division; meiotic cell cycle; and spermatogenesis. Part of cyclin A1-CDK2 complex. Is expressed in several structures, including blastocyst; liver; testis; and tooth. Human ortholog(s) of this gene implicated in prostate cancer. Orthologous to human CCNA1 (cyclin A1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in testis adult (RPKM 38.8) and limb E14.5 (RPKM 0.7) See more
Orthologs
human all
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Genomic context

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Location:
3 C; 3 26.52 cM
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (54952890..54965055, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (55045469..55057634, complement)

Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene serine rich and transmembrane domain containing 1 Neighboring gene predicted gene, 31358 Neighboring gene STARR-seq mESC enhancer starr_07690 Neighboring gene RIKEN cDNA 4931419H13 gene Neighboring gene STARR-seq mESC enhancer starr_07692 Neighboring gene STARR-seq mESC enhancer starr_07693 Neighboring gene STARR-seq mESC enhancer starr_07694 Neighboring gene spartin Neighboring gene coiled-coil domain containing 169

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Hyperactivation of cyclin A-CDK induces centrosome overduplication and chromosome tetraploidization in mouse cells. Niwa T, et al. Biochem Biophys Res Commun, 2021 Apr 16. PMID 33667714
  2. Overexpression of cyclin A1 promotes meiotic resumption but induces premature chromosome separation in mouse oocyte. Li J, et al. J Cell Physiol, 2020 Oct. PMID 32030765
  3. Meiotic failure in cyclin A1-deficient mouse spermatocytes triggers apoptosis through intrinsic and extrinsic signaling pathways and 14-3-3 proteins. Panigrahi SK, et al. PLoS One, 2017. PMID 28301569, Free PMC Article
  4. A Limited Role for the Cell Cycle Regulator Cyclin A1 in Murine Leukemogenesis. Bäumer N, et al. PLoS One, 2015. PMID 26080083, Free PMC Article
  5. Cyclin A1 is expressed in mouse ovary. Wei H, et al. Int J Med Sci, 2014. PMID 24904232, Free PMC Article

See all (113) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Cyclin A1 (CCNA1) inhibits osteoporosis by suppressing transforming growth factor-beta (TGF-beta) pathway in osteoblasts.
    Title: Cyclin A1 (CCNA1) inhibits osteoporosis by suppressing transforming growth factor-beta (TGF-beta) pathway in osteoblasts.
  2. Galectin-12 modulates sebocyte proliferation and cell cycle progression by regulating cyclin A1 and CDK2.
    Title: Galectin-12 modulates sebocyte proliferation and cell cycle progression by regulating cyclin A1 and CDK2.
  3. Hyperactivation of cyclin A-CDK induces centrosome overduplication and chromosome tetraploidization in mouse cells.
    Title: Hyperactivation of cyclin A-CDK induces centrosome overduplication and chromosome tetraploidization in mouse cells.
  4. Overexpression of cyclin A1 promotes meiotic resumption but induces premature chromosome separation in mouse oocyte.
    Title: Overexpression of cyclin A1 promotes meiotic resumption but induces premature chromosome separation in mouse oocyte.
  5. Cyclin A1 in Oocytes Prevents Chromosome Segregation And Anaphase Entry.
    Title: Cyclin A1 in Oocytes Prevents Chromosome Segregation And Anaphase Entry.
  6. wild type control, 14-3-3 is detected in both cytosolic and nuclear fractions whereas it is restricted to the cytoplasm in mutant testes. This differential distribution of 14-3-3 may contribute to the induction of apoptosis in Ccna1-deficient spermatocytes
    Title: Meiotic failure in cyclin A1-deficient mouse spermatocytes triggers apoptosis through intrinsic and extrinsic signaling pathways and 14-3-3 proteins.
  7. cyclin A1 in association with vascular endothelial growth factor receptor 1 (VEGFR1), is required for HSPC and their niches to maintain their function and proper interaction
    Title: Cyclin A1 regulates the interactions between mouse haematopoietic stem and progenitor cells and their niches.
  8. Neither overexpression nor loss of cyclin A1 significantly altered leukemogenesis in PML-RARalpha-knockin mice.
    Title: A Limited Role for the Cell Cycle Regulator Cyclin A1 in Murine Leukemogenesis.
  9. With the recent data on the functions of cyclins in somatic and stem cells, we also discussed the possibilities of further studies of cyclin A1 in mouse oocytes and perhaps in the oogonial stem cells
    Title: Cyclin A1 is expressed in mouse ovary.
  10. Sp1 and possibly GATA1 bind concomitantly to the Ccna1 promoter and suppress its activity in vivo.
    Title: Sp1 transcription factor and GATA1 cis-acting elements modulate testis-specific expression of mouse cyclin A1.
Submit: New GeneRIF Correction See all GeneRIFs (17)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2)  1 citation
  • Endonuclease-mediated (2) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC159139

