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Cry2 cryptochrome circadian regulator 2 [ Mus musculus (house mouse) ]

Gene ID: 12953, updated on 11-Apr-2024

Summary

Official Symbol
Cry2provided by MGI
Official Full Name
cryptochrome circadian regulator 2provided by MGI
Primary source
MGI:MGI:1270859
See related
Ensembl:ENSMUSG00000068742 AllianceGenome:MGI:1270859
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
D130054K12Rik
Summary
This gene encodes a flavin adenine dinucleotide-binding protein that is a key component of the circadian core oscillator complex, which regulates the circadian clock. This gene is upregulated by Clock/Arntl heterodimers but then represses this upregulation in a feedback loop using Per/Cry heterodimers to interact with Clock/Arntl. Polymorphisms in this gene have been associated with altered sleep patterns. The encoded protein is widely conserved across plants and animals. [provided by RefSeq, Feb 2014]
Expression
Ubiquitous expression in cortex adult (RPKM 22.9), frontal lobe adult (RPKM 22.1) and 28 other tissues See more
Orthologs
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Genomic context

Location:
2; 2 E1
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (92233991..92264426, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (92403646..92434085, complement)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene mitogen-activated protein kinase 8 interacting protein 1 Neighboring gene Frey regulator of sperm-oocyte fusion 1 Neighboring gene microRNA 7000 Neighboring gene RIKEN cDNA D930015M05 gene Neighboring gene STARR-positive B cell enhancer ABC_E1248 Neighboring gene STARR-positive B cell enhancer ABC_E4481 Neighboring gene solute carrier family 35, member C1 Neighboring gene STARR-positive B cell enhancer mm9_chr2:92324700-92325001 Neighboring gene predicted gene 13817

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (5)  1 citation
  • Endonuclease-mediated (3) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables DNA binding ISO
Inferred from Sequence Orthology
more info
 
enables FAD binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables FAD binding IDA
Inferred from Direct Assay
more info
PubMed 
enables damaged DNA binding ISO
Inferred from Sequence Orthology
more info
 
enables kinase binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables nuclear receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables phosphatase binding ISO
Inferred from Sequence Orthology
more info
 
enables photoreceptor activity IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein kinase binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables single-stranded DNA binding ISO
Inferred from Sequence Orthology
more info
 
enables transcription cis-regulatory region binding IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
involved_in circadian regulation of gene expression IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in circadian regulation of gene expression IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in circadian regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within circadian rhythm IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in circadian rhythm IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in entrainment of circadian clock by photoperiod IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in entrainment of circadian clock by photoperiod IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in glucose homeostasis IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in lipid storage IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in negative regulation of DNA-templated transcription IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in negative regulation of DNA-templated transcription IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of DNA-templated transcription IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in negative regulation of DNA-templated transcription IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of circadian rhythm IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of glucocorticoid receptor signaling pathway IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in negative regulation of glucocorticoid secretion IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in negative regulation of phosphoprotein phosphatase activity ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within protein import into nucleus IPI
Inferred from Physical Interaction
more info
PubMed 
involved_in regulation of circadian rhythm IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in response to activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in response to insulin IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in response to light stimulus IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in response to light stimulus ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within response to stimulus IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within rhythmic process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in mitochondrion IDA
Inferred from Direct Assay
more info
PubMed 
located_in nuclear speck ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm TAS
Traceable Author Statement
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
cryptochrome-2
Names
cryptochrome 2 (photolyase-like)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_009963.4NP_034093.1  cryptochrome-2

    See identical proteins and their annotated locations for NP_034093.1

    Status: VALIDATED

    Source sequence(s)
    AK172994, BC054794, CJ164467
    Consensus CDS
    CCDS16447.1
    UniProtKB/Swiss-Prot
    O08706, Q6A024, Q9R194
    Related
    ENSMUSP00000088047.6, ENSMUST00000090559.12
    Conserved Domains (2) summary
    COG0415
    Location:21509
    PhrB; Deoxyribodipyrimidine photolyase [Replication, recombination and repair]
    pfam03441
    Location:306504
    FAD_binding_7; FAD binding domain of DNA photolyase

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    92233991..92264426 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030247073.1XP_030102933.1  cryptochrome-2 isoform X2

    Conserved Domains (1) summary
    pfam03441
    Location:129327
    FAD_binding_7; FAD binding domain of DNA photolyase
  2. XM_017315281.3XP_017170770.1  cryptochrome-2 isoform X1

    UniProtKB/Swiss-Prot
    O08706, Q6A024, Q9R194
    Related
    ENSMUSP00000106909.2, ENSMUST00000111278.2
    Conserved Domains (2) summary
    COG0415
    Location:21509
    PhrB; Deoxyribodipyrimidine photolyase [Replication, recombination and repair]
    pfam03441
    Location:306504
    FAD_binding_7; FAD binding domain of DNA photolyase

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001113333.1: Suppressed sequence

    Description
    NM_001113333.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript.