Ednrb endothelin receptor type B [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Ednrbprovided by MGI
Official Full Name: endothelin receptor type Bprovided by MGI
Primary source: MGI:MGI:102720
See related: Ensembl:ENSMUSG00000022122 AllianceGenome:MGI:102720
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: ETb; ET-B; ET-BR; ETR-b; Sox10m1
Summary: This gene encodes a member of the G-protein coupled receptor family. It encodes a receptor for endothelins, peptides that are involved in vasocontriction. The encoded protein activates a phosphatidylinositol-calcium second messenger system and is required for the development of enteric neurons and melanocytes. Gene disruption causes pigmentation anomalies, deafness, and abnormal dilation of the colon due to defects of neural crest-derived cells. Mutations in this gene are found in the piebald mouse, and mouse models of Hirschsprung's disease and Waardenburg syndrome type 4. Renal collecting duct-specific gene deletion causes sodium retention and hypertension. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2013]
Expression: Broad expression in cerebellum adult (RPKM 11.7), CNS E11.5 (RPKM 11.1) and 24 other tissues See more
Orthologs: human all
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Genomic context

Location:: 14 E2.3; 14 53.05 cM

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	14	NC_000080.7 (104052055..104081764, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	14	NC_000080.6 (103814615..103844508, complement)

Chromosome 14 - NC_000080.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Putative role of endothelin receptor B in the development and maintenance of taste buds within the circumvallate papillae.
Title: Putative role of endothelin receptor B in the development and maintenance of taste buds within the circumvallate papillae.
Endothelin receptor B-deficient mice are protected from high-fat diet-induced metabolic syndrome.
Title: Endothelin receptor B-deficient mice are protected from high-fat diet-induced metabolic syndrome.
Endothelin receptor B enhances liver injury and pro-inflammatory responses by increasing G-protein-coupled receptor kinase-2 expression in primary biliary cholangitis.
Title: Endothelin receptor B enhances liver injury and pro-inflammatory responses by increasing G-protein-coupled receptor kinase-2 expression in primary biliary cholangitis.
Endothelin B Receptor Immunodynamics in Pulmonary Arterial Hypertension.
Title: Endothelin B Receptor Immunodynamics in Pulmonary Arterial Hypertension.
Irreversible and sustained upregulation of endothelin axis during oncogene-associated pancreatic inflammation and cancer.
Title: Irreversible and sustained upregulation of endothelin axis during oncogene-associated pancreatic inflammation and cancer.
Endothelin type B receptor promotes cofilin rod formation and dendritic loss in neurons by inducing oxidative stress and cofilin activation.
Title: Endothelin type B receptor promotes cofilin rod formation and dendritic loss in neurons by inducing oxidative stress and cofilin activation.
Here the authors define a pathway in which endothelin, signalling through the G protein-coupled receptor endothelin receptor B and PKC epsilon, regulates the number of myelin sheaths formed by individual oligodendrocytes in mouse and zebrafish.
Title: Endothelin signalling mediates experience-dependent myelination in the CNS.
Our current study systematically confirms, both genetically and pharmacologically, the protective role of a lower EDNRB under extreme hypoxia stress. Overall, it supports our hypothesis that studies on human hypoxia adaptation provide new insight to common disease pathogenesis and treatments.
Title: Cardiac-specific knockout and pharmacological inhibition of Endothelin receptor type B lead to cardiac resistance to extreme hypoxia.
these results indicate that epilation induces McSCs activation through EDN3/EDNRB signaling and in turn leads to skin and hair hyperpigmentation. The findings suggest that EDN/EDNRB signaling may serve as a potential therapeutic target to promote repigmentation in hypopigmentation disorders.
Title: Epilation induces hair and skin pigmentation through an EDN3/EDNRB-dependent regenerative response of melanocyte stem cells.
Knocking down basolateral amygdala (BLA) ET1 expression enhanced anxiety-like behaviors, whereas over-expressing ETBRs, but not A-type receptors (ETARs), had an anxiolytic effect
Title: Amygdalar Endothelin-1 Regulates Pyramidal Neuron Excitability and Affects Anxiety.

Submit: New GeneRIF Correction See all GeneRIFs (83)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Spontaneous (4) 1 citation
Chemically induced (other) (11) 1 citation
Chemically and radiation induced (2) 1 citation
Targeted (11) 1 citation
Radiation induced (18) 1 citation
Chemically induced (ENU) (4)
Endonuclease-mediated (2)