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables cyclin-dependent protein serine/threonine kinase regulator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within cell cycle IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within cell differentiation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within cell division IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within meiotic cell cycle IEA
Inferred from Electronic Annotation
more info
  
involved_in mitotic cell cycle phase transition IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within multicellular organism development IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of cyclin-dependent protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within spermatogenesis IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in centrosome IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of cyclin A1-CDK2 complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of cyclin A2-CDK2 complex IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
located_in microtubule cytoskeleton ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
cyclin-A1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001305221.2 → NP_001292150.1  cyclin-A1 isoform 1

    See identical proteins and their annotated locations for NP_001292150.1

    Status: VALIDATED

    Source sequence(s)
    AC127334
    Consensus CDS
    CCDS17356.1
    UniProtKB/Swiss-Prot
    Q61456, Q8C5U1
    Related
    ENSMUSP00000143447.2, ENSMUST00000198320.5
    Conserved Domains (3) summary
    pfam16500
    Location:27 → 101
    Cyclin_N2; N-terminal region of cyclin_N
    cd20560
    Location:132 → 294
    CYCLIN_CCNA1_rpt1; first cyclin box found in cyclin-A1 (CCNA1)
    cd20563
    Location:298 → 420
    CYCLIN_CCNA1_rpt2; second cyclin box found in cyclin-A1 (CCNA1) and similar proteins

  2. NM_001428404.1 → NP_001415333.1  cyclin-A1 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC127334
    UniProtKB/Swiss-Prot
    Q61456, Q8C5U1

  3. NM_001428405.1 → NP_001415334.1  cyclin-A1 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC127334

  4. NM_001428406.1 → NP_001415335.1  cyclin-A1 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC127334

  5. NM_001428407.1 → NP_001415336.1  cyclin-A1 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC127334

  6. NM_007628.4 → NP_031654.2  cyclin-A1 isoform 1

    See identical proteins and their annotated locations for NP_031654.2

    Status: VALIDATED

    Source sequence(s)
    AC127334
    Consensus CDS
    CCDS17356.1
    UniProtKB/Swiss-Prot
    Q61456, Q8C5U1
    Related
    ENSMUSP00000029368.3, ENSMUST00000029368.7
    Conserved Domains (3) summary
    pfam16500
    Location:27 → 101
    Cyclin_N2; N-terminal region of cyclin_N
    cd20560
    Location:132 → 294
    CYCLIN_CCNA1_rpt1; first cyclin box found in cyclin-A1 (CCNA1)
    cd20563
    Location:298 → 420
    CYCLIN_CCNA1_rpt2; second cyclin box found in cyclin-A1 (CCNA1) and similar proteins

RNA

  1. NR_190341.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC127334

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000069.7 Reference GRCm39 C57BL/6J

    Range
    54952890..54965055 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030252400.1 → XP_030108260.1  cyclin-A1 isoform X2

    Conserved Domains (3) summary
    pfam00134
    Location:170 → 296
    Cyclin_N; Cyclin, N-terminal domain
    pfam02984
    Location:298 → 360
    Cyclin_C; Cyclin, C-terminal domain
    pfam16500
    Location:27 → 101
    Cyclin_N2; N-terminal region of cyclin_N

  2. XM_030252402.1 → XP_030108262.1  cyclin-A1 isoform X5

    UniProtKB/TrEMBL
    A0A0G2JEB5
    Related
    ENSMUSP00000142706.2, ENSMUST00000198102.5
    Conserved Domains (2) summary
    pfam00134
    Location:30 → 132
    Cyclin_N; Cyclin, N-terminal domain
    pfam02984
    Location:134 → 196
    Cyclin_C; Cyclin, C-terminal domain

  3. XM_006500951.4 → XP_006501014.1  cyclin-A1 isoform X1

    See identical proteins and their annotated locations for XP_006501014.1

    UniProtKB/Swiss-Prot
    Q61456, Q8C5U1
    Conserved Domains (3) summary
    pfam16500
    Location:27 → 101
    Cyclin_N2; N-terminal region of cyclin_N
    cd20560
    Location:132 → 294
    CYCLIN_CCNA1_rpt1; first cyclin box found in cyclin-A1 (CCNA1)
    cd20563
    Location:298 → 420
    CYCLIN_CCNA1_rpt2; second cyclin box found in cyclin-A1 (CCNA1) and similar proteins

