Col10a1 collagen, type X, alpha 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Col10a1provided by MGI
Official Full Name: collagen, type X, alpha 1provided by MGI
Primary source: MGI:MGI:88445
See related: Ensembl:ENSMUSG00000039462 AllianceGenome:MGI:88445
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Col10; Col10a-1
Summary: Predicted to be an extracellular matrix structural constituent. Predicted to be involved in cartilage development; endochondral ossification; and extracellular matrix organization. Located in cell cortex and extracellular matrix. Part of collagen trimer. Is expressed in several structures, including brain; cartilage; limb; pelvic girdle musculature; and skeletal system. Used to study Schmid metaphyseal chondrodysplasia. Human ortholog(s) of this gene implicated in Schmid metaphyseal chondrodysplasia and osteochondrodysplasia. Orthologous to human COL10A1 (collagen type X alpha 1 chain). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in limb E14.5 (RPKM 58.1) and CNS E14 (RPKM 6.3) See more
Orthologs: human all
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Genomic context

Location:: 10 B1; 10 18.85 cM

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	10	NC_000076.7 (34265977..34273081)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	10	NC_000076.6 (34389981..34397085)

Chromosome 10 - NC_000076.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

M2 macrophage-derived exosomal miR-26b-5p regulates macrophage polarization and chondrocyte hypertrophy by targeting TLR3 and COL10A1 to alleviate osteoarthritis.
Title: M2 macrophage-derived exosomal miR-26b-5p regulates macrophage polarization and chondrocyte hypertrophy by targeting TLR3 and COL10A1 to alleviate osteoarthritis.
Cancer-Associated Fibroblasts Hinder Lung Squamous Cell Carcinoma Oxidative Stress-Induced Apoptosis via METTL3 Mediated m(6)A Methylation of COL10A1.
Title: Cancer-Associated Fibroblasts Hinder Lung Squamous Cell Carcinoma Oxidative Stress-Induced Apoptosis via METTL3 Mediated m(6)A Methylation of COL10A1.
COL10A1 is a novel factor in the development of choroidal neovascularization.
Title: COL10A1 is a novel factor in the development of choroidal neovascularization.
A quantitative serum biomarker of circulating collagen X effectively correlates with endochondral fracture healing.
Title: A quantitative serum biomarker of circulating collagen X effectively correlates with endochondral fracture healing.
The mechanistic link between COL10A1 and the TGF-beta1-SOX9 axis.
Title: TGF-β1-SOX9 axis-inducible COL10A1 promotes invasion and metastasis in gastric cancer via epithelial-to-mesenchymal transition.
treatment of the mice with carbamazepine (CBZ), a drug which stimulates intracellular proteolysis and alleviates ER stress, effectively reduced the disease severity in this model of metaphyseal chondrodysplasia type Schmid caused by a premature stop codon in the Col10a1 gene
Title: Carbamazepine reduces disease severity in a mouse model of metaphyseal chondrodysplasia type Schmid caused by a premature stop codon (Y632X) in the Col10a1 gene.
Metaphyseal chondrodysplasia Schmid type disease severity in mice is increased by ATF6alpha ablation and decreased by ATF6beta ablation triggered by mutations in collagen X.
Title: Paradoxical roles of ATF6α and ATF6β in modulating disease severity caused by mutations in collagen X.
Results indicate that Cox-2 promotes Col10a1 expression and chondrocyte hypertrophy in vitro.
Title: In vitro functional characterization of prostaglandin-endoperoxide synthase 2 during chondrocyte hypertrophic differentiation.
In a model of instability-induced osteoarthritis, Col X was overexpressed in articular chondrocytes and osteophyte-forming cells in LOX-1(+)/(+) mice and was significantly downregulated in articular chondrocytes and osteophyte-forming cells in LOX-1(-)/(-) mice.
Title: Lectin-like oxidized low density lipoprotein receptor 1-deficient mice show resistance to instability-induced osteoarthritis.
Col10 expression was seen in the hypertrophic zone at and below the tidemark of the mandibular condyle cartilage.
Title: Cell and matrix response of temporomandibular cartilage to mechanical loading.

Submit: New GeneRIF Correction See all GeneRIFs (31)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (9) 1 citation
Endonuclease-mediated (2) 1 citation

General gene information

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Markers

Col10a1 (e-PCR), detects polymorphism
- UniSTS:508439

Col10a1 (e-PCR), detects polymorphism
- UniSTS:507421

PMC156609P4 (e-PCR)
- UniSTS:271416

Col10a1 (e-PCR), detects polymorphism
- UniSTS:265064

Col10a1 (e-PCR), detects polymorphism
- UniSTS:547954

Col10a1 (e-PCR), detects polymorphism
- UniSTS:502678

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables extracellular matrix structural constituent conferring tensile strength	IBA Inferred from Biological aspect of Ancestor more info
enables extracellular matrix structural constituent conferring tensile strength	RCA inferred from Reviewed Computational Analysis more info	PubMed
enables metal ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in cartilage development	ISO Inferred from Sequence Orthology more info
involved_in endochondral ossification	ISO Inferred from Sequence Orthology more info
involved_in extracellular matrix organization	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in cell cortex	IDA Inferred from Direct Assay more info	PubMed
part_of collagen trimer	IDA Inferred from Direct Assay more info	PubMed
part_of collagen type X trimer	ISO Inferred from Sequence Orthology more info
located_in collagen-containing extracellular matrix	HDA more info	PubMed
is_active_in collagen-containing extracellular matrix	IBA Inferred from Biological aspect of Ancestor more info
located_in collagen-containing extracellular matrix	ISO Inferred from Sequence Orthology more info
located_in collagen-containing extracellular matrix	NAS Non-traceable Author Statement more info	PubMed
located_in extracellular matrix	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular region	IEA Inferred from Electronic Annotation more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
part_of receptor complex	ISO Inferred from Sequence Orthology more info	PubMed

General protein information

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Preferred Names: collagen alpha-1(X) chain

Names: procollagen, type X, alpha 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.