General gene information

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Markers

U32329 (e-PCR)
- UniSTS:125721

AU022549 (e-PCR)
- UniSTS:165918

Ednrb (e-PCR), detects polymorphism
- UniSTS:142966

Ednrb (e-PCR), detects polymorphism
- UniSTS:142967

PMC24270P1 (e-PCR)
- UniSTS:272250

U32329 (e-PCR)
- UniSTS:180718

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables G protein-coupled receptor activity	IEA Inferred from Electronic Annotation more info
enables endothelin receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables endothelin receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables endothelin receptor activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables endothelin receptor activity	ISO Inferred from Sequence Orthology more info
enables peptide hormone binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables type 1 angiotensin receptor binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within G protein-coupled receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within G protein-coupled receptor signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
involved_in aldosterone metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cGMP-mediated signaling	ISO Inferred from Sequence Orthology more info
involved_in calcium ion transmembrane transport	IDA Inferred from Direct Assay more info	PubMed
involved_in calcium ion transmembrane transport	IGI Inferred from Genetic Interaction more info	PubMed
involved_in calcium ion transmembrane transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in calcium-mediated signaling	ISO Inferred from Sequence Orthology more info
involved_in canonical Wnt signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
involved_in chordate pharynx development	IDA Inferred from Direct Assay more info	PubMed
involved_in chordate pharynx development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in developmental pigmentation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within developmental pigmentation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in endothelin receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in endothelin receptor signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
involved_in endothelin receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in endothelin receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in enteric nervous system development	IDA Inferred from Direct Assay more info	PubMed
involved_in enteric smooth muscle cell differentiation	IDA Inferred from Direct Assay more info	PubMed
involved_in epithelial fluid transport	ISO Inferred from Sequence Orthology more info
involved_in establishment of endothelial barrier	IDA Inferred from Direct Assay more info	PubMed
involved_in gene expression	IGI Inferred from Genetic Interaction more info	PubMed
involved_in gene expression	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in heparin metabolic process	IGI Inferred from Genetic Interaction more info	PubMed
involved_in macrophage chemotaxis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within melanocyte differentiation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within melanocyte differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in melanocyte differentiation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of neuron maturation	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of protein metabolic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within neural crest cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within neuroblast migration	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within peripheral nervous system development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in phospholipase C-activating G protein-coupled receptor signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within pigmentation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in pigmentation	ISO Inferred from Sequence Orthology more info
involved_in podocyte differentiation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of canonical NF-kappaB signal transduction	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cytosolic calcium ion concentration	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of penile erection	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of urine volume	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within posterior midgut development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein transmembrane transport	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of blood pressure	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within regulation of blood pressure	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of blood pressure	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of blood pressure	ISO Inferred from Sequence Orthology more info
involved_in regulation of epithelial cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in regulation of fever generation	ISO Inferred from Sequence Orthology more info
involved_in regulation of heart rate	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of heart rate	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of pH	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in renal albumin absorption	IGI Inferred from Genetic Interaction more info	PubMed
involved_in renal sodium excretion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in renal sodium ion absorption	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in renin secretion into blood stream	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to endothelin	ISO Inferred from Sequence Orthology more info
involved_in response to lipopolysaccharide	ISO Inferred from Sequence Orthology more info
involved_in response to organic substance	IGI Inferred from Genetic Interaction more info	PubMed
involved_in response to pain	ISO Inferred from Sequence Orthology more info
involved_in response to sodium phosphate	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within signal transduction	IEA Inferred from Electronic Annotation more info
involved_in sodium ion homeostasis	IGI Inferred from Genetic Interaction more info	PubMed
involved_in vasoconstriction	IBA Inferred from Biological aspect of Ancestor more info
involved_in vasoconstriction	ISO Inferred from Sequence Orthology more info
involved_in vasodilation	ISO Inferred from Sequence Orthology more info
involved_in vein smooth muscle contraction	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in nuclear membrane	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: endothelin receptor type B

Names: endothelin B receptor; endothelin receptor non-selective type; piebald

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001136061.3 → NP_001129533.1 endothelin receptor type B isoform 1 precursor

See identical proteins and their annotated locations for NP_001129533.1

Status: REVIEWED

Source sequence(s)

AC110092, AC154670

Consensus CDS

CCDS27317.1

UniProtKB/Swiss-Prot

P48302, Q542M3

UniProtKB/TrEMBL

Q8K1V9

Related

ENSMUSP00000022718.4, ENSMUST00000022718.11

Conserved Domains (1) summary

cd15976
Location:102 → 397

7tmA_ET-BR; endothelin B receptor, member of the class A family of seven-transmembrane G protein-coupled receptors
NM_001276296.2 → NP_001263225.1 endothelin receptor type B isoform 1 precursor

See identical proteins and their annotated locations for NP_001263225.1

Status: REVIEWED

Source sequence(s)

AC110092, AC154670

Consensus CDS

CCDS27317.1

UniProtKB/Swiss-Prot

P48302, Q542M3

UniProtKB/TrEMBL

Q8K1V9

Related

ENSMUSP00000154806.2, ENSMUST00000227824.2

Conserved Domains (1) summary

cd15976
Location:102 → 397

7tmA_ET-BR; endothelin B receptor, member of the class A family of seven-transmembrane G protein-coupled receptors
NM_001422171.1 → NP_001409100.1 endothelin receptor type B isoform 1 precursor

Status: REVIEWED

Source sequence(s)

AC110092, AC154670

UniProtKB/Swiss-Prot

P48302, Q542M3
NM_001422172.1 → NP_001409101.1 endothelin receptor type B isoform 2 precursor

Status: REVIEWED

Source sequence(s)

AC110092, AC154670
NM_007904.5 → NP_031930.1 endothelin receptor type B isoform 1 precursor

See identical proteins and their annotated locations for NP_031930.1

Status: REVIEWED

Source sequence(s)

AC110092, AC154670

Consensus CDS

CCDS27317.1

UniProtKB/Swiss-Prot

P48302, Q542M3

UniProtKB/TrEMBL

Q8K1V9

Related

ENSMUSP00000126057.2, ENSMUST00000172237.2

Conserved Domains (1) summary

cd15976
Location:102 → 397

7tmA_ET-BR; endothelin B receptor, member of the class A family of seven-transmembrane G protein-coupled receptors