  4. XM_006500952.4 → XP_006501015.1  cyclin-A1 isoform X1

    See identical proteins and their annotated locations for XP_006501015.1

    UniProtKB/Swiss-Prot
    Q61456, Q8C5U1
    Related
    ENSMUSP00000142692.2, ENSMUST00000197238.5
    Conserved Domains (3) summary
    pfam16500
    Location:27 → 101
    Cyclin_N2; N-terminal region of cyclin_N
    cd20560
    Location:132 → 294
    CYCLIN_CCNA1_rpt1; first cyclin box found in cyclin-A1 (CCNA1)
    cd20563
    Location:298 → 420
    CYCLIN_CCNA1_rpt2; second cyclin box found in cyclin-A1 (CCNA1) and similar proteins

  5. XM_036162875.1 → XP_036018768.1  cyclin-A1 isoform X4

    Conserved Domains (2) summary
    pfam16500
    Location:27 → 101
    Cyclin_N2; N-terminal region of cyclin_N
    cl40454
    Location:132 → 270
    CYCLIN_SF; Cyclin box fold superfamily

  6. XM_036162876.1 → XP_036018769.1  cyclin-A1 isoform X4

    Conserved Domains (2) summary
    pfam16500
    Location:27 → 101
    Cyclin_N2; N-terminal region of cyclin_N
    cl40454
    Location:132 → 270
    CYCLIN_SF; Cyclin box fold superfamily

  7. XM_006500954.5 → XP_006501017.1  cyclin-A1 isoform X3

    Conserved Domains (3) summary
    COG5024
    Location:134 → 386
    COG5024; Cyclin [Cell division and chromosome partitioning]
    pfam00134
    Location:170 → 272
    Cyclin_N; Cyclin, N-terminal domain
    pfam16500
    Location:27 → 101
    Cyclin_N2; N-terminal region of cyclin_N

  8. XM_030252399.2 → XP_030108259.1  cyclin-A1 isoform X2

    Conserved Domains (3) summary
    pfam00134
    Location:170 → 296
    Cyclin_N; Cyclin, N-terminal domain
    pfam02984
    Location:298 → 360
    Cyclin_C; Cyclin, C-terminal domain
    pfam16500
    Location:27 → 101
    Cyclin_N2; N-terminal region of cyclin_N

  9. XM_006500950.5 → XP_006501013.1  cyclin-A1 isoform X1

    See identical proteins and their annotated locations for XP_006501013.1

    UniProtKB/Swiss-Prot
    Q61456, Q8C5U1
    Conserved Domains (3) summary
    pfam16500
    Location:27 → 101
    Cyclin_N2; N-terminal region of cyclin_N
    cd20560
    Location:132 → 294
    CYCLIN_CCNA1_rpt1; first cyclin box found in cyclin-A1 (CCNA1)
    cd20563
    Location:298 → 420
    CYCLIN_CCNA1_rpt2; second cyclin box found in cyclin-A1 (CCNA1) and similar proteins

  10. XM_006500949.4 → XP_006501012.1  cyclin-A1 isoform X1

    Conserved Domains (3) summary
    pfam16500
    Location:27 → 101
    Cyclin_N2; N-terminal region of cyclin_N
    cd20560
    Location:132 → 294
    CYCLIN_CCNA1_rpt1; first cyclin box found in cyclin-A1 (CCNA1)
    cd20563
    Location:298 → 420
    CYCLIN_CCNA1_rpt2; second cyclin box found in cyclin-A1 (CCNA1) and similar proteins

  11. XM_036162873.1 → XP_036018766.1  cyclin-A1 isoform X1

    UniProtKB/Swiss-Prot
    Q61456, Q8C5U1
    Conserved Domains (3) summary
    pfam16500
    Location:27 → 101
    Cyclin_N2; N-terminal region of cyclin_N
    cd20560
    Location:132 → 294
    CYCLIN_CCNA1_rpt1; first cyclin box found in cyclin-A1 (CCNA1)
    cd20563
    Location:298 → 420
    CYCLIN_CCNA1_rpt2; second cyclin box found in cyclin-A1 (CCNA1) and similar proteins

  12. XM_036162874.1 → XP_036018767.1  cyclin-A1 isoform X4

    Conserved Domains (2) summary
    pfam16500
    Location:27 → 101
    Cyclin_N2; N-terminal region of cyclin_N
    cl40454
    Location:132 → 270
    CYCLIN_SF; Cyclin box fold superfamily

  13. XM_030252401.1 → XP_030108261.1  cyclin-A1 isoform X3

    Conserved Domains (3) summary
    COG5024
    Location:134 → 386
    COG5024; Cyclin [Cell division and chromosome partitioning]
    pfam00134
    Location:170 → 272
    Cyclin_N; Cyclin, N-terminal domain
    pfam16500
    Location:27 → 101
    Cyclin_N2; N-terminal region of cyclin_N

RNA

  1. XR_003954275.2 RNA Sequence

  2. XR_004941269.1 RNA Sequence

  3. XR_004941268.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q61456.2 GenPept UniProtKB/Swiss-Prot:Q61456

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